LOCUS       XM_047437411            7917 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens NEDD4 like E3 ubiquitin protein ligase
            (NEDD4L), transcript variant X24, mRNA.
ACCESSION   XM_047437411
VERSION     XM_047437411.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000018.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7917
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
     gene            1..7917
                     /gene="NEDD4L"
                     /gene_synonym="hNEDD4-2; NEDD4-2; NEDD4.2; PVNH7; RSP5"
                     /note="NEDD4 like E3 ubiquitin protein ligase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 4 mRNAs, 86 ESTs, 1426 long SRA reads, 16 Proteins,
                     and 98% coverage of the annotated genomic feature by
                     RNAseq alignments, including 9 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:23327"
                     /db_xref="HGNC:HGNC:7728"
                     /db_xref="MIM:606384"
     CDS             394..2646
                     /gene="NEDD4L"
                     /gene_synonym="hNEDD4-2; NEDD4-2; NEDD4.2; PVNH7; RSP5"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NEDD4-like isoform
                     X20"
                     /protein_id="XP_047293367.1"
                     /db_xref="GeneID:23327"
                     /db_xref="HGNC:HGNC:7728"
                     /db_xref="MIM:606384"
                     /translation="MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSD
                     QRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHR
                     PSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVN
                     IAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLR
                     SCSVTDAVAEQGHLPPGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
                     GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIH
                     LDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNR
                     FEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEM
                     FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIR
                     PFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLK
                     PNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELE
                     LLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSR
                     VPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV
                     ENAQGFEGVD"
ORIGIN      
        1 ggagagtccc gtattctcag agtaaaagtt gtttctggaa ttgatctcgc caaaaaggac
       61 atctttggag ccagcttctg ctccattgct gttgaacttt tttttggtcg tgacatcaga
      121 aaaataacca agtgtgagtc tgataatagc aatgatccgt atgtgaaact ttcattgtac
      181 gtagcggatg agaatagaga acttgctttg gtccagacaa aaacaattaa aaagacactg
      241 aacccaaaat ggaatgaaga attttatttc agggtaaacc catctaatca cagactccta
      301 tttgaagtat ttgacgaaaa tagactgaca cgagacgact tcctgggcca ggtggacgtg
      361 ccccttagtc accttccgac agaagatcca accatggagc gaccctatac atttaaggac
      421 tttctcctca gaccaagaag tcataagtct cgagttaagg gatttttgcg attgaaaatg
      481 gcctatatgc caaaaaatgg aggtcaagat gaagaaaaca gtgaccagag ggatgacatg
      541 gagcatggat gggaagttgt tgactcaaat gactcggctt ctcagcacca agaggaactt
      601 cctcctcctc ctctgcctcc cgggtgggaa gaaaaagtgg acaatttagg ccgaacttac
      661 tatgtcaacc acaacaaccg gaccactcag tggcacagac caagcctgat ggacgtgtcc
      721 tcggagtcgg acaataacat cagacagatc aaccaggagg cagcacaccg gcgcttccgc
      781 tcccgcaggc acatcagcga agacttggag cccgagccct cggagggcgg ggatgtcccc
      841 gagccttggg agaccatttc agaggaagtg aatatcgctg gagactctct cggtctggct
      901 ctgcccccac caccggcctc cccaggatct cggaccagcc ctcaggagct gtcagaggaa
      961 ctaagcagaa ggcttcagat cactccagac tccaatgggg aacagttcag ctctttgatt
     1021 caaagagaac cctcctcaag gttgaggtca tgcagtgtca ccgacgcagt tgcagaacag
     1081 ggccatctac caccgggtgc caaggactca cccgtacgtc gggctgtgaa agacaccctt
     1141 tccaacccac agtccccaca gccatcacct tacaactccc ccaaaccaca acacaaagtc
     1201 acacagagct tcttgccacc cggctgggaa atgaggatag cgccaaacgg ccggcccttc
     1261 ttcattgatc ataacacaaa gactacaacc tgggaagatc cacgtttgaa atttccagta
     1321 catatgcggt caaagacatc tttaaacccc aatgaccttg gcccccttcc tcctggctgg
     1381 gaagaaagaa ttcacttgga tggccgaacg ttttatattg atcataatag caaaattact
     1441 cagtgggaag acccaagact gcagaaccca gctattactg gtccggctgt cccttactcc
     1501 agagaattta agcagaaata tgactacttc aggaagaaat taaagaaacc tgctgatatc
     1561 cccaataggt ttgaaatgaa acttcacaga aataacatat ttgaagagtc ctatcggaga
     1621 attatgtccg tgaaaagacc agatgtccta aaagctagac tgtggattga gtttgaatca
     1681 gagaaaggtc ttgactatgg gggtgtggcc agagaatggt tcttcttact gtccaaagag
     1741 atgttcaacc cctactacgg cctctttgag tactctgcca cggacaacta cacccttcag
     1801 atcaacccta attcaggcct ctgtaatgag gatcatttgt cctacttcac ttttattgga
     1861 agagttgctg gtctggccgt atttcatggg aagctcttag atggtttctt cattagacca
     1921 ttttacaaga tgatgttggg aaagcagata accctgaatg acatggaatc tgtggatagt
     1981 gaatattaca actctttgaa atggatcctg gagaatgacc ctactgagct ggacctcatg
     2041 ttctgcatag acgaagaaaa ctttggacag acatatcaag tggatttgaa gcccaatggg
     2101 tcagaaataa tggtcacaaa tgaaaacaaa agggaatata tcgacttagt catccagtgg
     2161 agatttgtga acagggtcca gaagcagatg aacgccttct tggagggatt cacagaacta
     2221 cttcctattg atttgattaa aatttttgat gaaaatgagc tggagttgct catgtgcggc
     2281 ctcggtgatg tggatgtgaa tgactggaga cagcattcta tttacaagaa cggctactgc
     2341 ccaaaccacc ccgtcattca gtggttctgg aaggctgtgc tactcatgga cgccgaaaag
     2401 cgtatccggt tactgcagtt tgtcacaggg acatcgcgag tacctatgaa tggatttgcc
     2461 gaactttatg gttccaatgg tcctcagctg tttacaatag agcaatgggg cagtcctgag
     2521 aaactgccca gagctcacac atgctttaat cgccttgact tacctccata tgaaaccttt
     2581 gaagatttac gagagaaact tctcatggcc gtggaaaatg ctcaaggatt tgaaggggtg
     2641 gattaagcac cctgtgcctc gggggtggtt gttcttcaag caagttctgc ttgcactttt
     2701 gcatttgcct aacagacttt tgcagaggcg atggcagaga gcagctgcag gcatggtccc
     2761 tggagccgag ccttcaccac gcactcgtcc aagttcggat gcgggaacct ggtcccagct
     2821 tgagttcctg cctttcccac cacaaattat caactggttg atgtgtacac taattacatt
     2881 tcaggaggac ttaatgctat ttatgttgtg cctctgcagg caaagccctt aataaatatt
     2941 ttacatcctt tctaatgaca atgaatggaa ttaatcactc aacaggtata gtattacgac
     3001 tcatgtttac tttttaaaat gatttagacc gattttcaga ttttatttcg ttatgattaa
     3061 agatgtctca tgtacttgga aaagtgagca tttttttttt ttttgtattt cactttcata
     3121 ccaggcttaa tgtcaatgac atttttattt ttgaagtact ctgacacctc caccctctac
     3181 tttattagaa ttggaaggca aatttttgtc caaaaaccta cagacaagta ctttgagaga
     3241 atttccaata taatattaga cataatgata attttttcca tactcagaat gaaaaactgg
     3301 atattacgtt tttgttttgg ggtttttttg tacaaattta gctaatagct acaggctgag
     3361 agaattgtaa catagcatga caaattttgt gttgacttga aaggaatcac accattattc
     3421 cttagaagta attacatgtg ttctaacaca tttgagacag ggttggactc ccatttctca
     3481 tccgagaaat tacttaaccc ttcctggcgc tgtacagtca tcttttattc tatttcctct
     3541 ttgctgtttg tagtagagac attttgaatg aaacttggca ctgcttgatt caaaactgtg
     3601 gaaaccagat ctgtttagtc tcctgtttgt atgcgtttgc taatggtagc taaataacca
     3661 gtttttgttg taaatgcacc aattctgaag gcactttatg tactacatgg aggtcatatc
     3721 tggttttgtt tttatttttt tatcatgaac attaaatgtg atgatgattt cttttccctg
     3781 cacacatctt tccggtgcaa tatctatcaa ttgtgaatct ggctgctggt gtataaaaac
     3841 ctggatgtaa agctgagcct acagacctgt cctcaccaac tgttttgtga tttctactca
     3901 actacaaaga tttatttaat gtactcttaa tctaactgag ttttgttacc aatgacctgt
     3961 tgcatgcttc aataccgtgt actgcctgag ttgtgcctct tgtgtgctag attaaaagtg
     4021 agacagagac ttgacttgat cctctgagct caagctattg agctggtagt ggcagaggac
     4081 tgagggtacc tgcacagttt gattcttttc cacgtgtaag tctccattgc agaattgtcg
     4141 tgctttgaga aaacacctga ggcagtgtgg gagttgaacg accctgctgt cctttttaac
     4201 ctgtgttgtc ctagaccctg tcggggcagt caggggacac tagagatttg atctcatgcg
     4261 agtcatcaat aggacaaaaa agttgtggtt tggggaggtc tgtttgttac ataaaaagga
     4321 cctttcggtg taagaaattg ccgtttttac cctgccctgg ctggcatgtg agaagccatg
     4381 gaaggttgtg gttgtaaatg agttgtctaa aggggtgcag aggcctgagg tttctaaaag
     4441 aaggtagatt tctacagagc tgagtgttgg ttcctttttc ttattggttg aaaattacct
     4501 ggtagtgatc agaaaactta gatgctatgt aactaaaaaa aaaaaaaaaa aaaaaaaaaa
     4561 aaaaaaaaaa attcccgctc atgagttttg actattggtg agatgttttc cgctacagtt
     4621 aacatgacaa atgtctcagt ggcaaaaatc ccctttttgt aagcccccat agtctagagg
     4681 cagttttctt tttaagaatc atgccagagc ctgagtcgag cagtatgctt tcttggtttt
     4741 tgagagtaat tgtgtaattg tagagggaga aatccaattc taacctaaga actgggattc
     4801 ttctgtcatc ttgtaaaccg tatattgaaa aaaacagaat gtcactaaat gcatattaag
     4861 tcaagtattg gaaagtataa aagaaaaatc attctgacaa tttctaagcc agaagcaaac
     4921 aagaattact gaaatctacc ccatgaatac ttggaaggca gtaattgtga gtgacacctc
     4981 agttcatcaa ccccttaata atatcagctt aattttaatg acaactaaat atgctgaagt
     5041 gaggatttag tattttttaa aaaagcaaaa caaggttcag tagtcctcag caattctcca
     5101 agtttctctc tttgcctaaa atggtcatag atcttgattt ctctgaatcg tgatgaccac
     5161 acccagtcat cttcacagca taattgcagg tggcagtaaa gagagtgtgc tgggtaagga
     5221 gcagttgctg ggtcattcct tgggccccga cctgcccggg gagtagccct gggggagaga
     5281 gggcagtgtt gcctatccca gaggtcccag cagtcacact gctctgcagg ccgggctctc
     5341 tttatagcca gagaaatcac cttaatgcag tctctttagt tgtctgctga agctgtagtt
     5401 attatgggcc acttacatga ggctgagaag tacgtgccgg agctcacaca ctgcctgttg
     5461 cggttctctt aacatcagtt atcacagctg cctgtgggtc ccgggtattt ccattcctgc
     5521 cccttgttgg cccgaggaag gatgtggaaa gagcacctgg tgggatgaag gtccaacagc
     5581 ctgtgcctct ccactgctgg ccctggagcc ggcagcagtg aggcattcat tgtctgtgtt
     5641 gcggtgtatt cccagcttca gtgctctttt cctttttgcc tgaaatgttt atgcttctct
     5701 gcagccagtc ctctaacaaa tctcaagaac aaaggtaaga cacttggttt ttgtttccag
     5761 gacccttcag aaggtgacat cagatattcc ctaaattcag acaatgaggg atacagagcg
     5821 acttggcatg tattatttct cccatgtaag gacaaaggga cagattatta ttgttatttc
     5881 tgagacagag tcttgctctg tagctcaggc tggagtgcag tggctcaatc tcagctcacc
     5941 acaacctctg cctcctggct tcaagcgatt cttctgcctc agcctccccg aatagttggg
     6001 attacaggca cccaccacca cgcctggcta atttttgtat ttttagtaga gatggtttca
     6061 ccatgctggc caggctggtc ttgaactcct gacctcaggt gatcctcccg cctcagcctt
     6121 ccaaagtgct gggattacaa gcatgagcca ccgcacccgg cctcacagtg acagattctg
     6181 agaaacagca tgcaaaacat ttgaaccatt ttctacatct cccattgttg catagagagt
     6241 gtgcaccgct gctatcttgc cagatccaca ctggtcctcc cgaaagccag gttcatacac
     6301 agcaactttt taattattct aacagttacc cattaacagt cgactcctgt atttctgaga
     6361 gtcttgtact cacctctgaa atttaaaaac gtataaagag agcctgggtt aatcagttct
     6421 gcagccccta cgtgacactg tgctagttct ccttcttctg tctcctcctt accctggccc
     6481 tgcacccctg tacttaagag ggagaggtgg gaggtgctgt ctggtatcat ttgctgcctc
     6541 gccagtagag ggtgccgctg tgcagggtaa ctgcccgcct gctcccttcc tgacctcccc
     6601 tgaccccgaa gatcactacc tctgtcattc aggcattggg gtacatcctg ataagtcgtg
     6661 tcagaactgc caatttcagg actgagatgt gtttttaaaa aacaaatcct tataaactcc
     6721 actttgtact ttagatttta aaactgggga aaaatgtgat attctttgga ccactttttt
     6781 aatttatata agccttaatg aacagtgtct atacatttgc atacacacac ccccacccca
     6841 gagtgttctc agtatgtcag agaaagtgcc acagcattag gacgggagct tggagaacgt
     6901 tttctagaaa agggttagct tcctgttggc atgaaatttt ccaagcaaac ctcattaaac
     6961 atctgttgtt tgttaaagat gttccactga aagcaacgca tgtttcaaag gcacgtcttt
     7021 ccgttcgttg gttttctgtg tgtaaggagt agcattgctg ttggcgccta acctcgcgtg
     7081 cactgcattc tcaaccccgt accagtgcat catcagaagc cttcctcgtg accataactc
     7141 tgtgtctgca gatatgtgtt cccgtgtaag ccagttttcc ccttttactc agactgattt
     7201 cacctagatt gtcacggttt ccttcatgtt aactttgcgt gactttgttc ttcctttact
     7261 actctgtatg taatatatat acatatatac gtacatatgc tgtccaaata tatttgtata
     7321 tatttgtata gcatttttac acctttattg agtaatctgg tttcgaaagg aggtgagagt
     7381 ttagtccctt ctgcagtttt ctccaagctg tgtcctgtga atttcaaccc ttggagccta
     7441 agaaaaccct aggaagatga tgttaatttg ctgtcatttc ctaattcagg atctatcatc
     7501 aaatgaaaca tgaaaaaaac agtgactttt aaggtgaaaa gagtttcaag cattccaaat
     7561 aaattatcaa tgtttcataa ctttttatta taaacccacc tcctaatagg aagccaagta
     7621 ctatttgata cagtggtaaa aaccaaacta ccttgaattt ttttaaggca acttatgaat
     7681 aatgctcatt ttcacagtca gaatagcttt aaaatatggt tgaatttgat acacacagga
     7741 agttttcttg aagaacaatc ctttcgcttt tcttttttct tgagagatct aaagagaaac
     7801 tgtagattgt tttcctgaca gcaaaagact aatgtgacaa aatgaagtca ttgtaaagaa
     7861 gcgatgcaac ttgtcaaata tttaataaag aattatggaa gctggaacat tttctac
//
