LOCUS       NM_032013               2971 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NDRG family member 3 (NDRG3), transcript variant 1,
            mRNA.
ACCESSION   NM_032013
VERSION     NM_032013.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2971)
  AUTHORS   Wang,X., Rong,S., Sun,Y., Yin,B., Yang,X., Lu,X., Sun,H., Yan,Y.,
            Sun,G., Liang,Y., Wang,P., Xie,S. and Li,Y.
  TITLE     NDRG3 regulates imatinib resistance by promoting beta-catenin
            accumulation in the nucleus in chronic myelogenous leukemia
  JOURNAL   Oncol Rep 50 (2) (2023)
   PUBMED   37350410
  REMARK    GeneRIF: NDRG3 regulates imatinib resistance by promoting
            beta-catenin accumulation in the nucleus in chronic myelogenous
            leukemia.
REFERENCE   2  (bases 1 to 2971)
  AUTHORS   Xu,Y., Kusuyama,J., Osana,S., Matsuhashi,S., Li,L., Takada,H.,
            Inada,H. and Nagatomi,R.
  TITLE     Lactate promotes neuronal differentiation of SH-SY5Y cells by
            lactate-responsive gene sets through NDRG3-dependent and
            -independent manners
  JOURNAL   J Biol Chem 299 (6), 104802 (2023)
   PUBMED   37172727
  REMARK    GeneRIF: Lactate promotes neuronal differentiation of SH-SY5Y cells
            by lactate-responsive gene sets through NDRG3-dependent and
            -independent manners.
REFERENCE   3  (bases 1 to 2971)
  AUTHORS   Liu,Y., Xia,J., Zhou,Y. and Shao,S.
  TITLE     High expression of NDRG3 correlates with poor prognosis in gastric
            cancer patients
  JOURNAL   Rev Esp Enferm Dig 113 (7), 524-528 (2021)
   PUBMED   33562989
  REMARK    GeneRIF: High expression of NDRG3 correlates with poor prognosis in
            gastric cancer patients.
REFERENCE   4  (bases 1 to 2971)
  AUTHORS   Ma,W., Zhao,X., Xue,N., Gao,Y. and Xu,Q.
  TITLE     The LINC01410/miR-122-5p/NDRG3 axis is involved in the
            proliferation and migration of osteosarcoma cells
  JOURNAL   IUBMB Life 73 (4), 705-717 (2021)
   PUBMED   33583123
  REMARK    GeneRIF: The LINC01410/miR-122-5p/NDRG3 axis is involved in the
            proliferation and migration of osteosarcoma cells.
REFERENCE   5  (bases 1 to 2971)
  AUTHORS   Kim,K.R., Kim,K.A., Park,J.S., Jang,J.Y., Choi,Y., Lee,H.H.,
            Lee,D.C., Park,K.C., Yeom,Y.I., Kim,H.J. and Han,B.W.
  TITLE     Structural and Biophysical Analyses of Human N-Myc
            Downstream-Regulated Gene 3 (NDRG3) Protein
  JOURNAL   Biomolecules 10 (1), 90 (2020)
   PUBMED   31935861
  REMARK    GeneRIF: Structural and Biophysical Analyses of Human N-Myc
            Downstream-Regulated Gene 3 (NDRG3) Protein.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2971)
  AUTHORS   Qu,X., Zhai,Y., Wei,H., Zhang,C., Xing,G., Yu,Y. and He,F.
  TITLE     Characterization and expression of three novel
            differentiation-related genes belong to the human NDRG gene family
  JOURNAL   Mol Cell Biochem 229 (1-2), 35-44 (2002)
   PUBMED   11936845
  REMARK    GeneRIF: Cloning and expression of the gene; highly expressed in
            brain and testis
REFERENCE   7  (bases 1 to 2971)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 2971)
  AUTHORS   Zhao,W., Tang,R., Huang,Y., Wang,W., Zhou,Z., Gu,S., Dai,J.,
            Ying,K., Xie,Y. and Mao,Y.
  TITLE     Cloning and expression pattern of the human NDRG3 gene
  JOURNAL   Biochim Biophys Acta 1519 (1-2), 134-138 (2001)
   PUBMED   11406283
REFERENCE   9  (bases 1 to 2971)
  AUTHORS   Zhou,R.H., Kokame,K., Tsukamoto,Y., Yutani,C., Kato,H. and
            Miyata,T.
  TITLE     Characterization of the human NDRG gene family: a newly identified
            member, NDRG4, is specifically expressed in brain and heart
  JOURNAL   Genomics 73 (1), 86-97 (2001)
   PUBMED   11352569
REFERENCE   10 (bases 1 to 2971)
  AUTHORS   Kalaydjieva,L., Gresham,D., Gooding,R., Heather,L., Baas,F., de
            Jonge,R., Blechschmidt,K., Angelicheva,D., Chandler,D., Worsley,P.,
            Rosenthal,A., King,R.H. and Thomas,P.K.
  TITLE     N-myc downstream-regulated gene 1 is mutated in hereditary motor
            and sensory neuropathy-Lom
  JOURNAL   Am J Hum Genet 67 (1), 47-58 (2000)
   PUBMED   10831399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL132768.15, AB044943.1, AF308609.1 and AA903471.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032013.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.265734.1,
                                           SRR1803617.275290.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349004.6/ ENSP00000345292.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL132768.15        45189-45200         c
            13-2331             AB044943.1         1-2319
            2332-2969           AF308609.1         2242-2879
            2970-2971           AA903471.1         13-14               c
FEATURES             Location/Qualifiers
     source          1..2971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..2971
                     /gene="NDRG3"
                     /note="NDRG family member 3"
                     /db_xref="GeneID:57446"
                     /db_xref="HGNC:HGNC:14462"
                     /db_xref="MIM:605273"
     exon            1..46
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            47..151
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1222
                     /gene="NDRG3"
                     /note="isoform a is encoded by transcript variant 1;
                     protein NDRG3; N-myc downstream-regulated gene 3 protein"
                     /codon_start=1
                     /product="protein NDRG3 isoform a"
                     /protein_id="NP_114402.1"
                     /db_xref="CCDS:CCDS13285.1"
                     /db_xref="GeneID:57446"
                     /db_xref="HGNC:HGNC:14462"
                     /db_xref="MIM:605273"
                     /translation="MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETTHGVVHV
                     TIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAP
                     SFPTGYQYPTMDELAEMLPPVLTHLSLKSIIGIGVGAGAYILSRFALNHPELVEGLVL
                     INVDPCAKGWIDWAASKLSGLTTNVVDIILAHHFGQEELQANLDLIQTYRMHIAQDIN
                     QDNLQLFLNSYNGRRDLEIERPILGQNDNKSKTLKCSTLLVVGDNSPAVEAVVECNSR
                     LNPINTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSS
                     SLGSGESPFSRSVTSNQSDGTQESCESPDVLDRHQTMEVSC"
     exon            152..187
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            188..293
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            294..414
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            415..477
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            478..538
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            539..625
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..682
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            683..786
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            787..852
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            853..904
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            905..952
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            953..988
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1040
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..2971
                     /gene="NDRG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2945..2950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDRG3"
                     /note="hexamer: AATAAA"
     polyA_site      2971
                     /gene="NDRG3"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgccg ctgctgctgc actgacggcg ggtgcccgcg cctcagagtt actgatttat
       61 tcttgagatt cctctactct cgttatctga cctcatggat gaacttcagg atgttcagct
      121 cacagagatc aaaccacttc taaatgataa gaatggtaca agaaacttcc aggactttga
      181 ctgtcaggaa catgatatag aaacaactca tggtgtggtc cacgtcacta taagaggctt
      241 acccaaagga aacagaccag ttatactaac atatcatgac attggcctca accataaatc
      301 ctgtttcaat gcattcttta actttgagga tatgcaagag atcacccagc actttgctgt
      361 ctgtcatgtg gatgccccag gccagcagga aggtgcaccc tctttcccaa cagggtatca
      421 gtaccccaca atggatgagc tggctgaaat gctgcctcct gttcttaccc acctaagcct
      481 gaaaagcatc attggaattg gagttggagc tggagcttac atcctcagca gatttgcact
      541 caaccatcca gagcttgtgg aaggccttgt gctcattaat gttgaccctt gcgctaaagg
      601 ctggattgac tgggcagctt ccaaactctc tggcctgaca accaatgttg tggacattat
      661 tttggctcat cactttgggc aggaagagtt acaggccaac ctggacctga tccaaaccta
      721 cagaatgcat attgcccaag acatcaacca agacaacctg cagctcttct tgaattccta
      781 caatggacgc agagacctgg agatcgaaag acccatactg ggccaaaatg ataacaaatc
      841 aaaaacatta aagtgttcta ctttactggt ggtaggggac aattcgcctg cagttgaggc
      901 tgtggtcgaa tgcaattccc gcctgaaccc tataaataca actttgctaa agatggcgga
      961 ctgtggggga ctgccccagg tagttcagcc tgggaagctc accgaggcct tcaagtactt
     1021 tttgcaggga atgggctaca taccatctgc cagcatgact cggctcgccc gatcacgaac
     1081 ccactcaacc tcgagtagcc tcggctctgg agaaagtccc ttcagccggt ctgtcaccag
     1141 caatcagtca gatggaactc aagaatcctg tgagtcccct gatgtcctgg acagacacca
     1201 gaccatggag gtgtcctgct aagcagatgc tcctcccctg gaccattgca agtccatcct
     1261 tcaaatgacc actccataat ataacatttc atccagtaaa ctggcctcta ctatctttaa
     1321 ctcatgcatg gccactgaac ctctctctag tagcctggat ttatcattct ctctgcctgc
     1381 ccaccccctt ttttgtatag cccaagaacc acttccatgc catactgtaa cattccaaca
     1441 tctttagctg atcagatctc tccatatcct ctcttgccag ctttttcccg tgctccccca
     1501 actatgtatc agataagatt ctttgatccc gactctgtgt gtgcgagcac gcgtgtctgt
     1561 gtttgtgtgt gcatagttct gtggttttag acacgctttc ttgtagtgct tctgcaaaaa
     1621 acaaaaaagg gacttatttt gcattctcaa tggtgttttt aagggaatta ggcagaacag
     1681 atttctaggt tgggtaggcc actgcattct cttttgtttg caaattggtc aacaaaattt
     1741 gcaaagtgat ttcaggagag agcagctttg aggaatgtgg aaaatcataa ttgccgtctg
     1801 gaccattgat tgattgtgac cagtagcaga agggtgcctg ttacatagag aggctccttc
     1861 tgtccaaatg aatttctgta tactcttcta taaataaaag ggaggaatat attctgctgg
     1921 aagcccatga accatcgctg aggttctgat acaacataga gttttttcca aggagtgaat
     1981 gtggtttaat tactggactc tcttagcaca ggaaggtgga aacaaaatgc caggcctctg
     2041 ctctgaagag caaaactgct gtcgctgcag tatctgatac cagacatcca catatccaca
     2101 agaagtgcct cttaggtctg tgacagagag tgtgtctcca ttcctcagtt cccagaaagg
     2161 ggagaggttt ggcctaaaaa gcatgtagat gggggagaaa tgggtggggg gagaggaaca
     2221 gccattaaca cagtatcatg tttaacaagt atagccttga tttcagtaga tgtaatggaa
     2281 gccaaattaa attgatacag aacccatttc tcagagtctt tttttttttt tgagacagag
     2341 tctcgctgtt acccaggctg gagtgcaatg gcgcaaactt ggctcactgc aacctctgcc
     2401 ccctgggttc aagcgattct cctgcctcag cctcccgagt agctgagact acaggcacct
     2461 gccaccatac ccagctaagt tatgtatttt tagtagagat ggagtttcac catgttggcc
     2521 aggctggtct caaactcctg acctcaggtg atccacctgc ctcagcctcc caaagtgctg
     2581 ggattacagg catgagtcat tgctcccagc cattagaaag attgttaatc ctatgaactc
     2641 ccttttgtag gagagaaagg gccaatctgt aggggtagcc ctgtccaggt aaagttgttt
     2701 tcagcctcat gtctactgtt aggtgaggga gtcacagcca gacagagagt attgctggag
     2761 ggtgagagaa ttgtggagac caactaccac atagcaagag cccagctctt gggagcattg
     2821 agatgtaagc tcagggttac acagttccaa atcttgggaa ggggcttttc agacagactg
     2881 tttgctttct gctgagataa ggaatgcatc actctgccag agtatgactt tttacagatt
     2941 attaaataaa gctgcatatg tctcattgtt a
//
