LOCUS       NM_015965                521 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens NADH:ubiquinone oxidoreductase subunit A13 (NDUFA13),
            mRNA.
ACCESSION   NM_015965
VERSION     NM_015965.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 521)
  AUTHORS   Wang,B., Yang,Y., Ye,J., Han,X., Yang,L., Huang,Y. and Chao,L.
  TITLE     GRIM-19 deficiency promotes macrophage polarization to the M1
            phenotype partly through glycolysis in unexplained recurrent
            spontaneous abortiondagger
  JOURNAL   Biol Reprod 110 (4), 739-749 (2024)
   PUBMED   38206868
  REMARK    GeneRIF: GRIM-19 deficiency promotes macrophage polarization to the
            M1 phenotype partly through glycolysis in unexplained recurrent
            spontaneous abortiondagger.
REFERENCE   2  (bases 1 to 521)
  AUTHORS   Yang,L., Yang,Y., Han,X., Huang,C., Wang,Y., Jiang,D. and Chao,L.
  TITLE     GRIM19 deficiency aggravates metabolic disorder and ovarian
            dysfunction in PCOS
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167063 (2024)
   PUBMED   38360073
  REMARK    GeneRIF: GRIM19 deficiency aggravates metabolic disorder and
            ovarian dysfunction in PCOS.
REFERENCE   3  (bases 1 to 521)
  AUTHORS   Zeng,X., Yang,M., Ye,T., Feng,J., Xu,X., Yang,H., Wang,X., Bao,L.,
            Li,R., Xue,B., Zang,J. and Huang,Y.
  TITLE     Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic
            polypeptide-expressing metaplasia through NLR family pyrin
            domain-containing 3 (NLRP3)-mediated IL-33 activation via a
            reactive oxygen species (ROS) -NRF2- Heme
            oxygenase-1(HO-1)-NF-small ka, CyrillicB axis
  JOURNAL   Free Radic Biol Med 202, 46-61 (2023)
   PUBMED   36990300
  REMARK    GeneRIF: Mitochondrial GRIM-19 loss in parietal cells promotes
            spasmolytic polypeptide-expressing metaplasia through NLR family
            pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a
            reactive oxygen species (ROS) -NRF2- Heme
            oxygenase-1(HO-1)-NF-small ka, CyrillicB axis.
REFERENCE   4  (bases 1 to 521)
  AUTHORS   Lu,H. and Cao,X.
  TITLE     GRIM-19 is essential for maintenance of mitochondrial membrane
            potential
  JOURNAL   Mol Biol Cell 19 (5), 1893-1902 (2008)
   PUBMED   18287540
  REMARK    GeneRIF: GRIM-19 is required for electron transfer activity of
            complex I, and disruption of mitochondrial transmembrane potential
            by GRIM-19 mutants enhances the cells' sensitivity to apoptotic
            stimuli.
REFERENCE   5  (bases 1 to 521)
  AUTHORS   Yeo,W.M., Isegawa,Y. and Chow,V.T.
  TITLE     The U95 protein of human herpesvirus 6B interacts with human
            GRIM-19: silencing of U95 expression reduces viral load and
            abrogates loss of mitochondrial membrane potential
  JOURNAL   J Virol 82 (2), 1011-1020 (2008)
   PUBMED   17928352
  REMARK    GeneRIF: results indicate that the high affinity between U95 early
            viral protein and GRIM-19 may be closely linked to the detrimental
            effect of HHV-6B infection on mitochondria.
REFERENCE   6  (bases 1 to 521)
  AUTHORS   Kalakonda,S., Nallar,S.C., Lindner,D.J., Hu,J., Reddy,S.P. and
            Kalvakolanu,D.V.
  TITLE     Tumor-suppressive activity of the cell death activator GRIM-19 on a
            constitutively active signal transducer and activator of
            transcription 3
  JOURNAL   Cancer Res 67 (13), 6212-6220 (2007)
   PUBMED   17616678
  REMARK    GeneRIF: GRIM-19 suppresses constitutive STAT3-induced cellular
            transformation in vitro and in vivo by down-regulating the
            expression of a number of cellular genes involved in cell
            proliferation and apoptosis
REFERENCE   7  (bases 1 to 521)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   8  (bases 1 to 521)
  AUTHORS   Angell,J.E., Lindner,D.J., Shapiro,P.S., Hofmann,E.R. and
            Kalvakolanu,D.V.
  TITLE     Identification of GRIM-19, a novel cell death-regulatory gene
            induced by the interferon-beta and retinoic acid combination, using
            a genetic approach
  JOURNAL   J Biol Chem 275 (43), 33416-33426 (2000)
   PUBMED   10924506
REFERENCE   9  (bases 1 to 521)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 521)
  AUTHORS   Chidambaram,N.V., Angell,J.E., Ling,W., Hofmann,E.R. and
            Kalvakolanu,D.V.
  TITLE     Chromosomal localization of human GRIM-19, a novel IFN-beta and
            retinoic acid-activated regulator of cell death
  JOURNAL   J Interferon Cytokine Res 20 (7), 661-665 (2000)
   PUBMED   10926209
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC009189.2 and BG705222.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015965.6.
            
            Summary: This gene encodes a subunit of the mitochondrial membrane
            respiratory chain NADH dehydrogenase (Complex I), which functions
            in the transfer of electrons from NADH to the respiratory chain.
            The protein is required for complex I assembly and electron
            transfer activity. The protein binds the signal transducers and
            activators of transcription 3 (STAT3) transcription factor, and can
            function as a tumor suppressor. The human protein purified from
            mitochondria migrates at approximately 16 kDa. Transcripts
            originating from an upstream promoter and capable of expressing a
            protein with a longer N-terminus have been found, but their
            biological validity has not been determined. [provided by RefSeq,
            Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF261134.1, SRR5189667.105639.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 12611891, 17928352;
                                                  reported by MitoCarta
            MANE Ensembl match                 :: ENST00000507754.9/
                                                  ENSP00000423673.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               BC009189.2         3-520
            519-521             BG705222.1         523-525
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..521
                     /gene="NDUFA13"
                     /gene_synonym="B16.6; CDA016; CGI-39; GRIM-19; GRIM19;
                     MC1DN28"
                     /note="NADH:ubiquinone oxidoreductase subunit A13"
                     /db_xref="GeneID:51079"
                     /db_xref="HGNC:HGNC:17194"
                     /db_xref="MIM:609435"
     exon            1..108
                     /gene="NDUFA13"
                     /gene_synonym="B16.6; CDA016; CGI-39; GRIM-19; GRIM19;
                     MC1DN28"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..449
                     /gene="NDUFA13"
                     /gene_synonym="B16.6; CDA016; CGI-39; GRIM-19; GRIM19;
                     MC1DN28"
                     /EC_number="7.1.1.2"
                     /note="complex I B16.6 subunit; cell death-regulatory
                     protein GRIM19; CI-B16.6; complex I-B16.6; cell death
                     regulatory protein GRIM-19; NADH-ubiquinone oxidoreductase
                     B16.6 subunit; gene associated with retinoic and
                     IFN-induced mortality 19 protein; gene associated with
                     retinoic and interferon-induced mortality 19 protein; NADH
                     dehydrogenase (ubiquinone) 1 alpha subcomplex, 13"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 13"
                     /protein_id="NP_057049.5"
                     /db_xref="CCDS:CCDS12404.2"
                     /db_xref="GeneID:51079"
                     /db_xref="HGNC:HGNC:17194"
                     /db_xref="MIM:609435"
                     /translation="MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLI
                     YGHWSIMKWNRERRRLQIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVP
                     DWKVGESVFHTTRWVPPLIGELYGLRTTEEALHASHGFMWYT"
     exon            109..187
                     /gene="NDUFA13"
                     /gene_synonym="B16.6; CDA016; CGI-39; GRIM-19; GRIM19;
                     MC1DN28"
                     /inference="alignment:Splign:2.1.0"
     exon            188..259
                     /gene="NDUFA13"
                     /gene_synonym="B16.6; CDA016; CGI-39; GRIM-19; GRIM19;
                     MC1DN28"
                     /inference="alignment:Splign:2.1.0"
     exon            260..329
                     /gene="NDUFA13"
                     /gene_synonym="B16.6; CDA016; CGI-39; GRIM-19; GRIM19;
                     MC1DN28"
                     /inference="alignment:Splign:2.1.0"
     exon            330..521
                     /gene="NDUFA13"
                     /gene_synonym="B16.6; CDA016; CGI-39; GRIM-19; GRIM19;
                     MC1DN28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      500..505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFA13"
                     /gene_synonym="B16.6; CDA016; CGI-39; GRIM-19; GRIM19;
                     MC1DN28"
                     /note="hexamer: AATAAA"
     polyA_site      521
                     /gene="NDUFA13"
                     /gene_synonym="B16.6; CDA016; CGI-39; GRIM-19; GRIM19;
                     MC1DN28"
                     /note="major polyA site"
ORIGIN      
        1 gggatactgc gagtatggcg gcgtcaaagg tgaagcagga catgcctccg ccggggggct
       61 atgggcccat cgactacaaa cggaacttgc cgcgtcgagg actgtcgggc tacagcatgc
      121 tggccatagg gattggaacc ctgatctacg ggcactggag cataatgaag tggaaccgtg
      181 agcgcaggcg cctacaaatc gaggacttcg aggctcgcat cgcgctgttg ccactgttac
      241 aggcagaaac cgaccggagg accttgcaga tgcttcggga gaacctggag gaggaggcca
      301 tcatcatgaa ggacgtgccc gactggaagg tgggggagtc tgtgttccac acaacccgct
      361 gggtgccccc cttgatcggg gagctgtacg ggctgcgcac cacagaggag gctctccatg
      421 ccagccacgg cttcatgtgg tacacgtagg ccctgtgccc tccggccacc tggatccctg
      481 cccctcccca ctgggacgga ataaatgctc tgcagacctg g
//
