LOCUS       NM_015480               5197 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nectin cell adhesion molecule 3 (NECTIN3), transcript
            variant 1, mRNA.
ACCESSION   NM_015480
VERSION     NM_015480.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5197)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5197)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5197)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5197)
  AUTHORS   Hirabayashi,K., Tajiri,T., Bosch,D.E., Morimachi,M., Miyaoka,M.,
            Inomoto,C., Nakamura,N. and Yeh,M.M.
  TITLE     Loss of nectin-3 expression as a marker of tumor aggressiveness in
            pancreatic neuroendocrine tumor
  JOURNAL   Pathol Int 70 (2), 84-91 (2020)
   PUBMED   31855317
  REMARK    GeneRIF: Loss of nectin-3 expression as a marker of tumor
            aggressiveness in pancreatic neuroendocrine tumor.
REFERENCE   5  (bases 1 to 5197)
  AUTHORS   Lachke,S.A., Higgins,A.W., Inagaki,M., Saadi,I., Xi,Q., Long,M.,
            Quade,B.J., Talkowski,M.E., Gusella,J.F., Fujimoto,A.,
            Robinson,M.L., Yang,Y., Duong,Q.T., Shapira,I., Motro,B.,
            Miyoshi,J., Takai,Y., Morton,C.C. and Maas,R.L.
  TITLE     The cell adhesion gene PVRL3 is associated with congenital ocular
            defects
  JOURNAL   Hum Genet 131 (2), 235-250 (2012)
   PUBMED   21769484
REFERENCE   6  (bases 1 to 5197)
  AUTHORS   Reymond,N., Fabre,S., Lecocq,E., Adelaide,J., Dubreuil,P. and
            Lopez,M.
  TITLE     Nectin4/PRR4, a new afadin-associated member of the nectin family
            that trans-interacts with nectin1/PRR1 through V domain interaction
  JOURNAL   J Biol Chem 276 (46), 43205-43215 (2001)
   PUBMED   11544254
REFERENCE   7  (bases 1 to 5197)
  AUTHORS   Reymond,N., Borg,J.P., Lecocq,E., Adelaide,J., Campadelli-Fiume,G.,
            Dubreuil,P. and Lopez,M.
  TITLE     Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family
            that interacts with afadin
  JOURNAL   Gene 255 (2), 347-355 (2000)
   PUBMED   11024295
REFERENCE   8  (bases 1 to 5197)
  AUTHORS   Satoh-Horikawa,K., Nakanishi,H., Takahashi,K., Miyahara,M.,
            Nishimura,M., Tachibana,K., Mizoguchi,A. and Takai,Y.
  TITLE     Nectin-3, a new member of immunoglobulin-like cell adhesion
            molecules that shows homophilic and heterophilic cell-cell adhesion
            activities
  JOURNAL   J Biol Chem 275 (14), 10291-10299 (2000)
   PUBMED   10744716
REFERENCE   9  (bases 1 to 5197)
  AUTHORS   Takahashi,K., Nakanishi,H., Miyahara,M., Mandai,K., Satoh,K.,
            Satoh,A., Nishioka,H., Aoki,J., Nomoto,A., Mizoguchi,A. and
            Takai,Y.
  TITLE     Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited
            to cadherin-based adherens junctions through interaction with
            Afadin, a PDZ domain-containing protein
  JOURNAL   J Cell Biol 145 (3), 539-549 (1999)
   PUBMED   10225955
REFERENCE   10 (bases 1 to 5197)
  AUTHORS   Lopez,M., Aoubala,M., Jordier,F., Isnardon,D., Gomez,S. and
            Dubreuil,P.
  TITLE     The human poliovirus receptor related 2 protein is a new
            hematopoietic/endothelial homophilic adhesion molecule
  JOURNAL   Blood 92 (12), 4602-4611 (1998)
   PUBMED   9845526
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI464010.1, AF282874.1,
            AC137833.3 and AA555086.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015480.2.
            
            Summary: This gene encodes a member of the nectin family of
            proteins, which function as adhesion molecules at adherens
            junctions. This family member interacts with other nectin-like
            proteins and with afadin, a filamentous actin-binding protein
            involved in the regulation of directional motility, cell
            proliferation and survival. This gene plays a role in ocular
            development involving the ciliary body. Mutations in this gene are
            believed to result in congenital ocular defects. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.100385.1, AF282874.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000485303.6/ ENSP00000418070.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               BI464010.1         69-270
            203-1852            AF282874.1         1-1650
            1853-4827           AC137833.3         12246-15220
            4828-5197           AA555086.1         12-381              c
FEATURES             Location/Qualifiers
     source          1..5197
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.13"
     gene            1..5197
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /note="nectin cell adhesion molecule 3"
                     /db_xref="GeneID:25945"
                     /db_xref="HGNC:HGNC:17664"
                     /db_xref="MIM:607147"
     exon            1..362
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1852
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; nectin 3; poliovirus receptor-related protein
                     3; poliovirus receptor-related 3"
                     /codon_start=1
                     /product="nectin-3 isoform 1 precursor"
                     /protein_id="NP_056295.1"
                     /db_xref="CCDS:CCDS2957.1"
                     /db_xref="GeneID:25945"
                     /db_xref="HGNC:HGNC:17664"
                     /db_xref="MIM:607147"
                     /translation="MARTLRPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLF
                     PLLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTV
                     AVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQS
                     STTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTT
                     SFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGY
                     DGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSG
                     VYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLS
                     TLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQ
                     KESQIDVLQQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNRFERPM
                     DYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV"
     exon            363..704
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /inference="alignment:Splign:2.1.0"
     exon            705..1001
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1119
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1271
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..5197
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2581..2586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /note="hexamer: AATACA"
     polyA_site      2602
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /note="major polyA site"
     regulatory      3001..3006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /note="hexamer: ATTAAA"
     polyA_site      3019
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /note="major polyA site"
     regulatory      4228..4233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /note="hexamer: AATAAA"
     polyA_site      4248
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
     regulatory      4491..4496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /note="hexamer: AATACA"
     polyA_site      4507
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
     regulatory      4980..4985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /note="hexamer: CATAAA"
     polyA_site      5001
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
     regulatory      5168..5173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
                     /note="hexamer: AATAAA"
     polyA_site      5197
                     /gene="NECTIN3"
                     /gene_synonym="CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3;
                     PVRR3"
ORIGIN      
        1 agcctcggca gtggcgtcgg cgacggcggt gtcgaggcag ccgccagcgt tcggccaagt
       61 gtcagccggc agcgacggcg ctagagctgg gagctgggga cgcgcgcgcc ggaccttcca
      121 cagcctccgc ccagagcctg aggcgccggg gccgggggag ccggggggcg ggcgggcgag
      181 cgggccgggg ggagggtggg ggatggcgcg gaccctgcgg ccgtccccgc tgtgtcctgg
      241 aggcggcaaa gcacaacttt cctccgcttc tctcctcgga gccgggctcc tgctgcagcc
      301 cccgacgcca cctccgctgc tgctgctgct cttcccgctg ctgctcttct ccaggctctg
      361 tggtgcctta gctggaccaa ttattgtgga gccacatgtc acagcagtat ggggaaagaa
      421 tgtttcatta aagtgtttaa ttgaagtaaa tgaaaccata acacagattt catgggagaa
      481 gatacatggc aaaagttcac agactgttgc agttcaccat ccccaatatg gattctctgt
      541 tcaaggagaa tatcagggaa gagtcttgtt taaaaattac tcacttaatg atgcaacaat
      601 tactctgcat aacataggat tctctgattc tggaaaatac atctgcaaag ctgttacatt
      661 cccgcttgga aatgcccagt cctctacaac tgtaactgtg ttagttgaac ccactgtgag
      721 cctgataaaa gggccagatt ctttaattga tggaggaaat gaaacagtag cagccatttg
      781 catcgcagcc actggaaaac ccgttgcaca tattgactgg gaaggtgatc ttggtgaaat
      841 ggaatccact acaacttctt ttccaaatga aacggcaacg attatcagcc agtacaagct
      901 atttccaacc agatttgcta gaggaaggcg aattacttgt gttgtaaaac atccagcctt
      961 ggaaaaggac atccgatact ctttcatatt agacatacag tatgctcctg aagtttcggt
     1021 aacaggatat gatggaaatt ggtttgtagg aagaaaaggt gttaatctca aatgtaatgc
     1081 tgatgcaaat ccaccaccct tcaaatctgt gtggagcagg ttggatggac aatggcctga
     1141 tggtttattg gcttcagaca atactcttca ttttgtccat ccattgactt tcaattattc
     1201 tggtgtttat atctgtaaag tgaccaattc ccttggtcaa agaagtgacc aaaaagtcat
     1261 ctacatttca gatcctccta ctactaccac ccttcagcct acaattcagt ggcatccctc
     1321 aactgctgac atcgaggatc tagcaacaga acctaaaaaa ttgcccttcc cattgtcaac
     1381 tttggcaaca attaaggatg acacaattgc cacgatcatt gctagtgtag tgggtggggc
     1441 tctcttcata gtacttgtaa gtgttttggc tggaatattc tgctatagga gaagacggac
     1501 gtttcgtgga gactactttg ccaagaacta cattccacca tcagatatgc aaaaagaatc
     1561 acaaatagat gttcttcaac aagatgagct tgattcttac ccagacagtg taaaaaaaga
     1621 aaacaaaaat ccagtgaaca atctaatacg taaagactat ttagaagagc ctgaaaaaac
     1681 tcagtggaac aatgtagaaa atctcaatag gtttgaaaga ccaatggatt attatgaaga
     1741 tctaaaaatg ggaatgaagt ttgtcagtga tgaacattat gatgaaaacg aagatgactt
     1801 agtttcacat gtagatggtt ccgtaatttc caggagggag tggtatgttt agcaaccact
     1861 gaatgtgact taactatgta caatgttcat tcacactagt tgatcatttt cagattgttc
     1921 atactttttc ttgaggaaga ataagctttt tcaagttgat tttcaagctt actttttata
     1981 ttctaatctg acaaatgaaa atgtaaaatc tgagttcagt gtatctaagc tgctttacaa
     2041 ttttttttca atgctgtact actgtctcaa gatttaaatt ttaatgcaga gtactttatt
     2101 ggtgtgaggc acacaggtaa gaagaaatgt caacattaaa tgtatgactt acttggtaca
     2161 aaaatttttt aaaaagggaa ctaccttgac attgtgtatt aaatgtttac ctaagactat
     2221 aatctcaagt atgatgtttg tttaacatat acctctcaaa atttatcacc actcaatgac
     2281 actgcatcaa aattgactat aaaactaatt caagaaatat ttatatatat tttttaatat
     2341 acaaaaaata tttagcctga tggaatggct ttccttttca aacattattt tctaagtttc
     2401 tatacaaatg aaatctttac ctctgcatat taatgagcct tgccataatt actgtagagt
     2461 ggcttttcaa agatattttg ttgcactaaa actgtggtag taaactcagt gaacatgatg
     2521 tgtggaagag cataattagc tggtcaatat ttttgtccaa aatacctgca agagtaataa
     2581 aatacatacc tttcaaacat gataattatt agtttttttt tttcctttct ggaacatgga
     2641 ttttggtaca ttagcagtag ccttatttta atgctttatg tcctaaacat actaatagaa
     2701 atgaaaagac gcagagagag catttcggaa tactgaagta ctagttttag aaatgagact
     2761 ttcagccaac aatctataga aagaatttta tggaccatct tgttttagtt atttaatgtt
     2821 gatgttgttc aaatgggtaa atgtacagaa agaaaatttt agagtaaact tggaactttg
     2881 gatataacta gaaaaaacta gattatagaa ttagtcggta acacttgcta atggacattg
     2941 gcattcatct cctttttcct cctaagtgta tgtatgtgtt ttaagatttc tgtttttacg
     3001 attaaaactg gaaacatgag gttttttgtt tttgtttttt tacataatta catatattcc
     3061 ttctgaatca tttatctttt gagaaagaaa tgttacctaa acttcaaatg tgctttttgt
     3121 ttgtgaggta attaaattgc ttctacagtg gaggcttaca aaattattgt gacaactatt
     3181 ttgaagctga aaggatagtt tttctattgc taagtcattt gaaaaagtga ccattttgcc
     3241 agtgaaatga agtggaagtt agtaggagaa tcataaatta aatatattat tttgttaata
     3301 aaaaggcaaa gtagtaggta ctttttaaac cctcccaacc agccctttct caatattcat
     3361 caaatctaaa acatttaggg ggcaaaattc taacatgttc atggtatctt gcaaatagtg
     3421 aaagctttat tctgaaggat tataaactag ttttcttcat tttaactagc actattttgt
     3481 ggaaattaga aacctctttt atttctcttc ccaaaagtaa tacttattat aaggctgtag
     3541 tatcaggtta aggatacaga taaataaagt tcacttatat cttcttacaa atgtctgggt
     3601 tttaatatgg ttaatcactt atatacaaat attacaactt tttagtgcaa gtttttggaa
     3661 gaaaactttt tgataaaaca ctgtgattga tgtgacttta tttttaattt aaacgatgag
     3721 gtggccagaa gaaagatggg tctaaaattt ctccccatga aagatgtaaa actatggctt
     3781 tttttaaaat caaaatttca tcttttaaaa taatggtttg aaatactgta tggatctgaa
     3841 cagaataatc acatttagga ttctatataa atctcaactg gagtataatc tgaaggaaat
     3901 tagcagtgta ttttaagaaa tatatttcaa aaatataaat actgattatg aacttccttt
     3961 tacattgtgg ttatttgtgc gattaggttt ttttgtttgt ttcttttgtg tttgtttggc
     4021 gggagagggt gacctggaaa gccacaagtg agtatttgac atattctgta tccttaatcc
     4081 aatcatttgg caaactaaaa ggtttctgtg ttgtaagaat ctgatactag tgcttaagac
     4141 tttgggaagc attgcactgt tgtttattag aactttatgt atatttactg tacatagaga
     4201 cttgtttgaa aacatgaata gtcattaaat aaagacattg ttaaattagt ttttgaatac
     4261 cagtgatatt cataactact tgacaggtat atatgaaaat tctactatcg tgaaaaaaaa
     4321 tgaatatttg tactattttt ggccatattt atatttattt ctttcatatg gtttgaactg
     4381 ttttagcatt ttgtaaattc acttgagagt tttctttcat actggttaaa atatttcaat
     4441 gatataatga agatgaatgc aactcttatt tttctgccat tttttattaa aatacattga
     4501 aactaaagta ggctcggggt taactttaaa agtgatattt gagaagtgct ttagagttga
     4561 aagatttagt attttaccac gtgcctagta gggttctatt tgctaactct aatattgagg
     4621 aaactattaa ggttttcagt agtaagtgtt gcttctaata gccatataca ggaaagtttt
     4681 ataagataac ccacggctaa atattttgca ttaaggagct gtaggagtac agtgtataag
     4741 tacagaaatt gagagaaatg tagtcatttt atatgtgaaa acatctgatt tgagtttttg
     4801 ataaatactg ctaaaacaca gtatatgaac aagtaagaag tttatgtatg aaagtaatca
     4861 atgtaaaata taagaaagga ataaatggta cccattttga atttttaatt ctaataggag
     4921 agtagattgt agattgaatt gtctttcctg tttacttgtt aattagaaaa tgcatccttc
     4981 ataaacagct cctttctcaa attttttgta tattgtgttt gtgtttgggt tttagtttgt
     5041 acccgcgcta agttttggtt ttgttgtgtt tggtgttttt tgttttgttt tgttttgttt
     5101 tgttttttct tttttaacca acctgtgtat taggtgttag ccccaatagc catgcatgaa
     5161 atctttaaat aaaagttaaa aaagttcttt agaggca
//
