LOCUS       NM_005003                665 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_005003
VERSION     NM_005003.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 665)
  AUTHORS   Suo,Y., Chen,A., La Clair,J.J. and Burkart,M.D.
  TITLE     Substrate Sequestration and Chain Flipping in Human Mitochondrial
            Acyl Carrier Protein
  JOURNAL   Biochemistry 62 (24), 3548-3553 (2023)
   PUBMED   38039071
  REMARK    GeneRIF: Substrate Sequestration and Chain Flipping in Human
            Mitochondrial Acyl Carrier Protein.
REFERENCE   2  (bases 1 to 665)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 665)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 665)
  AUTHORS   Herrera,M.G., Noguera,M.E., Sewell,K.E., Agudelo Suarez,W.A.,
            Capece,L., Klinke,S. and Santos,J.
  TITLE     Structure of the Human ACP-ISD11 Heterodimer
  JOURNAL   Biochemistry 58 (46), 4596-4609 (2019)
   PUBMED   31664822
  REMARK    GeneRIF: In this work, the structure of the human mitochondrial
            ACP-ISD11 heterodimer was determined at 2.0 A resolution.
REFERENCE   5  (bases 1 to 665)
  AUTHORS   Fox,N.G., Yu,X., Feng,X., Bailey,H.J., Martelli,A., Nabhan,J.F.,
            Strain-Damerell,C., Bulawa,C., Yue,W.W. and Han,S.
  TITLE     Structure of the human frataxin-bound iron-sulfur cluster assembly
            complex provides insight into its activation mechanism
  JOURNAL   Nat Commun 10 (1), 2210 (2019)
   PUBMED   31101807
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 665)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   7  (bases 1 to 665)
  AUTHORS   Triepels,R., Smeitink,J., Loeffen,J., Smeets,R., Buskens,C.,
            Trijbels,F. and van den Heuvel,L.
  TITLE     The human nuclear-encoded acyl carrier subunit (NDUFAB1) of the
            mitochondrial complex I in human pathology
  JOURNAL   J Inherit Metab Dis 22 (2), 163-173 (1999)
   PUBMED   10234612
REFERENCE   8  (bases 1 to 665)
  AUTHORS   Loeffen,J.L., Triepels,R.H., van den Heuvel,L.P., Schuelke,M.,
            Buskens,C.A., Smeets,R.J., Trijbels,J.M. and Smeitink,J.A.
  TITLE     cDNA of eight nuclear encoded subunits of NADH:ubiquinone
            oxidoreductase: human complex I cDNA characterization completed
  JOURNAL   Biochem Biophys Res Commun 253 (2), 415-422 (1998)
   PUBMED   9878551
REFERENCE   9  (bases 1 to 665)
  AUTHORS   Emahazion,T., Beskow,A., Gyllensten,U. and Brookes,A.J.
  TITLE     Intron based radiation hybrid mapping of 15 complex I genes of the
            human electron transport chain
  JOURNAL   Cytogenet Cell Genet 82 (1-2), 115-119 (1998)
   PUBMED   9763677
REFERENCE   10 (bases 1 to 665)
  AUTHORS   Runswick,M.J., Fearnley,I.M., Skehel,J.M. and Walker,J.E.
  TITLE     Presence of an acyl carrier protein in NADH:ubiquinone
            oxidoreductase from bovine heart mitochondria
  JOURNAL   FEBS Lett 286 (1-2), 121-124 (1991)
   PUBMED   1907568
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI603093.1, BC058920.1 and AF087660.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005003.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.6881.1,
                                           SRR5189655.145856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000007516.8/
                                                  ENSP00000007516.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               BI603093.1         42-243
            203-398             BC058920.1         195-390
            399-448             AF087660.1         397-446
            449-665             BC058920.1         441-657
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..665
                     /gene="NDUFAB1"
                     /gene_synonym="ACP; ACP1; FASN2A; SDAP"
                     /note="NADH:ubiquinone oxidoreductase subunit AB1"
                     /db_xref="GeneID:4706"
                     /db_xref="HGNC:HGNC:7694"
                     /db_xref="MIM:603836"
     exon            1..194
                     /gene="NDUFAB1"
                     /gene_synonym="ACP; ACP1; FASN2A; SDAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..497
                     /gene="NDUFAB1"
                     /gene_synonym="ACP; ACP1; FASN2A; SDAP"
                     /note="mitochondrial acyl carrier protein; complex I SDAP
                     subunit; acyl carrier protein, mitochondrial;
                     NADH:ubiquinone oxidoreductase SDAP subunit; CI-SDAP;
                     NADH-ubiquinone oxidoreductase 9.6 kDa subunit; NADH
                     dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1,
                     8kDa"
                     /codon_start=1
                     /product="acyl carrier protein, mitochondrial precursor"
                     /protein_id="NP_004994.1"
                     /db_xref="CCDS:CCDS10614.1"
                     /db_xref="GeneID:4706"
                     /db_xref="HGNC:HGNC:7694"
                     /db_xref="MIM:603836"
                     /translation="MASRVLSAYVSRLPAAFAPLPRVRMLAVARPLSTALCSAGTQTR
                     LGTLQPALVLAQVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNS
                     HFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE"
     exon            195..317
                     /gene="NDUFAB1"
                     /gene_synonym="ACP; ACP1; FASN2A; SDAP"
                     /inference="alignment:Splign:2.1.0"
     exon            318..405
                     /gene="NDUFAB1"
                     /gene_synonym="ACP; ACP1; FASN2A; SDAP"
                     /inference="alignment:Splign:2.1.0"
     exon            406..505
                     /gene="NDUFAB1"
                     /gene_synonym="ACP; ACP1; FASN2A; SDAP"
                     /inference="alignment:Splign:2.1.0"
     exon            506..665
                     /gene="NDUFAB1"
                     /gene_synonym="ACP; ACP1; FASN2A; SDAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      647..652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFAB1"
                     /gene_synonym="ACP; ACP1; FASN2A; SDAP"
                     /note="hexamer: AATAAA"
     polyA_site      665
                     /gene="NDUFAB1"
                     /gene_synonym="ACP; ACP1; FASN2A; SDAP"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcatc ctgggttggc gtagccatgg cgtctcgtgt cctttcagcc tatgtcagcc
       61 gcctgcccgc ggcctttgcg ccgctgcccc gggtccggat gctggccgtg gcccggcctc
      121 tcagcaccgc tctctgctcc gcggggaccc agacgaggct cgggactttg cagccggcct
      181 tagtgctcgc gcaggttcct ggtagagtta cacagttgtg ccgccagtat agcgacatgc
      241 ctcctttgac gttagagggc atccaggacc gtgttcttta cgtattgaaa ctctatgaca
      301 agattgaccc agagaagctt tcagtaaatt ctcattttat gaaagacctg ggcttagaca
      361 gtttggacca agtggagatt atcatggcca tggaagacga atttgggttt gaaattcctg
      421 atatagatgc tgaaaagtta atgtgtccac aagaaattgt agattacatt gcagataaga
      481 aggatgtata tgaataaagt atcagaccct ttggctttgc tgagagagga ctcagatgat
      541 agtgacgaat gtctggcagt gaggacacat tttggcattc ttgctgactc tgacagagtg
      601 attctgatgg acttgtattt aaattgtatg tgttttactc tttgaaaata aatctataaa
      661 accaa
//
