LOCUS       NM_201540               2046 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens NDRG family member 2 (NDRG2), transcript variant 7,
            mRNA.
ACCESSION   NM_201540
VERSION     NM_201540.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2046)
  AUTHORS   Wu,S., Zhang,J., Chen,S., Zhou,X., Liu,Y., Hua,H., Qi,X., Mao,Y.,
            Young,K.H. and Lu,T.
  TITLE     Low NDRG2, regulated by the MYC/MIZ-1 complex and methylation,
            predicts poor outcomes in DLBCL patients
  JOURNAL   Ann Hematol 103 (8), 2877-2892 (2024)
   PUBMED   38842567
  REMARK    GeneRIF: Low NDRG2, regulated by the MYC/MIZ-1 complex and
            methylation, predicts poor outcomes in DLBCL patients.
REFERENCE   2  (bases 1 to 2046)
  AUTHORS   Ichikawa,T., Suekane,A., Nakahata,S., Iha,H., Shimoda,K.,
            Murakami,T. and Morishita,K.
  TITLE     Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity
            Causes Cancer Vulnerability in NDRG2low Adult T-Cell
            Leukemia/Lymphoma
  JOURNAL   Int J Mol Sci 25 (5), 2842 (2024)
   PUBMED   38474089
  REMARK    GeneRIF: Inhibition of PRMT5/MEP50 Arginine Methyltransferase
            Activity Causes Cancer Vulnerability in NDRG2[low] Adult T-Cell
            Leukemia/Lymphoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2046)
  AUTHORS   Kurdi,M., Baeesa,S., Fadul,M.M., Alkhotani,A., Alkhayyat,S.,
            Karami,M.M., Alsinani,T., Katib,Y., Fathaddin,A.A., Faizo,E.,
            Lary,A.I., Almansouri,M., Maghrabi,Y., Alyousef,M.A. and Addass,B.
  TITLE     The effect of p53 on the activity of NRF2 and NDRG2 genes through
            apoptotic pathway in IDH-wildtype glioblastoma
  JOURNAL   Pathol Res Pract 254, 155118 (2024)
   PUBMED   38241776
  REMARK    GeneRIF: The effect of p53 on the activity of NRF2 and NDRG2 genes
            through apoptotic pathway in IDH-wildtype glioblastoma.
REFERENCE   4  (bases 1 to 2046)
  AUTHORS   Zhao,Y., Fan,X., Wang,Q., Zhen,J., Li,X., Zhou,P., Lang,Y.,
            Sheng,Q., Zhang,T., Huang,T., Zhao,Y., Lv,Z. and Wang,R.
  TITLE     ROS promote hyper-methylation of NDRG2 promoters in a
            DNMTS-dependent manner: Contributes to the progression of renal
            fibrosis
  JOURNAL   Redox Biol 62, 102674 (2023)
   PUBMED   36989575
  REMARK    GeneRIF: ROS promote hyper-methylation of NDRG2 promoters in a
            DNMTS-dependent manner: Contributes to the progression of renal
            fibrosis.
REFERENCE   5  (bases 1 to 2046)
  AUTHORS   Wang,J., Yuan,Y., Zhang,K., Sun,X., Bu,X., Dong,J., Wu,Y., Tian,H.
            and Shen,L.
  TITLE     [NDRG2 inhibits tumorigenesis of hepatocellular carcinoma by
            regulating metabolism of phospholipids and triglyceride: a
            metabonomic analysis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (12), 1765-1773 (2022)
   PUBMED   36651243
  REMARK    GeneRIF: [NDRG2 inhibits tumorigenesis of hepatocellular carcinoma
            by regulating metabolism of phospholipids and triglyceride: a
            metabonomic analysis].
REFERENCE   6  (bases 1 to 2046)
  AUTHORS   Deng,Y., Yao,L., Chau,L., Ng,S.S., Peng,Y., Liu,X., Au,W.S.,
            Wang,J., Li,F., Ji,S., Han,H., Nie,X., Li,Q., Kung,H.F., Leung,S.Y.
            and Lin,M.C.
  TITLE     N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma
            cell proliferation
  JOURNAL   Int J Cancer 106 (3), 342-347 (2003)
   PUBMED   12845671
  REMARK    GeneRIF: Down-Regulation of N-Myc downstream-regulated gene 2 is
            associated with glioblastoma
            Erratum:[Int J Cancer. 2003 Oct 10;106(6):984]
REFERENCE   7  (bases 1 to 2046)
  AUTHORS   Ohki,T., Hongo,S., Nakada,N., Maeda,A. and Takeda,M.
  TITLE     Inhibition of neurite outgrowth by reduced level of NDRG4 protein
            in antisense transfected PC12 cells
  JOURNAL   Brain Res Dev Brain Res 135 (1-2), 55-63 (2002)
   PUBMED   11978393
REFERENCE   8  (bases 1 to 2046)
  AUTHORS   Qu,X., Zhai,Y., Wei,H., Zhang,C., Xing,G., Yu,Y. and He,F.
  TITLE     Characterization and expression of three novel
            differentiation-related genes belong to the human NDRG gene family
  JOURNAL   Mol Cell Biochem 229 (1-2), 35-44 (2002)
   PUBMED   11936845
  REMARK    GeneRIF: Cloning and expression of the gene; highly expressed in
            adult skeletal muscle and brain
REFERENCE   9  (bases 1 to 2046)
  AUTHORS   Zhou,R.H., Kokame,K., Tsukamoto,Y., Yutani,C., Kato,H. and
            Miyata,T.
  TITLE     Characterization of the human NDRG gene family: a newly identified
            member, NDRG4, is specifically expressed in brain and heart
  JOURNAL   Genomics 73 (1), 86-97 (2001)
   PUBMED   11352569
REFERENCE   10 (bases 1 to 2046)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161668.6.
            
            On Oct 2, 2020 this sequence version replaced NM_201540.1.
            
            Summary: This gene is a member of the N-myc downregulated gene
            family which belongs to the alpha/beta hydrolase superfamily. The
            protein encoded by this gene is a cytoplasmic protein that may play
            a role in neurite outgrowth. This gene may be involved in
            glioblastoma carcinogenesis. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024521.1, SRR5189664.71666.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL161668.6         78365-78397         c
            34-100              AL161668.6         77366-77432         c
            101-181             AL161668.6         76577-76657         c
            182-223             AL161668.6         76200-76241         c
            224-329             AL161668.6         75728-75833         c
            330-450             AL161668.6         75398-75518         c
            451-513             AL161668.6         75153-75215         c
            514-574             AL161668.6         74120-74180         c
            575-661             AL161668.6         73832-73918         c
            662-718             AL161668.6         73256-73312         c
            719-822             AL161668.6         72975-73078         c
            823-867             AL161668.6         72452-72496         c
            868-919             AL161668.6         72099-72150         c
            920-967             AL161668.6         71793-71840         c
            968-1003            AL161668.6         71540-71575         c
            1004-1055           AL161668.6         71323-71374         c
            1056-2046           AL161668.6         70108-71098         c
FEATURES             Location/Qualifiers
     source          1..2046
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..2046
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /note="NDRG family member 2"
                     /db_xref="GeneID:57447"
                     /db_xref="HGNC:HGNC:14460"
                     /db_xref="MIM:605272"
     exon            1..33
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            34..100
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            101..181
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1222
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /note="isoform a is encoded by transcript variant 7;
                     cytoplasmic protein Ndr1; NDR1-related protein NDR2; N-myc
                     downstream regulator 2; syld709613 protein; protein NDRG2;
                     N-myc downstream-regulated gene 2 protein"
                     /codon_start=1
                     /product="protein NDRG2 isoform a"
                     /protein_id="NP_963834.1"
                     /db_xref="CCDS:CCDS9565.1"
                     /db_xref="GeneID:57447"
                     /db_xref="HGNC:HGNC:14460"
                     /db_xref="MIM:605272"
                     /translation="MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVE
                     TPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDA
                     PGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHP
                     DTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYR
                     NIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNS
                     KLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLT
                     SAASVDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC"
     exon            182..223
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            224..329
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            330..450
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            451..513
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            514..574
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            575..661
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            662..718
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            719..822
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            823..867
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            868..919
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            920..967
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1003
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1055
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..2046
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2025..2030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /note="hexamer: AATAAA"
     polyA_site      2046
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /note="major polyA site"
ORIGIN      
        1 aagtgaaggt ggaagcggcc gcggcggcag cagaccccag agtcagaagg agtgagaacc
       61 ctgaccccta atcccactgc atccagccaa taggagccca gccaccatgg cggagctgca
      121 ggaggtgcag atcacagagg agaagccact gttgccagga cagacgcctg aggcggccaa
      181 ggaggctgag ttagctgccc gaatcctcct ggaccaggga cagactcact ctgtggagac
      241 accatacggc tctgtcactt tcactgtcta tggcaccccc aaacccaaac gcccagcgat
      301 ccttacctac cacgatgtgg gactcaacta taaatcttgc ttccagccac tgtttcagtt
      361 cgaggacatg caggaaatca ttcagaactt tgtgcgggtt catgtggatg cccctggaat
      421 ggaagaggga gcccctgtgt tccctttggg atatcagtac ccatctctgg accagcttgc
      481 agacatgatc ccttgcgtcc tgcagtacct aaatttctct acaataattg gagttggtgt
      541 tggagctgga gcctacatcc tggcgagata tgctcttaac cacccggaca ctgttgaagg
      601 tcttgtcctc atcaacattg atcccaatgc caagggttgg atggattggg cagcccacaa
      661 gctaacaggc ctcacctctt ccattccgga gatgatcctt ggacatcttt tcagccagga
      721 agagctctct ggaaattctg agttgataca aaagtacaga aatatcatta cacatgcacc
      781 caacctggat aacattgaat tgtactggaa cagctacaac aaccgccgag acctgaactt
      841 tgagcgtgga ggtgatatca ccctcaggtg tcctgtgatg ctggtggtag gagaccaagc
      901 acctcatgaa gatgcagtgg tggaatgtaa ctcaaaactg gaccccaccc agacctcgtt
      961 cctcaagatg gctgactccg gaggtcagcc ccagctgact cagccaggca agctgaccga
     1021 ggccttcaag tacttcctgc aaggcatggg ctacatggcc tcatcctgca tgactcgcct
     1081 gtcccggtct cgtacagcct ctctgaccag tgcagcatcc gttgatggca accggtcccg
     1141 ctctcgcacc ctgtcccaga gcagcgagtc tggaactctt tcttcggggc ccccggggca
     1201 caccatggag gtctcctgtt gaatggccct tgttgcccta gagtgggacc cagccctcac
     1261 ctcccccaga gctaacctgg gaggtgctga aggggcattg ggccaccgta agcaagggaa
     1321 aaagggcaga tcatgcgggg agatgacctt gatctttgat tgctacccta accttgacct
     1381 ttaacccgtg attcccccca gctcctggaa gagatgtcct aatatctctt agggacccag
     1441 acccctaaat tctcctcctc ccccattttg atgttaaggt ggagagggca tatgcatcct
     1501 ctgtcctgat ctaggtgtct atagctgagg ggtaagaggt tgttgtagtt gtcctggtgc
     1561 ctccatcaga ctctccctac ttgtcccata tttgcaaggg gaggggattt ggggctgggg
     1621 ctccattcac caaagctgag gtggcttctc attaaccctt taggactctg aagggtatgg
     1681 acctacgtga atgtgtgtca gggggagact tgctggtggg ttagtggtcc tcaggatgtg
     1741 atagaaacat ccagtgtaaa aaggaagttg gaatgggagt tggcgggcag tgaacgagtg
     1801 tggggaagga ttggtgctgg ggcaacagga aggggcctgg ggccgtttgg ctgcactaac
     1861 tttggtagct cagtgtgcat ctagagtggg actggggagg gagctaagct tgggctgggc
     1921 tgcttggggc ttggcatagg gtggaaaggg ctaccctggg gctctgacca cactgtagta
     1981 tgtgtggagg gtgccctccc gtctcccaca acttctgcta taacaataaa ctgtagagga
     2041 atctga
//
