LOCUS       NM_006156                616 bp    mRNA    linear   PRI 15-DEC-2024
DEFINITION  Homo sapiens NEDD8 ubiquitin like modifier (NEDD8), mRNA.
ACCESSION   NM_006156
VERSION     NM_006156.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 616)
  AUTHORS   Papakyriacou,I., Kutkaite,G., Rubies Bedos,M., Nagarajan,D.,
            Alford,L.P., Menden,M.P. and Mao,Y.
  TITLE     Loss of NEDD8 in cancer cells causes vulnerability to immune
            checkpoint blockade in triple-negative breast cancer
  JOURNAL   Nat Commun 15 (1), 3581 (2024)
   PUBMED   38678024
  REMARK    GeneRIF: Loss of NEDD8 in cancer cells causes vulnerability to
            immune checkpoint blockade in triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 616)
  AUTHORS   Wang,T., Li,X., Ma,R., Sun,J., Huang,S., Sun,Z. and Wang,M.
  TITLE     Advancements in colorectal cancer research: Unveiling the cellular
            and molecular mechanisms of neddylation (Review)
  JOURNAL   Int J Oncol 64 (4) (2024)
   PUBMED   38391033
  REMARK    GeneRIF: Advancements in colorectal cancer research: Unveiling the
            cellular and molecular mechanisms of neddylation (Review).
            Review article
REFERENCE   3  (bases 1 to 616)
  AUTHORS   Meng,C., Yan,B., Huang,Y., Wang,C. and Zhang,L.
  TITLE     [Differential expression of NEDD8 in different pathological types
            of chronic rhinosinusitis with nasal polyps]
  JOURNAL   Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 37 (11), 897-901
            (2023)
   PUBMED   37905484
  REMARK    GeneRIF: [Differential expression of NEDD8 in different
            pathological types of chronic rhinosinusitis with nasal polyps].
REFERENCE   4  (bases 1 to 616)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 616)
  AUTHORS   Abounouh,K., Kayesh,M.E.H., Altawalah,H., Kitab,B., Murakami,S.,
            Ogawa,S., Tanaka,Y., Dehbi,H., Pineau,P., Kohara,M., Benjelloun,S.,
            Tsukiyama-Kohara,K. and Ezzikouri,S.
  TITLE     Blocking neddylation elicits antiviral effect against hepatitis B
            virus replication
  JOURNAL   Mol Biol Rep 49 (1), 403-412 (2022)
   PUBMED   34716866
  REMARK    GeneRIF: Blocking neddylation elicits antiviral effect against
            hepatitis B virus replication.
REFERENCE   6  (bases 1 to 616)
  AUTHORS   Whitby,F.G., Xia,G., Pickart,C.M. and Hill,C.P.
  TITLE     Crystal structure of the human ubiquitin-like protein NEDD8 and
            interactions with ubiquitin pathway enzymes
  JOURNAL   J Biol Chem 273 (52), 34983-34991 (1998)
   PUBMED   9857030
REFERENCE   7  (bases 1 to 616)
  AUTHORS   Wada,H., Kito,K., Caskey,L.S., Yeh,E.T. and Kamitani,T.
  TITLE     Cleavage of the C-terminus of NEDD8 by UCH-L3
  JOURNAL   Biochem Biophys Res Commun 251 (3), 688-692 (1998)
   PUBMED   9790970
REFERENCE   8  (bases 1 to 616)
  AUTHORS   Osaka,F., Kawasaki,H., Aida,N., Saeki,M., Chiba,T., Kawashima,S.,
            Tanaka,K. and Kato,S.
  TITLE     A new NEDD8-ligating system for cullin-4A
  JOURNAL   Genes Dev 12 (15), 2263-2268 (1998)
   PUBMED   9694792
REFERENCE   9  (bases 1 to 616)
  AUTHORS   Kamitani,T., Kito,K., Nguyen,H.P. and Yeh,E.T.
  TITLE     Characterization of NEDD8, a developmentally down-regulated
            ubiquitin-like protein
  JOURNAL   J Biol Chem 272 (45), 28557-28562 (1997)
   PUBMED   9353319
REFERENCE   10 (bases 1 to 616)
  AUTHORS   Kumar,S., Yoshida,Y. and Noda,M.
  TITLE     Cloning of a cDNA which encodes a novel ubiquitin-like protein
  JOURNAL   Biochem Biophys Res Commun 195 (1), 393-399 (1993)
   PUBMED   8395831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF130271.1, BC104200.1 and BE548741.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006156.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ061101.1, SRR5189658.162891.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250495.10/ ENSP00000250495.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CF130271.1         4-15
            13-433              BC104200.1         1-421
            434-616             BE548741.1         412-594
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..616
                     /gene="NEDD8"
                     /gene_synonym="NEDD-8"
                     /note="NEDD8 ubiquitin like modifier"
                     /db_xref="GeneID:4738"
                     /db_xref="HGNC:HGNC:7732"
                     /db_xref="MIM:603171"
     exon            1..118
                     /gene="NEDD8"
                     /gene_synonym="NEDD-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..346
                     /gene="NEDD8"
                     /gene_synonym="NEDD-8"
                     /note="neddylin; neural precursor cell expressed,
                     developmentally down-regulated 8"
                     /codon_start=1
                     /product="ubiquitin-like protein NEDD8"
                     /protein_id="NP_006147.1"
                     /db_xref="CCDS:CCDS9621.1"
                     /db_xref="GeneID:4738"
                     /db_xref="HGNC:HGNC:7732"
                     /db_xref="MIM:603171"
                     /translation="MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLI
                     YSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLRQ"
     exon            119..166
                     /gene="NEDD8"
                     /gene_synonym="NEDD-8"
                     /inference="alignment:Splign:2.1.0"
     exon            167..249
                     /gene="NEDD8"
                     /gene_synonym="NEDD-8"
                     /inference="alignment:Splign:2.1.0"
     exon            250..616
                     /gene="NEDD8"
                     /gene_synonym="NEDD-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      590..595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEDD8"
                     /gene_synonym="NEDD-8"
                     /note="hexamer: AATAAA"
     polyA_site      616
                     /gene="NEDD8"
                     /gene_synonym="NEDD-8"
                     /note="major polyA site"
ORIGIN      
        1 agaagtggcc cttgcaggca agagtgctgg agggcggcag cggcgaccgg agcggtagga
       61 gcagcaattt atccgtgtgc agccccaaac tggaaagaag atgctaatta aagtgaagac
      121 gctgaccgga aaggagattg agattgacat tgaacctaca gacaaggtgg agcgaatcaa
      181 ggagcgtgtg gaggagaaag agggaatccc cccacaacag cagaggctca tctacagtgg
      241 caagcagatg aatgatgaga agacagcagc tgattacaag attttaggtg gttcagtcct
      301 tcacctggtg ttggctctga gaggaggagg tggtcttagg cagtgatgga ccctccattt
      361 tacctcttta ccctgtcgct cataatgagg catcatatat cctctcactc tctgggacac
      421 catagccact gccccctccc ctggatgccc agtaatgtat gtctactggt gggagactgt
      481 gaggatccca ggattcagta ttcctggccc agagggccct tgctggctac tgggtgttag
      541 tttgcagtcc tgtgtgcttc cctctcttat gactgtgtcc ctggttgtca ataaaatatt
      601 tcctggcctc ctggaa
//
