LOCUS       NM_005001                580 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens NADH:ubiquinone oxidoreductase subunit A7 (NDUFA7),
            mRNA.
ACCESSION   NM_005001
VERSION     NM_005001.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 580)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 580)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   3  (bases 1 to 580)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 580)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 580)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 580)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
REFERENCE   7  (bases 1 to 580)
  AUTHORS   Acierno,J.S. Jr., Kennedy,J.C., Falardeau,J.L., Leyne,M.,
            Bromley,M.C., Colman,M.W., Sun,M., Bove,C., Ashworth,L.K.,
            Chadwick,L.H., Schiripo,T., Ma,S., Goldin,E., Schiffmann,R. and
            Slaugenhaupt,S.A.
  TITLE     A physical and transcript map of the MCOLN1 gene region on human
            chromosome 19p13.3-p13.2
  JOURNAL   Genomics 73 (2), 203-210 (2001)
   PUBMED   11318610
REFERENCE   8  (bases 1 to 580)
  AUTHORS   Loeffen,J.L., Triepels,R.H., van den Heuvel,L.P., Schuelke,M.,
            Buskens,C.A., Smeets,R.J., Trijbels,J.M. and Smeitink,J.A.
  TITLE     cDNA of eight nuclear encoded subunits of NADH:ubiquinone
            oxidoreductase: human complex I cDNA characterization completed
  JOURNAL   Biochem Biophys Res Commun 253 (2), 415-422 (1998)
   PUBMED   9878551
REFERENCE   9  (bases 1 to 580)
  AUTHORS   Emahazion,T. and Brookes,A.J.
  TITLE     Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron
            transport chain genes by intron based radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 82 (1-2), 114 (1998)
   PUBMED   9763676
REFERENCE   10 (bases 1 to 580)
  AUTHORS   Dunbar,D.R., Shibasaki,Y., Dobbie,L., Andersson,B. and Brookes,A.J.
  TITLE     In situ hybridisation mapping of genomic clones for five human
            respiratory chain complex I genes
  JOURNAL   Cytogenet Cell Genet 78 (1), 21-24 (1997)
   PUBMED   9345899
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003102.1 and AC010323.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005001.4.
            
            Summary: This gene encodes a subunit of NADH:ubiquinone
            oxidoreductase (complex I), which is a multiprotein complex located
            in the inner mitochondrial membrane. Complex I functions in the
            transfer of electrons from NADH to the respiratory chain. [provided
            by RefSeq, Mar 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA189271.1, DA017636.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1970526 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000301457.3/
                                                  ENSP00000301457.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-514               BC003102.1         22-535
            515-580             AC010323.8         61436-61501         c
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..580
                     /gene="NDUFA7"
                     /gene_synonym="B14.5a; CI-B14.5a"
                     /note="NADH:ubiquinone oxidoreductase subunit A7"
                     /db_xref="GeneID:4701"
                     /db_xref="HGNC:HGNC:7691"
                     /db_xref="MIM:602139"
     exon            1..68
                     /gene="NDUFA7"
                     /gene_synonym="B14.5a; CI-B14.5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..359
                     /gene="NDUFA7"
                     /gene_synonym="B14.5a; CI-B14.5a"
                     /note="complex I B14.5a subunit; NADH dehydrogenase
                     (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa;
                     NADH-ubiquinone oxidoreductase subunit B14.5a"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 7"
                     /protein_id="NP_004992.2"
                     /db_xref="CCDS:CCDS42492.1"
                     /db_xref="GeneID:4701"
                     /db_xref="HGNC:HGNC:7691"
                     /db_xref="MIM:602139"
                     /translation="MASATRLIQRLRNWASGHDLQGKLQLRYQEISKRTQPPPKLPVG
                     PSHKLSNNYYCTRDGRRESVPPSIIMSSQKALVSGKPAESSAVAATEKKAVTPAPPIK
                     RWELSSDQPYL"
     exon            69..118
                     /gene="NDUFA7"
                     /gene_synonym="B14.5a; CI-B14.5a"
                     /inference="alignment:Splign:2.1.0"
     exon            119..268
                     /gene="NDUFA7"
                     /gene_synonym="B14.5a; CI-B14.5a"
                     /inference="alignment:Splign:2.1.0"
     exon            269..580
                     /gene="NDUFA7"
                     /gene_synonym="B14.5a; CI-B14.5a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      479..484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFA7"
                     /gene_synonym="B14.5a; CI-B14.5a"
                     /note="hexamer: AATAAA"
     regulatory      487..492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFA7"
                     /gene_synonym="B14.5a; CI-B14.5a"
                     /note="hexamer: AATAGA"
     polyA_site      488
                     /gene="NDUFA7"
                     /gene_synonym="B14.5a; CI-B14.5a"
                     /note="major polyA site"
     polyA_site      529
                     /gene="NDUFA7"
                     /gene_synonym="B14.5a; CI-B14.5a"
ORIGIN      
        1 agtatcgcgg acggaagatg gcgtccgcca cccgtctcat ccagcggctg cggaactggg
       61 cgtccgggca tgacctgcag gggaagctgc agctacgcta ccaggagatc tccaagcgaa
      121 ctcagcctcc tcccaagctc cctgtgggtc ctagccacaa gctctccaac aattactatt
      181 gcactcgcga tggccgccgg gaatctgtgc ccccttccat catcatgtcg tcgcagaagg
      241 cgctggtgtc aggcaagcca gcagagagct ctgctgtagc tgccactgag aagaaggcgg
      301 tgactccagc tcctcccata aagaggtggg agctgtcctc ggaccagcct tacctgtgac
      361 actgcaccct cacggccacc cgactacttt gcctccttgg atttcctcca gggagaatgt
      421 gacctaattt atgacaaata cgtagagctc aggtatcact tctagtttta ctttaaaaaa
      481 taaaaaaata gagacagagt ctcaccatgt ttcccaggct gatcttgaac tcctggcctc
      541 aagcgatcct cctgccttga cctcccaaag tgctgggatt
//
