LOCUS       NM_006157               3235 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens neural EGFL like 1 (NELL1), transcript variant 1,
            mRNA.
ACCESSION   NM_006157
VERSION     NM_006157.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3235)
  AUTHORS   Bidkhori,M., Akbarzadeh,M., Fahimfar,N., Jahangiri,M., Seddiq,S.,
            Larijani,B., Nabipour,I., Mohammad Amoli,M., Panahi,N., Dehghan,A.,
            Holakouie-Naieni,K. and Ostovar,A.
  TITLE     Neural EGFL like 1 as a novel gene for Trabecular Bone Score in
            older adults: The Bushehr Elderly Health (BEH) program
  JOURNAL   PLoS One 19 (9), e0309401 (2024)
   PUBMED   39255297
  REMARK    GeneRIF: Neural EGFL like 1 as a novel gene for Trabecular Bone
            Score in older adults: The Bushehr Elderly Health (BEH) program.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3235)
  AUTHORS   Tang,X.L., DU,Y.Y., Yu,J., Ye,T., Zhu,H., Chen,Y.F. and Li,X.H.
  TITLE     [Clinical Significance of Thrombospondin Type 1 Domain-Containing
            7A and Neural Epidermal Growth Factor-Like 1 Protein in M-Type
            Phospholipase A2 Receptor-Negative Membranous Nephropathy]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 45 (2), 235-244 (2023)
   PUBMED   37157070
  REMARK    GeneRIF: [Clinical Significance of Thrombospondin Type 1
            Domain-Containing 7A and Neural Epidermal Growth Factor-Like 1
            Protein in M-Type Phospholipase A2 Receptor-Negative Membranous
            Nephropathy].
REFERENCE   3  (bases 1 to 3235)
  AUTHORS   Miyaguchi,M., Nakanishi,Y., Maturana,A.D., Mizutani,K. and Niimi,T.
  TITLE     Conformational Change of the Hairpin-like-structured Robo2
            Ectodomain Allows NELL1/2 Binding
  JOURNAL   J Mol Biol 434 (19), 167777 (2022)
   PUBMED   35940226
  REMARK    GeneRIF: Conformational Change of the Hairpin-like-structured Robo2
            Ectodomain Allows NELL1/2 Binding.
REFERENCE   4  (bases 1 to 3235)
  AUTHORS   Zeng,L., He,H., Sun,M., Gong,X., Zhou,M., Hong,Y., Wu,Y., Chen,X.
            and Chen,Q.
  TITLE     Runx2 and Nell-1 in dental follicle progenitor cells regulate bone
            remodeling and tooth eruption
  JOURNAL   Stem Cell Res Ther 13 (1), 486 (2022)
   PUBMED   36175952
  REMARK    GeneRIF: Runx2 and Nell-1 in dental follicle progenitor cells
            regulate bone remodeling and tooth eruption.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3235)
  AUTHORS   Qin,Q., Gomez-Salazar,M., Tower,R.J., Chang,L., Morris,C.D.,
            McCarthy,E.F., Ting,K., Zhang,X. and James,A.W.
  TITLE     NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
  JOURNAL   Cancer Res 82 (15), 2734-2747 (2022)
   PUBMED   35700263
  REMARK    GeneRIF: NELL1 Regulates the Matrisome to Promote Osteosarcoma
            Progression.
REFERENCE   6  (bases 1 to 3235)
  AUTHORS   Maeda,K., Matsuhashi,S., Tabuchi,K., Watanabe,T., Katagiri,T.,
            Oyasu,M., Saito,N. and Kuroda,S.
  TITLE     Brain specific human genes, NELL1 and NELL2, are predominantly
            expressed in neuroblastoma and other embryonal neuroepithelial
            tumors
  JOURNAL   Neurol Med Chir (Tokyo) 41 (12), 582-8 (2001)
   PUBMED   11803583
REFERENCE   7  (bases 1 to 3235)
  AUTHORS   Kuroda,S., Oyasu,M., Kawakami,M., Kanayama,N., Tanizawa,K.,
            Saito,N., Abe,T., Matsuhashi,S. and Ting,K.
  TITLE     Biochemical characterization and expression analysis of neural
            thrombospondin-1-like proteins NELL1 and NELL2
  JOURNAL   Biochem Biophys Res Commun 265 (1), 79-86 (1999)
   PUBMED   10548494
REFERENCE   8  (bases 1 to 3235)
  AUTHORS   Luce,M.J. and Burrows,P.D.
  TITLE     The neuronal EGF-related genes NELL1 and NELL2 are expressed in
            hemopoietic cells and developmentally regulated in the B lineage
  JOURNAL   Gene 231 (1-2), 121-126 (1999)
   PUBMED   10231576
REFERENCE   9  (bases 1 to 3235)
  AUTHORS   Ting,K., Vastardis,H., Mulliken,J.B., Soo,C., Tieu,A., Do,H.,
            Kwong,E., Bertolami,C.N., Kawamoto,H., Kuroda,S. and Longaker,M.T.
  TITLE     Human NELL-1 expressed in unilateral coronal synostosis
  JOURNAL   J Bone Miner Res 14 (1), 80-89 (1999)
   PUBMED   9893069
REFERENCE   10 (bases 1 to 3235)
  AUTHORS   Watanabe,T.K., Katagiri,T., Suzuki,M., Shimizu,F., Fujiwara,T.,
            Kanemoto,N., Nakamura,Y., Hirai,Y., Maekawa,H. and Takahashi,Ei.
  TITLE     Cloning and characterization of two novel human cDNAs (NELL1 and
            NELL2) encoding proteins with six EGF-like repeats
  JOURNAL   Genomics 38 (3), 273-276 (1996)
   PUBMED   8975702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313445.1, BC069674.1,
            JX565026.1, DB327365.1 and BX112939.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006157.4.
            
            Summary: This gene encodes a cytoplasmic protein that contains
            epidermal growth factor (EGF)-like repeats. The encoded
            heterotrimeric protein may be involved in cell growth regulation
            and differentiation. A similar protein in rodents is involved in
            craniosynostosis. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.52787.1,
                                           SRR1803612.211131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357134.10/ ENSP00000349654.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               AK313445.1         16-397
            383-383             BC069674.1         309-309
            384-1994            AK313445.1         399-2009
            1995-3003           JX565026.1         1738-2746
            3004-3230           DB327365.1         1-227               c
            3231-3235           BX112939.1         10-14               c
FEATURES             Location/Qualifiers
     source          1..3235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..3235
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /note="neural EGFL like 1"
                     /db_xref="GeneID:4745"
                     /db_xref="HGNC:HGNC:7750"
                     /db_xref="MIM:602319"
     exon            1..193
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2571
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; neural epidermal growth factor-like 1; protein
                     kinase C-binding protein NELL1; nel-related protein 1"
                     /codon_start=1
                     /product="protein kinase C-binding protein NELL1 isoform 1
                     precursor"
                     /protein_id="NP_006148.2"
                     /db_xref="CCDS:CCDS7855.1"
                     /db_xref="GeneID:4745"
                     /db_xref="HGNC:HGNC:7750"
                     /db_xref="MIM:602319"
                     /translation="MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLG
                     VAQVSGMHNASKAFLFQDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGV
                     ILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASH
                     LLLHVDCNRIYERVIDPPDTNLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYIT
                     QCPNLNHTCPTCSDFLSLVQGIMDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVS
                     GLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPK
                     CIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGH
                     NFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTV
                     CVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGY
                     VGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRC
                     VNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLC
                     PSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFC
                     CPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAI
                     LEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRV
                     CCSVDFECLQNN"
     exon            194..322
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..473
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..644
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..741
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..814
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..897
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1032
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1135
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1209
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1309
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1438
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1564
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1687
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1783
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1924
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2118
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2295
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2520
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..3235
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2985..2990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /note="hexamer: AATAAA"
     polyA_site      3004
                     /gene="NELL1"
                     /gene_synonym="IDH3GL; NRP1"
                     /note="major polyA site"
ORIGIN      
        1 acccggcgct gccgagccac ctcccccgcc gcccgctagc aagtttggcg gctccaagcc
       61 aggcgcgcct caggatccag gctcatttgc ttccacctag cttcggtgcc ccctgctagg
      121 cggggaccct cgagagcgat gccgatggat ttgattttag ttgtgtggtt ctgtgtgtgc
      181 actgccagga cagtggtggg ctttgggatg gaccctgacc ttcagatgga tatcgtcacc
      241 gagcttgacc ttgtgaacac cacccttgga gttgctcagg tgtctggaat gcacaatgcc
      301 agcaaagcat ttttatttca agacatagaa agagagatcc atgcagctcc tcatgtgagt
      361 gagaaattaa ttcagctgtt ccggaacaag agtgaattca ccattttggc cactgtacag
      421 cagaagccat ccacttcagg agtgatactg tccattcgag aactggagca cagctatttt
      481 gaactggaga gcagtggcct gagggatgag attcggtatc actacataca caatgggaag
      541 ccaaggacag aggcacttcc ttaccgcatg gcagatggac aatggcacaa ggttgcactg
      601 tcagttagcg cctctcatct cctgctccat gtcgactgta acaggattta tgagcgtgtg
      661 atagaccctc cagataccaa ccttccccca ggaatcaatt tatggcttgg ccagcgcaac
      721 caaaagcatg gcttattcaa agggatcatc caagatggga agatcatctt tatgccgaat
      781 ggatatataa cacagtgtcc aaatctaaat cacacttgcc caacctgcag tgatttctta
      841 agcctggtgc aaggaataat ggatttacaa gagcttttgg ccaagatgac tgcaaaacta
      901 aattatgcag agacaagact tagtcaattg gaaaactgtc attgtgagaa gacttgtcaa
      961 gtgagtggac tgctctatcg agatcaagac tcttgggtag atggtgacca ttgcaggaac
     1021 tgcacttgca aaagtggtgc cgtggaatgc cgaaggatgt cctgtccccc tctcaattgc
     1081 tccccagact ccctcccagt gcacattgct ggccagtgct gtaaggtctg ccgaccaaaa
     1141 tgtatctatg gaggaaaagt tcttgcagaa ggccagcgga ttttaaccaa gagctgtcgg
     1201 gaatgccgag gtggagtttt agtaaaaatt acagaaatgt gtcctccttt gaactgctca
     1261 gaaaaggatc acattcttcc tgagaatcag tgctgccgtg tctgtagagg tcataacttt
     1321 tgtgcagaag gacctaaatg tggtgaaaac tcagagtgca aaaactggaa tacaaaagct
     1381 acttgtgagt gcaagagtgg ttacatctct gtccagggag actctgccta ctgtgaagat
     1441 attgatgagt gtgcagctaa gatgcattac tgtcatgcca atactgtgtg tgtcaacctt
     1501 cctgggttat atcgctgtga ctgtgtccca ggatacattc gtgtggatga cttctcttgt
     1561 acagaacacg atgaatgtgg cagcggccag cacaactgtg atgagaatgc catctgcacc
     1621 aacactgtcc agggacacag ctgcacctgc aaaccgggct acgtggggaa cgggaccatc
     1681 tgcagagctt tctgtgaaga gggctgcaga tacggtggaa cgtgtgtggc tcccaacaaa
     1741 tgtgtctgtc catctggatt cacaggaagc cactgcgaga aagatattga tgaatgttca
     1801 gagggaatca ttgagtgcca caaccattcc cgctgcgtta acctgccagg gtggtaccac
     1861 tgtgagtgca gaagcggttt ccatgacgat gggacctatt cactgtccgg ggagtcctgt
     1921 attgacattg atgaatgtgc cttaagaact cacacctgtt ggaacgattc tgcctgcatc
     1981 aacctggcag ggggctttga ctgtctctgc ccctctgggc cctcctgctc tggtgactgt
     2041 cctcatgaag gggggctgaa gcacaatggc caggtgtgga ccttgaaaga agacaggtgt
     2101 tctgtctgct cctgcaagga tggcaagata ttctgccgac ggacagcttg tgattgccag
     2161 aatccaagtg ctgacctatt ctgttgccca gaatgtgaca ccagagtcac aagtcaatgt
     2221 ttagaccaaa atggtcacaa gctgtatcga agtggagaca attggaccca tagctgtcag
     2281 cagtgtcggt gtctggaagg agaggtagat tgctggccac tcacttgccc caacttgagc
     2341 tgtgagtata cagctatctt agaaggggaa tgttgtcccc gctgtgtcag tgacccctgc
     2401 ctagctgata acatcaccta tgacatcaga aaaacttgcc tggacagcta tggtgtttca
     2461 cggcttagtg gctcagtgtg gacgatggct ggatctccct gcacaacctg taaatgcaag
     2521 aatggaagag tctgttgttc tgtggatttt gagtgtcttc aaaataattg aagtatttac
     2581 agtggactca acgcagaaga atggacgaaa tgaccatcca acgtgattaa ggataggaat
     2641 cggtagtttg gtttttttgt ttgttttgtt tttttaacca cagataattg ccaaagtttc
     2701 cacctgagga cggtgtttgg aggttgcctt ttggacctac cactttgctc attcttgcta
     2761 acctagtcta ggtgacctac agtgccgtgc atttaagtca atggttgtta aaagaagttt
     2821 cccgtgttgt aaatcatgtt tcccttatca gatcatttgc aaatacattt aaatgatctc
     2881 atggtaaatg ttgatgtatt ttttggttta ttttgtgtac taacataata gagagagact
     2941 cagctccttt tatttatttt gttgatttat ggatcaaatt ctaaaataaa gttgcctgtt
     3001 gtgacttttg tcccatctac tgcatactta gtgctgagat ccctgtaaaa tgttttgatg
     3061 aaaatatgta tgtagagtcc agtcgcatta tacatacatt tcatagtgct gaaccttctt
     3121 aaatgcctac tcattcagct taaacaggct gaagccaagt atgacaaaga ggggaagggc
     3181 caaaaacata atcaaagaat aattttaaag agaattcttg tctctcttgc aaaaa
//
