LOCUS       NM_022569               3095 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens N-deacetylase and N-sulfotransferase 4 (NDST4), mRNA.
ACCESSION   NM_022569
VERSION     NM_022569.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3095)
  AUTHORS   Li,Y.J., Yin,F.X., Zhang,X.K., Yu,J., Zheng,S., Song,X.L.,
            Wang,F.S. and Sheng,J.Z.
  TITLE     Characterization of heparan sulfate
            N-deacetylase/N-sulfotransferase isoform 4 using synthetic
            oligosaccharide substrates
  JOURNAL   Biochim Biophys Acta Gen Subj 1862 (3), 547-556 (2018)
   PUBMED   29158133
  REMARK    GeneRIF: Highly-purified recombinant NDST-4 and a selective library
            of structurally-defined oligosaccharides were employed to determine
            the substrate specificity of rNDST-4. Full-length rNDST-4 lacks
            obvious N-deacetylase activity, and displays only
            N-sulfotransferase activity. NDST-4 did not show directional
            N-sulfotransferase activity while the N-deacetylase domain was
            inactive.
REFERENCE   2  (bases 1 to 3095)
  AUTHORS   Pan,Y., Luo,X., Liu,X., Wu,L.Y., Zhang,Q., Wang,L., Wang,W., Zuo,L.
            and Wang,K.S.
  TITLE     Genome-wide association studies of maximum number of drinks
  JOURNAL   J Psychiatr Res 47 (11), 1717-1724 (2013)
   PUBMED   23953852
  REMARK    GeneRIF: The rs12108602 near NDST4 showed significant associations
            with MaxDrinks.
REFERENCE   3  (bases 1 to 3095)
  AUTHORS   Wang,H., St Julien,K.R., Stevenson,D.K., Hoffmann,T.J., Witte,J.S.,
            Lazzeroni,L.C., Krasnow,M.A., Quaintance,C.C., Oehlert,J.W.,
            Jelliffe-Pawlowski,L.L., Gould,J.B., Shaw,G.M. and O'Brodovich,H.M.
  TITLE     A genome-wide association study (GWAS) for bronchopulmonary
            dysplasia
  JOURNAL   Pediatrics 132 (2), 290-297 (2013)
   PUBMED   23897914
REFERENCE   4  (bases 1 to 3095)
  AUTHORS   Tzeng,S.T., Tsai,M.H., Chen,C.L., Lee,J.X., Jao,T.M., Yu,S.L.,
            Yen,S.J. and Yang,Y.C.
  TITLE     NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26
            and its genetic loss predicts adverse prognosis in colorectal
            cancer
  JOURNAL   PLoS One 8 (6), e67040 (2013)
   PUBMED   23825612
  REMARK    GeneRIF: NDST4 gene is a novel candidate tumor suppressor gene in
            human cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3095)
  AUTHORS   Qi,Q., Menzaghi,C., Smith,S., Liang,L., de Rekeneire,N.,
            Garcia,M.E., Lohman,K.K., Miljkovic,I., Strotmeyer,E.S.,
            Cummings,S.R., Kanaya,A.M., Tylavsky,F.A., Satterfield,S., Ding,J.,
            Rimm,E.B., Trischitta,V., Hu,F.B., Liu,Y. and Qi,L.
  TITLE     Genome-wide association analysis identifies TYW3/CRYZ and NDST4
            loci associated with circulating resistin levels
  JOURNAL   Hum Mol Genet 21 (21), 4774-4780 (2012)
   PUBMED   22843503
  REMARK    GeneRIF: Our results suggest that genetic variants in TYW3/CRYZ and
            NDST4 loci may be involved in the regulation of circulating
            resistin levels
REFERENCE   6  (bases 1 to 3095)
  AUTHORS   Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
            Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
            Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
            Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
            Riley,B.P.
  TITLE     A systematic gene-based screen of chr4q22-q32 identifies
            association of a novel susceptibility gene, DKK2, with the
            quantitative trait of alcohol dependence symptom counts
  JOURNAL   Hum Mol Genet 19 (12), 2497-2506 (2010)
   PUBMED   20332099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
            Victor [added]; Tischfield, Jay A [added]]
REFERENCE   7  (bases 1 to 3095)
  AUTHORS   Aikawa,J., Grobe,K., Tsujimoto,M. and Esko,J.D.
  TITLE     Multiple isozymes of heparan sulfate/heparin GlcNAc
            N-deacetylase/GlcN N-sulfotransferase. Structure and activity of
            the fourth member, NDST4
  JOURNAL   J Biol Chem 276 (8), 5876-5882 (2001)
   PUBMED   11087757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB036429.1, BC012326.1, AK289670.1 and AC110777.3.
            
            On May 17, 2019 this sequence version replaced NM_022569.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.260201.1,
                                           SRR1803612.146520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMN03267773
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264363.7/ ENSP00000264363.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AB036429.1         257-385
            130-130             BC012326.1         359-359
            131-3083            AB036429.1         387-3339
            3084-3085           AK289670.1         3318-3319
            3086-3095           AC110777.3         133075-133084       c
FEATURES             Location/Qualifiers
     source          1..3095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..3095
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /note="N-deacetylase and N-sulfotransferase 4"
                     /db_xref="GeneID:64579"
                     /db_xref="HGNC:HGNC:20779"
                     /db_xref="MIM:615039"
     exon            1..177
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            178..1401
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..3042
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /EC_number="2.8.2.8"
                     /note="glucosaminyl N-deacetylase/N-sulfotransferase 4;
                     N-heparan sulfate sulfotransferase 4;
                     N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4"
                     /codon_start=1
                     /product="bifunctional heparan sulfate
                     N-deacetylase/N-sulfotransferase 4"
                     /protein_id="NP_072091.1"
                     /db_xref="CCDS:CCDS3706.1"
                     /db_xref="GeneID:64579"
                     /db_xref="HGNC:HGNC:20779"
                     /db_xref="MIM:615039"
                     /translation="MNLIVKLRRSFRTLIVLLATFCLVSIVISAYFLYSGYKQEMTLI
                     ETTAEAECTDIKILPYRSMELKTVKPIDTSKTDPTVLLFVESQYSQLGQDIIAILESS
                     RFQYHMVIAPGKGDIPPLTDNGKGKYTLVIYENILKYVSMDSWNRELLEKYCVEYSVS
                     IIGFHKANENSLPSTQLKGFPLNLFNNLALKDCFVNPQSPLLHITKAPKVEKGPLPGE
                     DWTIFQYNHSTYQPVLLTELQTEKSLSSLSSKTLFATVIQDLGLHDGIQRVLFGNNLN
                     FWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNVKDVKALLETQNL
                     LRTQVANFTFNLGFSGKFYHTGTEEEDEGDDLLLRSVDEFWWFPHMWSHMQPHLFHNE
                     SSLVEQMILNKEFALEHGIPINMGYAVAPHHSGVYPVHIQLYAAWKKVWGIQVTSTEE
                     YPHLKPARYRKGFIHNSIMVLPRQTCGLFTHTIFYKEYPGGPQELDKSIRGGELFLTI
                     LLNPISIFMTHLSNYGNDRLGLYTFVNLVNFVQSWTNLKLQTLPPVQLAHQYFELFPE
                     QKDPLWQNPCDDKRHKDIWSREKTCDHLPKFLVIGPQKTGTTALYLFLLMHPSIISNL
                     PSPKTFEEVQFFNGNNYHKGIDWYMDFFPTPSNTTSDFLFEKSANYFHSEEAPRRAAS
                     LVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALRFNFYEVISTGHWAPSDLKTLQRR
                     CLVPGWYAVHIERWLTYFATSQLLIIDGQQLRSDPATVMDEVQKFLGVTPRYNYSEAL
                     TFDPQKGFWCQLLEGGKTKCLGKSKGRKYPPMDPESRTFLSNYYRDHNVELSKLLHRL
                     GQPLPSWLRQELQKVR"
     exon            1402..1489
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1644
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1830
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1959
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2142
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2239
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2363
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2538
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2709
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2819
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2922
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3095
                     /gene="NDST4"
                     /gene_synonym="N-HSST; N-HSST 4; NDST-4; NHSST4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacactaag actggagcta gagagtgctc ttggaatatt gttgaggcag attgcatgaa
       61 ctgaaagctc cttctaatta acctggagcc aagtgaacct gaatactgga tatctcatgt
      121 tctaacacgg gataaattca agttagaaaa agacaaaata ttgaaatgct tctctagatt
      181 atgcttagag gattctgcag caattctcag tattggacat attcaaaatc tcctcaacgt
      241 atatccttcc catctattgc cttccagctt taactcagtt gtgctccctt caaacatttt
      301 acatgatttg cgatggttac atgaactctg gggaagtgat atttgcaaca tctcatactt
      361 tattcactat ggcactttag gaaacgaaat tgggaaaaag cttccaaaac attattctaa
      421 aaaatgaatc ttattgtgaa acttcggaga agttttcgaa cattgattgt tctcttagct
      481 accttttgct tggtgagcat tgtcatttct gcctattttc tctactctgg ctacaaacag
      541 gaaatgacac ttattgaaac cactgcagaa gcagaatgca ctgacatcaa aattctacca
      601 tataggtcaa tggagctgaa aacagttaaa cctattgaca catccaaaac ggaccctact
      661 gtccttctct tcgtggagag ccaatactct caactcggtc aagatatcat agctattttg
      721 gagtccagcc gatttcagta ccacatggtt attgcccctg gaaagggaga tatacctcct
      781 cttacagata atggcaaagg gaaatatact ttagttattt atgaaaatat tctgaagtat
      841 gtcagcatgg actcatggaa tcgagagctt ttagaaaaat actgtgtgga atacagtgtt
      901 agtataatcg gttttcataa agccaatgag aacagcttac caagtacaca attaaaaggc
      961 tttccgttaa accttttcaa taatctagct ctaaaggact gttttgttaa ccctcaatct
     1021 cctttgctgc atattaccaa agcccccaag gttgagaaag gccctcttcc tggggaagac
     1081 tggactattt tccaatataa tcattcaacc taccagcctg tacttttaac tgagttacag
     1141 acagaaaaat ccctgtcatc cttgtctagc aaaacactct ttgcaacggt gattcaggat
     1201 ctggggcttc atgatggaat tcagagagta ctttttggca acaacttgaa cttttggctg
     1261 cacaagctca tcttcataga tgccatctcc ttcttgtcag ggaagaggct gacattgtcc
     1321 ttggacaggt acatccttgt ggacattgat gatatatttg ttgggaaaga gggaacaagg
     1381 atgaatgtca aagatgtgaa ggcattacta gagactcaaa atttactgcg cactcaggtt
     1441 gcaaatttta ccttcaacct tggattttca gggaagtttt accacacagg gactgaagag
     1501 gaagatgaag gagatgacct tttacttcgg tctgtggatg agttctggtg gtttcctcac
     1561 atgtggagcc acatgcagcc ccacctcttc cacaacgagt catctttagt agagcagatg
     1621 attctcaaca aggaatttgc actggaacat ggaataccaa tcaacatggg ctatgctgtg
     1681 gccccacatc actcaggggt ctacccggtt cacattcagc tgtatgcagc ttggaagaag
     1741 gtctggggta ttcaagtcac cagcactgaa gaatatccac atctgaaacc tgcccggtac
     1801 agaaagggct tcattcacaa tagcatcatg gtcctccctc gacagacttg tgggttgttc
     1861 actcacacta ttttctacaa agaatatcca ggaggacccc aagaactgga taaaagtatc
     1921 agaggaggtg aactttttct cacaatcctt ctaaacccaa tcagcatttt catgacccat
     1981 ttatcaaact atggaaatga ccgcctaggg ttatatacct ttgtgaactt ggtcaacttt
     2041 gtgcagagct ggaccaacct gaaattgcaa actctgcctc cagtgcaact ggcccaccag
     2101 tattttgagc tcttccctga gcagaaagac cctctatggc agaatccatg tgatgataaa
     2161 cgacacaaag acatctggtc cagagagaaa acttgtgacc acttaccaaa atttctagta
     2221 attggtccac aaaaaacagg aacaactgca ctttatttat ttcttcttat gcatccttca
     2281 atcatcagca atctccctag tccaaagaca tttgaggaag ttcagttctt taatggcaac
     2341 aactatcaca aaggaataga ctggtatatg gactttttcc ctacaccatc caatactaca
     2401 agtgactttc tgtttgaaaa gagtgctaat tacttccatt cggaagaagc tccaagacga
     2461 gccgcatctc ttgtccccaa agccaagatc atcaccatcc tcattgaccc ctcagacagg
     2521 gcatactctt ggtaccagca ccaacgatca catgaagatc cagctgctct gaggttcaat
     2581 ttctatgaag ttatttcaac aggacattgg gctccatctg acttaaaaac tttgcagaga
     2641 agatgcctag tacctggatg gtatgcagtc cacatagaaa gatggctaac ttactttgct
     2701 acttctcagt tgctaattat tgatggacag cagctgagat ctgacccagc tactgtgatg
     2761 gatgaagtcc agaagtttct gggagttaca cctcgttata attactctga agcactaacg
     2821 tttgatcccc aaaagggttt ttggtgtcaa ttactggaag gaggaaagac aaaatgcctt
     2881 ggaaaaagca aaggccgaaa atatccacct atggatccag agtctagaac gttcctctct
     2941 aattactacc gagatcataa tgtggaacta tccaaactgc tacacagact gggacagcct
     3001 ctgccatcgt ggctgagaca ggaactgcag aaagtgagat agcactggag acaagaacta
     3061 agcctctcaa gatactttta gtgttaaaaa aaaaa
//
