LOCUS       NM_004784               5806 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens N-deacetylase and N-sulfotransferase 3 (NDST3),
            transcript variant 1, mRNA.
ACCESSION   NM_004784
VERSION     NM_004784.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5806)
  AUTHORS   Oppelaar,J.J., Ferwerda,B., Romman,M.A., Sahebdin,G.N.,
            Zwinderman,A.H., Galenkamp,H., Boekholdt,S.M., van den Born,B.H.,
            Olde Engberink,R.H.G. and Vogt,L.
  TITLE     Genetic Variance in Heparan Sulfation Is Associated With Salt
            Sensitivity
  JOURNAL   Hypertension 81 (10), 2101-2112 (2024)
   PUBMED   39247955
  REMARK    GeneRIF: Genetic Variance in Heparan Sulfation Is Associated With
            Salt Sensitivity.
REFERENCE   2  (bases 1 to 5806)
  AUTHORS   Tang,Q., Liu,M., Liu,Y., Hwang,R.D., Zhang,T. and Wang,J.
  TITLE     NDST3 deacetylates alpha-tubulin and suppresses V-ATPase assembly
            and lysosomal acidification
  JOURNAL   EMBO J 40 (19), e107204 (2021)
   PUBMED   34435379
  REMARK    GeneRIF: NDST3 deacetylates alpha-tubulin and suppresses V-ATPase
            assembly and lysosomal acidification.
REFERENCE   3  (bases 1 to 5806)
  AUTHORS   Li,T., Li,Y., Zhang,W. and Zhang,J.
  TITLE     Hsa_circ_0001017 inhibits proliferation and metastasis via
            regulating the let-7g-3p/NDST3 axis in glioma
  JOURNAL   Folia Neuropathol 59 (2), 174-188 (2021)
   PUBMED   34284545
  REMARK    GeneRIF: Hsa_circ_0001017 inhibits proliferation and metastasis via
            regulating the let-7g-3p/NDST3 axis in glioma.
REFERENCE   4  (bases 1 to 5806)
  AUTHORS   Wang,L., Chen,J., Li,Z., Sun,W., Chen,B., Li,S., Li,W., Lu,D.,
            Wang,Y. and Shi,Y.
  TITLE     Association study of NDST3 gene for schizophrenia, bipolar
            disorder, major depressive disorder in the Han Chinese population
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 177 (1), 3-9 (2018)
   PUBMED   29140583
  REMARK    GeneRIF: Study does not support that the NDST3 gene plays a major
            role in schizophrenia, bipolar disorder, and major depressive
            disorder in the Han Chinese population.
REFERENCE   5  (bases 1 to 5806)
  AUTHORS   Zhang,C., Lu,W., Wang,Z., Ni,J., Zhang,J., Tang,W. and Fang,Y.
  TITLE     A comprehensive analysis of NDST3 for schizophrenia and bipolar
            disorder in Han Chinese
  JOURNAL   Transl Psychiatry 6 (1), e701 (2016)
   PUBMED   26731438
  REMARK    GeneRIF: A genome-wide association study provided suggestive
            evidence that the NDST3 variation predisposed patients to
            schizophrenia and bipolar disorder.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5806)
  AUTHORS   Krenn,E.C., Wille,I., Gesslbauer,B., Poteser,M., van Kuppevelt,T.H.
            and Kungl,A.J.
  TITLE     Glycanogenomics: a qPCR-approach to investigate biological glycan
            function
  JOURNAL   Biochem Biophys Res Commun 375 (3), 297-302 (2008)
   PUBMED   18692483
REFERENCE   7  (bases 1 to 5806)
  AUTHORS   Grobe,K., Ledin,J., Ringvall,M., Holmborn,K., Forsberg,E.,
            Esko,J.D. and Kjellen,L.
  TITLE     Heparan sulfate and development: differential roles of the
            N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes
  JOURNAL   Biochim Biophys Acta 1573 (3), 209-215 (2002)
   PUBMED   12417402
  REMARK    Review article
REFERENCE   8  (bases 1 to 5806)
  AUTHORS   Grobe,K. and Esko,J.D.
  TITLE     Regulated translation of heparan sulfate N-acetylglucosamine
            N-deacetylase/n-sulfotransferase isozymes by structured
            5'-untranslated regions and internal ribosome entry sites
  JOURNAL   J Biol Chem 277 (34), 30699-30706 (2002)
   PUBMED   12070138
REFERENCE   9  (bases 1 to 5806)
  AUTHORS   Aikawa,J., Grobe,K., Tsujimoto,M. and Esko,J.D.
  TITLE     Multiple isozymes of heparan sulfate/heparin GlcNAc
            N-deacetylase/GlcN N-sulfotransferase. Structure and activity of
            the fourth member, NDST4
  JOURNAL   J Biol Chem 276 (8), 5876-5882 (2001)
   PUBMED   11087757
REFERENCE   10 (bases 1 to 5806)
  AUTHORS   Aikawa,J. and Esko,J.D.
  TITLE     Molecular cloning and expression of a third member of the heparan
            sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family
  JOURNAL   J Biol Chem 274 (5), 2690-2695 (1999)
   PUBMED   9915799
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF074924.1, BC034037.1 and
            BE348441.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004784.2.
            
            Summary: This gene encodes a member of the heparan sulfate/heparin
            GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme
            is a type II transmembrane protein that resides in the Golgi
            apparatus. This monomeric bifunctional enzyme catalyzes the
            N-deacetylation and N-sulfation of N-acetylglucosamine residues in
            heparan sulfate and heparin, which are the initial chemical
            modifications required for the biosynthesis of the functional
            oligosaccharide sequences that define the specific ligand binding
            activities of heparan sulfate and heparin. [provided by RefSeq, Nov
            2008].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.196714.1,
                                           SRR1803614.284579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296499.6/ ENSP00000296499.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3040              AF074924.1         142-3181
            3041-4657           BC034037.1         3070-4686
            4658-4658           BE348441.1         168-168
            4659-5806           BC034037.1         4688-5835
FEATURES             Location/Qualifiers
     source          1..5806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..5806
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /note="N-deacetylase and N-sulfotransferase 3"
                     /db_xref="GeneID:9348"
                     /db_xref="HGNC:HGNC:7682"
                     /db_xref="MIM:603950"
     exon            1..107
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            108..1243
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..2884
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /EC_number="2.8.2.8"
                     /note="glucosaminyl N-deacetylase/N-sulfotransferase 3;
                     GlcNAc N-deacetylase/ N-sulfotransferase 3;
                     N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3;
                     N-heparan sulfate sulfotransferase 3"
                     /codon_start=1
                     /product="bifunctional heparan sulfate
                     N-deacetylase/N-sulfotransferase 3"
                     /protein_id="NP_004775.1"
                     /db_xref="CCDS:CCDS3708.1"
                     /db_xref="GeneID:9348"
                     /db_xref="HGNC:HGNC:7682"
                     /db_xref="MIM:603950"
                     /translation="MSFIMKLHRHFQRTVILLATFCMVSIIISAYYLYSGYKQENELS
                     ETASEVDCGDLQHLPYQLMEVKAMKLFDASRTDPTVLVFVESQYSSLGQDIIMILESS
                     RFQYHIEIAPGKGDLPVLIDKMKGKYILIIYENILKYINMDSWNRSLLDKYCVEYGVG
                     VIGFHKTSEKSVQSFQLKGFPFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGT
                     DWTVFQINHSAYQPVIFAKVKTPENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNL
                     NFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQN
                     LLRAQITNFTFNLGFSGKFYHTGTEEEDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHN
                     ESSLVEQMILNKKFALEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKKVWNIKITSTE
                     EYPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPKELDKSIQGGELFFT
                     VVLNPISIFMTHLSNYGNDRLGLYTFVNLANFVKSWTNLRLQTLPPVQLAHKYFELFP
                     DQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLVIGPQKTGTTALYLFLVMHPSILSN
                     SPSPKTFEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYFHSEEAPKRAA
                     SLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFSFYEVISAGPRAPSELRALQK
                     RCLVPGWYASHIERWLVYFPPFQLLIIDGQQLRTDPATVMDEVQKFLGVLPHYNYSEA
                     LTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRTFLSSYYRDHNVELSKLLHK
                     LGQPLPSWLRQELQKVR"
     exon            1244..1331
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1486
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1672
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1801
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1984
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2081
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2205
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2380
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2551
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2661
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2764
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..5806
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5785..5790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /note="hexamer: AATAAA"
     polyA_site      5806
                     /gene="NDST3"
                     /gene_synonym="HSST3"
                     /note="major polyA site"
ORIGIN      
        1 gtaaagtcaa aaagcctgag ccgatggtaa cgagtggtac tgtttccgtt tcttttccat
       61 ctattgcaac tttctcaagc attttcagct ctgaacttta attccagact gtattttctg
      121 tgagtcctga tcaagtgata caaatgagct gcaatggtga cataaactct tgacagagat
      181 tggaaaagta gctggaacac catcttttct tttaactttt tatggtgctt ctgttggcat
      241 agttggggaa agcacctaca acatgagttt tatcatgaag cttcacagac actttcaaag
      301 aacagtcatt ctgcttgcca ctttttgtat ggtgagcatt atcatttctg cttactacct
      361 gtacagtggc tacaaacagg aaaatgaact ctctgagacg gcttcagaag ttgactgtgg
      421 cgacctccaa cacctaccat atcaactaat ggaagtgaaa gcaatgaagc tttttgatgc
      481 ctcaaggaca gaccccacag tcctagtatt tgtagagagc cagtactcat ctcttggtca
      541 agacatcatt atgattctag aatcaagtag attccagtat cacattgaaa ttgcccctgg
      601 aaagggagat ctcccagtgc ttatagacaa aatgaaaggc aaatacattc tcattattta
      661 tgagaatatt ttaaagtata taaatatgga ttcctggaat cgaagccttc tagataaata
      721 ctgtgtagaa tatggtgtgg gtgtcattgg attccacaaa actagtgaga agagtgtaca
      781 gagctttcag ttaaaaggtt tccctttttc catatatgga aatcttgcag taaaagattg
      841 ttgtattaat cctcattctc cattgattcg tgtgaccaaa tcttccaagc ttgaaaaagg
      901 ttctttacct ggaactgact ggacagtttt tcagattaat cattcagcct atcaaccagt
      961 aatatttgcc aaagtaaaga ccccagaaaa cctttctcct tccatctcta aaggtgcttt
     1021 ttatgccact attatacatg acctggggct tcatgatgga attcaaaggg ttctttttgg
     1081 caacaacttg aacttttggc tgcacaagct catcttcata gatgccatct ccttcttatc
     1141 agggaagagg ctgacattgt ccttggacag gtacattctt gtggatattg atgatatatt
     1201 tgtgggaaaa gagggaacaa gaatgaacac caatgatgta aaggccctgc ttgatactca
     1261 gaatcttttg cgtgcacaaa tcacaaattt tacattcaac ctgggatttt cagggaaatt
     1321 ttaccataca ggaactgaag aggaagatga aggagatgac tgtctgttgg ggtctgtgga
     1381 tgagttctgg tggtttcctc acatgtggag ccatatgcag ccccacctct tccacaatga
     1441 gtcatctttg gtggagcaga tgattctcaa caaaaaattt gccttagagc acggcattcc
     1501 aacggacatg ggctacgctg tggcccctca ccattcgggc gtctaccctg tacatgttca
     1561 gctttatgag gcctggaaga aggtctggaa tattaaaatc accagcactg aagaatatcc
     1621 acatctgaag ccagctagat accggagggg ttttatccac aaaaacatca tggttctccc
     1681 aagacaaacc tgtgggcttt tcactcacac cattttctac aaagaatatc cagggggtcc
     1741 taaagagctg gataagagta tccaaggagg agaacttttc ttcactgtcg tcctcaaccc
     1801 tatcagcatt ttcatgaccc atttgtccaa ctatgggaat gaccgactgg gattatatac
     1861 atttgttaat ctggccaact ttgtgaagag ctggaccaac ctgcgacttc agactctgcc
     1921 tccagtacaa ctggcccaca agtattttga gctgtttcct gatcagaaag accctctctg
     1981 gcagaatcct tgcgatgaca aacgccacag agacatttgg tctaaagaaa aaacttgtga
     2041 tcgcttacca aaattcttgg taataggacc ccagaaaact ggtaccactg ctttgtattt
     2101 gttcctggtt atgcatcctt ccatccttag taactccccc agcccaaaaa cctttgagga
     2161 ggtacagttc tttaatagaa ataactacca cagggggatt gattggtata tggatttctt
     2221 cccagtccca tctaatgtca ctaccgactt tttgtttgag aagagtgcca attacttcca
     2281 ctcagaggaa gcccctaaaa gagctgcttc tctggttccc aaagccaaga ttatcaccat
     2341 tctcattgac ccttcagacc gagcatactc ctggtaccag catcagcgat cacatgaaga
     2401 ccctgcagct ctgaagttta gcttctacga agtgatctca gcagggcccc gtgcaccctc
     2461 ggagctcaga gccttgcaga agagatgttt ggtcccgggg tggtatgcca gccacatcga
     2521 gagatggctt gtttatttcc ccccatttca gttgctaatt attgatgggc aacaactaag
     2581 aactgatcct gctacagtga tggatgaagt acagaagttt ctaggagtct tgcctcatta
     2641 taattactca gaagctttaa cgtttgattc tcataaaggt ttctggtgtc agttactgga
     2701 agaaggtaaa acaaaatgcc ttggaaagag caaaggaaga aaataccctc caatggattc
     2761 tgatagcagg acatttctgt caagctacta tcgagatcac aacgtggaac tctcaaagct
     2821 gctgcacaaa ctgggtcagc ctctgccatc ctggctgaga caggagctgc agaaagtaag
     2881 atagcactga gagaaaactt gagacttcat cgtccatgta gaacacacct tttccaaagc
     2941 ttccagaagc taccaaaagg cagttgaaaa atatacctct tcaaatgaga aaaaagaaca
     3001 gtttcttcca tgtgctggca cgtggatgat tagaaaaaaa gaaaaagtat gtgttacaag
     3061 ccttgaggcc tgtggccttt ctcttaaccc atatctgagc ctgtgggatt attgtagact
     3121 actgtgcact catgtggaag tcaattgcaa ccaacataaa tatcaaacac aaatgcagaa
     3181 ctgttccatt tcatagtaat atttacactt ttatatatca actaagattg tgtctctgta
     3241 ggtttttaga ccactgtttg cctgtacgat gttttcttat tattttattc tataaagtgt
     3301 cctatgaaac aagaagcaaa ataaacatca caatgtagca taaaatgtca aaagcataac
     3361 acccatgaaa aatgcttgcc aaaatttaaa tccacttaag tatttagaaa taattgtaaa
     3421 ttataatttg tgctagatca gagtggaaaa gttatatatg agtgttatct gcaccaaaaa
     3481 aaaataagtg ctatagcaaa agtgattttt tcatatacat agtctagtga atatatgtaa
     3541 aaattactaa ctcttccatc acaacgtaat tgttatactg aaatatatac tgtaaagctg
     3601 ttggatggta aatagaaaca catcaagtac accaaaacag taaataacaa tgtaaagtgt
     3661 actgactgaa tcctctaaaa gggagaaatt gtaggggtct aaaaacatat catcgagaat
     3721 tctatgtcca cttgctgtaa gctgtgaatc tatcccagta gtcctcacta gttctacaga
     3781 aatgcatgcc tagagtctga ggtatgtgtc atctccagaa acaggttgac ttttaaatgt
     3841 gaatagctat ttttaatgct ccccaaaaca aaacctatta aactaaaact aaaaacagtt
     3901 tccctagatg atgtggttag gctatttaca tttaggttat taaaaaattg cattttccca
     3961 gatagttcaa aataaaatta tgtaatgtag tagagattta taacaaaaaa caaattaata
     4021 tattatttgt aatctaatgt ttgcaatgat acttttgata taaggcaaag aaacataagc
     4081 agagcagagg cccatttttg aaaatatttc acccatcact ctggtggaag taacagatca
     4141 taggtacaat taaggattag ctactaaatt aaatgcagga agtacaaaga tgagcaagtc
     4201 atgctcttga aatatattta catttcaatt gtaaataata tatatggtta ataaagtttc
     4261 caaaaaagaa aagaatacat catacttatt ttcctgttaa tatttactta attttttttt
     4321 ttgagagggg gacagagtct cactatgtca cccaggctgg agtgcaatgg tgtgatctca
     4381 gctcactgca acctccgcct cctgggttca agtgattctc ctgcctcagc ctcctgagga
     4441 gctgggatta cagccatgca ccaccacgcc cgggtaattt ttgtattttt agtagtgaca
     4501 gggtttcacc atgttgacta ggctgatctt gaactcctga cctcatgatc cacccacctt
     4561 ggcctctcaa agtgctgaga ttacaagcgt gagccaccat gccctgacta cttaattttt
     4621 aaatgtactg tacatataca taaaatttaa gtagtaaatt aattccctgc tatgattata
     4681 agcctttata aaatattatc aaaggtatga ttagaaacaa atgggaggaa aacccatagt
     4741 aaaaatattt tcattgtcat tttaatgggt aaaactatca attactaatt agaaaatgaa
     4801 ttgtgagatc cacttactat aaatttttaa ctgtacatta taattacttt tttaaagttt
     4861 catgtaccta aagcatatgc taatttttaa atatactatt agcagaaaaa attggaaaaa
     4921 tcaccaattt ttaagactct tgactctaaa agcaaaatca aagtgatttg gacaaatatg
     4981 ggaaacacag tcttcatgct tactgctgtc tcttttatag cagcagatgc cagacatgct
     5041 aggaaaatta ctatagtctt ccatctccac caacttaaga aaactggctt aggaaggtta
     5101 aacatgagaa taggcctcag cagttatata cagtgtcatg ttttcatttg gcaacaacat
     5161 ttattctaat aaaaaaagaa aagaaaaact gatacattta tgctttaatg gtaagatgta
     5221 catttgaact gctaagcaaa gctgctaatg gcctattttg tttaggtaaa tcgagttgac
     5281 tgaacacttc atccttttaa atagatgtca aaaacatact ccgtgtttgt ataaagacag
     5341 gagaaaaagg aagagatctt accaaaattt attcattcac aagtacatgt attacgctag
     5401 ctagagcagc aaacctgtga aaggattttt gaccactcaa tgtgtcttga agacagcatc
     5461 aaattctaga ggacatgcat actttccaca ttatatactc caactggtta atatgctaat
     5521 ctgaaagtaa cataaataca tatgagagaa taatgagaga taatctgatt taaaactagc
     5581 tttgtataga attccctttt tcattgttta aaatatgaaa cttcctcagg aagaaatgaa
     5641 atggttattt caatgtttat agctgtaata ttcttgtcat tcacattgaa tgaaaattac
     5701 tggaaacatt tttttctctg agttttttaa aataaaaaac ctagatataa ttctgatagt
     5761 agcatggtac ctcatatgta caacaataaa ctgataggaa aatgaa
//
