LOCUS       NM_018248               2363 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens nei like DNA glycosylase 3 (NEIL3), mRNA.
ACCESSION   NM_018248
VERSION     NM_018248.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2363)
  AUTHORS   Zhang,M., Jiang,Y., Wang,J., Yue,Y., Liu,W., Wang,L., Li,Y.,
            Wang,W., Cai,H., Yang,Z., Ma,M., Lu,S. and Fan,J.
  TITLE     NEIL3 promotes cell proliferation of ccRCC via the cyclin
            D1-Rb-E2F1 feedback loop regulation
  JOURNAL   DNA Repair (Amst) 133, 103604 (2024)
   PUBMED   37992567
  REMARK    GeneRIF: NEIL3 promotes cell proliferation of ccRCC via the cyclin
            D1-Rb-E2F1 feedback loop regulation.
REFERENCE   2  (bases 1 to 2363)
  AUTHORS   Wang,G.N., Zhang,Y.P., Wang,M.C., Han,W. and Zhang,Y.C.
  TITLE     [Overexpression of Nei endonuclease VIII-like protein 3 in
            hepatocellular carcinoma indicates increased levels of immune
            infiltration and an unfavorable prognosis]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 31 (9), 986-995 (2023)
   PUBMED   37872095
  REMARK    GeneRIF: [Overexpression of Nei endonuclease VIII-like protein 3 in
            hepatocellular carcinoma indicates increased levels of immune
            infiltration and an unfavorable prognosis].
REFERENCE   3  (bases 1 to 2363)
  AUTHORS   Pan,Z., Zhao,R., Li,B., Qi,Y., Qiu,W., Guo,Q., Zhang,S., Zhao,S.,
            Xu,H., Li,M., Gao,Z., Fan,Y., Xu,J., Wang,H., Wang,S., Qiu,J.,
            Wang,Q., Guo,X., Deng,L., Zhang,P., Xue,H. and Li,G.
  TITLE     EWSR1-induced circNEIL3 promotes glioma progression and
            exosome-mediated macrophage immunosuppressive polarization via
            stabilizing IGF2BP3
  JOURNAL   Mol Cancer 21 (1), 16 (2022)
   PUBMED   35031058
  REMARK    GeneRIF: EWSR1-induced circNEIL3 promotes glioma progression and
            exosome-mediated macrophage immunosuppressive polarization via
            stabilizing IGF2BP3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2363)
  AUTHORS   Wang,Y., Xu,L., Shi,S., Wu,S., Meng,R., Chen,H. and Jiang,Z.
  TITLE     Deficiency of NEIL3 Enhances the Chemotherapy Resistance of
            Prostate Cancer
  JOURNAL   Int J Mol Sci 22 (8), 4098 (2021)
   PUBMED   33921035
  REMARK    GeneRIF: Deficiency of NEIL3 Enhances the Chemotherapy Resistance
            of Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2363)
  AUTHORS   Shen,P., Yang,T., Chen,Q., Yuan,H., Wu,P., Cai,B., Meng,L.,
            Huang,X., Liu,J., Zhang,Y., Hu,W., Miao,Y., Lu,Z. and Jiang,K.
  TITLE     CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma
            progression via miRNA sponging and A-to-I RNA-editing
  JOURNAL   Mol Cancer 20 (1), 51 (2021)
   PUBMED   33750389
  REMARK    GeneRIF: CircNEIL3 regulatory loop promotes pancreatic ductal
            adenocarcinoma progression via miRNA sponging and A-to-I
            RNA-editing.
            Erratum:[Mol Cancer. 2022 Aug 19;21(1):165. doi:
            10.1186/s12943-022-01636-3.. PMID: 35986360]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2363)
  AUTHORS   Newton-Cheh,C., Guo,C.Y., Wang,T.J., O'donnell,C.J., Levy,D. and
            Larson,M.G.
  TITLE     Genome-wide association study of electrocardiographic and heart
            rate variability traits: the Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S7 (2007)
   PUBMED   17903306
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2363)
  AUTHORS   Rosenquist,T.A., Zaika,E., Fernandes,A.S., Zharkov,D.O., Miller,H.
            and Grollman,A.P.
  TITLE     The novel DNA glycosylase, NEIL1, protects mammalian cells from
            radiation-mediated cell death
  JOURNAL   DNA Repair (Amst) 2 (5), 581-591 (2003)
   PUBMED   12713815
REFERENCE   8  (bases 1 to 2363)
  AUTHORS   Morland,I., Rolseth,V., Luna,L., Rognes,T., Bjoras,M. and
            Seeberg,E.
  TITLE     Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an
            alternative pathway for the repair of 8-oxoguanine and other
            oxidation products in DNA
  JOURNAL   Nucleic Acids Res 30 (22), 4926-4936 (2002)
   PUBMED   12433996
  REMARK    GeneRIF: hFPG1 and hFPG2 repair 8-oxoguanine and other DNA
            oxidation products. (hFPG1 and hFPG2)
REFERENCE   9  (bases 1 to 2363)
  AUTHORS   Takao,M., Kanno,S., Kobayashi,K., Zhang,Q.M., Yonei,S., van der
            Horst,G.T. and Yasui,A.
  TITLE     A back-up glycosylase in Nth1 knock-out mice is a functional Nei
            (endonuclease VIII) homologue
  JOURNAL   J Biol Chem 277 (44), 42205-42213 (2002)
   PUBMED   12200441
REFERENCE   10 (bases 1 to 2363)
  AUTHORS   Bandaru,V., Sunkara,S., Wallace,S.S. and Bond,J.P.
  TITLE     A novel human DNA glycosylase that removes oxidative DNA damage and
            is homologous to Escherichia coli endonuclease VIII
  JOURNAL   DNA Repair (Amst) 1 (7), 517-529 (2002)
   PUBMED   12509226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027627.6.
            
            On Nov 23, 2018 this sequence version replaced NM_018248.2.
            
            Summary: NEIL3 belongs to a class of DNA glycosylases homologous to
            the bacterial Fpg/Nei family. These glycosylases initiate the first
            step in base excision repair by cleaving bases damaged by reactive
            oxygen species and introducing a DNA strand break via the
            associated lyase reaction (Bandaru et al., 2002 [PubMed
            12509226]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001720.1, SRR1803615.54197.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264596.4/ ENSP00000264596.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AC027627.6         60412-60647
            237-358             AC027627.6         72997-73118
            359-493             AC027627.6         86226-86360
            494-707             AC027627.6         86646-86859
            708-782             AC027627.6         90321-90395
            783-949             AC027627.6         92014-92180
            950-1119            AC027627.6         101918-102087
            1120-1540           AC027627.6         103846-104266
            1541-1715           AC027627.6         111041-111215
            1716-2363           AC027627.6         112827-113474
FEATURES             Location/Qualifiers
     source          1..2363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.3"
     gene            1..2363
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /note="nei like DNA glycosylase 3"
                     /db_xref="GeneID:55247"
                     /db_xref="HGNC:HGNC:24573"
                     /db_xref="MIM:608934"
     exon            1..236
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1898
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /EC_number="4.2.99.18"
                     /note="DNA glycosylase hFPG2; endonuclease VIII-like 3;
                     nei-like protein 3; DNA glycosylase FPG2; zinc finger,
                     GRF-type containing 3; nei endonuclease VIII-like 3; DNA
                     glycosylase/AP lyase Neil3"
                     /codon_start=1
                     /product="endonuclease 8-like 3"
                     /protein_id="NP_060718.3"
                     /db_xref="CCDS:CCDS3828.1"
                     /db_xref="GeneID:55247"
                     /db_xref="HGNC:HGNC:24573"
                     /db_xref="MIM:608934"
                     /translation="MVEGPGCTLNGEKIRARVLPGQAVTGVRGSALRSLQGRALRLAA
                     STVVVSPQAAALNNDSSQNVLSLFNGYVYSGVETLGKELFMYFGPKALRIHFGMKGFI
                     MINPLEYKYKNGASPVLEVQLTKDLICFFDSSVELRNSMESQQRIRMMKELDVCSPEF
                     SFLRAESEVKKQKGRMLGDVLMDQNVLPGVGNIIKNEALFDSGLHPAVKVCQLTDEQI
                     HHLMKMIRDFSILFYRCRKAGLALSKHYKVYKRPNCGQCHCRITVCRFGDNNRMTYFC
                     PHCQKENPQHVDICKLPTRNTIISWTSSRVDHVMDSVARKSEEHWTCVVCTLINKPSS
                     KACDACLTSRPIDSVLKSEENSTVFSHLMKYPCNTFGKPHTEVKINRKTAFGTTTLVL
                     TDFSNKSSTLERKTKQNQILDEEFQNSPPASVCLNDIQHPSKKTTNDITQPSSKVNIS
                     PTISSESKLFSPAHKKPKTAQYSSPELKSCNPGYSNSELQINMTDGPRTLNPDSPRCS
                     KHNRLCILRVVGKDGENKGRQFYACPLPREAQCGFFEWADLSFPFCNHGKRSTMKTVL
                     KIGPNNGKNFFVCPLGKEKQCNFFQWAENGPGIKIIPGC"
     exon            237..358
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /inference="alignment:Splign:2.1.0"
     exon            359..493
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /inference="alignment:Splign:2.1.0"
     exon            494..707
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /inference="alignment:Splign:2.1.0"
     exon            708..782
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /inference="alignment:Splign:2.1.0"
     exon            783..949
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1119
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1540
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1715
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..2363
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2251..2256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /note="hexamer: AATAAG"
     polyA_site      2275
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /note="major polyA site"
     regulatory      2313..2318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /note="hexamer: ATTAAA"
     regulatory      2334..2339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /note="hexamer: ATTAAA"
     polyA_site      2339
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /note="major polyA site"
     regulatory      2344..2349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
                     /note="hexamer: AAGAAA"
     polyA_site      2354
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
     polyA_site      2363
                     /gene="NEIL3"
                     /gene_synonym="FGP2; FPG2; hFPG2; hNEI3; NEI3; ZGRF3"
ORIGIN      
        1 agtgcccgcg cagcgttgag ttgcacagcg gtattctcac caggccctgc aatcggtggg
       61 ccacagtgcc ggccacagag atggtggaag gaccaggctg tactctgaat ggagagaaga
      121 ttcgcgcgcg ggtgctcccg ggccaggcgg tgaccggcgt gcggggaagc gctctgcgga
      181 gtctgcaggg ccgcgccttg cggctcgcag cctccacggt tgtggtctcc ccgcaggctg
      241 ctgcactgaa taatgattcc agccagaatg tcttgagcct gtttaatgga tatgtttaca
      301 gtggcgtgga aactttgggg aaggagctct ttatgtactt tggaccaaaa gctttacgga
      361 ttcatttcgg aatgaaaggc ttcatcatga ttaatccact tgagtataaa tataaaaatg
      421 gagcttctcc tgttttggaa gtgcagctca ccaaagattt gatttgtttc tttgactcat
      481 cagtagaact cagaaactca atggaaagcc aacagagaat aagaatgatg aaagaattag
      541 atgtatgttc acctgaattt agtttcttga gagcagaaag tgaagttaaa aaacagaaag
      601 gccggatgct aggtgatgtg ctaatggatc agaacgtatt gcctggagta gggaacatca
      661 tcaaaaatga agctctcttt gacagtggtc tccacccagc tgttaaagtt tgtcaattaa
      721 cagatgaaca gatccatcac ctcatgaaaa tgatacgtga tttcagcatt ctcttttaca
      781 ggtgccgtaa agcaggactt gctctctcta aacactataa ggtttacaag cgtcctaatt
      841 gtggtcagtg ccactgcaga ataactgtgt gccgctttgg ggacaataac agaatgacat
      901 atttctgtcc tcactgtcaa aaagaaaatc ctcaacatgt tgacatatgc aagctaccga
      961 ctagaaatac tataatcagt tggacatcta gcagggtgga tcatgttatg gactccgtgg
     1021 ctcggaagtc ggaagagcac tggacctgtg tggtgtgtac tttaatcaat aagccctctt
     1081 ctaaggcatg tgatgcttgc ttgacctcaa ggcctattga ttcagtgctc aagagtgaag
     1141 aaaattctac tgtctttagc cacttaatga agtacccgtg taatactttt ggaaaacctc
     1201 atacagaagt caagatcaac agaaaaactg catttggaac tacaactctt gtcttgactg
     1261 attttagcaa taaatccagt actttggaaa gaaaaacaaa gcaaaaccag atactagatg
     1321 aggagtttca aaactctcct cctgctagtg tttgtttgaa tgatatacag cacccctcca
     1381 agaagacaac aaacgatata actcaaccat ccagcaaagt aaacatatca cctacaatca
     1441 gttcagaatc taaattattt agtccagcac ataaaaaacc gaaaacagcc caatactcat
     1501 caccagagct taaaagctgc aaccctggat attctaacag tgaacttcaa attaatatga
     1561 cagatggccc tcgtacctta aatcctgaca gccctcgctg cagtaaacac aaccgcctct
     1621 gcattctccg agttgtgggg aaggatgggg aaaacaaggg caggcagttt tatgcctgtc
     1681 ctctacctag agaagcacaa tgtggatttt ttgaatgggc agatttgtcc ttcccattct
     1741 gcaaccatgg caagcgttcc accatgaaaa cagtattgaa gattggacct aacaatggaa
     1801 agaatttttt tgtgtgtcct cttgggaagg aaaaacaatg caattttttc cagtgggcag
     1861 aaaatgggcc aggaataaaa attattcctg gatgctaata tctgtagatt ctctggcatt
     1921 tagtctcttc aaactgtgta taatgtttgg tcctcctctg tttcatagaa aagtcataga
     1981 atatctatga tacattgaaa agttactgca atatttgaga actgttcttt ttttttcttg
     2041 tgtgtgccat ctttccattg ttggctacgt cttttctttt gccttgatga acgttctatg
     2101 tatttcatcg gatatacagc atattccatt taggatgtgt atttaatgca tttagtaatg
     2161 acgataaagt gtttttagta tgcttttagt ctcttgtaac tggggagaag cagtgttttt
     2221 tttttaggaa aggattatgc gacacaataa aataagatat tctgtctgta gtgaatacat
     2281 ttctcatgta ctaacactat ttataatata tgattaaaga tatttcttgt tttattaaat
     2341 aataagaaat aagatctcct tta
//
