LOCUS       NM_001353039            2760 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens NIMA related kinase 11 (NEK11), transcript variant 25,
            mRNA.
ACCESSION   NM_001353039
VERSION     NM_001353039.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2760)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   2  (bases 1 to 2760)
  AUTHORS   Christodoulou,E., van Doorn,R., Visser,M., Teunisse,A.,
            Versluis,M., van der Velden,P., Hayward,N.K., Jochemsen,A. and
            Gruis,N.
  TITLE     NEK11 as a candidate high-penetrance melanoma susceptibility gene
  JOURNAL   J Med Genet 57 (3), 203-210 (2020)
   PUBMED   31704778
  REMARK    GeneRIF: NEK11 as a candidate high-penetrance melanoma
            susceptibility gene.
REFERENCE   3  (bases 1 to 2760)
  AUTHORS   Alhaidan,Y., Larsen,M.J., Schou,A.J., Stenlid,M.H., Al Balwi,M.A.,
            Christesen,H.T. and Brusgaard,K.
  TITLE     Exome sequencing revealed DNA variants in NCOR1, IGF2BP1, SGLT2 and
            NEK11 as potential novel causes of ketotic hypoglycemia in children
  JOURNAL   Sci Rep 10 (1), 2114 (2020)
   PUBMED   32034166
  REMARK    GeneRIF: Exome sequencing revealed DNA variants in NCOR1, IGF2BP1,
            SGLT2 and NEK11 as potential novel causes of ketotic hypoglycemia
            in children.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2760)
  AUTHORS   Sabir,S.R., Sahota,N.K., Jones,G.D. and Fry,A.M.
  TITLE     Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in
            HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging
            Agents
  JOURNAL   PLoS One 10 (10), e0140975 (2015)
   PUBMED   26501353
  REMARK    GeneRIF: contributes to response of colorectal cancer cells to
            genotoxic agents and is essential for survival either with or
            without exposure to DNA damage
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2760)
  AUTHORS   Fry,A.M., O'Regan,L., Sabir,S.R. and Bayliss,R.
  TITLE     Cell cycle regulation by the NEK family of protein kinases
  JOURNAL   J Cell Sci 125 (Pt 19), 4423-4433 (2012)
   PUBMED   23132929
  REMARK    Review article
REFERENCE   6  (bases 1 to 2760)
  AUTHORS   Sorensen,C.S., Melixetian,M., Klein,D.K. and Helin,K.
  TITLE     NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling
  JOURNAL   Cell Cycle 9 (3), 450-455 (2010)
   PUBMED   20090422
  REMARK    GeneRIF: NEK11 controls degradation of CDC25A by directly
            phosphorylating CDC25A on residues whose phosphorylation is
            required for beta-TrCP mediated CDC25A polyubiquitylation and
            degradation.
REFERENCE   7  (bases 1 to 2760)
  AUTHORS   Melixetian,M., Klein,D.K., Sorensen,C.S. and Helin,K.
  TITLE     NEK11 regulates CDC25A degradation and the IR-induced G2/M
            checkpoint
  JOURNAL   Nat Cell Biol 11 (10), 1247-1253 (2009)
   PUBMED   19734889
  REMARK    GeneRIF: NEK11 regulates CDC25A degradation and the IR-induced G2/M
            checkpoint.
REFERENCE   8  (bases 1 to 2760)
  AUTHORS   Noguchi,K., Fukazawa,H., Murakami,Y. and Uehara,Y.
  TITLE     Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells
  JOURNAL   J Biol Chem 279 (31), 32716-32727 (2004)
   PUBMED   15161910
  REMARK    GeneRIF: Nucleolar Nek11 is a novel target of Nek2A in
            G1/S-arrested cells
REFERENCE   9  (bases 1 to 2760)
  AUTHORS   O'Connell,M.J., Krien,M.J. and Hunter,T.
  TITLE     Never say never. The NIMA-related protein kinases in mitotic
            control
  JOURNAL   Trends Cell Biol 13 (5), 221-228 (2003)
   PUBMED   12742165
  REMARK    Review article
REFERENCE   10 (bases 1 to 2760)
  AUTHORS   Noguchi,K., Fukazawa,H., Murakami,Y. and Uehara,Y.
  TITLE     Nek11, a new member of the NIMA family of kinases, involved in DNA
            replication and genotoxic stress responses
  JOURNAL   J Biol Chem 277 (42), 39655-39665 (2002)
   PUBMED   12154088
  REMARK    GeneRIF: Nek11 has a role in the S-phase checkpoint downstream of
            the caffeine-sensitive pathway
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055733.16, AC121332.4,
            AC083908.19, AC010210.24 and CK903563.1.
            
            On May 31, 2019 this sequence version replaced NM_001353039.1.
            
            Summary: This gene encodes a member of the never in mitosis gene A
            family of kinases. The encoded protein localizes to the nucleoli,
            and may function with NEK2A in the S-phase checkpoint. The encoded
            protein appears to play roles in DNA replication and response to
            genotoxic stress. Alternatively spliced transcript variants have
            been described.[provided by RefSeq, Mar 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.51231.1,
                                           SRR14372080.1422964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC055733.16        16992-17121         c
            131-203             AC055733.16        15996-16068         c
            204-469             AC055733.16        14120-14385         c
            470-588             AC121332.4         9424-9542
            589-653             AC083908.19        105459-105523       c
            654-780             AC083908.19        104312-104438       c
            781-930             AC083908.19        85731-85880         c
            931-1009            AC083908.19        85559-85637         c
            1010-1095           AC083908.19        83147-83232         c
            1096-1215           AC083908.19        75741-75860         c
            1216-1309           AC083908.19        72749-72842         c
            1310-1417           AC083908.19        69331-69438         c
            1418-1532           AC083908.19        67381-67495         c
            1533-1693           AC083908.19        9580-9740           c
            1694-1754           AC010210.24        7173-7233
            1755-1851           AC010210.24        37215-37311
            1852-2759           AC010210.24        113294-114201
            2760-2760           CK903563.1         14-14               c
FEATURES             Location/Qualifiers
     source          1..2760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..2760
                     /gene="NEK11"
                     /note="NIMA related kinase 11"
                     /db_xref="GeneID:79858"
                     /db_xref="HGNC:HGNC:18593"
                     /db_xref="MIM:609779"
     exon            1..130
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            131..203
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            204..469
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            470..588
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     CDS             578..2071
                     /gene="NEK11"
                     /EC_number="2.7.11.1"
                     /note="isoform 15 is encoded by transcript variant 25;
                     serine/threonine-protein kinase NEK11; NIMA (never in
                     mitosis gene a)- related kinase 11"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek11 isoform
                     15"
                     /protein_id="NP_001339968.1"
                     /db_xref="GeneID:79858"
                     /db_xref="HGNC:HGNC:18593"
                     /db_xref="MIM:609779"
                     /translation="MHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTL
                     TGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTP
                     SLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNL
                     DCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEE
                     KYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQ
                     GREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVAEEYYADA
                     FDSYCEESDEEEEEIALERPEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGCTSL
                     DTKTITTMAEDMSPGPPIFNSVMARTKMKRMRESAMQKLGTEVFEEVYNYLKRARHQN
                     ASEAEIRECLEKVVPQASDCFEVDQLLYFEEQLLITMGKEPTLQNHL"
     exon            589..653
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            654..780
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            781..930
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1009
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1095
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1215
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1309
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1417
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1532
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1693
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1754
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1851
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2760
                     /gene="NEK11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2706..2711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEK11"
                     /note="hexamer: AATAAA"
     regulatory      2732..2737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEK11"
                     /note="hexamer: AATAAA"
     polyA_site      2737
                     /gene="NEK11"
                     /note="major polyA site"
     polyA_site      2760
                     /gene="NEK11"
                     /note="major polyA site"
ORIGIN      
        1 acggttccaa acagccgtgg cccgcggtgt ctggcgctcg gtgggtgtgg ttgcccctag
       61 tttgaggcct gcccgattac ccgcaagact tgggcagccc cgggcgccgc tccgaccacg
      121 acagggaaag gaaccttaat ctcatcttta aaataaggag aattactgag tgacctgaag
      181 gacccttttc agctggaaag tctgaactga ccaacactgg atgaatttga ccatttctta
      241 ggagactgga atgttaagtt tctataaatg aatgaaccag ttctctcttg tttggagcaa
      301 tgctgaaatt ccaagaggca gctaagtgtg tgagtggatc aacagccatt tccacttatc
      361 caaagacctt gattgcaaga agatacgtgc ttcaacaaaa acttggcagt ggaagttttg
      421 gaactgtcta tctggtttca gacaagaaag ccaaacgagg agaggaattg gccgagatct
      481 ggacgataaa attcaggaat ataaacaagc tggaaaaatc tttccagaaa atcaaataat
      541 agaatggttt atccagctgc tgctgggagt tgactacatg catgagagga ggatacttca
      601 tcgagactta aagtcaaaga atgtatttct gaaaaataat ctccttaaaa ttggagattt
      661 tggagtttct cgacttctaa tgggatcctg tgacctggcc acaactttaa ctggaactcc
      721 ccattatatg agtcctgagg ctctgaaaca ccaaggctat gacacaaagt cggacatctg
      781 gtcactggca tgcattttgt atgagatgtg ctgcatgaat catgcattcg ctggctccaa
      841 tttcttatcc attgttttaa aaattgttga aggtgacaca ccttctctcc ctgagagata
      901 tccaaaagaa ctaaatgcca tcatggaaag catgttgaac aagaatcctt cattaagacc
      961 atctgctatc gaaattttaa aaatccctta ccttgatgag cagctacaga acctaatgtg
     1021 tagatattca gaaatgactc tggaagacaa aaatttggat tgtcagaagg aggctgctca
     1081 tataattaat gccatgcaaa aaaggatcca cctgcagact ctgagggcac tgtcagaagt
     1141 acagaaaatg acgccaagag aaaggatgcg gctgaggaag ctccaggcgg ctgatgagaa
     1201 agccaggaag ctgaaaaaga ttgtggaaga aaaatatgaa gaaaatagca aacgaatgca
     1261 agaattgaga tctcggaact ttcagcagct gagtgttgat gtactccatg aaaaaacaca
     1321 tttaaaagga atggaagaaa aggaggagca acctgaggga agactttctt gttcacccca
     1381 ggacgaggat gaagagaggt ggcaaggcag ggaagaggaa tctgatgaac caactttaga
     1441 gaacctgcct gagtctcagc ctattccttc catggacctc cacgaacttg aatcaattgt
     1501 agaggatgcc acatctgacc ttggatacca tgagatccca gaagacccac ttgtggctga
     1561 agagtactac gctgatgcat ttgattccta ttgtgaagag agtgatgagg aggaagaaga
     1621 aatagcgtta gaaagaccag agaaagaaat caggaatgag ggatcccagc ctgcttacag
     1681 aacaaaccaa caggacagtg atatcgaagc gttggccagg tgtttggaaa atgtcctggg
     1741 ttgcacttct ctagacacaa agaccatcac caccatggct gaagacatgt ccccaggacc
     1801 accaattttc aacagtgtga tggccaggac caagatgaaa cgcatgaggg aatcagccat
     1861 gcagaagctg gggacagaag tatttgaaga ggtctataat tacctcaaga gagcaaggca
     1921 tcagaatgct agcgaagcag agatccgcga gtgtttggaa aaagtggtgc ctcaagccag
     1981 cgactgtttt gaagtggacc agctcctgta ctttgaagag cagttgctga tcacgatggg
     2041 aaaagaacct actctccaga accatctcta ggcaactatc aaaaagaagc agaagttcaa
     2101 gtggacaaat ttatgtgaaa attcatttaa catataagct gaactctatt atggggaatg
     2161 gatacaaaag cagagctccc atcttgactt tcaattcctc atcagaagta ctggcttctt
     2221 tagagagtag taagcatggc tgcctatgct tggagtcata agtgttattt ggactatacc
     2281 ctgagataag cttatagatc aagtttggct cccttgaaaa gcatttctct catgtgcgcc
     2341 ctcagggctt ccagcaggat tgagtcaccc tgacgatgac cggggagaag ccgtgtgctc
     2401 ttcattattt tcagctggag gacagagctc agtgcctgac tgcctagggt ctcatggact
     2461 gtaggcagcc tgccagtgaa ggtcactgga ctctagccta caacatgctg agctacagcc
     2521 cagaagccag acatgcctgt cttagctgac ctgtttttgg tccacttttg cccttccatg
     2581 actaataagg aagatatgtg tgtatttcat acacacacaa ggacctggat taaaaatcca
     2641 aaaagtgatt ctcttctatg atttatttca aactcatcca tagataattc aagatttgta
     2701 ttcaaaataa acatagtttt cacagttaca aaataaatca cctattttat cttttcctta
//
