LOCUS       NM_024800               2926 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens NIMA related kinase 11 (NEK11), transcript variant 1,
            mRNA.
ACCESSION   NM_024800
VERSION     NM_024800.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2926)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   2  (bases 1 to 2926)
  AUTHORS   Christodoulou,E., van Doorn,R., Visser,M., Teunisse,A.,
            Versluis,M., van der Velden,P., Hayward,N.K., Jochemsen,A. and
            Gruis,N.
  TITLE     NEK11 as a candidate high-penetrance melanoma susceptibility gene
  JOURNAL   J Med Genet 57 (3), 203-210 (2020)
   PUBMED   31704778
  REMARK    GeneRIF: NEK11 as a candidate high-penetrance melanoma
            susceptibility gene.
REFERENCE   3  (bases 1 to 2926)
  AUTHORS   Alhaidan,Y., Larsen,M.J., Schou,A.J., Stenlid,M.H., Al Balwi,M.A.,
            Christesen,H.T. and Brusgaard,K.
  TITLE     Exome sequencing revealed DNA variants in NCOR1, IGF2BP1, SGLT2 and
            NEK11 as potential novel causes of ketotic hypoglycemia in children
  JOURNAL   Sci Rep 10 (1), 2114 (2020)
   PUBMED   32034166
  REMARK    GeneRIF: Exome sequencing revealed DNA variants in NCOR1, IGF2BP1,
            SGLT2 and NEK11 as potential novel causes of ketotic hypoglycemia
            in children.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2926)
  AUTHORS   Sabir,S.R., Sahota,N.K., Jones,G.D. and Fry,A.M.
  TITLE     Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in
            HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging
            Agents
  JOURNAL   PLoS One 10 (10), e0140975 (2015)
   PUBMED   26501353
  REMARK    GeneRIF: contributes to response of colorectal cancer cells to
            genotoxic agents and is essential for survival either with or
            without exposure to DNA damage
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2926)
  AUTHORS   Fry,A.M., O'Regan,L., Sabir,S.R. and Bayliss,R.
  TITLE     Cell cycle regulation by the NEK family of protein kinases
  JOURNAL   J Cell Sci 125 (Pt 19), 4423-4433 (2012)
   PUBMED   23132929
  REMARK    Review article
REFERENCE   6  (bases 1 to 2926)
  AUTHORS   Sorensen,C.S., Melixetian,M., Klein,D.K. and Helin,K.
  TITLE     NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling
  JOURNAL   Cell Cycle 9 (3), 450-455 (2010)
   PUBMED   20090422
  REMARK    GeneRIF: NEK11 controls degradation of CDC25A by directly
            phosphorylating CDC25A on residues whose phosphorylation is
            required for beta-TrCP mediated CDC25A polyubiquitylation and
            degradation.
REFERENCE   7  (bases 1 to 2926)
  AUTHORS   Melixetian,M., Klein,D.K., Sorensen,C.S. and Helin,K.
  TITLE     NEK11 regulates CDC25A degradation and the IR-induced G2/M
            checkpoint
  JOURNAL   Nat Cell Biol 11 (10), 1247-1253 (2009)
   PUBMED   19734889
  REMARK    GeneRIF: NEK11 regulates CDC25A degradation and the IR-induced G2/M
            checkpoint.
REFERENCE   8  (bases 1 to 2926)
  AUTHORS   Noguchi,K., Fukazawa,H., Murakami,Y. and Uehara,Y.
  TITLE     Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells
  JOURNAL   J Biol Chem 279 (31), 32716-32727 (2004)
   PUBMED   15161910
  REMARK    GeneRIF: Nucleolar Nek11 is a novel target of Nek2A in
            G1/S-arrested cells
REFERENCE   9  (bases 1 to 2926)
  AUTHORS   O'Connell,M.J., Krien,M.J. and Hunter,T.
  TITLE     Never say never. The NIMA-related protein kinases in mitotic
            control
  JOURNAL   Trends Cell Biol 13 (5), 221-228 (2003)
   PUBMED   12742165
  REMARK    Review article
REFERENCE   10 (bases 1 to 2926)
  AUTHORS   Noguchi,K., Fukazawa,H., Murakami,Y. and Uehara,Y.
  TITLE     Nek11, a new member of the NIMA family of kinases, involved in DNA
            replication and genotoxic stress responses
  JOURNAL   J Biol Chem 277 (42), 39655-39665 (2002)
   PUBMED   12154088
  REMARK    GeneRIF: Nek11 has a role in the S-phase checkpoint downstream of
            the caffeine-sensitive pathway
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK297300.1, AB071996.1,
            BX328072.2 and AL833472.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024800.4.
            
            Summary: This gene encodes a member of the never in mitosis gene A
            family of kinases. The encoded protein localizes to the nucleoli,
            and may function with NEK2A in the S-phase checkpoint. The encoded
            protein appears to play roles in DNA replication and response to
            genotoxic stress. Alternatively spliced transcript variants have
            been described.[provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) encodes isoform (1), also
            known as NEK11L.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB071996.1, SRR1803612.70146.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383366.9/ ENSP00000372857.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AK297300.1         28-33
            7-1761              AB071996.1         1-1755
            1762-1762           BX328072.2         784-784
            1763-2920           AB071996.1         1757-2914
            2921-2926           AL833472.1         2749-2754
FEATURES             Location/Qualifiers
     source          1..2926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..2926
                     /gene="NEK11"
                     /note="NIMA related kinase 11"
                     /db_xref="GeneID:79858"
                     /db_xref="HGNC:HGNC:18593"
                     /db_xref="MIM:609779"
     exon            1..130
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            131..203
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            204..469
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..2237
                     /gene="NEK11"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase NEK11; NIMA (never in
                     mitosis gene a)- related kinase 11"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek11 isoform 1"
                     /protein_id="NP_079076.3"
                     /db_xref="CCDS:CCDS3069.1"
                     /db_xref="GeneID:79858"
                     /db_xref="HGNC:HGNC:18593"
                     /db_xref="MIM:609779"
                     /translation="MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVY
                     LVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQD
                     NFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLK
                     SKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSL
                     ACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRP
                     SAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALS
                     EVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLH
                     EKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLH
                     ELESIVEDATSDLGYHEIPEDPLVAEEYYADAFDSYCEESDEEEEEIALERPEKEIRN
                     EGSQPAYRTNQQDSDIEALARCLENVLGCTSLDTKTITTMAEDMSPGPPIFNSVMART
                     KMKRMRESAMQKLGTEVFEEVYNYLKRARHQNASEAEIRECLEKVVPQASDCFEVDQL
                     LYFEEQLLITMGKEPTLQNHL"
     exon            470..635
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            636..754
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            755..819
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            820..946
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1096
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1175
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1261
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1381
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1475
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1583
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1698
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1859
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1920
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2017
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2926
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2872..2877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEK11"
                     /note="hexamer: AATAAA"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEK11"
                     /note="hexamer: AATAAA"
     polyA_site      2903
                     /gene="NEK11"
                     /note="major polyA site"
     polyA_site      2926
                     /gene="NEK11"
                     /note="major polyA site"
ORIGIN      
        1 acggttccaa acagccgtgg cccgcggtgt ctggcgctcg gtgggtgtgg ttgcccctag
       61 tttgaggcct gcccgattac ccgcaagact tgggcagccc cgggcgccgc tccgaccacg
      121 acagggaaag gaaccttaat ctcatcttta aaataaggag aattactgag tgacctgaag
      181 gacccttttc agctggaaag tctgaactga ccaacactgg atgaatttga ccatttctta
      241 ggagactgga atgttaagtt tctataaatg aatgaaccag ttctctcttg tttggagcaa
      301 tgctgaaatt ccaagaggca gctaagtgtg tgagtggatc aacagccatt tccacttatc
      361 caaagacctt gattgcaaga agatacgtgc ttcaacaaaa acttggcagt ggaagttttg
      421 gaactgtcta tctggtttca gacaagaaag ccaaacgagg agaggaatta aaggtactta
      481 aggaaatatc tgttggagaa ctaaatccaa atgaaactgt acaggccaat ttggaagccc
      541 aactcctctc caagctggac cacccagcca ttgtcaagtt ccatgcaagt tttgtggagc
      601 aagataattt ctgcattatc acggagtact gtgagggccg agatctggac gataaaattc
      661 aggaatataa acaagctgga aaaatctttc cagaaaatca aataatagaa tggtttatcc
      721 agctgctgct gggagttgac tacatgcatg agaggaggat acttcatcga gacttaaagt
      781 caaagaatgt atttctgaaa aataatctcc ttaaaattgg agattttgga gtttctcgac
      841 ttctaatggg atcctgtgac ctggccacaa ctttaactgg aactccccat tatatgagtc
      901 ctgaggctct gaaacaccaa ggctatgaca caaagtcgga catctggtca ctggcatgca
      961 ttttgtatga gatgtgctgc atgaatcatg cattcgctgg ctccaatttc ttatccattg
     1021 ttttaaaaat tgttgaaggt gacacacctt ctctccctga gagatatcca aaagaactaa
     1081 atgccatcat ggaaagcatg ttgaacaaga atccttcatt aagaccatct gctatcgaaa
     1141 ttttaaaaat cccttacctt gatgagcagc tacagaacct aatgtgtaga tattcagaaa
     1201 tgactctgga agacaaaaat ttggattgtc agaaggaggc tgctcatata attaatgcca
     1261 tgcaaaaaag gatccacctg cagactctga gggcactgtc agaagtacag aaaatgacgc
     1321 caagagaaag gatgcggctg aggaagctcc aggcggctga tgagaaagcc aggaagctga
     1381 aaaagattgt ggaagaaaaa tatgaagaaa atagcaaacg aatgcaagaa ttgagatctc
     1441 ggaactttca gcagctgagt gttgatgtac tccatgaaaa aacacattta aaaggaatgg
     1501 aagaaaagga ggagcaacct gagggaagac tttcttgttc accccaggac gaggatgaag
     1561 agaggtggca aggcagggaa gaggaatctg atgaaccaac tttagagaac ctgcctgagt
     1621 ctcagcctat tccttccatg gacctccacg aacttgaatc aattgtagag gatgccacat
     1681 ctgaccttgg ataccatgag atcccagaag acccacttgt ggctgaagag tactacgctg
     1741 atgcatttga ttcctattgt gaagagagtg atgaggagga agaagaaata gcgttagaaa
     1801 gaccagagaa agaaatcagg aatgagggat cccagcctgc ttacagaaca aaccaacagg
     1861 acagtgatat cgaagcgttg gccaggtgtt tggaaaatgt cctgggttgc acttctctag
     1921 acacaaagac catcaccacc atggctgaag acatgtcccc aggaccacca attttcaaca
     1981 gtgtgatggc caggaccaag atgaaacgca tgagggaatc agccatgcag aagctgggga
     2041 cagaagtatt tgaagaggtc tataattacc tcaagagagc aaggcatcag aatgctagcg
     2101 aagcagagat ccgcgagtgt ttggaaaaag tggtgcctca agccagcgac tgttttgaag
     2161 tggaccagct cctgtacttt gaagagcagt tgctgatcac gatgggaaaa gaacctactc
     2221 tccagaacca tctctaggca actatcaaaa agaagcagaa gttcaagtgg acaaatttat
     2281 gtgaaaattc atttaacata taagctgaac tctattatgg ggaatggata caaaagcaga
     2341 gctcccatct tgactttcaa ttcctcatca gaagtactgg cttctttaga gagtagtaag
     2401 catggctgcc tatgcttgga gtcataagtg ttatttggac tataccctga gataagctta
     2461 tagatcaagt ttggctccct tgaaaagcat ttctctcatg tgcgccctca gggcttccag
     2521 caggattgag tcaccctgac gatgaccggg gagaagccgt gtgctcttca ttattttcag
     2581 ctggaggaca gagctcagtg cctgactgcc tagggtctca tggactgtag gcagcctgcc
     2641 agtgaaggtc actggactct agcctacaac atgctgagct acagcccaga agccagacat
     2701 gcctgtctta gctgacctgt ttttggtcca cttttgccct tccatgacta ataaggaaga
     2761 tatgtgtgta tttcatacac acacaaggac ctggattaaa aatccaaaaa gtgattctct
     2821 tctatgattt atttcaaact catccataga taattcaaga tttgtattca aaataaacat
     2881 agttttcaca gttacaaaat aaatcaccta ttttatcttt tcctta
//
