LOCUS       NM_001042724            2690 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens nectin cell adhesion molecule 2 (NECTIN2), transcript
            variant delta, mRNA.
ACCESSION   NM_001042724
VERSION     NM_001042724.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2690)
  AUTHORS   Hu,S., Han,P., Wang,M., Cao,X., Liu,H., Zhang,S., Zhang,S., Liu,J.,
            Han,Y., Xiao,J., Chen,Q., Miao,K., Qi,J., Tan,S., Gao,G.F. and
            Wang,H.
  TITLE     Structural basis for the immune recognition and selectivity of the
            immune receptor PVRIG for ligand Nectin-2
  JOURNAL   Structure 32 (7), 918-929 (2024)
   PUBMED   38626767
  REMARK    GeneRIF: Structural basis for the immune recognition and
            selectivity of the immune receptor PVRIG for ligand Nectin-2.
REFERENCE   2  (bases 1 to 2690)
  AUTHORS   Baker,F.L., Smith,K.A., Mylabathula,P.L., Zuniga,T.M., Diak,D.M.,
            Batatinha,H., Niemiro,G.M., Seckeler,M.D., Pedlar,C.R.,
            O'Connor,D.P., Colombo,J., Katsanis,E. and Simpson,R.J.
  TITLE     Exercise-induced beta2-adrenergic Receptor Activation Enhances the
            Antileukemic Activity of Expanded gammadelta T-Cells via DNAM-1
            Upregulation and PVR/Nectin-2 Recognition
  JOURNAL   Cancer Res Commun 4 (5), 1253-1267 (2024)
   PUBMED   38592213
  REMARK    GeneRIF: Exercise-induced beta2-adrenergic Receptor Activation
            Enhances the Antileukemic Activity of Expanded gammadelta T-Cells
            via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.
REFERENCE   3  (bases 1 to 2690)
  AUTHORS   Yang,J., Wang,L., Byrnes,J.R., Kirkemo,L.L., Driks,H., Belair,C.D.,
            Aguilar,O.A., Lanier,L.L., Wells,J.A., Fong,L. and Blelloch,R.
  TITLE     PVRL2 Suppresses Antitumor Immunity through PVRIG- and
            TIGIT-independent Pathways
  JOURNAL   Cancer Immunol Res 12 (5), 575-591 (2024)
   PUBMED   38588410
  REMARK    GeneRIF: PVRL2 Suppresses Antitumor Immunity through PVRIG- and
            TIGIT-independent Pathways.
REFERENCE   4  (bases 1 to 2690)
  AUTHORS   Haghayegh Jahromi,N., Gkountidi,A.O., Collado-Diaz,V., Blatter,K.,
            Bauer,A., Zambounis,L., Medina-Sanchez,J.D., Russo,E., Runge,P.,
            Restivo,G., Gousopoulos,E., Lindenblatt,N., Levesque,M.P. and
            Halin,C.
  TITLE     CD112 Supports Lymphatic Migration of Human Dermal Dendritic Cells
  JOURNAL   Cells 13 (5), 424 (2024)
   PUBMED   38474388
  REMARK    GeneRIF: CD112 Supports Lymphatic Migration of Human Dermal
            Dendritic Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2690)
  AUTHORS   Rajendrakumar,A.L., Arbeev,K.G., Bagley,O., Yashin,A.I. and
            Ukraintseva,S.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     The SNP rs6859 in NECTIN2 gene is associated with underlying
            heterogeneous trajectories of cognitive changes in older adults
  JOURNAL   BMC Neurol 24 (1), 78 (2024)
   PUBMED   38408961
  REMARK    GeneRIF: The SNP rs6859 in NECTIN2 gene is associated with
            underlying heterogeneous trajectories of cognitive changes in older
            adults.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2690)
  AUTHORS   Shukla,D., Rowe,C.L., Dong,Y., Racaniello,V.R. and Spear,P.G.
  TITLE     The murine homolog (Mph) of human herpesvirus entry protein B
            (HveB) mediates entry of pseudorabies virus but not herpes simplex
            virus types 1 and 2
  JOURNAL   J Virol 73 (5), 4493-4497 (1999)
   PUBMED   10196354
REFERENCE   7  (bases 1 to 2690)
  AUTHORS   Lopez,M., Aoubala,M., Jordier,F., Isnardon,D., Gomez,S. and
            Dubreuil,P.
  TITLE     The human poliovirus receptor related 2 protein is a new
            hematopoietic/endothelial homophilic adhesion molecule
  JOURNAL   Blood 92 (12), 4602-4611 (1998)
   PUBMED   9845526
REFERENCE   8  (bases 1 to 2690)
  AUTHORS   Warner,M.S., Geraghty,R.J., Martinez,W.M., Montgomery,R.I.,
            Whitbeck,J.C., Xu,R., Eisenberg,R.J., Cohen,G.H. and Spear,P.G.
  TITLE     A cell surface protein with herpesvirus entry activity (HveB)
            confers susceptibility to infection by mutants of herpes simplex
            virus type 1, herpes simplex virus type 2, and pseudorabies virus
  JOURNAL   Virology 246 (1), 179-189 (1998)
   PUBMED   9657005
REFERENCE   9  (bases 1 to 2690)
  AUTHORS   Freistadt,M.S. and Eberle,K.E.
  TITLE     Physical association between CD155 and CD44 in human monocytes
  JOURNAL   Mol Immunol 34 (18), 1247-1257 (1997)
   PUBMED   9683266
REFERENCE   10 (bases 1 to 2690)
  AUTHORS   Eberle,F., Dubreuil,P., Mattei,M.G., Devilard,E. and Lopez,M.
  TITLE     The human PRR2 gene, related to the human poliovirus receptor gene
            (PVR), is the true homolog of the murine MPH gene
  JOURNAL   Gene 159 (2), 267-272 (1995)
   PUBMED   7622062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN410857.1, X80038.1,
            CN359643.1 and AJ708439.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001042724.1.
            
            Summary: This gene encodes a single-pass type I membrane
            glycoprotein with two Ig-like C2-type domains and an Ig-like V-type
            domain. This protein is one of the plasma membrane components of
            adherens junctions. It also serves as an entry for certain mutant
            strains of herpes simplex virus and pseudorabies virus, and it is
            involved in cell to cell spreading of these viruses. Variations in
            this gene have been associated with differences in the severity of
            multiple sclerosis. Alternate transcriptional splice variants,
            encoding different isoforms, have been characterized. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (delta) represents the longer
            transcript and encodes the longer isoform (delta).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.422840.1,
                                           SRR1660809.219310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252483.10/ ENSP00000252483.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               CN410857.1         134-362
            230-1843            X80038.1           1-1614
            1844-2377           CN359643.1         14-547
            2378-2690           AJ708439.1         87-399
FEATURES             Location/Qualifiers
     source          1..2690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2690
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /note="nectin cell adhesion molecule 2"
                     /db_xref="GeneID:5819"
                     /db_xref="HGNC:HGNC:9707"
                     /db_xref="MIM:600798"
     exon            1..317
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1846
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /note="isoform delta precursor is encoded by transcript
                     variant delta; poliovirus receptor-like 2; herpesvirus
                     entry protein B; nectin-2; poliovirus receptor-related 2
                     (herpesvirus entry mediator B)"
                     /codon_start=1
                     /product="nectin-2 isoform delta precursor"
                     /protein_id="NP_001036189.1"
                     /db_xref="CCDS:CCDS42576.1"
                     /db_xref="GeneID:5819"
                     /db_xref="HGNC:HGNC:9707"
                     /db_xref="MIM:600798"
                     /translation="MARAAALLPSRSPPTPLLWPLLLLLLLETGAQDVRVQVLPEVRG
                     QLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSER
                     LSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIA
                     KPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
                     VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGR
                     TDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNA
                     VGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQ
                     GAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQE
                     MPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVEDVSLDLEDEEGEEEEEYLDK
                     INPIYDALSYSSPSDSYQGKGFVMSRAMYV"
     exon            318..707
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1004
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1122
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1271
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1425
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1489
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1576
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..2690
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2690
                     /gene="NECTIN2"
                     /gene_synonym="CD112; HVEB; PRR2; PVRL2; PVRR2"
                     /note="major polyA site"
ORIGIN      
        1 gtgacgtcag cgggttcgaa ccgccggagc tgagcgagag gccgggggtg ccgagccggg
       61 cggggagagc tgggccggga gagcagaaca gggaggctag agcgcagcgg gaaccggccc
      121 ggagccggag ccggagcccc acaggcacct actaaaccgc ccagccgatc ggcccccaca
      181 gagtggcccg cgggcctccg gccgggccca gtcccctccc gggccctcca tggcccgggc
      241 cgctgccctc ctgccgtcga gatcgccgcc gacgccgctg ctgtggccgc tgctgctgct
      301 gctgctcctg gaaaccggag cccaggatgt gcgagttcaa gtgctacccg aggtgcgagg
      361 ccagctcggg ggcaccgtgg agctgccgtg ccacctgctg ccacctgttc ctggactgta
      421 catctccctg gtgacctggc agcgcccaga tgcacctgcg aaccaccaga atgtggccgc
      481 cttccaccct aagatgggtc ccagcttccc cagcccgaag cctggcagcg agcggctgtc
      541 cttcgtctct gccaagcaga gcactgggca agacacagag gcagagctcc aggacgccac
      601 gctggccctc cacgggctca cggtggagga cgagggcaac tacacttgcg agtttgccac
      661 cttccccaag gggtccgtcc gagggatgac ctggctcaga gtcatagcca agcccaagaa
      721 ccaagctgag gcccagaagg tcacgttcag ccaggaccct acgacagtgg ccctctgcat
      781 ctccaaagag ggccgcccac ctgcccggat ctcctggctc tcatccctgg actgggaagc
      841 caaagagact caggtgtcag ggaccctggc cggaactgtc actgtcacca gccgcttcac
      901 cttggtgccc tcgggccgag cagatggtgt cacggtcacc tgcaaagtgg agcatgagag
      961 cttcgaggaa ccagccctga tacctgtgac cctctctgta cgctaccctc ctgaagtgtc
     1021 catctccggc tatgatgaca actggtacct cggccgtact gatgccaccc tgagctgtga
     1081 cgtccgcagc aacccagagc ccacgggcta tgactggagc acgacctcag gcaccttccc
     1141 gacctccgca gtggcccagg gctcccagct ggtcatccac gcagtggaca gtctgttcaa
     1201 taccaccttc gtctgcacag tcaccaatgc cgtgggcatg ggccgcgctg agcaggtcat
     1261 ctttgtccga gagaccccca acacagcagg cgcaggggcc acaggcggca tcatcggggg
     1321 catcatcgcc gccatcattg ctactgctgt ggctgccacg ggcatcctta tctgccggca
     1381 gcagcggaag gagcagacgc tgcagggggc agaggaggac gaagacctgg agggacctcc
     1441 ctcctacaag ccaccgaccc caaaagcgaa gctggaggca caggagatgc cctcccagct
     1501 cttcactctg ggggcctcgg agcacagccc actcaagacc ccctactttg atgctggcgc
     1561 ctcatgcact gagcaggaaa tgcctcgata ccatgagctg cccaccttgg aagaacggtc
     1621 aggacccttg caccctggag ccacaagcct ggggtccccc atcccggtgc ctccagggcc
     1681 acctgctgtg gaagacgttt ccctggatct agaggatgag gagggggagg aggaggaaga
     1741 gtatctggac aagatcaacc ccatctatga tgctctgtcc tatagcagcc cctctgattc
     1801 ctaccagggc aaaggctttg tcatgtcccg ggccatgtat gtgtgagctg ccatgcgcct
     1861 ggcgtctcac atctcacctg ttgatccctt agctttcttg ccaaggatct agtgccccct
     1921 gacctctggc caggccactg tcagttaaca catatgcatt ccatttgtga tgtctacctt
     1981 ggtggctcca ctatgacccc taacccatga gcccagagaa attcaccgtg ataatggaat
     2041 cctggcaacc ttatctcatg aggcaggagg tggggaaggt gcttctgcac aacctctgat
     2101 cccaaggact cctctcccag actgtgacct tagaccatac ctctcacccc ccaatgcctc
     2161 gactccccca aaatcacaaa gaagacccta gacctataat ttgtcttcag gtagtaaatt
     2221 cccaataggt ctgctggagt gggcgctgag ggctccctgc tgctcagacc tgagccctcc
     2281 aggcagcagg gtcccactta ccccctcccc accctgttcc ccaaaggtgg gaaagagggg
     2341 attccccagc ccaaggcagg gttttcccag caccctcctg taagcagaag tctcagggtc
     2401 cagacccttc cctgagcccc cacccccacc ccaattcctg cctaccaagc aagcagcccc
     2461 agcctagggt cagacagggt gagcctcata cagactgtgc cttgatggcc ccagccttgg
     2521 gagaagaatt tactgttaac ctggaagact actgaatcat tttacccttg cccagtggaa
     2581 taggacctaa acatccccct tccggggaaa gtgggtcatc tgaattgggg gtagcaattg
     2641 atactgtttt gtaaactaca tttcctacaa aatatgaatt tatactttga
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