LOCUS       NM_173808              12613 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens neuronal growth regulator 1 (NEGR1), mRNA.
ACCESSION   NM_173808
VERSION     NM_173808.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12613)
  AUTHORS   Huang,T., Zhang,X., Li,Q., Li,X., Yao,J., Song,J., Chen,Y., Ye,L.,
            Li,C., Xiran,P. and Wen,Y.
  TITLE     The Association between Obesity Susceptibility and Polymorphisms of
            MC4R, SH2B1, and NEGR1 in Tibetans
  JOURNAL   Genet Test Mol Biomarkers 28 (7), 267-274 (2024)
   PUBMED   39034913
  REMARK    GeneRIF: The Association between Obesity Susceptibility and
            Polymorphisms of MC4R, SH2B1, and NEGR1 in Tibetans.
REFERENCE   2  (bases 1 to 12613)
  AUTHORS   Steffen,B.T., McDonough,D.J., Pankow,J.S., Tang,W., Rooney,M.R.,
            Demmer,R.T., Lutsey,P.L., Guan,W., Gabriel,K.P., Palta,P.,
            Moser,E.D. and Pereira,M.A.
  TITLE     Plasma Neuronal Growth Regulator 1 May Link Physical Activity to
            Reduced Risk of Type 2 Diabetes: A Proteome-Wide Study of ARIC
            Participants
  JOURNAL   Diabetes 73 (2), 318-324 (2024)
   PUBMED   37935012
  REMARK    GeneRIF: Plasma Neuronal Growth Regulator 1 May Link Physical
            Activity to Reduced Risk of Type 2 Diabetes: A Proteome-Wide Study
            of ARIC Participants.
REFERENCE   3  (bases 1 to 12613)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12613)
  AUTHORS   Qiu,L., He,J., Chen,H., Xu,X. and Tao,Y.
  TITLE     CircDLGAP4 overexpression relieves oxygen-glucose
            deprivation-induced neuronal injury by elevating NEGR1 through
            sponging miR-503-3p
  JOURNAL   J Mol Histol 53 (2), 321-332 (2022)
   PUBMED   34739656
  REMARK    GeneRIF: CircDLGAP4 overexpression relieves oxygen-glucose
            deprivation-induced neuronal injury by elevating NEGR1 through
            sponging miR-503-3p.
REFERENCE   5  (bases 1 to 12613)
  AUTHORS   Leyden,G.M., Shapland,C.Y., Davey Smith,G., Sanderson,E.,
            Greenwood,M.P., Murphy,D. and Richardson,T.G.
  TITLE     Harnessing tissue-specific genetic variation to dissect putative
            causal pathways between body mass index and cardiometabolic
            phenotypes
  JOURNAL   Am J Hum Genet 109 (2), 240-252 (2022)
   PUBMED   35090585
  REMARK    GeneRIF: Harnessing tissue-specific genetic variation to dissect
            putative causal pathways between body mass index and
            cardiometabolic phenotypes.
REFERENCE   6  (bases 1 to 12613)
  AUTHORS   Hom,G., Graham,R.R., Modrek,B., Taylor,K.E., Ortmann,W.,
            Garnier,S., Lee,A.T., Chung,S.A., Ferreira,R.C., Pant,P.V.,
            Ballinger,D.G., Kosoy,R., Demirci,F.Y., Kamboh,M.I., Kao,A.H.,
            Tian,C., Gunnarsson,I., Bengtsson,A.A., Rantapaa-Dahlqvist,S.,
            Petri,M., Manzi,S., Seldin,M.F., Ronnblom,L., Syvanen,A.C.,
            Criswell,L.A., Gregersen,P.K. and Behrens,T.W.
  TITLE     Association of systemic lupus erythematosus with C8orf13-BLK and
            ITGAM-ITGAX
  JOURNAL   N Engl J Med 358 (9), 900-909 (2008)
   PUBMED   18204098
REFERENCE   7  (bases 1 to 12613)
  AUTHORS   Yang,Q., Kathiresan,S., Lin,J.P., Tofler,G.H. and O'Donnell,C.J.
  TITLE     Genome-wide association and linkage analyses of hemostatic factors
            and hematological phenotypes in the Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S12 (2007)
   PUBMED   17903294
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 12613)
  AUTHORS   Elortza,F., Mohammed,S., Bunkenborg,J., Foster,L.J., Nuhse,T.S.,
            Brodbeck,U., Peck,S.C. and Jensen,O.N.
  TITLE     Modification-specific proteomics of plasma membrane proteins:
            identification and characterization of
            glycosylphosphatidylinositol-anchored proteins released upon
            phospholipase D treatment
  JOURNAL   J Proteome Res 5 (4), 935-943 (2006)
   PUBMED   16602701
REFERENCE   9  (bases 1 to 12613)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 12613)
  AUTHORS   Funatsu,N., Miyata,S., Kumanogoh,H., Shigeta,M., Hamada,K.,
            Endo,Y., Sokawa,Y. and Maekawa,S.
  TITLE     Characterization of a novel rat brain
            glycosylphosphatidylinositol-anchored protein (Kilon), a member of
            the IgLON cell adhesion molecule family
  JOURNAL   J Biol Chem 274 (12), 8224-8230 (1999)
   PUBMED   10075727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645724.10, AL356600.13, AL359821.11, AL354949.10 and AL627317.7.
            
            On Nov 22, 2018 this sequence version replaced NM_173808.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.104298.1,
                                           SRR1803614.27095.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357731.10/ ENSP00000350364.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AL645724.10        5607-5827           c
            222-454             AL356600.13        129837-130069       c
            455-580             AL359821.11        86881-87006         c
            581-712             AL359821.11        8717-8848           c
            713-833             AL354949.10        136081-136201       c
            834-985             AL354949.10        117872-118023       c
            986-5614            AL627317.7         19630-24258         c
            5615-12613          AL627317.7         12631-19629         c
FEATURES             Location/Qualifiers
     source          1..12613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..12613
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /note="neuronal growth regulator 1"
                     /db_xref="GeneID:257194"
                     /db_xref="HGNC:HGNC:17302"
                     /db_xref="MIM:613173"
     exon            1..221
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1110
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /note="a kindred of IgLON; neurotractin; IgLON family
                     member 4"
                     /codon_start=1
                     /product="neuronal growth regulator 1 precursor"
                     /protein_id="NP_776169.2"
                     /db_xref="CCDS:CCDS661.1"
                     /db_xref="GeneID:257194"
                     /db_xref="HGNC:HGNC:17302"
                     /db_xref="MIM:613173"
                     /translation="MDMMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAA
                     VDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYS
                     LQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTC
                     LATGKPEPSISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVK
                     VVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNF
                     STRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITGSADVLFSCWY
                     LVLTLSSFTSIFYLKNAILQ"
     exon            222..454
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     exon            455..580
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     exon            581..712
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     exon            713..833
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     exon            834..985
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     exon            986..12613
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4661..4666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /note="hexamer: AATAAA"
     polyA_site      4679
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /note="major polyA site"
     regulatory      4797..4802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /note="hexamer: TATAAA"
     polyA_site      4821
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /note="major polyA site"
     regulatory      5062..5067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /note="hexamer: AATAAA"
     polyA_site      5080
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
     regulatory      5593..5598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /note="hexamer: AATAAA"
     polyA_site      5614
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
     regulatory      12593..12598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
                     /note="hexamer: AATAAA"
     polyA_site      12613
                     /gene="NEGR1"
                     /gene_synonym="DMML2433; IGLON4; KILON; Ntra"
ORIGIN      
        1 gagtgcgagc tgaaagctgc tggagagtga gcagccctag cagggatgga catgatgctg
       61 ttggtgcagg gtgcttgttg ctcgaaccag tggctggcgg cggtgctcct cagcctgtgc
      121 tgcctgctac cctcctgcct cccggctgga cagagtgtgg acttcccctg ggcggccgtg
      181 gacaacatga tggtcagaaa aggggacacg gcggtgctta ggtgttattt ggaagatgga
      241 gcttcaaagg gtgcctggct gaaccggtca agtattattt ttgcgggagg tgataagtgg
      301 tcagtggatc ctcgagtttc aatttcaaca ttgaataaaa gggactacag cctccagata
      361 cagaatgtag atgtgacaga tgatggccca tacacgtgtt ctgttcagac tcaacataca
      421 cccagaacaa tgcaggtgca tctaactgtg caagttcctc ctaagatata tgacatctca
      481 aatgatatga ccgtcaatga aggaaccaac gtcactctta cttgtttggc cactgggaaa
      541 ccagagcctt ccatttcttg gcgacacatc tccccatcag caaaaccatt tgaaaatgga
      601 caatatttgg acatttatgg aattacaagg gaccaggctg gggaatatga atgcagtgcg
      661 gaaaatgatg tgtcattccc agatgtgagg aaagtaaaag ttgttgtcaa ctttgctcct
      721 actattcagg aaattaaatc tggcaccgtg acccccggac gcagtggcct gataagatgt
      781 gaaggtgcag gtgtgccgcc tccagccttt gaatggtaca aaggagagaa gaagctcttc
      841 aatggccaac aaggaattat tattcaaaat tttagcacaa gatccattct cactgttacc
      901 aacgtgacac aggagcactt cggcaattat acctgtgtgg ctgccaacaa gctaggcaca
      961 accaatgcga gcctgcctct taaccctcca agtacagccc agtatggaat taccgggagc
     1021 gctgatgttc ttttctcctg ctggtacctt gtgttgacac tgtcctcttt caccagcata
     1081 ttctacctga agaatgccat tctacaataa attcaaagac ccataaaagg cttttaagga
     1141 ttctctgaaa gtgctgatgg ctggatccaa tctggtacag tttgttaaaa gcagcgtggg
     1201 atataatcag cagtgcttac atggggatga tcgccttctg tagaattgct cattatgtaa
     1261 atactttaat tctactcttt tttgattagc tacattacct tgtgaagcag tacacattgt
     1321 ccttttttta agacgtgaaa gctctgaaat tacttttaga ggatattaat tgtgatttca
     1381 tgtttgtaat ctacaacttt tcaaaagcat tcagtcatgg tctgctaggt tgcaggctgt
     1441 agtttacaaa aacgaatatt gcagtgaata tgtgattctt taaggctgca atacaagcat
     1501 tcagttccct gtttcaataa gagtcaatcc acatttacaa agatgcattt ttttcttttt
     1561 tgataaaaaa gcaaataata ttgccttcag attatttctt caaaatataa cacatatcta
     1621 gatttttctg ctcgcatgat attcaggttt caggaatgag ccttgtaata taactggctg
     1681 tgcagctctg cttctctttc ctgtaagttc agcatgggtg tgccttcata caataatatt
     1741 tttctctttg tctccaacta atataaaatg ttttgctaaa tcttacaatt tgaaagtaaa
     1801 aataaaccag agtgatcaag ttaaaccata cactatctct aagtaacgaa ggagctattg
     1861 gactgtaaaa atctcttcct gcactgacaa tggggtttga gaattttgcc ccacactaac
     1921 tcagttcttg tgatgagaga caatttaata acagtatagt aaatatacca tatgatttct
     1981 ttagttgtag ctaaatgtta gatccaccgt gggaaatcat tccctttaaa atgacagcac
     2041 agtccactca aaggattgcc tagcaataca gcatcttttc ctttcactag tccaagccaa
     2101 aaattttaag atgatttgtc agaaagggca caaagtccta tcacctaata ttacaagagt
     2161 tggtaagcgc tcatcattaa ttttattttg tggcagctaa gttagtatga cagaggcagt
     2221 gctcctgtgg acaggagcat tttgcatatt ttccatctga aagtatcact cagttgatag
     2281 tctggaatgc atgttatata ttttaaaact tccaaaatat attataacaa acattctata
     2341 tcggtatgta gcagaccaat ctctaaaata gctaattctt caataaaatc tttctatata
     2401 gccatttcag tgcaaacaag taaaatcaaa aaagaccatc ctttattttt ccttacatga
     2461 tatatgtaag atgcgatcaa ataaagacaa aacaccagtg atgagaatat cttaagataa
     2521 gtaattatca aattattgtg aatgttaaat tatttctact ataaagaagc aaaactacat
     2581 ttttgaagga aaatgctgtt actctaacat taatttacag gaatagtttg atggtttcac
     2641 tctttactaa agaaaggcca tcaccttgaa agccatttta caggtttgat gaagttacca
     2701 atttcagtac acctaaattt ctacaaatag tcccctttta caagttgtaa caacaaagac
     2761 cctataataa aattagatac aagaaatttt gcagtggtta tacatatttg agatatctag
     2821 tatgttgccc tagcagggat ggcttaaaaa ctgtgatttt ttttcttcaa gtaaaactta
     2881 gtcccaaagt acatcataaa tcaattttaa ttagaaaaat gaatcttaaa tgaggggaca
     2941 taagtatact ctttccacaa aatggcaata ataaggcata aagctagtaa atctactaac
     3001 tgtaataaat gtatgacatt attttgattg atacattaaa aaagagtttt tagaacaaat
     3061 atggcattta actttattat ttatttgctt ttaagaaata ttctttgtgg aattgttgaa
     3121 taaactataa aatattattt tgtattgcag ctttaaagtg gcacactcca taataatcta
     3181 cttactagaa atagtggtgc taccacaaaa aatgttaacc atcagtacca ttgtttggga
     3241 gaaagaaaca gatcaagaat gcatattatt cagtgaccgc tttcctagag ttaaaatacc
     3301 tcctctttgt aaggtttgta ggtaaattga ggtataaact atggatgaac caaataatta
     3361 gttcaaagtg ttgtcatgat tccaaatttg tggagtctgg tgtttttacc atagaatgtg
     3421 acagaagtac agtcatagct cagtagctat atgtatttgc ctttatgtta gaagagactt
     3481 tcttgagtga catttttaaa tagaggaggt attcactatg tttttctgta tcacagcagc
     3541 attcctagtc cttaggccct cggacagagt gaaatcatga gtatttatga gttcaatatt
     3601 gtcaaataag gctacagtat ttgctttttt gtgtgaatgt attgcatata atgttcaagt
     3661 agatgatttt acatttatgg acatataaaa tgtctgatta ccccatttta tcagtcctga
     3721 ctgtacaaga ttgttgcaat ttcagaatag cagttttata aattgattta tcttttaatc
     3781 tataacaatt tgtgttagct gttcatttca ggattatatt ttctacaagt tccacttgtg
     3841 ggactccttt tgttgcccct attttttttt aaagaaggaa gaaagaaaaa taagtagcag
     3901 tttaaaaatg agaatggaga gaaaagaaaa agaatgaaaa ggaaaggcag taaagaggga
     3961 aaaaaaggaa ggatggaagg aatgaaggaa ggaagggagg aaggggagaa ggtaggaaga
     4021 aagaaaggat gagagggaag gaagaatcag agtattaggg tagttaactt acacatttgc
     4081 attcttagtt taactgcaag tggtgtaact acgtttttca atgatcgcat ttgaaacata
     4141 agtcctatta taccattaag ttcctattat gcagcaatta tataataaaa agtactgccc
     4201 aagttatagt aatgtgggtg tttttgagac actaaaagat ttgagaggga gaatttcaaa
     4261 cttaaagcca cttttggggg gtttataact taactgaaaa attaatgctt catcataaca
     4321 tttaagctat atctagaaag tagactggag aactgagaaa attacccagg taattcaggg
     4381 aaaaaaaaaa atatatatat atataaatac ccctacattt gaagtcagaa aactctgaaa
     4441 aactgaatta tcaaagtcaa tcatctataa tgatcaaatt tactgaacaa ttgttaattt
     4501 atccattgtg cttagctttg tgacacagcc aaaagttacc tatttaatct tttcaataaa
     4561 aattgttttt tgaaatccag aaatgattta aaaagaggtc aggtttttaa ctatttattg
     4621 aagtatgtgg atgtacagta tttcaataga tatgaatatg aataaatggt atgccttaag
     4681 attctttgaa tatgtattta ctttaaagac tggaaaaagc tcttcctgtc ttttagtaaa
     4741 acatccatat ttcataacct gatgtaaaat atgttgtact gtttccaata ggtgaatata
     4801 aactcagttt atcaattaaa atatgtattt gactcatttt aaaactctat tagcttaaga
     4861 gaaagaagga agaaataata atttgaagat atttctgcta ttctctttat ttcctgtatt
     4921 acactcatct ttctgcttac tctaaagcag tacagggtaa aaattctaga tgctacagtt
     4981 tcaaatgact ccacactata ttctttcttg ctgttgctga ttcctaaaag gtttgatgag
     5041 ctgaactaca tctaaactaa aaataaattt tctggaaaca ttttattatt aattatttag
     5101 aacctttacc tggtaaaata cagcagagtt agcaacagag actaaatatc ctgttgataa
     5161 aatcctgatg atcttacagg ctaaacaact gaaaactcaa acgcttgtaa gagccaggca
     5221 gagtgtaatt tcttaacagc tgggtataaa acaacgggca cctgaaggta ttcagataca
     5281 atttccttaa aaataccttg gtttccaagc aaaacacgtt atttggctga gaacctttag
     5341 tttgtaaata ccaaaccata atatacaaat gagatctcaa gccaaatgaa ttttttaagc
     5401 cctctttccc atatctgttc atctatgata gtcaactgaa taaatgagaa caatgtgata
     5461 gataaaacaa caaagcataa aaaagattca tgcttggttt tataagctat tttgaaatat
     5521 aagtatcatt gctattctga gaaatctata tacaccaaag ccctccctcc acaaaaaaac
     5581 tggaaatgtt ctaataaatg tctgatttcc cccacagctt cattatttct tcccttttca
     5641 acatctatct tatctatctt gcataaatta catcacagaa acagaaacat caagtatcag
     5701 acatggaaaa ccagcacatg aaacagagct agtttccctc tcaaaagaat agggcaaaac
     5761 atagatgctt caaaatcata tcttggtata cagaaaataa ttattcactt taacctgaca
     5821 gtcagaaatg taagtaagaa tttgtagaga taattttcca aggtaattca ttcaagttag
     5881 tggaatttga tccaaacacc cgtcaatgta ctccctctga actttccaag aatcatacac
     5941 cttcacattt acattcactg tttttctagt aattccaaac ttactcaaaa gtatttcaga
     6001 attgatatca ctggtggaaa gagagcaatt tagcaaacaa atacatgctt tccggtattc
     6061 ctagagaaaa ggaaaagagg aatacgtttc attcttctcc ctagaagctc tacccacagt
     6121 catcctaaag ctagaccaat ctctcccagg gctttccttc agtctaagaa acatgcttca
     6181 tttcagagac aattgtggca actatagttt tccccaaagg gtcacaacta cctctccttt
     6241 gcattttaca atggagcact tttgcaagtg ttgctattgt ggctttctca acactttcaa
     6301 atacttaaag gagaaaatat tactattgtc atgtattgat ggtgaaaacg agattcagaa
     6361 attttgagtc acttgctgaa gattatactt caactaagtg gcagatctga gccaaatatg
     6421 caatgaaaaa tgttcccaat ttgtttccag tcccagacta cctaggaaaa agaaaagcat
     6481 ataatcacat tgctagcttc atagacaact atttgcatat ttttatttat atatttatat
     6541 aaatataagc acattttaaa tataaatata gatatttatg acatccttgt attttccaat
     6601 acctgcagag ggtatgagat ttaaaggcta atcagattgt acatgtcatc taaaactttg
     6661 gaaacgtgaa actcacagta cagttgcctt tggacacaca gccttgggtt gtatgagact
     6721 ggtcacacca agtggagaat cttgtcataa tcgcatgtat cttctttttg tatagcattt
     6781 tgcaaaaaat gtgtcaagtt tgggataatc cactaagact attcctcaga catctgcaat
     6841 caacagaatt ttgggggaaa tggagatcag aatacataca cacttttaaa aaaattcaca
     6901 atactgattt taatctgagt gatgttgttt gaggccattt atattgaaat actaacatga
     6961 acatctgttt gtgctgggac agtagaacaa gagaaagatt ctaattctag aaattaaatg
     7021 atatgcaacc taagaaatac atttgtactt tgttttcaaa atatgaatat aatacaaatc
     7081 ctatggatat caccacttag tttgaaaaac ataaaaagtg tgattttcat acacttatga
     7141 aatgaataaa ttaattcatt aatgaaggac ctgataagac attacaacca gataaaagga
     7201 taatttaaag aacatacaca tttatagatc aaaaaccttg aaattaatgt actaatagag
     7261 gcaaaactgg cttccagagt gaggaggaga attcaattga atctttaccc ctcagaattt
     7321 atttccatat ctgtagacga gaaatatttt gccttagtat tatttattta caacttgaaa
     7381 aagagttcaa atataatgaa aaatacagag gctccaaaag aatcagaatc aggtaacctg
     7441 taaaagtgtg ttccaagtaa ttagtggttt ttcatttcag caaaaattct tctctgcaat
     7501 gaagagacat aatttttttt tctttttcag agttttgctc ggttgccctg gatggagtgc
     7561 agtggtgtga tcttggctca ctgcaacctc cgcctcctgg gttcaagcga ttctcctgca
     7621 tcagcctccc cagtagctgg gattataggc acgtgccacc acacctggct aagttttgta
     7681 tttttagtag aggtggggtt tcaccatgtt ggccagtctg gtctagaact cctgacctca
     7741 agtgatccac ttccctcggc ctcctaaagt gctgggatta caggcgtgag ccaccgctcc
     7801 cagacgagat gtaaaatttt taaagccatt gaattaaatt cattgctaac attttgagct
     7861 ttgataatgt aatgcctact ttaatgaccc aaaaaaaaaa aaacccaagt aacctatcta
     7921 tctaataatc tatgtttttt aattactcct tttcttcctt atctcacaaa ccataatcca
     7981 atagtctagg acatgtgaaa gagaaagtaa acagtcacaa gaactacctt gcttcgagaa
     8041 tccaccttgt tgaaaaaata atatattttg ggcacttgtt aaaaagaatt aacagaaaaa
     8101 gtcttttttt ttttgtcaca ggggcattta attcatggta taacaggaat tttatatcaa
     8161 aaacagtaag aaaaatgaag taacagttga gatagcaata attcatcaac caaatactat
     8221 gataatgata aaaacattgc aagaagctat agccagaact gagtgttctg ctcctactta
     8281 gtgctaatga gcccagtcct agcacacatc ttggtttggt agaaactaca ggaggtagca
     8341 tggttcatta caccttcaaa actttaaaat gttaaagagg gtggtttccc tccttcattt
     8401 caaatggatt gctaaaagca ctgggctatt ccttggtgga aatttgaatt tgccagtttc
     8461 ttcatcaatt ttgacttttt acattcaaaa aggagttaac tttacactaa gtcacagcag
     8521 acttagacct cccgcagttc tgaattgtgc ttaaacaagt attcaagcac atggggattt
     8581 ctcaagaaaa tttggggacc atatcttaga aaaaaaactt acaaaatatt cgttgaagac
     8641 tataatatgc taaagctaag gaacaaaatt ctcttgattg ttctaaaaat acctagtaag
     8701 agccacagaa ctcttccata gttttctaag tagtttcata agtgtggatt gtggttgccc
     8761 tgaaacttga catctcccta ccaagtactt gacaagtgac ctggcaaaaa tgtgttcaat
     8821 agctcatttt tgacatactc cttaagaaat cattgccaga gatttgaaac tgcttcaagc
     8881 tgatgtcttt ttcaaaacaa aacacatact cacacacaaa tacaaaatcg cattgctatc
     8941 agtgatctgg aaaataagct tgcaagctgg ccatgtggtg ttctgaataa tttttttaaa
     9001 gtagaagaag aaatgacaac agtgcaacca acagtttctg tttaagtttt atttgctaag
     9061 acgttagcat aaggaacatc ttgtgattta attaatcaga agatggcacc tgctgtaaat
     9121 actgacatgg agaaaagcag atttttaaaa aaatttggaa taaattaatt tcttgtaata
     9181 catttttctt gttgataaac aactaaatta tgctttgaaa tgtgttactg tctaataact
     9241 ttaaatgttg acaaggagaa agactgggtt ttttttttta catttgaata agcaattttt
     9301 ttctggaaac atatatattt ctaatttata gataaactag tatgtgtgtt cagaattcct
     9361 gctctctcat tattcaggtt tcaaaatgta ttaacaaagc ttttatggtt ttataataga
     9421 caattagata tctttcatca ggtaatgtaa gaacttgtat agtggtatat tagtcagttt
     9481 tcacactgct gataaagata tacccgagac agggcaatat gcaaaagaaa gaggtttttt
     9541 tggacctaca gttccatgtg gctggggaag cctcacaatc acagtggaag gtgaaaggca
     9601 cgtctcatat ggcagcagac aagagaaaag agcttgtgca gataaactcc cccttataaa
     9661 accatcagat ctcatgagac ccattcacta tcacaagaac agcatgggaa agacctgctc
     9721 ccatgattca attacctccc accaagtccc tcccacaatc cgtgggaatt ccaaatgaga
     9781 cttgggtggg gacacagcca aaccatatca ttccacccct ggtccctccc aaatctcatg
     9841 tcctcacatt tcaaaaccaa tcatgctttc ccaacagtcc ctcaaagtct taactcattt
     9901 cagcactatc tcaaaagtcc acagtctaaa gtctcatctg agacaaggca agtctcttct
     9961 gcctatgagc agccagtaaa atcaaaagca agttagttac ttcctagatg caatggaagt
    10021 acaggcattg ggtaagcata gccattccaa gtggaagaaa ttggccagaa caaagggact
    10081 acaggggcgg tcaagtctta aagctccaaa atgatctcct ttgactccat ttctcacatc
    10141 caggtcatgc tgatgcaaga ggtgggctcc catggcctta ggcagctccg cctctgcagc
    10201 tttgcagggt atagccctcc tcctggctgc tttcaccagc tggcattgag tgtctgtgcc
    10261 ttttccaggt gcatggtgca agctgttagt ggatttatga ttctgggatc tggaggacag
    10321 tggcccactt ctcacagctc cactacgtgg tgtcccagta gggactctgt gtggggctca
    10381 ctccacattt tccttctgca ctgccctagc agaggttctc catgaggaga acttcattct
    10441 gggcatccag gcatttctat acatcctctg aaatttaggt ggtggtttcc aagcctcaat
    10501 ttttgacttc catgcaccca caggctcaac accatgtgga agctgccaag gcttggggct
    10561 tccactgtct gaagcaacag cccaagctgt accttggctt catttaaatc atcctgggag
    10621 caactgggag gcagagcacc aagttcctag actgcacata gcagagggac cctgggccag
    10681 gcccacaaaa ccattttttt cctccaaaac ctaggggcct gtgatggcag gggctgctgc
    10741 aaaggtctct gacgtgccct ggagacatat tccccactgt cttggtgaca ttcagctcct
    10801 cattacttat gcaattttct gcagccagct tgaatttctc ctcaggaaat gggattttct
    10861 tttctatcac attttcagtc tgtaaatttt tcaaactttt atactgtttc ccttttaaaa
    10921 ctgaatgcca gccaggtgca ctggctcatg cttgtaatct cagcactttg ggagtctgag
    10981 acaggcagat cacctgaggt cacgaatttg agaccaacct ggccaacatg ataaaacccc
    11041 aactctacta aaaatataaa aattagtgag gcatggtggc acatgcctgt aatctcaact
    11101 gcttgggagg ctgaagcaga agaattgctt gaacccagga ggcagaggtt gcagtgagct
    11161 gagatcatgc cactgcactc ctgcctgggt gacaaagtga gactctgtct caaaaacaaa
    11221 acaaaacaga acagaacact gaatgccttt aacaacaccc aagtcacctg ttgaatgctt
    11281 tgctgcttag aaatttcttc ctccaaatat cctaaatcac ctctctcaac ttcaaagttc
    11341 tacacatctc tagggcaagg gcaaaatgct acccatctct ttgctaaaac ataacaagag
    11401 tcacctttgc tccagttccc aacaagttat tcatttccat ctgagaccac ctcagcctgg
    11461 attttattgt ccatatcatt atcagcattt tggtcaaaac cattcaacaa gtctctagga
    11521 agttccaaac tttcccacat tttcctgtct tcttctgagc cctccaaact attccaaccc
    11581 ctgcctgtta cccagttcca aagtcacttc cacattttca ggtatctttt cagcagcact
    11641 ccactcctga tactaattta ctatattagt cagttttcac actgctgata aagacatacc
    11701 tgaggctggg caatttacaa aagaaagagg tttatcagac ttacagttcc acgtggctgg
    11761 ggaggcctca caatcatggt ggaaggtgaa aggcacatct cacatggcag cagagaagag
    11821 aagagaactt gtgaaggaaa actcccgctt ataaaaccat cagatctcat gagacttact
    11881 cactgtcatg agaacagcat gggaaagacc tgcccccatg gttcaattac ctcccaccaa
    11941 gtccctctca caatatgtgg gaattcaaaa tgagatttgt gtggggacat ggccaaacaa
    12001 tatcaaatgg ttttgatttt tatgttgagg cacattctca agctagtatc atttcaagaa
    12061 gaacctgtta tttgttgatt ttggaaattt taaaaatcag atttaattta cactgaaaag
    12121 tggttgacct taacgtttct cagataacct gaaatgttca tgtggcattc attcattcat
    12181 taatccatcc acttatttga caataaaata tgatttaggt gacctctgaa gagctgtcta
    12241 aaaagaatta cctggtagag ttaatctgga tgtttaggac actatgatca aactgaagaa
    12301 aaaggcaccc atttctctaa tcctttcttt gggaagctga tttcacttta aactgaaagt
    12361 gagaaaggaa aaggaagaag aaaagaaaca gagggtaaaa gaagagaaag aggaagggaa
    12421 agaaagagat taatgtatat tttctcctaa gaaaggctct tttgtgtgtg tcggtgtgtg
    12481 tgtgcatgtg tgtttcctgt tgcctggatc tatcataaaa agcaatgtct tctctggaat
    12541 ggggcttcag tttccacatt tacaattagt acatattaca attagtgata tgaataaagg
    12601 ctgttatcct aca
//
