LOCUS       NM_152905               4015 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens NEDD1 gamma-tubulin ring complex targeting factor
            (NEDD1), transcript variant 2, mRNA.
ACCESSION   NM_152905
VERSION     NM_152905.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4015)
  AUTHORS   Timon Perez,K., Scrofani,J. and Vernos,I.
  TITLE     NEDD1-S411 phosphorylation plays a critical function in the
            coordination of microtubule nucleation during mitosis
  JOURNAL   Biol Open 11 (11) (2022)
   PUBMED   36318115
  REMARK    GeneRIF: NEDD1-S411 phosphorylation plays a critical function in
            the coordination of microtubule nucleation during mitosis.
REFERENCE   2  (bases 1 to 4015)
  AUTHORS   Chi,W., Wang,G., Xin,G., Jiang,Q. and Zhang,C.
  TITLE     PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and
            centriole biogenesis initiations
  JOURNAL   J Cell Biol 220 (1) (2021)
   PUBMED   33351100
  REMARK    GeneRIF: PLK4-phosphorylated NEDD1 facilitates cartwheel assembly
            and centriole biogenesis initiations.
REFERENCE   3  (bases 1 to 4015)
  AUTHORS   Courtheoux,T., Reboutier,D., Vazeille,T., Cremet,J.Y., Benaud,C.,
            Vernos,I. and Prigent,C.
  TITLE     Microtubule nucleation during central spindle assembly requires
            NEDD1 phosphorylation on serine 405 by Aurora A
  JOURNAL   J Cell Sci 132 (10) (2019)
   PUBMED   31028180
  REMARK    GeneRIF: Authors show here that the expression of a NEDD1 isoform
            mimicking phosphorylation by Aurora A is sufficient to restore
            microtubule nucleation in the midzone under conditions of Aurora A
            inhibition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4015)
  AUTHORS   Fang,C.T., Kuo,H.H., Pan,T.S., Yu,F.C. and Yih,L.H.
  TITLE     HSP70 regulates the function of mitotic centrosomes
  JOURNAL   Cell Mol Life Sci 73 (20), 3949-3960 (2016)
   PUBMED   27137183
REFERENCE   5  (bases 1 to 4015)
  AUTHORS   Xia,K., Guo,H., Hu,Z., Xun,G., Zuo,L., Peng,Y., Wang,K., He,Y.,
            Xiong,Z., Sun,L., Pan,Q., Long,Z., Zou,X., Li,X., Li,W., Xu,X.,
            Lu,L., Liu,Y., Hu,Y., Tian,D., Long,L., Ou,J., Liu,Y., Li,X.,
            Zhang,L., Pan,Y., Chen,J., Peng,H., Liu,Q., Luo,X., Su,W., Wu,L.,
            Liang,D., Dai,H., Yan,X., Feng,Y., Tang,B., Li,J.,
            Miedzybrodzka,Z., Xia,J., Zhang,Z., Luo,X., Zhang,X., St Clair,D.,
            Zhao,J. and Zhang,F.
  TITLE     Common genetic variants on 1p13.2 associate with risk of autism
  JOURNAL   Mol Psychiatry 19 (11), 1212-1219 (2014)
   PUBMED   24189344
REFERENCE   6  (bases 1 to 4015)
  AUTHORS   Haren,L. and Merdes,A.
  TITLE     Direct binding of NuMA to tubulin is mediated by a novel sequence
            motif in the tail domain that bundles and stabilizes microtubules
  JOURNAL   J Cell Sci 115 (Pt 9), 1815-1824 (2002)
   PUBMED   11956313
REFERENCE   7  (bases 1 to 4015)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   8  (bases 1 to 4015)
  AUTHORS   Hsu,H.L. and Yeh,N.H.
  TITLE     Dynamic changes of NuMA during the cell cycle and possible
            appearance of a truncated form of NuMA during apoptosis
  JOURNAL   J Cell Sci 109 (Pt 2), 277-288 (1996)
   PUBMED   8838651
REFERENCE   9  (bases 1 to 4015)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   10 (bases 1 to 4015)
  AUTHORS   Takai,S., Yoshida,Y., Noda,M., Yamada,K. and Kumar,S.
  TITLE     Assignment of the developmentally regulated gene NEDD1 to human
            chromosome 12q22 by fluorescence in situ hybridization
  JOURNAL   Hum Genet 95 (1), 96-98 (1995)
   PUBMED   7814034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK315821.1, AK290058.1, AL832466.1, AA236927.1 and AC013417.4.
            
            On Jun 2, 2019 this sequence version replaced NM_152905.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            a downstream translation initiation codon, compared to variant 1,
            resulting in an isoform (b) that has a shorter N-terminus, compared
            to isoform a. Both variants 2 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.21787.1, AK315821.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266742.9/ ENSP00000266742.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2411              AK315821.1         1-2411
            2412-2710           AK290058.1         2446-2744
            2711-3586           AL832466.1         2459-3334
            3587-3926           AA236927.1         18-357              c
            3927-4015           AC013417.4         5554-5642
FEATURES             Location/Qualifiers
     source          1..4015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..4015
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /note="NEDD1 gamma-tubulin ring complex targeting factor"
                     /db_xref="GeneID:121441"
                     /db_xref="HGNC:HGNC:7723"
                     /db_xref="MIM:600372"
     exon            1..44
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            45..297
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            298..441
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..2288
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /note="isoform b is encoded by transcript variant 2;
                     protein NEDD1; NEDD-1; neural precursor cell expressed
                     developmentally down-regulated protein 1; tubulin gamma
                     complex associated protein 7; neural precursor cell
                     expressed, developmentally down-regulated 1"
                     /codon_start=1
                     /product="protein NEDD1 isoform b"
                     /protein_id="NP_690869.1"
                     /db_xref="CCDS:CCDS9063.1"
                     /db_xref="GeneID:121441"
                     /db_xref="HGNC:HGNC:7723"
                     /db_xref="MIM:600372"
                     /translation="MQENLRFASSGDDIKIWDASSMTLVDKFNPHTSPHGISSICWSS
                     NNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVNLNSTSMYLVSGGLNNTVN
                     IWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHG
                     SNQSVRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSVHKAPASGICFSPVN
                     ELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYD
                     LRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSSLNKGCSNKPTTVNKRSVNVNAASGG
                     VQNSGIVREAPATSIATVLPQPMTSAMGKGTVAVQEKAGLPRSINTDTLSKETDSGKN
                     QDFSSFDDTGKSSLGDMFSPIRDDAVVNKGSDESIGKGDGFDFLPQLNSVFPPRKNPV
                     TSSTSVLHSSPLNVFMGSPGKEENENRDLTAESKKIYMGKQESKDSFKQLAKLVTSGA
                     ESGNLNTSPSSNQTRNSEKFEKPENEIEAQLICEPPINGSSTPNPKIASSVTAGVASS
                     LSEKIADSIGNNRQNAPLTSIQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHM
                     QLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF"
     exon            442..536
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            537..653
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            654..794
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1024
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1226
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1422
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1551
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1599
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1802
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1959
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2116
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2183
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..4015
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3562..3567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /note="hexamer: AATAAA"
     polyA_site      3586
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
     regulatory      3902..3907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /note="hexamer: AATAAA"
     polyA_site      3924
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /note="major polyA site"
     regulatory      3993..3998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
                     /note="hexamer: ATTAAA"
     polyA_site      4006
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
     polyA_site      4015
                     /gene="NEDD1"
                     /gene_synonym="GCP-WD; TUBGCP7"
ORIGIN      
        1 agcgcggagc cggccgcggc cccctgttgt gttgctgcgg agaggtactt ggatgcattt
       61 tacaggttag cctcacttga gctgttgtcc tgcaagtaaa gtgtattttt ggtgattgaa
      121 agttggagaa ctttcatttc agctgagtgg tgtagttgaa ttggttcctg tagccgctgt
      181 ccctaaaccc aggccgacgt taccgccttg tgtcctgact gctagctttc gacgggaccg
      241 tctttgaggg actcatgtaa agtctctccc ttaatgctca gttcttagaa gaccgaggcg
      301 cagtcatgca ggaaaacctc agatttgctt catcaggaga tgatattaaa atatgggatg
      361 cttcatctat gacattggtg gataaattca acccacacac atcaccacat ggaatcagct
      421 caatatgttg gagcagcaat aataactttt tagtaacagc atcttccagt ggcgacaaaa
      481 tagttgtctc aagttgcaaa tgtaaacctg ttccactttt agagcttgct gaagggcaaa
      541 agcagacatg tgtcaattta aattctacat ctatgtattt ggtaagcgga ggcctaaata
      601 acactgttaa tatttgggat ttaaaatcaa aaagagttca tcgatctctt aaggatcata
      661 aagatcaagt aacttgtgta acatacaatt ggaatgattg ctacattgct tctggatctc
      721 ttagtggtga aattatttta cacagtgtaa ccactaattt atctagtact ccttttggcc
      781 atggtagtaa ccagtctgtt cggcacttga agtactcctt gtttaagaaa tcactactgg
      841 gcagtgtttc ggataatgga atagtaactc tctgggatgt aaatagtcag agtccatacc
      901 ataactttga cagtgtacac aaagctccag cgtcaggcat ctgtttttct cctgtcaatg
      961 aattgctctt tgtaaccata ggcttggata aaagaatcat cctctatgac acttcaagta
     1021 agaagctagt gaaaacttta gtggctgaca ctcctctaac tgcggtagat ttcatgcctg
     1081 atggagccac tttggctatt ggatcttccc gggggaaaat atatcaatat gatttaagaa
     1141 tgttgaaatc accagttaag accatcagtg ctcacaagac atctgtgcag tgtatagcat
     1201 ttcagtactc cactgttctt actaagtcaa gtttaaataa aggctgttca aataagccca
     1261 caacagtgaa caaacgaagt gttaatgtga atgctgctag tggaggagtt cagaattccg
     1321 gaattgtcag agaagcacct gccacgtcca ttgccacagt tctaccacaa cctatgacat
     1381 cagctatggg gaaaggaaca gttgctgttc aagaaaaagc aggtttgcct cgaagcataa
     1441 acacagacac tttatctaag gaaacagaca gtggaaaaaa tcaggatttc tccagctttg
     1501 atgatactgg gaaaagtagt ttaggtgaca tgttctcacc tatcagagat gatgctgtag
     1561 ttaacaaggg aagtgatgag tccataggca aaggagatgg ctttgacttt ctaccgcagt
     1621 tgaactcagt gtttcctcca agaaaaaatc cagtaacttc aagtacttca gtattgcatt
     1681 ctagtcctct taatgttttt atgggatctc cagggaaaga ggaaaatgaa aaccgtgatc
     1741 taacagctga gtctaagaaa atatatatgg gaaaacagga atctaaagac tccttcaaac
     1801 agttagcaaa gttggtcaca tctggtgctg aaagtggaaa tctaaatacc tctccatcat
     1861 ctaaccaaac aagaaattct gagaaatttg aaaagccaga gaatgaaatt gaagcccagt
     1921 tgatatgtga acccccaatc aatggatcct caactccaaa tccaaagata gcatcttctg
     1981 tcactgctgg agttgccagt tcactctcag aaaaaatagc cgacagcatt ggaaataacc
     2041 ggcaaaatgc accattgact tccattcaaa ttcgttttat tcagaacatg atacaggaaa
     2101 cgttggatga ctttagagaa gcatgccata gggacattgt gaatttgcaa gtggagatga
     2161 ttaaacagtt tcatatgcaa ctgaatgaaa tgcattcttt gctggaaaga tactcagtga
     2221 atgaaggttt agtggctgaa attgaaagac tacgagaaga aaacaaaaga ttacgggccc
     2281 acttttgaaa tttcagtgaa taccttaatg ttctgtaatt tgggaagttt ctggcaacac
     2341 agaactacat agaatcagta ttgttttcat ggcctccagg gaaaaaatgt ttttcaagta
     2401 agagtaaaag gatgatggga ttttatacca acaactgttt catcttaaaa atatgtatat
     2461 ttttatatta aaaattgtac agtatgtcat ctacccaata ggaaagtcaa caggatcttt
     2521 attttttgaa agctttagcc atccactaag tgcccttttt cataagagaa gaaaattgtg
     2581 cataaaaatt ggttatgttt gttttttagt catctttttt aacatatatt tttgattgac
     2641 aaattgcctt tcaaattttt ggggctagtt gagatttaaa gagtttgata tgccttctat
     2701 ttttatggag aaagtaattt taaaatggca attggtgttt ctaagccatt gactaataaa
     2761 acatagggtt ggctagtaat tattttgtta acttgatgaa gtcaagtatg actattattt
     2821 attgtacatt tgataagaca atttttggaa ttttgaattg cacaaattac atgatatctt
     2881 ttgcatttat gttactatat tgtacttctg acaaatcttt attcctgggt ggtattttta
     2941 agatatcttt acctataaaa aatgtttaag gttcatagga ctcgacaaga gctatctggt
     3001 gattttctca ttagtaacat gcaacgttgt actgcaaaat ttcaatcaac atgacaactt
     3061 ataatgagtg gagatttcat attaggtact aaatattata gtattatttc tattttcttt
     3121 ttccaaataa gaagcttgga ttattttatt ttgtggtctt tatcattaac tttaattctt
     3181 tctgtactgt gtataatatt tttatattat tggccttacc ataaaattat ttagaaaggt
     3241 tgtcaaaata agttatacct ctttggcaat agatagatgt atacatctac ctactatgat
     3301 ctacaatttt aggttaagtg aagcttgggg gggctactga cttggttacc ttcttgtctc
     3361 ttgtcccaaa gatttaaact gtgtaccttt gtatagctct tctgccccat tttgacttct
     3421 gagatgaaag tatttactaa aattaaaaaa aaaaaaacaa aaaacaaacc tttagctcac
     3481 taactttatg ggtttctgaa gtgatggaaa tttttaagga tatatttaat aagcataaac
     3541 ttactaataa ttacttccaa aaataaaaac aggaatatta cttttaccca gtgtggttta
     3601 tagcatacat ttgtactgaa gcatataggg atgttaatgt gatcttttcc tgacagatta
     3661 tgaaagcatt atgacttgta acaagtttcc ttgtatatca ctaacaggtt tagaagacat
     3721 aaatattagt gtgttttgcc tacatggtgt atttaaatct attaatattt tcctgttgct
     3781 tttttaaaaa aataaataca cataatgtat attaaaagag gtgggatgaa ataattttag
     3841 taattatgtg tacagatgaa acatttttgt catggaattt aaaagctaag taagtataaa
     3901 aaataaaatg ttatatgcaa aaaataggaa acatgaaatt gaaatttcat tgttggccaa
     3961 aatgatatga gagatttacc ttcccacctg aaattaaaaa agaaaatatg tgaaa
//
