LOCUS       NP_071746                351 aa            linear   PRI 27-APR-2025
DEFINITION  N-terminal EF-hand calcium-binding protein 1 [Homo sapiens].
ACCESSION   NP_071746
VERSION     NP_071746.1
DBSOURCE    REFSEQ: accession NM_022351.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 351)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 351)
  AUTHORS   Zhang,M.D., Barde,S., Szodorai,E., Josephson,A., Mitsios,N.,
            Watanabe,M., Attems,J., Lubec,G., Kovacs,G.G., Uhlen,M., Mulder,J.,
            Harkany,T. and Hokfelt,T.
  TITLE     Comparative anatomical distribution of neuronal calcium-binding
            protein (NECAB) 1 and -2 in rodent and human spinal cord
  JOURNAL   Brain Struct Funct 221 (7), 3803-3823 (2016)
   PUBMED   26843217
  REMARK    GeneRIF: Study suggests that the phenotypic segregation of Neuronal
            calcium-binding protein 1 and -2 (NECAB1 and -2) to respective
            excitatory and inhibitory spinal systems can underpin functional
            modalities in determining the fidelity of synaptic
            neurotransmission and neuronal responsiveness, and might bear
            translational relevance to humans.
            Erratum:[Brain Struct Funct. 2016 Sep;221(7):3843. doi:
            10.1007/s00429-016-1236-7. PMID: 27206425]
REFERENCE   3  (residues 1 to 351)
  AUTHORS   Wu,H., Li,D., Shan,Y., Wan,B., Hexige,S., Guo,J., Wu,C. and Yu,L.
  TITLE     EFCBP1/NECAB1, a brain-specifically expressed gene with highest
            abundance in temporal lobe, encodes a protein containing EF-hand
            and antibiotic biosynthesis monooxygenase domains
  JOURNAL   DNA Seq 18 (1), 73-79 (2007)
   PUBMED   17364817
REFERENCE   4  (residues 1 to 351)
  AUTHORS   Sugita,S., Ho,A. and Sudhof,T.C.
  TITLE     NECABs: a family of neuronal Ca(2+)-binding proteins with an
            unusual domain structure and a restricted expression pattern
  JOURNAL   Neuroscience 112 (1), 51-63 (2002)
   PUBMED   12044471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF414126.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.195227.1,
                                           SRR1660809.70887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417640.7/ ENSP00000387380.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     Protein         1..351
                     /product="N-terminal EF-hand calcium-binding protein 1"
                     /note="synaptotagmin interacting protein 1; neuronal
                     calcium binding protein; EF-hand calcium-binding protein
                     1; neuronal calcium-binding protein 1"
                     /calculated_mol_wt=40440
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9ESB5; propagated from
                     UniProtKB/Swiss-Prot (Q8N987.1)"
     Region          <33..92
                     /region_name="FRQ1"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; COG5126"
                     /db_xref="CDD:444056"
     Region          180..203
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N987.1)"
     Site            192
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8BG18; propagated from
                     UniProtKB/Swiss-Prot (Q8N987.1)"
     Site            197
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8BG18; propagated from
                     UniProtKB/Swiss-Prot (Q8N987.1)"
     Region          254..324
                     /region_name="ABM"
                     /note="Antibiotic biosynthesis monooxygenase; pfam03992"
                     /db_xref="CDD:427635"
     CDS             1..351
                     /gene="NECAB1"
                     /gene_synonym="EFCBP1; STIP-1"
                     /coded_by="NM_022351.5:113..1168"
                     /db_xref="CCDS:CCDS47889.1"
                     /db_xref="GeneID:64168"
                     /db_xref="HGNC:HGNC:20983"
ORIGIN      
        1 medsqetsps snnsseelss alhlskgmsi fldilrradk nddgklsfee fkayfadgvl
       61 sgeelhelfh tidthntnnl dteelceyfs qhlgeyenvl aaledlnlsi lkamgktkkd
      121 yqeasnleqf vtrfllketl nqlqslqnsl ecametteeq trqerqgpak pevlsiqwpg
      181 krssrrvqrh nsfspnspqf nvsgpgllee dnqwmtqinr lqklidrlek kdlkleppee
      241 eiiegntksh imlvqrqmsv ieedleefql alkhyvesas sqsgclrisi qklsnesrym
      301 iyefwenssv wnshlqtnys ktfqrsnvdf letpeltstm lvpaswwiln n
//
