LOCUS       NM_001184989             696 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens NADH:ubiquinone oxidoreductase subunit C1 (NDUFC1),
            transcript variant 5, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001184989
VERSION     NM_001184989.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 696)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 696)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 696)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   4  (bases 1 to 696)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   5  (bases 1 to 696)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 696)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 696)
  AUTHORS   Loeffen,J.L., Triepels,R.H., van den Heuvel,L.P., Schuelke,M.,
            Buskens,C.A., Smeets,R.J., Trijbels,J.M. and Smeitink,J.A.
  TITLE     cDNA of eight nuclear encoded subunits of NADH:ubiquinone
            oxidoreductase: human complex I cDNA characterization completed
  JOURNAL   Biochem Biophys Res Commun 253 (2), 415-422 (1998)
   PUBMED   9878551
REFERENCE   8  (bases 1 to 696)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
REFERENCE   9  (bases 1 to 696)
  AUTHORS   Emahazion,T., Beskow,A., Gyllensten,U. and Brookes,A.J.
  TITLE     Intron based radiation hybrid mapping of 15 complex I genes of the
            human electron transport chain
  JOURNAL   Cytogenet Cell Genet 82 (1-2), 115-119 (1998)
   PUBMED   9763677
REFERENCE   10 (bases 1 to 696)
  AUTHORS   Ton,C., Hwang,D.M., Dempsey,A.A. and Liew,C.C.
  TITLE     Identification and primary structure of five human NADH-ubiquinone
            oxidoreductase subunits
  JOURNAL   Biochem Biophys Res Commun 241 (2), 589-594 (1997)
   PUBMED   9425316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB160001.1 and W56292.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001184989.1.
            
            Summary: The encoded protein is a subunit of the NADH:ubiquinone
            oxidoreductase (complex I), the first enzyme complex in the
            electron transport chain located in the inner mitochondrial
            membrane. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1 through 7 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB160001.1, SRR18074968.2785795.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000394223.2/
                                                  ENSP00000377770.1
            RefSeq Select criteria             :: based on conservation,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-596               CB160001.1         3-598
            597-696             W56292.1           15-114              c
FEATURES             Location/Qualifiers
     source          1..696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..696
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /note="NADH:ubiquinone oxidoreductase subunit C1"
                     /db_xref="GeneID:4717"
                     /db_xref="HGNC:HGNC:7705"
                     /db_xref="MIM:603844"
     exon            1..62
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /inference="alignment:Splign:2.1.0"
     exon            63..121
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /inference="alignment:Splign:2.1.0"
     exon            122..350
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..514
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /note="complex I KFYI subunit; CI-KFYI; complex I-KFYI;
                     NADH-ubiquinone oxidoreductase KFYI subunit; NADH
                     dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 subunit C1,
                     mitochondrial precursor"
                     /protein_id="NP_001171918.1"
                     /db_xref="CCDS:CCDS3746.1"
                     /db_xref="GeneID:4717"
                     /db_xref="HGNC:HGNC:7705"
                     /db_xref="MIM:603844"
                     /translation="MAPSALLRPLSRLLAPARLPSGPSVRSKFYVREPPNAKPDWLKV
                     GFTLGTTVFLWIYLIKQHNEDILEYKRRNGLE"
     exon            351..454
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /inference="alignment:Splign:2.1.0"
     exon            455..534
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /inference="alignment:Splign:2.1.0"
     exon            535..696
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      656..661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /note="hexamer: AATAAA"
     regulatory      666..671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /note="hexamer: AATAAA"
     polyA_site      675
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
                     /note="major polyA site"
     polyA_site      696
                     /gene="NDUFC1"
                     /gene_synonym="KFYI"
ORIGIN      
        1 agaaacgaga acaacggagg cagaggagct gaagactcca gtatgcaact gactacaagg
       61 agatgcagtt tcacatacag ctgggtactc caagtgtaca gttcccatca gctctaatat
      121 gacagaaggc tgaggccggg gtgctagaga accttgccgt gctggaattc acgttgacgc
      181 ccccacggag ctctgctgca gagccctcga gtcccgcact tccggccgcc aggtggcgct
      241 ggttctgttg ccaactcgga gagactgagc tgggccacgc aagatggcgc cgtccgcctt
      301 gctgcgtccc ctttcccggc tgctggcccc cgccaggctc ccgagcggcc cttcagtgcg
      361 atcaaagttc tacgtgcgag agccgccgaa tgccaaacct gactggctga aagttgggtt
      421 caccttgggc accactgtct tcttgtggat ctatctcatc aaacaacaca atgaagatat
      481 tttagagtac aaaagaagaa atgggctgga ataaactttt gaaacactaa tgtagtatgc
      541 tccgtatagt gattgtagct gttcctctgg attcaccatc tgttgagttg taaatgtgag
      601 agaaaaagtt atatgtgaat atatatcaag ccagcatttg tattttgcat cattaaataa
      661 aaagaaataa aaatacttct gtattcttca gataaa
//
