LOCUS       NM_001320329            2978 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens NDRG family member 2 (NDRG2), transcript variant 15,
            mRNA.
ACCESSION   NM_001320329 XM_011536994
VERSION     NM_001320329.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2978)
  AUTHORS   Wu,S., Zhang,J., Chen,S., Zhou,X., Liu,Y., Hua,H., Qi,X., Mao,Y.,
            Young,K.H. and Lu,T.
  TITLE     Low NDRG2, regulated by the MYC/MIZ-1 complex and methylation,
            predicts poor outcomes in DLBCL patients
  JOURNAL   Ann Hematol 103 (8), 2877-2892 (2024)
   PUBMED   38842567
  REMARK    GeneRIF: Low NDRG2, regulated by the MYC/MIZ-1 complex and
            methylation, predicts poor outcomes in DLBCL patients.
REFERENCE   2  (bases 1 to 2978)
  AUTHORS   Ichikawa,T., Suekane,A., Nakahata,S., Iha,H., Shimoda,K.,
            Murakami,T. and Morishita,K.
  TITLE     Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity
            Causes Cancer Vulnerability in NDRG2low Adult T-Cell
            Leukemia/Lymphoma
  JOURNAL   Int J Mol Sci 25 (5), 2842 (2024)
   PUBMED   38474089
  REMARK    GeneRIF: Inhibition of PRMT5/MEP50 Arginine Methyltransferase
            Activity Causes Cancer Vulnerability in NDRG2[low] Adult T-Cell
            Leukemia/Lymphoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2978)
  AUTHORS   Kurdi,M., Baeesa,S., Fadul,M.M., Alkhotani,A., Alkhayyat,S.,
            Karami,M.M., Alsinani,T., Katib,Y., Fathaddin,A.A., Faizo,E.,
            Lary,A.I., Almansouri,M., Maghrabi,Y., Alyousef,M.A. and Addass,B.
  TITLE     The effect of p53 on the activity of NRF2 and NDRG2 genes through
            apoptotic pathway in IDH-wildtype glioblastoma
  JOURNAL   Pathol Res Pract 254, 155118 (2024)
   PUBMED   38241776
  REMARK    GeneRIF: The effect of p53 on the activity of NRF2 and NDRG2 genes
            through apoptotic pathway in IDH-wildtype glioblastoma.
REFERENCE   4  (bases 1 to 2978)
  AUTHORS   Zhao,Y., Fan,X., Wang,Q., Zhen,J., Li,X., Zhou,P., Lang,Y.,
            Sheng,Q., Zhang,T., Huang,T., Zhao,Y., Lv,Z. and Wang,R.
  TITLE     ROS promote hyper-methylation of NDRG2 promoters in a
            DNMTS-dependent manner: Contributes to the progression of renal
            fibrosis
  JOURNAL   Redox Biol 62, 102674 (2023)
   PUBMED   36989575
  REMARK    GeneRIF: ROS promote hyper-methylation of NDRG2 promoters in a
            DNMTS-dependent manner: Contributes to the progression of renal
            fibrosis.
REFERENCE   5  (bases 1 to 2978)
  AUTHORS   Wang,J., Yuan,Y., Zhang,K., Sun,X., Bu,X., Dong,J., Wu,Y., Tian,H.
            and Shen,L.
  TITLE     [NDRG2 inhibits tumorigenesis of hepatocellular carcinoma by
            regulating metabolism of phospholipids and triglyceride: a
            metabonomic analysis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (12), 1765-1773 (2022)
   PUBMED   36651243
  REMARK    GeneRIF: [NDRG2 inhibits tumorigenesis of hepatocellular carcinoma
            by regulating metabolism of phospholipids and triglyceride: a
            metabonomic analysis].
REFERENCE   6  (bases 1 to 2978)
  AUTHORS   Deng,Y., Yao,L., Chau,L., Ng,S.S., Peng,Y., Liu,X., Au,W.S.,
            Wang,J., Li,F., Ji,S., Han,H., Nie,X., Li,Q., Kung,H.F., Leung,S.Y.
            and Lin,M.C.
  TITLE     N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma
            cell proliferation
  JOURNAL   Int J Cancer 106 (3), 342-347 (2003)
   PUBMED   12845671
  REMARK    GeneRIF: Down-Regulation of N-Myc downstream-regulated gene 2 is
            associated with glioblastoma
            Erratum:[Int J Cancer. 2003 Oct 10;106(6):984]
REFERENCE   7  (bases 1 to 2978)
  AUTHORS   Ohki,T., Hongo,S., Nakada,N., Maeda,A. and Takeda,M.
  TITLE     Inhibition of neurite outgrowth by reduced level of NDRG4 protein
            in antisense transfected PC12 cells
  JOURNAL   Brain Res Dev Brain Res 135 (1-2), 55-63 (2002)
   PUBMED   11978393
REFERENCE   8  (bases 1 to 2978)
  AUTHORS   Qu,X., Zhai,Y., Wei,H., Zhang,C., Xing,G., Yu,Y. and He,F.
  TITLE     Characterization and expression of three novel
            differentiation-related genes belong to the human NDRG gene family
  JOURNAL   Mol Cell Biochem 229 (1-2), 35-44 (2002)
   PUBMED   11936845
  REMARK    GeneRIF: Cloning and expression of the gene; highly expressed in
            adult skeletal muscle and brain
REFERENCE   9  (bases 1 to 2978)
  AUTHORS   Zhou,R.H., Kokame,K., Tsukamoto,Y., Yutani,C., Kato,H. and
            Miyata,T.
  TITLE     Characterization of the human NDRG gene family: a newly identified
            member, NDRG4, is specifically expressed in brain and heart
  JOURNAL   Genomics 73 (1), 86-97 (2001)
   PUBMED   11352569
REFERENCE   10 (bases 1 to 2978)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161668.6.
            
            On Oct 2, 2020 this sequence version replaced NM_001320329.1.
            
            Summary: This gene is a member of the N-myc downregulated gene
            family which belongs to the alpha/beta hydrolase superfamily. The
            protein encoded by this gene is a cytoplasmic protein that may play
            a role in neurite outgrowth. This gene may be involved in
            glioblastoma carcinogenesis. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.977057.1,
                                           SRR14243140.530578.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000556147.6/ ENSP00000451712.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1032              AL161668.6         77366-78397         c
            1033-1113           AL161668.6         76577-76657         c
            1114-1155           AL161668.6         76200-76241         c
            1156-1261           AL161668.6         75728-75833         c
            1262-1382           AL161668.6         75398-75518         c
            1383-1445           AL161668.6         75153-75215         c
            1446-1506           AL161668.6         74120-74180         c
            1507-1593           AL161668.6         73832-73918         c
            1594-1650           AL161668.6         73256-73312         c
            1651-1754           AL161668.6         72975-73078         c
            1755-1799           AL161668.6         72452-72496         c
            1800-1851           AL161668.6         72099-72150         c
            1852-1899           AL161668.6         71793-71840         c
            1900-1935           AL161668.6         71540-71575         c
            1936-1987           AL161668.6         71323-71374         c
            1988-2978           AL161668.6         70108-71098         c
FEATURES             Location/Qualifiers
     source          1..2978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..2978
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /note="NDRG family member 2"
                     /db_xref="GeneID:57447"
                     /db_xref="HGNC:HGNC:14460"
                     /db_xref="MIM:605272"
     exon            1..1032
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1113
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     CDS             1039..2154
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /note="isoform a is encoded by transcript variant 15;
                     cytoplasmic protein Ndr1; NDR1-related protein NDR2; N-myc
                     downstream regulator 2; syld709613 protein; protein NDRG2;
                     N-myc downstream-regulated gene 2 protein"
                     /codon_start=1
                     /product="protein NDRG2 isoform a"
                     /protein_id="NP_001307258.1"
                     /db_xref="CCDS:CCDS9565.1"
                     /db_xref="GeneID:57447"
                     /db_xref="HGNC:HGNC:14460"
                     /db_xref="MIM:605272"
                     /translation="MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVE
                     TPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDA
                     PGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHP
                     DTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYR
                     NIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNS
                     KLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLT
                     SAASVDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC"
     exon            1114..1155
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1261
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1382
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1445
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1506
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1593
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1650
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1754
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1799
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1851
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1899
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1935
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..1987
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2978
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2957..2962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /note="hexamer: AATAAA"
     polyA_site      2978
                     /gene="NDRG2"
                     /gene_synonym="SYLD"
                     /note="major polyA site"
ORIGIN      
        1 aagtgaaggt ggaagcggcc gcggcggcag caggtagggg gaggggcagg cgaggggccg
       61 tagggcctgg aaggcgccag ccgggccggc gggcggtgtg attgatccgc gtcccctgga
      121 gctggaggct cgggggaaag ggccagcacg gagcgggcgc tcggttgctg cgcacaaagg
      181 ctgaggctcc aagagctgca gggcgtgttt ggggtgcgcg cgaggttgtg tgcaaggtcc
      241 ggggcgcttg gcaccggcca cgcaagggtg tcagtctcca cgcggacggg ctgcgtaggg
      301 actcgtaggg acgggttccg ggtgctgggc ccggccggtc tcctctgtcc tacccatccc
      361 ttcccgatgg cgcttgcctt cgcgggccgt cgggggagaa cgggagaaga ttgtgggacc
      421 gctctcctct ccctttctcc actcgtggga cctacacgga gactgagtag aggagagaag
      481 cgacggcacc aatctttgtg tttgttttta aattgtggag ggaaacagcc atgctctgct
      541 accctcctct tactggagag ctgtcaaaaa ttttggggat cccctattcc cccgcgttta
      601 gtccccctgc agatagaaaa ttgaggccaa atgtagtaac taactggggc aaggtcacac
      661 tgggagtggc agagccggga ttcgaatccg gaggttctga cagggccacc ctcttacctc
      721 cacatcagca cttccttctc tcctccgcgc agcctgaact gatgcccttg tagcctatat
      781 tgattccggc tcgagcctag agaggacgtg ttctctggac ttaggggtag acagacactg
      841 gggagggtta gtgacccgag gaggttgatg accctgggag tctgggtctt ggctgaggct
      901 ttccgtccct gaaagacccc aggtctgtct cccatgtcat tcacctcgtt gctgtgtttt
      961 ctcagacccc agagtcagaa ggagtgagaa ccctgacccc taatcccact gcatccagcc
     1021 aataggagcc cagccaccat ggcggagctg caggaggtgc agatcacaga ggagaagcca
     1081 ctgttgccag gacagacgcc tgaggcggcc aaggaggctg agttagctgc ccgaatcctc
     1141 ctggaccagg gacagactca ctctgtggag acaccatacg gctctgtcac tttcactgtc
     1201 tatggcaccc ccaaacccaa acgcccagcg atccttacct accacgatgt gggactcaac
     1261 tataaatctt gcttccagcc actgtttcag ttcgaggaca tgcaggaaat cattcagaac
     1321 tttgtgcggg ttcatgtgga tgcccctgga atggaagagg gagcccctgt gttccctttg
     1381 ggatatcagt acccatctct ggaccagctt gcagacatga tcccttgcgt cctgcagtac
     1441 ctaaatttct ctacaataat tggagttggt gttggagctg gagcctacat cctggcgaga
     1501 tatgctctta accacccgga cactgttgaa ggtcttgtcc tcatcaacat tgatcccaat
     1561 gccaagggtt ggatggattg ggcagcccac aagctaacag gcctcacctc ttccattccg
     1621 gagatgatcc ttggacatct tttcagccag gaagagctct ctggaaattc tgagttgata
     1681 caaaagtaca gaaatatcat tacacatgca cccaacctgg ataacattga attgtactgg
     1741 aacagctaca acaaccgccg agacctgaac tttgagcgtg gaggtgatat caccctcagg
     1801 tgtcctgtga tgctggtggt aggagaccaa gcacctcatg aagatgcagt ggtggaatgt
     1861 aactcaaaac tggaccccac ccagacctcg ttcctcaaga tggctgactc cggaggtcag
     1921 ccccagctga ctcagccagg caagctgacc gaggccttca agtacttcct gcaaggcatg
     1981 ggctacatgg cctcatcctg catgactcgc ctgtcccggt ctcgtacagc ctctctgacc
     2041 agtgcagcat ccgttgatgg caaccggtcc cgctctcgca ccctgtccca gagcagcgag
     2101 tctggaactc tttcttcggg gcccccgggg cacaccatgg aggtctcctg ttgaatggcc
     2161 cttgttgccc tagagtggga cccagccctc acctccccca gagctaacct gggaggtgct
     2221 gaaggggcat tgggccaccg taagcaaggg aaaaagggca gatcatgcgg ggagatgacc
     2281 ttgatctttg attgctaccc taaccttgac ctttaacccg tgattccccc cagctcctgg
     2341 aagagatgtc ctaatatctc ttagggaccc agacccctaa attctcctcc tcccccattt
     2401 tgatgttaag gtggagaggg catatgcatc ctctgtcctg atctaggtgt ctatagctga
     2461 ggggtaagag gttgttgtag ttgtcctggt gcctccatca gactctccct acttgtccca
     2521 tatttgcaag gggaggggat ttggggctgg ggctccattc accaaagctg aggtggcttc
     2581 tcattaaccc tttaggactc tgaagggtat ggacctacgt gaatgtgtgt cagggggaga
     2641 cttgctggtg ggttagtggt cctcaggatg tgatagaaac atccagtgta aaaaggaagt
     2701 tggaatggga gttggcgggc agtgaacgag tgtggggaag gattggtgct ggggcaacag
     2761 gaaggggcct ggggccgttt ggctgcacta actttggtag ctcagtgtgc atctagagtg
     2821 ggactgggga gggagctaag cttgggctgg gctgcttggg gcttggcata gggtggaaag
     2881 ggctaccctg gggctctgac cacactgtag tatgtgtgga gggtgccctc ccgtctccca
     2941 caacttctgc tataacaata aactgtagag gaatctga
//
