LOCUS       NM_024608               3711 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens nei like DNA glycosylase 1 (NEIL1), transcript variant
            2, mRNA.
ACCESSION   NM_024608
VERSION     NM_024608.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3711)
  AUTHORS   Zuckerman,J.T., Jackson,A.S., Minko,I.G., Kant,M., Jaruga,P.,
            Stone,M.P., Dizdaroglu,M., McCullough,A.K. and Lloyd,R.S.
  TITLE     Functional characterization of single nucleotide polymorphic
            variants of DNA repair enzyme NEIL1 in South Asian populations
  JOURNAL   DNA Repair (Amst) 139, 103695 (2024)
   PUBMED   38795603
  REMARK    GeneRIF: Functional characterization of single nucleotide
            polymorphic variants of DNA repair enzyme NEIL1 in South Asian
            populations.
REFERENCE   2  (bases 1 to 3711)
  AUTHORS   Zuckerman,J.T., Minko,I.G., Kant,M., Jaruga,P., Stone,M.P.,
            Dizdaroglu,M., McCullough,A.K. and Lloyd,R.S.
  TITLE     Functional analyses of single nucleotide polymorphic variants of
            the DNA glycosylase NEIL1 in sub-Saharan African populations
  JOURNAL   DNA Repair (Amst) 129, 103544 (2023)
   PUBMED   37517321
  REMARK    GeneRIF: Functional analyses of single nucleotide polymorphic
            variants of the DNA glycosylase NEIL1 in sub-Saharan African
            populations.
REFERENCE   3  (bases 1 to 3711)
  AUTHORS   Lotsof,E.R., Krajewski,A.E., Anderson-Steele,B., Rogers,J.,
            Zhang,L., Yeo,J., Conlon,S.G., Manlove,A.H., Lee,J.K. and
            David,S.S.
  TITLE     NEIL1 Recoding due to RNA Editing Impacts Lesion-Specific
            Recognition and Excision
  JOURNAL   J Am Chem Soc 144 (32), 14578-14589 (2022)
   PUBMED   35917336
  REMARK    GeneRIF: NEIL1 Recoding due to RNA Editing Impacts Lesion-Specific
            Recognition and Excision.
REFERENCE   4  (bases 1 to 3711)
  AUTHORS   Teoh,P.J., An,O., Chung,T.H., Vaiyapuri,T., Raju,A., Hoppe,M.M.,
            Toh,S.H.M., Wang,W., Chan,M.C., Fullwood,M.J., Jeyasekharan,A.D.,
            Tergaonkar,V., Chen,L., Yang,H. and Chng,W.J.
  TITLE     p53-NEIL1 co-abnormalities induce genomic instability and promote
            synthetic lethality with Chk1 inhibition in multiple myeloma having
            concomitant 17p13(del) and 1q21(gain)
  JOURNAL   Oncogene 41 (14), 2106-2121 (2022)
   PUBMED   35190641
  REMARK    GeneRIF: p53-NEIL1 co-abnormalities induce genomic instability and
            promote synthetic lethality with Chk1 inhibition in multiple
            myeloma having concomitant 17p13(del) and 1q21(gain).
REFERENCE   5  (bases 1 to 3711)
  AUTHORS   Liu,M., Zhang,J., Zhu,C., Zhang,X., Xiao,W., Yan,Y., Liu,L.,
            Zeng,H., Gao,Y.Q. and Yi,C.
  TITLE     DNA repair glycosylase hNEIL1 triages damaged bases via competing
            interaction modes
  JOURNAL   Nat Commun 12 (1), 4108 (2021)
   PUBMED   34226550
  REMARK    GeneRIF: DNA repair glycosylase hNEIL1 triages damaged bases via
            competing interaction modes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3711)
  AUTHORS   Dou,H., Mitra,S. and Hazra,T.K.
  TITLE     Repair of oxidized bases in DNA bubble structures by human DNA
            glycosylases NEIL1 and NEIL2
  JOURNAL   J Biol Chem 278 (50), 49679-49684 (2003)
   PUBMED   14522990
  REMARK    GeneRIF: NEIL1 and NEIL2 are preferentially involved in repair of
            lesions in DNA bubbles generated during transcription and/or
            replication
REFERENCE   7  (bases 1 to 3711)
  AUTHORS   Morland,I., Rolseth,V., Luna,L., Rognes,T., Bjoras,M. and
            Seeberg,E.
  TITLE     Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an
            alternative pathway for the repair of 8-oxoguanine and other
            oxidation products in DNA
  JOURNAL   Nucleic Acids Res 30 (22), 4926-4936 (2002)
   PUBMED   12433996
  REMARK    GeneRIF: hFPG1 and hFPG2 repair 8-oxoguanine and other DNA
            oxidation products. (hFPG1 and hFPG2)
REFERENCE   8  (bases 1 to 3711)
  AUTHORS   Takao,M., Kanno,S., Kobayashi,K., Zhang,Q.M., Yonei,S., van der
            Horst,G.T. and Yasui,A.
  TITLE     A back-up glycosylase in Nth1 knock-out mice is a functional Nei
            (endonuclease VIII) homologue
  JOURNAL   J Biol Chem 277 (44), 42205-42213 (2002)
   PUBMED   12200441
REFERENCE   9  (bases 1 to 3711)
  AUTHORS   Bandaru,V., Sunkara,S., Wallace,S.S. and Bond,J.P.
  TITLE     A novel human DNA glycosylase that removes oxidative DNA damage and
            is homologous to Escherichia coli endonuclease VIII
  JOURNAL   DNA Repair (Amst) 1 (7), 517-529 (2002)
   PUBMED   12509226
  REMARK    GeneRIF: Pyrimidine dimer repair enzyme located on the long arm of
            chromosome 15 that is frequently deleted in human cancers.
REFERENCE   10 (bases 1 to 3711)
  AUTHORS   Hazra,T.K., Izumi,T., Boldogh,I., Imhoff,B., Kow,Y.W., Jaruga,P.,
            Dizdaroglu,M. and Mitra,S.
  TITLE     Identification and characterization of a human DNA glycosylase for
            repair of modified bases in oxidatively damaged DNA
  JOURNAL   Proc Natl Acad Sci U S A 99 (6), 3523-3528 (2002)
   PUBMED   11904416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB282730.1, AB079068.1, AC068338.14 and AK026055.1.
            
            On May 17, 2019 this sequence version replaced NM_024608.3.
            
            Summary: This gene is a member of the Nei endonuclease VIII-like
            gene family which encodes DNA glycosylases. The encoded enzyme
            participates in the DNA repair pathway by initiating base excision
            repair by removing damaged bases, primarily oxidized pyrimidines.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026055.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355059.9/ ENSP00000347170.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-457               DB282730.1         50-506
            458-1181            AB079068.1         1-724
            1182-1183           AC068338.14        21998-21999         c
            1184-1843           AK026055.1         1154-1813
            1844-3711           AC068338.14        18629-20496         c
FEATURES             Location/Qualifiers
     source          1..3711
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..3711
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /note="nei like DNA glycosylase 1"
                     /db_xref="GeneID:79661"
                     /db_xref="HGNC:HGNC:18448"
                     /db_xref="MIM:608844"
     exon            1..435
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..891
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..1630
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /EC_number="4.2.99.18"
                     /note="isoform 2 is encoded by transcript variant 2;
                     endonuclease 8-like 1; endonuclease VIII-like 1; NEH1; nei
                     endonuclease VIII-like 1; DNA endonuclease eight-like
                     glycosylase 1; nei homolog 1; nei-like protein 1; DNA
                     glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic
                     site) lyase Neil1"
                     /codon_start=1
                     /product="endonuclease 8-like 1 isoform 2"
                     /protein_id="NP_078884.2"
                     /db_xref="CCDS:CCDS10278.1"
                     /db_xref="GeneID:79661"
                     /db_xref="HGNC:HGNC:18448"
                     /db_xref="MIM:608844"
                     /translation="MPEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSA
                     YRISASARGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRFY
                     TAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRNLADKAFDRP
                     ICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEALQQHRPSPELTLSQKIRT
                     KLQNPDLLELCHSVPKEVVQLGGKGYGSESGEEDFAAFRAWLRCYGMPGMSSLQDRHG
                     RTIWFQGDPGPLAPKGRKSRKKKSKATQLSPEDRVEDALPPSKAPSRTRRAKRDLPKR
                     TATQRPEGTSLQQDPEAPTVPKKGRRKGRQAASGHCRPRKVKADIPSLEPEGTSAS"
     exon            892..1011
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1075
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1175
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1303
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1331
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1393
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1559
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..3711
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1824..1829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /note="hexamer: AATAAA"
     polyA_site      1843
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /note="major polyA site"
     regulatory      3689..3694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
                     /note="hexamer: AATAAA"
     polyA_site      3711
                     /gene="NEIL1"
                     /gene_synonym="FPG1; hFPG1; NEI1"
ORIGIN      
        1 cgtcgggttt cctcgttttt gcggactggc gctttctgat ttcagagact ctccgcaaca
       61 gaaccatctc aagtgggtct acctcctcgc ctttttttgt tgttgttgtt gcttggctgc
      121 gcttctgaca gggcaggccg tgatgatgtt tgtttatgag ttaggtctga ctgttcgttg
      181 gtgcttaaga tccccaccgg gtccctaggg cctgtgcgta ccgcgcacct gtgcacgtcc
      241 tgcgcgcagc tgcaggcgac tccgctctgg ctcgtcgctg ctgtttcctg ctgggggtgc
      301 cgaccctgtc ccacgctagc tgggtgactt cccccaaccg cagagacagc ggcgacccgg
      361 ggcctcagac ctgcccccgc atctcgccgg cgccaggcag tgggaagtca ggttcttccg
      421 ccacctccca gccaggactc tgccaccctc cctcaggatg cctgagggcc ccgagctgca
      481 cctggccagc cagtttgtga atgaggcctg cagggcgctg gtgttcggcg gctgcgtgga
      541 gaagtcctct gtcagccgca accctgaggt gccctttgag agcagtgcct accgcatctc
      601 agcttcagcc cgcggcaagg agctgcgcct gatactgagc cctctgcctg gggcccagcc
      661 ccaacaggag ccactggccc tggtcttccg cttcggcatg tccggctctt ttcagctggt
      721 gccccgcgag gagctgccac gccatgccca cctgcgcttt tacacggccc cgcctggccc
      781 ccggctcgcc ctatgtttcg tggacatccg ccggttcggc cgctgggacc ttgggggaaa
      841 gtggcagccg ggccgcgggc cctgtgtctt gcaggagtac cagcagttca gggagaatgt
      901 gctacgaaac ctagcggata aggcctttga ccggcccatc tgcgaggccc tcctggacca
      961 gaggttcttc aatggcattg gcaactatct gcgggcagag atcctgtacc ggctgaagat
     1021 cccccccttt gagaaggccc gctcggtcct ggaggccctg cagcagcaca ggccgagccc
     1081 ggagctgacc ctgagccaga agataaggac caagctgcag aatccagacc tgctggagct
     1141 atgtcactca gtgcccaagg aagtggtcca gttggggggc aaaggctacg ggtcagagag
     1201 cggggaggag gactttgctg cctttcgagc ctggctgcgc tgctatggca tgccaggcat
     1261 gagctccctg caggaccggc atggccgtac catctggttc cagggggatc ctggaccgtt
     1321 ggcacccaaa gggcgcaagt cccgcaaaaa gaaatccaag gccacacagc tgagtcctga
     1381 ggacagagtg gaggacgctt tgcctccaag caaggcccct tccaggacac gaagggcaaa
     1441 gagagacctt cctaagagga ctgcaaccca gcggcctgag gggaccagcc tccagcagga
     1501 cccagaagct cccacagtgc ccaagaaggg gaggaggaag gggcgacagg cagcctctgg
     1561 ccactgcaga ccccggaagg tcaaggctga catcccatcc ttggaaccag aggggacctc
     1621 agcctcttag caggaggctc tccttgcttg cactcaccct ttcttattgt cttgccctgc
     1681 atctgggggt ctgaattttt gggagcaggc aatatctgaa ggtgcaaaca ggccctacgg
     1741 ctgttccctg cacaactctc atggttttaa ttgtacccca tcttccacat ctttaaagct
     1801 catgtgaaaa atgctgcatt tttaataaac tgatacattt gaacttcttg gcacctcttg
     1861 gtctgagatg gccaggtagg aagggcctgc tgtccggtcc tggtgacaga aggcccagct
     1921 cctcacaagg caaactgagc ccccatccca gtcctcaagg ctctgactct atcagaggac
     1981 agtttgcctc tgcaaggaca gcccctcaga ggtggtacaa agaccctggc cccaggcagc
     2041 ccaggagcca gagctcctcc agtccagatt ctccagggtc cagggctgcc ccctcatcct
     2101 ggcaggagcc aggcaaaacc cacccttcgg cccctcccca gccccaggcc caggcccttt
     2161 acctgctggc acaggggagg ggcttctcaa ctcatggtct cttcactggc ttttggtggc
     2221 tcgaggtccc cagtctctcc tgtgggggct gcaacccaga ccctgcacgc acaggtacct
     2281 taggatcttg cccctaccca ccaaatacct gggaagccat cccaccccag acttcccacc
     2341 cccaccccaa gcgtgaggat gggccctaag gggactgagc agcagggttc ccgatccaag
     2401 gatttattcc acaagaaaag actgatccct gctttaggct ggggaagcag aaattaggag
     2461 tccccagagc cttctacaaa caaaacccca gccccaggga ctcagtgtgg cggaggctga
     2521 agcacgagca acagggacag cacttggaag ggagaaaagg tgagcttcag gcggttgtcc
     2581 cgaagggtca agtggccagc agggtctggt cgctccaaga gatcgcagct ggagaacagg
     2641 aggggccatg aaggctctgc gagggcgaga ctcgaccccc gccccaatcc cacaccgcca
     2701 ctcacaggat ggcctcctga accggcagcg acaagtgcag ccagcagtcc acgtggctgc
     2761 cgtgggcctc atacagcctc aggaccagcg agcggcgctg ggggctgctc tccgcctgca
     2821 gaggaacacg tctggtggga ggggccgagg gcaggcccag ttcggaaccc cgtccccagc
     2881 acgtcccacc ccttgcctgc ttgacggtct ccaatacgac cgcgggtgaa gacacggaaa
     2941 acgcactcca ggaggtggcg ggcgctgggc tgggggctgg cagagccaac agggggaagt
     3001 ttaggctgta ggcagcttgg ataacgccag catcctggaa agagcctggg gtacgaccag
     3061 gaaacaatgc tggtggagaa tgggggctac cctcccctgt ccctagaagg ggcaggaagc
     3121 caggttgctg gggtttgggc tcagggaagg gcagagaggt gtctagggct gcaggaaggc
     3181 cccaccgtcc ccagcactca cccttgtgcg gcatcagtgc ataggtgaac tcgtggcgcc
     3241 ccgtgtcagc agtagcgtcc ggggctttag gcgcccgcaa gctggggtga ggagggcgcg
     3301 taggggccac gctgaagctg ttggagttgt ggtcgggaag acccatttct ccatgccagc
     3361 tcccaggcct ggtgggtacc ccacttacag cgagaggctg aggatgctgc ctcgcactga
     3421 cgcgccatac ttgcagtcgt tgagcagggc cagcccaaag ccgtgttctg acagatccat
     3481 ccagcgatgg gcccacacct ggagggcaga tccaagaccc acttggtggc cctgtgcccc
     3541 tctttgtgct cccagactcc agagctcctg tcactaggcc gagcacaagc tctagaacca
     3601 cacaactgaa ctccagctcc cactgtacgg ggccctgggc atgccaccca acctgcctaa
     3661 gcctcagttt ccttatctgt gaaacgggaa taaataatag tactcacccc a
//
