LOCUS       NM_001365552            5971 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NIMA related kinase 5 (NEK5), transcript variant 2,
            mRNA.
ACCESSION   NM_001365552
VERSION     NM_001365552.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5971)
  AUTHORS   de Castro Ferezin,C., Lim Kam Sian,T.C.C., Wu,Y., Ma,X.,
            Chueh,A.C., Huang,C., Schittenhelm,R.B., Kobarg,J. and Daly,R.J.
  TITLE     Identification of biological pathways and processes regulated by
            NEK5 in breast epithelial cells via an integrated proteomic
            approach
  JOURNAL   Cell Commun Signal 20 (1), 197 (2022)
   PUBMED   36550548
  REMARK    GeneRIF: Identification of biological pathways and processes
            regulated by NEK5 in breast epithelial cells via an integrated
            proteomic approach.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5971)
  AUTHORS   Matossian,M.D., Elliott,S., Van Hoang,T., Burks,H.E., Wright,M.K.,
            Alzoubi,M.S., Yan,T., Chang,T., Wathieu,H., Windsor,G.O.,
            Hartono,A.B., Lee,S., Zuercher,W.J., Drewry,D.H., Wells,C.,
            Kapadia,N., Buechlein,A., Fang,F., Nephew,K.P., Collins-Burow,B.M.
            and Burow,M.E.
  TITLE     NEK5 activity regulates the mesenchymal and migratory phenotype in
            breast cancer cells
  JOURNAL   Breast Cancer Res Treat 189 (1), 49-61 (2021)
   PUBMED   34196902
  REMARK    GeneRIF: NEK5 activity regulates the mesenchymal and migratory
            phenotype in breast cancer cells.
REFERENCE   3  (bases 1 to 5971)
  AUTHORS   Ferezin,C.C., Basei,F.L., Melo-Hanchuk,T.D., de Oliveira,A.L.,
            Peres de Oliveira,A., Mori,M.P., de Souza-Pinto,N.C. and Kobarg,J.
  TITLE     NEK5 interacts with LonP1 and its kinase activity is essential for
            the regulation of mitochondrial functions and mtDNA maintenance
  JOURNAL   FEBS Open Bio 11 (3), 546-563 (2021)
   PUBMED   33547867
  REMARK    GeneRIF: NEK5 interacts with LonP1 and its kinase activity is
            essential for the regulation of mitochondrial functions and mtDNA
            maintenance.
REFERENCE   4  (bases 1 to 5971)
  AUTHORS   Matossian,M.D., Wells,C.I., Zuercher,W.J., Collins-Burow,B.M.,
            Drewry,D.H. and Burow,M.E.
  TITLE     Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review
  JOURNAL   Curr Med Chem 28 (30), 6096-6109 (2021)
   PUBMED   33749548
  REMARK    GeneRIF: Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A
            Review.
            Review article
REFERENCE   5  (bases 1 to 5971)
  AUTHORS   Zhao,C.H., Bai,X.F. and Hu,X.H.
  TITLE     Knockdown of lncRNA XIST inhibits hypoxia-induced glycolysis,
            migration and invasion through regulating miR-381-3p/NEK5 axis in
            nasopharyngeal carcinoma
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2505-2517 (2020)
   PUBMED   32196601
  REMARK    GeneRIF: Knockdown of lncRNA XIST inhibits hypoxia-induced
            glycolysis, migration and invasion through regulating
            miR-381-3p/NEK5 axis in nasopharyngeal carcinoma.
REFERENCE   6  (bases 1 to 5971)
  AUTHORS   Melo-Hanchuk,T.D., Slepicka,P.F., Pelegrini,A.L., Menck,C.F.M. and
            Kobarg,J.
  TITLE     NEK5 interacts with topoisomerase IIbeta and is involved in the DNA
            damage response induced by etoposide
  JOURNAL   J Cell Biochem 120 (10), 16853-16866 (2019)
   PUBMED   31090963
  REMARK    GeneRIF: NEK5 interacts with topoisomerase IIbeta and is involved
            in the DNA damage response induced by etoposide.
REFERENCE   7  (bases 1 to 5971)
  AUTHORS   Pei,J., Zhang,J., Yang,X., Wu,Z., Sun,C., Wang,Z. and Wang,B.
  TITLE     NEK5 promotes breast cancer cell proliferation through
            up-regulation of Cyclin A2
  JOURNAL   Mol Carcinog 58 (6), 933-943 (2019)
   PUBMED   30675923
  REMARK    GeneRIF: Data show that up-regulated NEK5 was significantly
            associated with breast tumor progression and poor overall
            prognosis; and that silencing of NEK5 can significantly suppress
            the proliferation both in vivo and in vitro, inhibiting migration,
            and invasion. NEK5 can up-regulate Cyclin A2 by direct interaction.
REFERENCE   8  (bases 1 to 5971)
  AUTHORS   Melo Hanchuk,T.D., Papa,P.F., La Guardia,P.G., Vercesi,A.E. and
            Kobarg,J.
  TITLE     Nek5 interacts with mitochondrial proteins and interferes
            negatively in mitochondrial mediated cell death and respiration
  JOURNAL   Cell Signal 27 (6), 1168-1177 (2015)
   PUBMED   25725288
  REMARK    GeneRIF: The hNek5 is mitochondrial localization and its role on
            cell death and cell respiration defects through COX11, MTX2 and
            BCLAF1.
REFERENCE   9  (bases 1 to 5971)
  AUTHORS   Prosser,S.L., Sahota,N.K., Pelletier,L., Morrison,C.G. and Fry,A.M.
  TITLE     Nek5 promotes centrosome integrity in interphase and loss of
            centrosome cohesion in mitosis
  JOURNAL   J Cell Biol 209 (3), 339-348 (2015)
   PUBMED   25963817
  REMARK    GeneRIF: Nek5 is required for the loss of centrosome linker
            proteins and enhanced microtubule nucleation that lead to timely
            centrosome separation and bipolar spindle formation in mitosis
REFERENCE   10 (bases 1 to 5971)
  AUTHORS   Lu,K.P. and Hunter,T.
  TITLE     The NIMA kinase: a mitotic regulator in Aspergillus nidulans and
            vertebrate cells
  JOURNAL   Prog Cell Cycle Res 1, 187-205 (1995)
   PUBMED   9552363
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139082.18.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000684899.1/ ENSP00000509632.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL139082.18        147492-147536       c
            46-113              AL139082.18        146058-146125       c
            114-252             AL139082.18        145829-145967       c
            253-349             AL139082.18        137782-137878       c
            350-447             AL139082.18        130731-130828       c
            448-531             AL139082.18        128957-129040       c
            532-602             AL139082.18        128803-128873       c
            603-689             AL139082.18        126781-126867       c
            690-744             AL139082.18        122961-123015       c
            745-945             AL139082.18        120555-120755       c
            946-1027            AL139082.18        120396-120477       c
            1028-1161           AL139082.18        118206-118339       c
            1162-1343           AL139082.18        111517-111698       c
            1344-1410           AL139082.18        107710-107776       c
            1411-1527           AL139082.18        105801-105917       c
            1528-1614           AL139082.18        104740-104826       c
            1615-1707           AL139082.18        101723-101815       c
            1708-1788           AL139082.18        94526-94606         c
            1789-1857           AL139082.18        94221-94289         c
            1858-1984           AL139082.18        90407-90533         c
            1985-2110           AL139082.18        83947-84072         c
            2111-2245           AL139082.18        80282-80416         c
            2246-2363           AL139082.18        68567-68684         c
            2364-5971           AL139082.18        52074-55681         c
FEATURES             Location/Qualifiers
     source          1..5971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..5971
                     /gene="NEK5"
                     /note="NIMA related kinase 5"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
     exon            1..45
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            46..113
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            114..252
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..2634
                     /gene="NEK5"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine-protein kinase Nek5; nimA-related protein
                     kinase 5; NIMA (never in mitosis gene a)-related kinase 5"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek5 isoform 2"
                     /protein_id="NP_001352481.1"
                     /db_xref="CCDS:CCDS91811.1"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
                     /translation="MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQE
                     KEASKKEVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSE
                     DQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMEL
                     ARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQ
                     AHFAPISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEF
                     SHMLICRAGAPASRHAGKVVQKCKIQKVRFQGKCPPRSRISVPIKRNAILHRNEWRPP
                     AGAQKARSIKMIERPKIAAVCGHYDYYYAQLDMLRRRAHKPSYHPIPQENTGVEDYGQ
                     ETRHGPSPSQWPAEYLQRKFEAQQYKLKVEKQLGLRPSSAEPNYNQRQELRSNGEEPR
                     FQELPFRKNEMKEQEYWKQLEEIRQQYHNDMKEIRKKMGREPEENSKISHKTYLVKKS
                     NLPVHQDASEGEAPVQDIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISD
                     ENILQEEEAMDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVA
                     AVGNRRQWDGGAPQTLLQMMAVADITSTCPTGPDNGQVIVIEGIPGNRKQWRHEAPGT
                     LMSVLAAAHLTSSSFSADEEFAMGTLKQWLPKEEDEGKVEMVSGIEVDEEQLEPRSDD
                     DDTNFEESEDELRDEVVEYLEKLATFKGEEKTEEASSTSKDSRKSREREGISMQKSEE
                     LREGLENISTTSNDHICITDEDQGTSTTSQNIQV"
     exon            253..349
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            350..447
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            448..531
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            532..602
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            603..689
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            690..744
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            745..945
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1027
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1161
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1343
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1410
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1527
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1614
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1707
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1788
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1857
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1984
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2110
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2245
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2363
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..5971
                     /gene="NEK5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3576..3581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEK5"
                     /note="hexamer: AATAAA"
     polyA_site      3595
                     /gene="NEK5"
     regulatory      5949..5954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEK5"
                     /note="hexamer: ATTAAA"
     polyA_site      5971
                     /gene="NEK5"
                     /note="major polyA site"
ORIGIN      
        1 atccttccgg gacgcttcgt tggccccgcg gagccggcgg agcagttatc tgtggccaca
       61 aagaaagtta tttgtctctg tcttggcaag gctgggagga aagttttagc taagaaactc
      121 agcccattgg agaccatgga taagtacgat gtgattaagg ccatcgggca aggtgccttc
      181 gggaaagcat acttagctaa agggaaatca gatagcaagc actgtgtcat aaaagagatc
      241 aattttgaaa agatgcccat acaagaaaaa gaagcttcaa agaaagaagt gattcttctg
      301 gaaaagatga aacatcccaa cattgtagcc ttcttcaatt catttcaaga gaatggcagg
      361 ctgtttattg taatggaata ttgtgatgga ggggatctca tgaaaaggat caatagacaa
      421 cggggtgtgt tatttagtga agatcagatc ctcggttggt ttgtacagat ttctctagga
      481 ctaaaacata ttcatgacag gaagatatta cacagggaca taaaagctca gaacattttt
      541 cttagcaaga acggaatggt ggcaaagctt ggggactttg gtatagcaag agtcctgaat
      601 aattccatgg aacttgctcg aacttgtatt ggaacacctt actacctgtc cccagagatc
      661 tgtcagaata aaccctacaa caataaaacg gatatttggt ctcttggctg tgtcttatat
      721 gagctctgca cacttaaaca tccttttgag ggtaacaact tacagcagct ggttctgaag
      781 atttgtcaag cacattttgc cccaatatct ccggggtttt ctcgtgagct ccattccttg
      841 atatctcagc tctttcaagt atctcctcga gaccgaccat ccataaattc cattttgaaa
      901 aggccctttt tagagaatct tattcccaaa tatttgactc ctgaggtcat tcaggaagaa
      961 ttcagtcaca tgcttatatg cagagcagga gcgccagctt ctcgacatgc tgggaaggtg
     1021 gtccagaagt gtaaaataca aaaagtgaga ttccagggaa agtgcccacc aagatcaagg
     1081 atatctgtgc caattaaaag gaatgctata ttgcatagaa atgaatggag accaccagct
     1141 ggagcccaga aggccagatc tataaaaatg atagaaagac ccaaaattgc tgctgtctgt
     1201 ggacattatg attattatta tgctcaactt gatatgctga ggaggagagc ccacaaacca
     1261 agttatcacc ctattcctca agaaaatact ggagttgagg attacggtca ggaaacgagg
     1321 catggtccat ccccaagtca atggcctgct gagtaccttc agagaaaatt tgaagctcaa
     1381 caatataagt tgaaagtgga gaagcaattg ggtcttcgtc catcttctgc cgagccaaat
     1441 tacaaccaga gacaagagct aagaagtaat ggagaagagc ctagattcca ggagctgcca
     1501 tttaggaaaa acgaaatgaa ggaacaggaa tattggaagc agttagagga aatacgccaa
     1561 cagtaccaca atgacatgaa agaaattaga aagaagatgg ggagagaacc agaggagaac
     1621 tcaaaaataa gtcataaaac ctatttggtg aagaagagta acctgcctgt ccatcaagat
     1681 gcatctgagg gagaagcacc tgtgcaggac attgaaaaag acttgaaaca aatgaggctt
     1741 cagaacacaa aggaaagtaa aaatccagaa cagaaatata aagctaagaa gggggtaaaa
     1801 tttgaaatta atttagacaa atgtatttct gatgaaaaca tcctccaaga ggaagaggca
     1861 atggatatac caaatgaaac tttgaccttt gaggatggca tgaagtttaa ggaatatgaa
     1921 tgtgtaaagg agcatggaga ttatacagac aaagcatttg aaaaacttca ctgcccagaa
     1981 gcagggtttt ccacgcagac tgtagctgct gtgggaaaca ggaggcagtg ggatggagga
     2041 gcgcctcaga ctctgctgca gatgatggca gtggccgaca tcacctccac ctgccccacg
     2101 gggcctgaca atggccaagt tattgtgatt gaaggcattc caggaaacag gaaacagtgg
     2161 cggcatgaag ctccaggaac tttaatgagt gttttggcag cagcacatct aacgagtagc
     2221 tcattttctg ccgatgaaga atttgcaatg ggaacattaa aacaatggct acccaaagaa
     2281 gaagatgaag ggaaggtaga aatggtctct ggcattgaag tagatgagga acaactagaa
     2341 ccaagatctg atgatgatga tacaaatttt gaagaatctg aagatgagtt gagagatgaa
     2401 gtagtagaat acttagaaaa actcgctact ttcaaagggg aagaaaaaac agaagaggcc
     2461 tccagtacct ctaaggactc tagaaagtca agagaaagag aggggataag tatgcagaaa
     2521 tctgaagaat taagggaggg cttggagaat atttctacta catctaatga ccacatttgt
     2581 attactgatg aagaccaagg aacatcaaca accagtcaaa atatacaagt gtgattattg
     2641 tactttttct taagtaataa gttagtgtct attacctata gtatttattt gggtacaagt
     2701 cataaatgct catttactgt aagggttttc tagtaatctc aaggatttat taatttttct
     2761 ttcaatttag gaagtagaac ttttgaatat agccattaat atttttactt taaagtttct
     2821 attaagaaat cttaggccgg gcagtctcat cactttggga ggccaaggca ggcagatcat
     2881 gaggtcagga gtttgagacc agtccaacca acatggtgaa accccgtctc tactaaaaat
     2941 acaaaattag ctgggcatgg tggtgcatgc ctgtaatccc agttacttgg gaggctgagg
     3001 caggagaatc acctgaaccc aggagatgga agttgcaagt gagccgagat tgtgccactg
     3061 cactccagcc tgggcaacaa gagcgaaact ctgtctcaaa aaaagaaaaa aaaaaaaaag
     3121 ctttcagcta atatatgtgg taggcagagt aatgtggctc aatgccccct ccaaaacatg
     3181 tcccatccta atccccacag tttgcaaata tggcaaagga gaattaaggt tgcaggtgaa
     3241 attgtttgct tatcagctga ccttaaaata gggaggttat cttggtttat ccacctgggt
     3301 gcagtgtaat cacaagggtc cttacaagtg gaagaggaag acaaaagaga aaaccagaga
     3361 gatcgcagca tgaaaaggac tcagcctgat gttgctggct ttgaagatgt tggacaaggc
     3421 cacaaactaa gaattcagac agcctctgga atctggaaaa ggcaaagaaa tggattcttc
     3481 cctagagcct ccagaaggaa cacagccctg ccaacaactt aattttagcc tagtgagttc
     3541 aatttcatac ttctgacttg cagaactgtt aagataataa atttgtgtta actaagtttg
     3601 tgataatttg ttaggacagc aatagaaaac aaatacaata tacaggttca ctcatttaac
     3661 ataatctgcc gttttacaaa actgtgattt tgaagtttct tgttgcattg aatacacttt
     3721 tttgaagctg atgttgacac aggaataagg caattgagca agaacaacaa ggcatggtgt
     3781 gttaattatg cactaaatga ccatggccat tttgtctaat agtttcaata gtttccaata
     3841 gtttcaagtg tataggttga gggcagggac tatatctggt ctttatatct tacaatgatt
     3901 ttcttatata gttattagca cagtgccaga aatgtttcct gaattaataa atgctaaaac
     3961 atttcctcat taagactgta agctgtttgg tgtaggaaaa ctaacttttt aaaattgatc
     4021 ataacaattc caacgttgaa catggcctgg agcttaacag atgtttattt aaatactaag
     4081 gagtatgtct gggcttagga aggagagggt ggttacattt cagggtggta gaattctgcc
     4141 tgaaatatct gctttataat aaaagtaaaa tgtctcaccg atacactgtt aaactgagaa
     4201 aacaaagatg aggtaaggtg ggtcagatta tttctaaggt ctgtttacta tttacatttc
     4261 atataatttt cattaaatgt ggagaatgca agtcttagga gtcacctgag gtacatccag
     4321 ttttttgtga ctatttcctg atgtttgaca gactgttctt tcaacttggt gtagagttac
     4381 agtctactct tttagggaga atgctgtttg ttcacatcat gaggctgtaa atatttaaaa
     4441 tgttctcacc attgtgttag tttccaactg acacatggcc tgagagattg gagtatcatt
     4501 aattctgcaa ctcttttagt gctccggatg tgcatgttta tttactttca ggactagttc
     4561 agacatagta aaactgctag tgacttcatg taatccttat tctgaactgt atttgaaagc
     4621 aagggaaatg aaacatgatc cctaataacc tcaaacatcc aaagatcaag tcaattaagg
     4681 gcaaaaaaaa aaaaaaaaaa gaaaaaaaag aatgtttaag gatggtaaat gaacacgcca
     4741 ggtgtggtgg cgcatgcctg taatcccaac actttgagag gctgaggcag gaggatcgct
     4801 tgagcccagg agtttgagac cagcctgggc aacataggga aacacccatc tctatccacc
     4861 cctcagaaaa aaaaaaaaaa aaaaaagaat tagctggtgt gttggtgtgc acctctggtc
     4921 ccagctcttc aggaggctga ggcgggagga tcactttagt ttcagcctgg gaggttgagg
     4981 ctacagtgag ccataatccg tgatcacatc actgcactcc accttgagtg acagagtaag
     5041 aaagaccctg tctcaaaaaa aaaaaaaaaa aaaaaaagca tgtcaggtta tcgggtttgt
     5101 tcccatgata aaagatgctt ggctaaagtc tagtctattt taggtaatag tcaccaagct
     5161 ttactcaaca attttgaatt ctttgctgta aactggaagt attcactgtg ataagtatac
     5221 atatctgcaa cactttcagc tgattttagt ccctaattct agaccttacc cattttacac
     5281 acactattag ctaaatcgtg ttcctgaggc atggctctga ttactttact ctggctttag
     5341 ccttggcctc atccgttaaa ttgaaactgt tcaccagacc tgtatgcatt aaaaattttt
     5401 ttattagaaa aatcagtgtc ttgctagcca tgtatgatag ctatcaaatt gatcattctg
     5461 taaatggtag caataagtgt atcaacactt tgacctcctc tgtgtctagt aacatttgca
     5521 tatagtacaa ctgagcacat agcaccagaa tattggaaca gatgcttctc caaagccaag
     5581 ggttgcctta catttagagt gggaaaagag gaaaatgagt tagcagagga gcagcgggga
     5641 ggggggtaaa ttacaggaca taatttgctt ctaaaaattt gtgtttcgtg ttgtagttat
     5701 ataattaact tttctattgt actgattgac agatttggca cagacatcct ctcattgtga
     5761 atatatatga atatatcaga gttttggact ctggggtata tttacataaa cacaagtatt
     5821 ctgaaagcat tgataaccac actggtgtct cttaattttg tctataagat gaccttataa
     5881 aatccctcaa gaattattta aatcaagtgt acgaagctct gcagtttttt gttatgtctg
     5941 aaatattcat taaaaagttt attaaacctg a
//
