LOCUS       NM_005002               8356 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens NADH:ubiquinone oxidoreductase subunit A9 (NDUFA9),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_005002
VERSION     NM_005002.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8356)
  AUTHORS   Nesti,C., Ticci,C., Rubegni,A., Doccini,S., Scaturro,G., Vetro,A.,
            Guerrini,R., Santorelli,F.M. and Procopio,E.
  TITLE     Additive effect of DNAJC30 and NDUFA9 mutations causing Leigh
            syndrome
  JOURNAL   J Neurol 270 (6), 3266-3269 (2023)
   PUBMED   36939934
  REMARK    GeneRIF: Additive effect of DNAJC30 and NDUFA9 mutations causing
            Leigh syndrome.
REFERENCE   2  (bases 1 to 8356)
  AUTHORS   Pinho,S.A., Costa,C.F., Deus,C.M., Pinho,S.L.C., Miranda-Santos,I.,
            Afonso,G., Bagshaw,O., Stuart,J.A., Oliveira,P.J. and
            Cunha-Oliveira,T.
  TITLE     Mitochondrial and metabolic remodelling in human skin fibroblasts
            in response to glucose availability
  JOURNAL   FEBS J 289 (17), 5198-5217 (2022)
   PUBMED   35213938
REFERENCE   3  (bases 1 to 8356)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 8356)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 8356)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   6  (bases 1 to 8356)
  AUTHORS   Triepels,R.H., Hanson,B.J., van den Heuvel,L.P., Sundell,L.,
            Marusich,M.F., Smeitink,J.A. and Capaldi,R.A.
  TITLE     Human complex I defects can be resolved by monoclonal antibody
            analysis into distinct subunit assembly patterns
  JOURNAL   J Biol Chem 276 (12), 8892-8897 (2001)
   PUBMED   11112787
REFERENCE   7  (bases 1 to 8356)
  AUTHORS   Loeffen,J.L., Triepels,R.H., van den Heuvel,L.P., Schuelke,M.,
            Buskens,C.A., Smeets,R.J., Trijbels,J.M. and Smeitink,J.A.
  TITLE     cDNA of eight nuclear encoded subunits of NADH:ubiquinone
            oxidoreductase: human complex I cDNA characterization completed
  JOURNAL   Biochem Biophys Res Commun 253 (2), 415-422 (1998)
   PUBMED   9878551
REFERENCE   8  (bases 1 to 8356)
  AUTHORS   Baens,M., Chaffanet,M., Cassiman,J.J., van den Berghe,H. and
            Marynen,P.
  TITLE     Construction and evaluation of a hncDNA library of human 12p
            transcribed sequences derived from a somatic cell hybrid
  JOURNAL   Genomics 16 (1), 214-218 (1993)
   PUBMED   8486360
REFERENCE   9  (bases 1 to 8356)
  AUTHORS   Rahman,S. and Thorburn,D.
  TITLE     Nuclear Gene-Encoded Leigh Syndrome Spectrum Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   26425749
REFERENCE   10 (bases 1 to 8356)
  AUTHORS   Fearnley,I.M., Finel,M., Skehel,J.M. and Walker,J.E.
  TITLE     NADH:ubiquinone oxidoreductase from bovine heart mitochondria. cDNA
            sequences of the import precursors of the nuclear-encoded 39 kDa
            and 42 kDa subunits
  JOURNAL   Biochem J 278 (Pt 3) (Pt 3), 821-829 (1991)
   PUBMED   1832859
  REMARK    GeneRIF: Study identifies mitochondrial transit peptide and
            determines mature protein cleavage site in cow ortholog.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB110957.1, BC009311.2,
            L04490.1, R44283.1 and AC005832.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005002.4.
            
            Summary: The encoded protein is a subunit of the hydrophobic
            protein fraction of the NADH:ubiquinone oxidoreductase (complex I),
            the first enzyme complex in the electron transport chain located in
            the inner mitochondrial membrane. A pseudogene has been identified
            on chromosome 12. [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.189911.1,
                                           SRR1660805.158793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000266544.10/
                                                  ENSP00000266544.5
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CB110957.1         17-19
            4-1272              BC009311.2         1-1269
            1273-1410           L04490.1           1255-1392
            1411-1593           R44283.1           13-195              c
            1594-8356           AC005832.1         789-7551            c
FEATURES             Location/Qualifiers
     source          1..8356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.32"
     gene            1..8356
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /note="NADH:ubiquinone oxidoreductase subunit A9"
                     /db_xref="GeneID:4704"
                     /db_xref="HGNC:HGNC:7693"
                     /db_xref="MIM:603834"
     exon            1..62
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1147
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase (ubiquinone) Fe-S protein 2-like
                     (NADH-coenzyme Q reductase); short chain
                     dehydrogenase/reductase family 22E, member 1; complex I
                     39kDa subunit; NADH dehydrogenase (ubiquinone) 1 alpha
                     subcomplex, 9, 39kDa; CI-39kD; NADH-ubiquinone
                     oxidoreductase 39 kDa subunit"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 9, mitochondrial precursor"
                     /protein_id="NP_004993.1"
                     /db_xref="CCDS:CCDS8532.1"
                     /db_xref="GeneID:4704"
                     /db_xref="HGNC:HGNC:7693"
                     /db_xref="MIM:603834"
                     /translation="MAAAAQSRVVRVLSMSRSAITAIATSVCHGPPCRQLHHALMPHG
                     KGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDKYDIMHLRPMGDLGQ
                     LLFLEWDARDKDSIRRVVQHSNVVINLIGRDWETKNFDFEDVFVKIPQAIAQLSKEAG
                     VEKFIHVSHLNANIKSSSRYLRNKAVGEKVVRDAFPEAIIVKPSDIFGREDRFLNSFA
                     SMHRFGPIPLGSLGWKTVKQPVYVVDVSKGIVNAVKDPDANGKSFAFVGPSRYLLFHL
                     VKYIFAVAHRLFLPFPLPLFAYRWVARVFEISPFEPWITRDKVERMHITDMKLPHLPG
                     LEDLGIQATPLELKAIEVLRRHRTYRWLSAEIEDVKPAKTVNI"
     exon            63..233
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..331
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..423
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..565
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..668
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..736
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..813
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..909
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..976
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..8356
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1252..1257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /note="hexamer: ATTAAA"
     polyA_site      1272
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /note="major polyA site"
     regulatory      1514..1519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /note="hexamer: ATTAAA"
     polyA_site      1544
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
     regulatory      4305..4310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /note="hexamer: ATTAAA"
     polyA_site      4328
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
     regulatory      8324..8329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
                     /note="hexamer: AATAAA"
     polyA_site      8356
                     /gene="NDUFA9"
                     /gene_synonym="CC6; CI-39k; CI39k; COQ11; MC1DN26;
                     NDUFS2L; SDR22E1"
ORIGIN      
        1 attgtgggaa aagatggcgg ctgccgcaca atcccgggtt gtccgggtcc tgtcaatgtc
       61 acgttctgcc attactgcaa tagccacatc tgtgtgtcac ggcccaccct gtcgccagct
      121 tcatcatgcc ctcatgcctc atgggaaagg tggacgttcc tcagtcagtg ggattgtggc
      181 cactgtgttt ggagcaacag gattcctggg gcgatatgtt gtcaaccacc ttggacgcat
      241 ggggtcacag gtaatcatac cctatcggtg tgataaatat gacatcatgc accttcgtcc
      301 catgggtgac ctgggccagc ttctgtttct ggaatgggac gcgagagata aagattctat
      361 ccgacgagta gtacaacaca gcaatgtggt catcaatctt attggacgag actgggaaac
      421 caaaaacttt gattttgagg atgtttttgt gaagattccc caagcaattg ctcaactgtc
      481 caaggaagct ggagttgaaa aattcattca tgtttcacat ctgaatgcga atattaaaag
      541 ctcttctaga tatttgagaa ataaggctgt tggagagaaa gtagtgagag atgcatttcc
      601 ggaagccatt atcgtaaagc cgtcggacat ctttggaaga gaggatagat tccttaattc
      661 ttttgcaagt atgcatcggt ttggtcctat accccttggt tccttgggct ggaagacagt
      721 taaacaacca gtatatgtcg tagatgtatc caaaggaatt gttaatgcag ttaaggatcc
      781 tgatgccaat gggaaatcct ttgctttcgt tggtcccagt cggtacctcc ttttccacct
      841 ggtgaagtac atctttgctg tggctcacag attgttcctc ccattcccct tgccgctttt
      901 tgcctatcga tgggtagcaa gagtctttga aataagccca tttgagccct ggataacaag
      961 ggataaagtg gagcggatgc acatcacaga catgaaattg cctcacctgc ctggcttaga
     1021 agaccttggt attcaggcaa caccactgga actcaaggcc attgaggtgc tgcggcgtca
     1081 tcgcacttac cgctggctgt ctgctgaaat tgaggatgtg aagccggcca agaccgtcaa
     1141 catttagtgc ctcctgagca gctcttggtt ttggcgtctt ttgggtcggc ccatgtggtt
     1201 tgagcaccca gccaggcggt ctctttagag gatcctgtac acagttccac tattaaaaca
     1261 tttcaggttg aattctgcag tattttcttc cttgatttac aaaatgagaa atgtagtcac
     1321 ttagaacttg agcatgattt ttgttaaaca tatttaataa tgatatatat actatttatt
     1381 ctctgaaatg ccagagagtt tgaattttcc tatgacaaac cacttctagc atacgttcta
     1441 gaagacaagg acccttttta atgtcaaagt attgtaaaga ccccaagtga tatgtgattg
     1501 ttttttaatt tccattaaat gagagagcat acagtatccc ctaacctgaa tgtgtttaca
     1561 ctgaaggtgt ttttaaaatt tattttaata atgtccatat gccttttaaa aatagtagta
     1621 catatataga aaaacattgt ccatagattc tcaaacccct tgcagtaatt ccacagtctt
     1681 cttggatctg agctatctga ggccagcccg atgcccttag taccacatct ggattatttc
     1741 agacacatag gtggagatag attctcttca catgcaaagg agatgcttca gcttctatgc
     1801 cagcagtgcc agcacttagg aattatgacc ttctaatgaa gttcttaaaa ttgcagccaa
     1861 gacccagatg aacatttggt ttagtgttgg caaatcccac cagtacagtg tgatttaaaa
     1921 ctcccacaat ttgtggtgaa gccaacatac caccatccta ggtgacccag ggttggtcat
     1981 tgtgtttcac tggacttcag cctcctgatc tatatttggg acagggatgt cagtaaaaac
     2041 gctgtttgat gagggaatgc ccgtctcctt acagagagaa aggtatatca gtgttgaagg
     2101 taagttctcc acctgccctt tctgcctgca tcagaatctt tttatcccaa aacggtcaac
     2161 agtgagctac tccaagtgtg gtccatagat caccagcatt gggatcatct tggggcttgt
     2221 tagaaatgca gaacccgggc tgggcacagt ggctcacacc tgtaatccca acgcttttga
     2281 gttgctgtgg tgggacggtc gcttgaggcc aggagtttga gaccagccta ggcaatatgg
     2341 caagaccttg tctctacaga aaaatttcaa aaagttagta gggcatggtg gcacgcacct
     2401 gtagtctcag ttattcggga ggctaaggta tgatgattgc ttgagcctgg gagttcaagg
     2461 ttacagtgag ctatgatagt gccactgcac ttcagcttgg actgaagatc ctgtctcaga
     2521 aaaaaaaaaa aaaaaaggca gaatcctagg ttttgtcctg tcccaggcgt gttgaatcag
     2581 aatctgcatt ttagcaaggt ctccaggaga tttgtatgca cattacagta tgagaagcac
     2641 tgccatacag aagagctgta tcagagttca gtgtgatccc tgttattaat ccaggttgct
     2701 gaccccaccc cagacctact gaatcagagt ctcaggaagg agggcccagg aattttagtt
     2761 ttattaaaca ttctagttta ttctcctgta cactagtatg tcagaatcag cgtactaggg
     2821 aaaggaacac aaacccaact tcacgttttt tcttcagatg ctgtctgtta ttttggatga
     2881 cacccctcct ggccataagc cagccattag gcacagagat gggtggattt aatttgaaaa
     2941 ggaactataa ttctataatg cacagtgtcc tctcttagaa tatctacact ttctttcctt
     3001 tttttgattc ttaaaaaaaa acttattgat acataataga tgtaaatatt gtcagggtat
     3061 atgtggtaat ttgatatatt catataatca atcagtgtaa ttgggatatc catcacctta
     3121 aacatttacc tttatgctag taacattcaa attactctct tctagctatt ttgaaatgta
     3181 cagtagatta gtattaactc tagttaccct actgatctat tgaacaccag gtcttacttc
     3241 ttctgtctta actgtaatta tcttcatttt ctagcaatgc tatttctcat ctctaacttg
     3301 tatcatctca ggatgctgta tatttctttt attttttatt ttttattttt ttatttttat
     3361 tgatcattct tgggtgtttc tcgcagaggg ggatttggca gggtcatagg acaatagtgg
     3421 agggaaggtc agcagataaa caagtgaaca aaggtctctg gttttcctag gcagaggacc
     3481 ctgcggcctt ccgcagtgtt tgtgtccctg ggtacttgag attagggagt ggtgatgact
     3541 cttaacgagc atgctgcctt caagcatctg tttaacaaag tacatcttgc accgccctta
     3601 atccatttaa ccctgagtgg acacagcaca tgtttcagag agcacagggt tgggggtaag
     3661 atcatagatc aacagcatcc caaggcagaa gaatttttct tagtacagaa caaagtgaag
     3721 tctcccatgt ctacttcttt ctacacagac acagcaacaa tgtgatttct ctatcttttc
     3781 cccacatttc ccccttttct attccgcaaa accaccatcg tcatcatggc ccgttctcaa
     3841 tgagctgttg ggtacacctc ccagacgtgg tggtggccgg gcagaggggc tcctcacttc
     3901 ccagtagggg cggccgggca gaagcgcccc ccacctcccg gactggtcgg ctggctgggc
     3961 ggaggcgccc cccacacaaa cactgaagcc gtagcattga ctaaggaaac aattttacca
     4021 tcctaagcta gtggatgtca ccctctcagt gtatggaggt tgcatatgac aagtaactgg
     4081 gagctgggca taagatctag gacactcata tccagggtga ttctcttcat aaggaggcat
     4141 gggctgagtc tccatttata ggggctgtcc ccatagagac ttcaagccac acctttctag
     4201 ggattcaggt tgcacattac ctgattctca cagttgattt gagcctgcaa gactgtaaac
     4261 ccatcccatt atcatgtttt cttcctcatt tacctacatt tatcattaaa cctttgtgat
     4321 tcagcaaatc tgtttacctt ctgattctac tttaaattcc gttcatgttc ttccttggcc
     4381 ctcctgtgta tttcccacag ctttgctagg ccttaagatc atctcacatt cttcatccta
     4441 atgacaaaaa taagttctat gggctgggcg cggtggctct tgcctgtaat cccagcactt
     4501 tgggaggctg atgggggtgg atcatgaggt taggagttca agaccagcct ggccaatatg
     4561 gtgaaacccc gtctctacta aaaaatacaa aaaatcagcc aggcatggtg gggcccacct
     4621 gtatatagtc ccagcccagg agggagactg aggcaggaga atcactgaaa cctgggaggc
     4681 agaggttgca gtgagctgag atcacaccac tgcactccag cctgggagac agagggagac
     4741 tctgtctaaa ataaataata ataataataa taataaaggt acatgatgga agcatatatg
     4801 ggaatatatg caaagatctc tgagaagata aagaaaggtc tctggaagga ttagcaaaaa
     4861 ctccatagaa aacggatttt taaagctgca tcttgatgtt aacctgctga aatgtgtgtg
     4921 ttggaccggg gtgaggagga agcagtcatt catgctgtgg aagagaacag catgagcaat
     4981 tgcagtgggg catgaatgag tgggtggtta tgagtgggag gcagagtccg tgagttggga
     5041 ggggcacaag cgagtttaac ctttaccttg gaggtgatgc agagcagttg agttccatac
     5101 agatttggct tcgaatatga gttccactac ttcttagttg tgagattgga caagtcactt
     5161 gacctctctt tgtcagcctc agttttcttg tttataaaat gggggtgata gtaataacta
     5221 catgatggga tagtgatgag gaattaaatg agatcatgca tgtaaaatgc tgagccctgc
     5281 acataataag aactaagtaa atgtgagcca ttatcattta agtagggaat atcatgccca
     5341 tctgagtcca tacatttgtt tcctgactta ataaaatagc tgccgttcct gagaaggagg
     5401 gattcctatt tcccaaatgc tggaaacagg gacttataga aggtaaattg ccccattagt
     5461 aagtagctga attggttttc caacctggat ctttctggct acaaaactga tgccttgttc
     5521 cagaaaggat ttaaggatgc tcaggaggaa gacattccca gagttacact ctagaaggtc
     5581 ttggagtgaa tgggaggtat agtggaatgg agggcgtatt tgaagaaacc cttcctgtga
     5641 aggaaaatcc aagagaatga agtaaggaga gacttaaact tgaaaagatt cttgtgagag
     5701 aaggaaaggg gctatttaca atagagaaga gactagaaga aagtctgaac tcacctccct
     5761 ggaagcagag ggtggtgggg tttttgaggg ctgtgtgaga gtgtagaagt actgagaaca
     5821 agaagccatg tggatcctgt gagggccagg atgggggggg gggtcatggg tcatctgtgt
     5881 ttgctgattg gctttatcca aaggaagagt aaacatctca tccttatgac aggaagtagt
     5941 cctgcagctt ggagcaaggt gcccaccaaa gttaggcaca tcccacagca agtgggagaa
     6001 aggagtgcta tctccttttg aggttacatt tcagagaatg gttcccctgg gtccttgaga
     6061 aagacagtcc tgggttgtaa aactggcaag aggctgaggg aagatgtatg tctcaaaggg
     6121 gaactcaaat aatttataat tttaagtttt ctgatgctct aagggaagtc aggtgcctaa
     6181 tattggtgat gtggtttgga tgtccccacc caaatctcat gttgcaatgt aatctccagt
     6241 gttggagttg gggcctagtg ggaggcgatt agatcatgga gtagatttat catgaatgat
     6301 ttagtaccat tctcttggta caatcctcaa gatagtgagt tcttacaaga tctggtcatt
     6361 taaaagtgtg aggcaactct cctcacccct tgttcctact cctaccatgt gaggtgcttg
     6421 ctcccttttc acctactgcc atgactggaa gcttcctgaa gcctccccag aagcagatgc
     6481 ctatgtgacg cttcctgtac agcctgcaga accatgagcc aattaaacct cttttcttta
     6541 tacattacct agactcagat atttctttat agcaatacaa gaatggccta atcgtgttag
     6601 gaagaagcct gtctgaagtg cagtcaggct gaggggagca tgaaggccat cttgatgggg
     6661 gaaatctttt agtaccctaa tgcgagcaga tgatgatgtt gttggcagag agggagggta
     6721 taacttgtgg tgcctagccc tagagggaat ggaagggcca gaatccagag cataggtggg
     6781 attgtgtggg ctgacaagta atagtatatg atagcatagt atatgatagc agtagtatac
     6841 gatagcatgt gtgtgagtcc attttgtatt gccataaagg agtacctgaa gctgggtaat
     6901 taataaagaa aaggggttta tttggctcac tgttctgtag gctgtacaag catggcacta
     6961 acatctgctt ggcatgagcc accacacccg gccagaattt tatttttagt gactaggctt
     7021 tcctttaaaa cctctgtact aggccgggtg cagtggctcg cgcctgtaat cccagcactt
     7081 tgggaggctg aggtgggagg atcacttgag cccaggagtt tgagaccagc ctgggcaaca
     7141 gagtgaaacc ccatctcttt aaaaaaataa agcacttgaa gcagaacttt ttatctgtca
     7201 taatcactgc tatgtccaca gcacctaaaa cagtcccaga catctgttga ataaatgaat
     7261 gaatgaggtg ggaagtcttt ctttacactt agatgaaaac tccatcggac cccaaattgt
     7321 tctggtcttg ttcaggtaat aattttaatt ctataataaa atctcaagtt ataataggct
     7381 caatttgata attaggatgc ccagtgttgt gtaataatta aagcgttaaa tttcctctct
     7441 gccccacagc tgggatccaa gaagaccctg tggctggcta ctcttctgta ttttcattta
     7501 tctccacccc cagtttacca gcagtggtta tcctctctcc aagactgggc caggggtgag
     7561 aagggcagtc ttaccaggca agggtctttg ctgacagatg tctgggcctt cttgacagca
     7621 ggtgtttaaa gctgaatctg gttctacttt caggagagtg atggtttgag atggtaactg
     7681 aagttgtaga agtagatgtt gaggatgaag tatcatatta ataaaacatt gcccattaac
     7741 accttagcac aaattaaaac tagctatacc tcactgataa ggacctgaat ggctaaataa
     7801 tgatgaatga tttatggatg tagcggggaa ctgggtggaa gcagtagtaa gaaatttgaa
     7861 ttaaggaatc gtaagggaat cgagattatc tagtttcccc tcgacatttt ataactgaat
     7921 aaacaataaa aaacaagaga agtgacagct ttatagcatc tgattgggga aaaacacatc
     7981 ttttctgggg ctagacagtc cataaatagg acttggaaat ggaagtgtag ggggagatcc
     8041 cattgtactt cagtggaaaa ctatgcattg tctggaatct agactctgga caaagaccct
     8101 tccttcctgg ctgtttgatt ttgattctat gggagctatc ttgcaactct gtaagctgta
     8161 ggtaactgat agcagagcaa aataattctt gtctatagac gtgtacattg tgtcttagcg
     8221 tagattcacc cgacctcctt ccccagtttt gcttctatta gcacatttat ttcagtaatt
     8281 ttgatctttg gattctcctt ggacattcct cactgaaaaa tgaaataaaa tttttggcat
     8341 gtgctcttct tttgca
//
