LOCUS       NM_006096               3025 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens N-myc downstream regulated 1 (NDRG1), transcript
            variant 2, mRNA.
ACCESSION   NM_006096
VERSION     NM_006096.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3025)
  AUTHORS   Atkinson,D., Chamova,T., Candayan,A., Kastreva,K., Asenov,O.,
            Litvinenko,I., Estrada-Cuzcano,A., De Vriendt,E., Kukushev,G.,
            Tournev,I. and Jordanova,A.
  TITLE     Identification and Characterization of Novel Founder Mutations in
            NDRG1: Refining the Genetic Landscape of Charcot-Marie-Tooth
            Disease Type 4D in Bulgaria
  JOURNAL   Int J Mol Sci 25 (16), 9047 (2024)
   PUBMED   39201732
  REMARK    GeneRIF: Identification and Characterization of Novel Founder
            Mutations in NDRG1: Refining the Genetic Landscape of
            Charcot-Marie-Tooth Disease Type 4D in Bulgaria.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3025)
  AUTHORS   Gholam Azad,M., Hussaini,M., Russell,T.M., Richardson,V., Kaya,B.,
            Dharmasivam,M. and Richardson,D.R.
  TITLE     Multi-modal mechanisms of the metastasis suppressor, NDRG1:
            Inhibition of WNT/beta-catenin signaling by stabilization of
            protein kinase Calpha
  JOURNAL   J Biol Chem 300 (7), 107417 (2024)
   PUBMED   38815861
  REMARK    GeneRIF: Multi-modal mechanisms of the metastasis suppressor,
            NDRG1: Inhibition of WNT/beta-catenin signaling by stabilization of
            protein kinase Calpha.
REFERENCE   3  (bases 1 to 3025)
  AUTHORS   Lian,Z., Tian,P., Ma,S., Chang,T., Liu,R., Feng,Q. and Li,J.
  TITLE     Long noncoding RNA MEG3 regulates cell proliferation and apoptosis
            by disrupting microRNA-9-5p-mediated inhibition of NDRG1 in
            prostate cancer
  JOURNAL   Aging (Albany NY) 16 (2), 1938-1951 (2024)
   PUBMED   38271137
  REMARK    GeneRIF: Long noncoding RNA MEG3 regulates cell proliferation and
            apoptosis by disrupting microRNA-9-5p-mediated inhibition of NDRG1
            in prostate cancer.
REFERENCE   4  (bases 1 to 3025)
  AUTHORS   Soror,A.A., Eshagh,R., Fahim,M.R., Jamshidian,A. and Monfared,G.H.
  TITLE     Prostate cancer invasion is promoted by the miR-96-5p-induced NDRG1
            deficiency through NF-kappaB regulation
  JOURNAL   Klin Onkol 38 (2), 95-101 (2024)
   PUBMED   38697817
  REMARK    GeneRIF: Prostate cancer invasion is promoted by the
            miR-96-5p-induced NDRG1 deficiency through NF-kappaB regulation.
REFERENCE   5  (bases 1 to 3025)
  AUTHORS   Hunter,M., Bernard,R., Freitas,E., Boyer,A., Morar,B.,
            Martins,I.J., Tournev,I., Jordanova,A., Guergelcheva,V.,
            Ishpekova,B., Kremensky,I., Nicholson,G., Schlotter,B.,
            Lochmuller,H., Voit,T., Colomer,J., Thomas,P.K., Levy,N. and
            Kalaydjieva,L.
  TITLE     Mutation screening of the N-myc downstream-regulated gene 1 (NDRG1)
            in patients with Charcot-Marie-Tooth Disease
  JOURNAL   Hum Mutat 22 (2), 129-135 (2003)
   PUBMED   12872253
  REMARK    GeneRIF: Two disease causing mutations in NDRG1 in
            Charcot-Marie-Tooth Disease patients.
            GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3025)
  AUTHORS   van Belzen,N., Dinjens,W.N., Diesveld,M.P., Groen,N.A., van der
            Made,A.C., Nozawa,Y., Vlietstra,R., Trapman,J. and Bosman,F.T.
  TITLE     A novel gene which is up-regulated during colon epithelial cell
            differentiation and down-regulated in colorectal neoplasms
  JOURNAL   Lab Invest 77 (1), 85-92 (1997)
   PUBMED   9251681
  REMARK    GeneRIF: NDRG1 up-regulation during colon epithelial cell
            differentiation. First publication on tissue and subcellular
            expression of NDRG1.
REFERENCE   7  (bases 1 to 3025)
  AUTHORS   Kokame,K., Kato,H. and Miyata,T.
  TITLE     Homocysteine-respondent genes in vascular endothelial cells
            identified by differential display analysis. GRP78/BiP and novel
            genes
  JOURNAL   J Biol Chem 271 (47), 29659-29665 (1996)
   PUBMED   8939898
REFERENCE   8  (bases 1 to 3025)
  AUTHORS   Kalaydjieva,L., Hallmayer,J., Chandler,D., Savov,A., Nikolova,A.,
            Angelicheva,D., King,R.H., Ishpekova,B., Honeyman,K., Calafell,F.,
            Shmarov,A., Petrova,J., Turnev,I., Hristova,A., Moskov,M.,
            Stancheva,S., Petkova,I., Bittles,A.H., Georgieva,V., Middleton,L.
            and Thomas,P.K.
  TITLE     Gene mapping in Gypsies identifies a novel demyelinating neuropathy
            on chromosome 8q24
  JOURNAL   Nat Genet 14 (2), 214-217 (1996)
   PUBMED   8841199
REFERENCE   9  (bases 1 to 3025)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 4 - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301641
REFERENCE   10 (bases 1 to 3025)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Hereditary Neuropathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC353531.1, BC003175.1,
            AF004162.1 and D87953.1.
            
            On Aug 31, 2019 this sequence version replaced NM_006096.3.
            
            Summary: This gene is a member of the N-myc downregulated gene
            family which belongs to the alpha/beta hydrolase superfamily. The
            protein encoded by this gene is a cytoplasmic protein involved in
            stress responses, hormone responses, cell growth, and
            differentiation. The encoded protein is necessary for p53-mediated
            caspase activation and apoptosis. Mutations in this gene are a
            cause of Charcot-Marie-Tooth disease type 4D, and expression of
            this gene may be a prognostic indicator for several types of
            cancer. Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, May
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003175.1, AF004162.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323851.13/ ENSP00000319977.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DC353531.1         53-72
            21-2012             BC003175.1         1-1992
            2013-2784           AF004162.1         1904-2675
            2785-3025           D87953.1           2770-3010
FEATURES             Location/Qualifiers
     source          1..3025
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.22"
     gene            1..3025
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /note="N-myc downstream regulated 1"
                     /db_xref="GeneID:10397"
                     /db_xref="HGNC:HGNC:7679"
                     /db_xref="MIM:605262"
     exon            1..119
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            120..200
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1322
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /note="isoform 1 is encoded by transcript variant 2;
                     differentiation-related gene 1 protein; nickel-specific
                     induction protein Cap43; reducing agents and
                     tunicamycin-responsive protein; protein regulated by
                     oxygen-1; protein NDRG1; N-myc downstream-regulated gene 1
                     protein"
                     /codon_start=1
                     /product="protein NDRG1 isoform 1"
                     /protein_id="NP_006087.2"
                     /db_xref="CCDS:CCDS34945.1"
                     /db_xref="GeneID:10397"
                     /db_xref="HGNC:HGNC:7679"
                     /db_xref="MIM:605262"
                     /translation="MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETLHGSV
                     HVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDG
                     AASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGL
                     VLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVND
                     MNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKL
                     DPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSV
                     TSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNSAGPKSMEV
                     SC"
     exon            201..236
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            237..342
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            343..463
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            464..526
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            527..587
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            588..674
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            675..731
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            732..835
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            836..892
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            893..944
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            945..992
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1028
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1080
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..3025
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3006..3011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /note="hexamer: AATAAA"
     polyA_site      3025
                     /gene="NDRG1"
                     /gene_synonym="CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL;
                     NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5"
                     /note="major polyA site"
ORIGIN      
        1 aaacctcgcc tggctcccag ctggtgctga agctcgtcag ttcaccatcc gccctcggct
       61 tccgcggggc gctgggccgc cagcctcggc accgtccttt cctttctccc tcgcgttagg
      121 caggtgacag cagggacatg tctcgggaga tgcaggatgt agacctcgct gaggtgaagc
      181 ctttggtgga gaaaggggag accatcaccg gcctcctgca agagtttgat gtccaggagc
      241 aggacatcga gactttacat ggctctgttc acgtcacgct gtgtgggact cccaagggaa
      301 accggcctgt catcctcacc taccatgaca tcggcatgaa ccacaaaacc tgctacaacc
      361 ccctcttcaa ctacgaggac atgcaggaga tcacccagca ctttgccgtc tgccacgtgg
      421 acgcccctgg ccagcaggac ggcgcagcct ccttccccgc agggtacatg tacccctcca
      481 tggatcagct ggctgaaatg cttcctggag tccttcaaca gtttgggctg aaaagcatta
      541 ttggcatggg aacaggagca ggcgcctaca tcctaactcg atttgctcta aacaaccctg
      601 agatggtgga gggccttgtc cttatcaacg tgaacccttg tgcggaaggc tggatggact
      661 gggccgcctc caagatctca ggatggaccc aagctctgcc ggacatggtg gtgtcccacc
      721 tttttgggaa ggaagaaatg cagagtaacg tggaagtggt ccacacctac cgccagcaca
      781 ttgtgaatga catgaacccc ggcaacctgc acctgttcat caatgcctac aacagccggc
      841 gcgacctgga gattgagcga ccaatgccgg gaacccacac agtcaccctg cagtgccctg
      901 ctctgttggt ggttggggac agctcgcctg cagtggatgc cgtggtggag tgcaactcaa
      961 aattggaccc aacaaagacc actctcctca agatggcgga ctgtggcggc ctcccgcaga
     1021 tctcccagcc ggccaagctc gctgaggcct tcaagtactt cgtgcagggc atgggataca
     1081 tgccctcggc tagcatgacc cgcctgatgc ggtcccgcac agcctctggt tccagcgtca
     1141 cttctctgga tggcacccgc agccgctccc acaccagcga gggcacccga agccgctccc
     1201 acaccagcga gggcacccgc agccgctcgc acaccagcga gggggcccac ctggacatca
     1261 cccccaactc gggtgctgct gggaacagcg ccgggcccaa gtccatggag gtctcctgct
     1321 aggcggcctg cccagctgcc gcccccggac tctgatctct gtagtggccc cctcctcccc
     1381 ggcccctttt cgccccctgc ctgccatact gcgcctaact cggtattaat ccaaagctta
     1441 ttttgtaaga gtgagctctg gtggagacaa atgaggtcta ttacgtgggt gccctctcca
     1501 aaggcggggt ggcggtggac caaaggaagg aagcaagcat ctccgcatcg catcctcttc
     1561 cattaaccag tggccggttg ccactctcct cccctccctc agagacacca aactgccaaa
     1621 aacaagacgc gtagcagcac acacttcaca aagccaagcc taggccgccc tgagcatcct
     1681 ggttcaaacg ggtgcctggt cagaaggcca gccgcccact tcccgtttcc tctttaactg
     1741 aggagaagct gatccagttt ccggaaacaa aatccttttc tcatttgggg aggggggtaa
     1801 tagtgacatg caggcacctc ttttaaacag gcaaaacagg aagggggaaa aggtgggatt
     1861 catgtcgagg ctagaggcat ttggaacaac aaatctacgt agttaacttg aagaaaccga
     1921 tttttaaagt tggtgcatct agaaagcttt gaatgcagaa gcaaacaagc ttgatttttc
     1981 tagcatcctc ttaatgtgca gcaaaagcag gcgacaaaat ctcctggctt tacagacaaa
     2041 aatatttcag caaacgttgg gcatcatggt ttttgaaggc tttagttctg ctttctgcct
     2101 ctcctccaca gccccaacct cccacccctg atacatgagc cagtgattat tcttgttcag
     2161 ggagaagatc atttagattt gttttgcatt ccttagaatg gagggcaaca ttccacagct
     2221 gccctggctg tgatgagtgt ccttgcaggg gccggagtag gagcactggg gtgggggtgg
     2281 aattggggtt actcgatgta agggattcct tgttgttgtg ttgagatcca gtgcagttgt
     2341 gatttctgtg gatcccagct tggttccagg aattttgtgt gattggctta aatccagttt
     2401 tcaatcttcg acagctgggc tggaacgtga actcagtagc tgaacctgtc tgacccggtc
     2461 acgttcttgg atcctcagaa ctctttgctc ttgtcggggt gggggtggga actcacgtgg
     2521 ggagcggtgg ctgagaaaat gtaaggattc tggaatacat attccatggg actttccttc
     2581 cctctcctgc ttcctctttt cctgctccct aacctttcgc cgaatggggc agcaccactg
     2641 acgtttctgg gcggccagtg cggctgccag gttcctgtac tactgccttg tacttttcat
     2701 tttggctcac cgtggatttt ctcataggaa gtttggtcag agtgaattga atattgtaag
     2761 tcagccactg ggacccgagg atttctggga ccccgcagtt gggaggagga agtagtccag
     2821 ccttccaggt ggcgtgagag gcaatgactc gttacctgcc gcccatcacc ttggaggcct
     2881 tccctggcct tgagtagaaa agtcggggat cggggcaaga gaggctgagt acggatggga
     2941 aactattgtg cacaagtctt tccagaggag tttcttaatg agatatttgt atttatttcc
     3001 agaccaataa atttgtaact ttgca
//
