LOCUS       NM_004544               4855 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens NADH:ubiquinone oxidoreductase subunit A10 (NDUFA10),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_004544
VERSION     NM_004544.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4855)
  AUTHORS   Yang,L., Pang,X., Guo,W., Zhu,C., Yu,L., Song,X., Wang,K. and
            Pang,C.
  TITLE     An Exploration of the Coherent Effects between METTL3 and NDUFA10
            on Alzheimer's Disease
  JOURNAL   Int J Mol Sci 24 (12), 10111 (2023)
   PUBMED   37373264
  REMARK    GeneRIF: An Exploration of the Coherent Effects between METTL3 and
            NDUFA10 on Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4855)
  AUTHORS   Molina-Granada,D., Gonzalez-Vioque,E., Dibley,M.G.,
            Cabrera-Perez,R., Vallbona-Garcia,A., Torres-Torronteras,J.,
            Sazanov,L.A., Ryan,M.T., Camara,Y. and Marti,R.
  TITLE     Most mitochondrial dGTP is tightly bound to respiratory complex I
            through the NDUFA10 subunit
  JOURNAL   Commun Biol 5 (1), 620 (2022)
   PUBMED   35739187
  REMARK    GeneRIF: Most mitochondrial dGTP is tightly bound to respiratory
            complex I through the NDUFA10 subunit.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4855)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 4855)
  AUTHORS   Zhang,H., Shao,Y., Chen,W. and Chen,X.
  TITLE     Identifying Mitochondrial-Related Genes NDUFA10 and NDUFV2 as
            Prognostic Markers for Prostate Cancer through Biclustering
  JOURNAL   Biomed Res Int 2021, 5512624 (2021)
   PUBMED   34124242
  REMARK    GeneRIF: Identifying Mitochondrial-Related Genes NDUFA10 and NDUFV2
            as Prognostic Markers for Prostate Cancer through Biclustering.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4855)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4855)
  AUTHORS   Smeitink,J. and van den Heuvel,L.
  TITLE     Human mitochondrial complex I in health and disease
  JOURNAL   Am J Hum Genet 64 (6), 1505-1510 (1999)
   PUBMED   10330338
  REMARK    Review article
REFERENCE   7  (bases 1 to 4855)
  AUTHORS   Loeffen,J.L., Triepels,R.H., van den Heuvel,L.P., Schuelke,M.,
            Buskens,C.A., Smeets,R.J., Trijbels,J.M. and Smeitink,J.A.
  TITLE     cDNA of eight nuclear encoded subunits of NADH:ubiquinone
            oxidoreductase: human complex I cDNA characterization completed
  JOURNAL   Biochem Biophys Res Commun 253 (2), 415-422 (1998)
   PUBMED   9878551
REFERENCE   8  (bases 1 to 4855)
  AUTHORS   Baens,M., Chaffanet,M., Aerssens,J., Cassiman,J.J. and Marynen,P.
  TITLE     Assignment of the gene for the human proliferating cell nucleolar
            protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ
            hybridization and polymerase chain reaction with somatic cell
            hybrids
  JOURNAL   Genomics 21 (1), 296-297 (1994)
   PUBMED   8088812
REFERENCE   9  (bases 1 to 4855)
  AUTHORS   Baens,M., Chaffanet,M., Cassiman,J.J., van den Berghe,H. and
            Marynen,P.
  TITLE     Construction and evaluation of a hncDNA library of human 12p
            transcribed sequences derived from a somatic cell hybrid
  JOURNAL   Genomics 16 (1), 214-218 (1993)
   PUBMED   8486360
REFERENCE   10 (bases 1 to 4855)
  AUTHORS   Rahman,S. and Thorburn,D.
  TITLE     Nuclear Gene-Encoded Leigh Syndrome Spectrum Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   26425749
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013469.8, AC114750.4 and
            AK025576.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004544.3.
            
            Summary: The protein encoded by this gene is a component of 42 kDa
            complex I, the first enzyme complex in the electron transport chain
            of mitochondria. This protein has NADH dehydrogenase activity and
            oxidoreductase activity. It transfers electrons from NADH to the
            respiratory chain. A mutation in this gene was found in an
            individual with Leigh syndrome. [provided by RefSeq, Apr 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.224608.1,
                                           SRR1660803.201444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000252711.7/
                                                  ENSP00000252711.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC013469.8         117936-118051
            117-285             AC013469.8         120938-121106
            286-501             AC013469.8         121866-122081
            502-588             AC013469.8         124639-124725
            589-710             AC013469.8         128418-128539
            711-790             AC013469.8         131582-131661
            791-845             AC013469.8         135908-135962
            846-931             AC013469.8         137983-138068
            932-1040            AC013469.8         153096-153204
            1041-4848           AC114750.4         12673-16480
            4849-4855           AK025576.1         1995-2001
FEATURES             Location/Qualifiers
     source          1..4855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..4855
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /note="NADH:ubiquinone oxidoreductase subunit A10"
                     /db_xref="GeneID:4705"
                     /db_xref="HGNC:HGNC:7684"
                     /db_xref="MIM:603835"
     exon            1..116
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1109
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /EC_number="7.1.1.2"
                     /EC_number="1.6.99.3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; complex I 42kDa subunit; NADH-ubiquinone
                     oxidoreductase 42 kDa subunit; NADH dehydrogenase
                     [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 10, mitochondrial isoform 1 precursor"
                     /protein_id="NP_004535.1"
                     /db_xref="CCDS:CCDS2531.1"
                     /db_xref="GeneID:4705"
                     /db_xref="HGNC:HGNC:7684"
                     /db_xref="MIM:603835"
                     /translation="MALRLLKLAATSASARVVAAGAQRVRGIHSSVQCKLRYGMWHFL
                     LGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGK
                     PLATDYNGNCSLEKFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLE
                     RSIFSDFVFLEAMYNQGFIRKQCVDHYNEVKSVTICDYLPPHLVIYIDVPVPEVQRRI
                     QKKGDPHEMKITSAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAQDSKKVVEDIEYL
                     KFDKGPWLKQDNRTLYHLRLLVQDKFEVLNYTSIPIFLPEVTIGAHQTDRVLHQFREL
                     PGRKYSPGYNTEVGDKWIWLK"
     exon            117..285
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /inference="alignment:Splign:2.1.0"
     exon            286..501
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /inference="alignment:Splign:2.1.0"
     exon            502..588
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /inference="alignment:Splign:2.1.0"
     exon            589..710
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /inference="alignment:Splign:2.1.0"
     exon            711..790
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /inference="alignment:Splign:2.1.0"
     exon            791..845
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /inference="alignment:Splign:2.1.0"
     exon            846..931
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1040
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..4855
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1467..1472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /note="hexamer: AATAAA"
     polyA_site      1488
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /note="major polyA site"
     regulatory      4834..4839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
                     /note="hexamer: AATAAA"
     polyA_site      4855
                     /gene="NDUFA10"
                     /gene_synonym="CI-42k; CI-42KD; MC1DN22"
ORIGIN      
        1 gcgtcccctt gggtccttga tcctgagctg accgggtagc catggccttg cggctcctga
       61 agctggcagc gacgtccgcg tccgcccggg tcgtggcggc gggcgcccag cgcgtgagag
      121 gaattcatag cagtgtgcag tgcaaactgc gctatggaat gtggcatttc ctacttgggg
      181 ataaagcaag caaaagactg acagaacgca gcagagtgat aactgtagat ggcaatatat
      241 gtactggaaa aggcaaactt gcaaaagaaa tagcagagaa actaggcttc aagcactttc
      301 ctgaagcggg gattcattat ccagacagta ccacaggaga tgggaagccc ctcgccaccg
      361 actataatgg caactgtagt ttggagaaat tttacgatga tccgagaagc aatgatggca
      421 acagttaccg cctgcagtcc tggttgtaca gcagtcgcct gctgcagtac tcagatgcct
      481 tggagcactt gctgaccaca ggacaaggtg ttgtgttgga gcgctccatc ttcagtgact
      541 ttgtgttcct ggaggcgatg tacaaccagg gattcatccg aaagcagtgt gtggaccact
      601 acaacgaggt gaagagcgtc accatctgcg attacctgcc cccccacctg gtgatttaca
      661 tcgatgtgcc cgttccagag gtccagaggc ggattcagaa gaaaggagat ccacatgaaa
      721 tgaagatcac ctctgcctat ctacaggaca ttgagaatgc ctataagaaa acctttctcc
      781 ctgagatgag tgaaaaatgt gaggttttac aatattctgc aagggaagct caagattcaa
      841 aaaaggtggt agaggacatt gaatacctga agttcgataa agggccgtgg ctcaagcagg
      901 acaatcgcac tttataccac ctgcgattac tggttcagga taagtttgag gtgctgaatt
      961 acacaagcat tcctatcttt ctcccggaag tcaccattgg agctcatcag actgaccgtg
     1021 tcttacatca gttcagagag ctgccgggcc gcaagtacag ccctgggtac aacaccgagg
     1081 tgggagacaa gtggatctgg ctgaagtgaa cgggccgcct tctgctccag ctgcatcaca
     1141 gtgatggcca agctgcatca gccgcactct cctggacgcc atatagcttt aagatcgggg
     1201 gagggtaaat aatgcaaaaa ttgcacagtg gaagaagggg tctcacaaaa agcaatccat
     1261 cctgtagtat aggtaatgga gttgggggaa gcagcttcca ttctggatgt ttggaaccct
     1321 ttagctttgt tttggaatgg cccaccattc tcactggaaa acagtggtct gctgtgaaag
     1381 gccagctctc ggcagcccct gtggtttcag cgctgccgct ctgtgtcatt caggttgtgc
     1441 acattgtttt tcttctgact tccagaaata aaagtgtttc catgggaatt tccccatcgt
     1501 acgtctatgt gcgtgcgggc acgtcgaaac tgcacacgtg cacacacgct gctctgggcc
     1561 ctgtttggtg tggtgtggtt taattgaggc ttacattatg ctgaagagtt tttctaaagg
     1621 cctactgtat ttattttagt aatgtgctac attagagtag aaaaaataag aacgtgaaga
     1681 agaaatagca aaaggagaaa attaccacag atttacagaa caatatgttt taagagagac
     1741 gttgagaaag attcacgtgg ccgtcctcag cgtctcaaac tcctttgaag ggagatttga
     1801 gcttaggctg ttgatgacat aagatgcaaa agcaaaataa tatactctct ttattaccca
     1861 gaaaatcaag ttgccagtca aaactgagaa atgagaaaga aaatcagatt tctttattca
     1921 tctctgttga agcctagaaa accaaaacaa gctggttgtg gttcagcatc atggtttagg
     1981 aatcaagctg tcagttgtga gtcctactga actgtgggtt ttccactgta aagctccact
     2041 gtgtccatta ggaatcaggc tgccagttgt gagtcctact gaactgtggg ttttccactg
     2101 taaagctcca ctgtgtccaa tatggtagct cctagccaca tgtgggtatt gaaatttaaa
     2161 tgagctaaaa tgtaatagag tttaaaattg ggttccttgg ttgcactggc catagttcag
     2221 gcactccaca gccgcctgtg ggcagtagtt ccagtgctgg tgcagaggac gatgctctgc
     2281 tccccgcgga agctctacca ggcctcgctg ctgcggagca tgcgaagaag atgcacactc
     2341 cttccctcct tgcgtccgcc tgcctttttc cctctcccct tccttccctc cttctttcct
     2401 cctccttccc tcccttcctt tcttccttcc atctgtcctt gttttcctcc cttcccttcc
     2461 tccctgcctc tttccttccc tccttctctt ccttccttcc gtctgtcctt gttttcctcc
     2521 ctgcctcttt ccttccctcc ttctcttcct tccttccttc cgtctgtcct tgttttcctc
     2581 ccttcccttc ctccctgcct ccttccttgt tttaagaatt tgaaaataaa gtttcccagg
     2641 agttttgaat tggagtcgag atttaagtgg ctgaagtttt gcatttcact aggaaaccaa
     2701 cagctttaat catgaaatga aagcacagct gggcattggg ccagtcacag agtgtctttt
     2761 gctctgagca cttcacaaac ccattgtgga ggggaggaaa gaaaaagaaa gccatcttta
     2821 attatcttag ctgttcctaa tgtctttggc tgcaaagagc tagctgtttc cttcaacctt
     2881 ggtggttgca cgggtagtgt cctcagcagt gagagggcag gtctgccctg tggtcaggat
     2941 tgcccttgtg aggggcagag ctctccaacc atgcagggct ccgtgtcggc atggtgtgga
     3001 ctcgggtgct ctgatcatcc cctgtgtttg cgtctgaccc tgtgtggttg cattcccttg
     3061 atggagtggg aagtatgtaa tttgtagtgc tgaggacatt cgtctgtttg attttctggt
     3121 gttttcaatg acatgcatgt tcagcagaga aagatgaata aacactgtcc aattcttctc
     3181 tccacataga agcctcaaga agaggtgagg agatgccccg atttccttat ttcagagcag
     3241 tacatgcgtt cgtctcacga aagctcttac aactaaaaca acagcaccaa caaaccagga
     3301 tcaaaataat cgtgcatttt ccaggattcc atgttggact tctcagtgct ttggagatca
     3361 ggaaataatc atgctgttgc agcagtatgg ttttgtgtct ggattttatt catacaggca
     3421 tgtgtttaca ggcatgagaa ttctgtattg aaaagaaagt ccttgttttt ttctaacgta
     3481 tctttctgtt ccatcaactg ttaaaaccaa attgttaaga acattgagct tcttaggaga
     3541 gattacatgc agctacttag gaccacctca gcaaaatgga gttgcctggg tagatagcag
     3601 cagcagctca ccagccccac gctgccaggc tgctggctgc tgtccaccag gcagctgtgg
     3661 aacctccatg ttctgcctag gtgttgtggc aagaacagca gggaaacagg cggccgcctc
     3721 caggccacag gtggacccag ggaccttcag ttacgccgct tcaattgaat tcgtggtggt
     3781 ttctctgcta cagcagaagt ggaagaagct cttgtcttgt ttggcatttg tcccattttt
     3841 tggctaataa ttggctttga atttctctgt gccctgctta ccaattatag ctttctggat
     3901 tggctgttct tagcagtgca aatgtcaatg caaagaagca agcaggcggc tactttctgg
     3961 gaagaagcat agtccgtgct cacactggat ataaatctgc aagatttggg ggtttggcaa
     4021 aataggggtg gagggaaagc tgccatggct gtcagaaatt ggggcttttt gaagaaaagc
     4081 ttgtgtaggc atcagccact ggctggccag aattccatga atggaagcag gtgcccgagt
     4141 gatctggggc tttacatgtg gatataaata gaagccggga gcctgaggct ttgctttagg
     4201 aaaatcatga gccagaaaac agaggaggtg attgtcagta gtcacctcac gccgctagtg
     4261 ttttctaata ctctctcgaa ttgtcaaagc aaaggacctt ataacagcaa cacgtgtgtg
     4321 actcgaagca gcgagcttcc cttgggaaaa ggagcctctt ctcagcagag ggtcccagcc
     4381 tttctgtcct tccccatcgg aatgccaggc tctgtgagtt tggatgttgg acattgccac
     4441 ctgaattcca ggaggccggg gagctccagt gatggacttg tccccaaaag agtggtgctg
     4501 ttctcagagc cataaatgtt ccactgaaag tgtctgtccc ctggctcacg ctggctgcgc
     4561 ttgcttgaag gaggctgatt taagggttct aataggaaga caaatgaaac tgtcaaattt
     4621 tatctttaag catgtgagta agtttgctca ttcgctttta ctattgatgt atagttttaa
     4681 aattcttaat ttaaaaatta ttttaatagt aaatttttca caagtgaaca ctttttatct
     4741 ttaaattaaa attctgaagc tccctagtta gttagatcca attgctggtt acattttggg
     4801 aagctctcat tttagtgcta tgtagtttca ttgaataaac atgtttttaa tgaga
//
