LOCUS       NM_001199823             763 bp    mRNA    linear   PRI 27-SEP-2022
DEFINITION  Homo sapiens NEDD8-MDP1 readthrough (NEDD8-MDP1), transcript
            variant 1, mRNA.
ACCESSION   NM_001199823
VERSION     NM_001199823.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 763)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL096870.5 and DN993851.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001199823.2.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring NEDD8 (neural precursor cell
            expressed, developmentally down-regulated 8) and MDP1
            (magnesium-dependent phosphatase 1) genes on chromosome 14. One of
            the read-through transcripts on this locus encodes a fusion protein
            that shares sequence identity with the products of each individual
            gene. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the allele encoded
            by the GRCh38 reference genome and encodes isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2151119,
                              SAMEA2158569 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 4738, 145553
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL096870.5         157588-157602
            16-536              DN993851.1         6-526
            537-555             DN993851.1         528-546
            556-610             DN993851.1         548-602
            611-763             AL096870.5         175860-176012
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..763
                     /gene="NEDD8-MDP1"
                     /note="NEDD8-MDP1 readthrough"
                     /db_xref="GeneID:100528064"
                     /db_xref="HGNC:HGNC:39551"
     exon            1..118
                     /gene="NEDD8-MDP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..682
                     /gene="NEDD8-MDP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NEDD8-MDP1 read-through transcript"
                     /codon_start=1
                     /product="NEDD8-MDP1 protein isoform 1"
                     /protein_id="NP_001186752.1"
                     /db_xref="GeneID:100528064"
                     /db_xref="HGNC:HGNC:39551"
                     /translation="MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLI
                     YSGKQIDGTVRDRRGQDVRLYPEVPEVLKRLQSLGVPGAAASRTSEIEGANQLLELFD
                     LFRYFVHREIYPGSKITHFERLQQKTGIPFSQMIFFDDERRNIVDVSKLGVTCIHIQN
                     GMNLQTLSQGLETFAKAQTGPLRSSLEESPFEA"
     exon            119..166
                     /gene="NEDD8-MDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..249
                     /gene="NEDD8-MDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..360
                     /gene="NEDD8-MDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..468
                     /gene="NEDD8-MDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..554
                     /gene="NEDD8-MDP1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..763
                     /gene="NEDD8-MDP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      728..733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEDD8-MDP1"
                     /note="hexamer: ATTAAA"
     polyA_site      763
                     /gene="NEDD8-MDP1"
                     /note="major polyA site"
ORIGIN      
        1 agaagtggcc cttgcaggca agagtgctgg agggcggcag cggcgaccgg agcggtagga
       61 gcagcaattt atccgtgtgc agccccaaac tggaaagaag atgctaatta aagtgaagac
      121 gctgaccgga aaggagattg agattgacat tgaacctaca gacaaggtgg agcgaatcaa
      181 ggagcgtgtg gaggagaaag agggaatccc cccacaacag cagaggctca tctacagtgg
      241 caagcagatt gatggaactg tacgagatag gcggggccaa gacgtccgac tgtacccaga
      301 ggtgcctgag gtcctaaaac gattgcagag ccttggggtg cccggtgcgg ctgcttcaag
      361 gacaagtgag atagaagggg ccaaccagct actggagctc tttgacctct tcaggtactt
      421 tgttcatcgg gaaatctatc caggcagcaa gatcacacac tttgagaggt tgcagcagaa
      481 gactggaatt cctttctccc agatgatctt ctttgatgat gagaggcgga atattgtaga
      541 cgtcagcaaa ctgggtgtta cctgcattca catccagaat ggaatgaatc ttcaaactct
      601 aagtcaaggg ttagagacat ttgcgaaggc ccaaactggg cctttgaggt ccagccttga
      661 ggagagccca tttgaggcct aaactgaaag gaaatcaaga aggcattttc aggtgcattt
      721 gtaatttatt aaagttcatc tgtgtgtgac agaagagatt tta
//
