LOCUS       NM_014434               4817 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens NADPH dependent diflavin oxidoreductase 1 (NDOR1),
            transcript variant 2, mRNA.
ACCESSION   NM_014434 XM_001131184
VERSION     NM_014434.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4817)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4817)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4817)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4817)
  AUTHORS   Camponeschi,F., Ciofi-Baffoni,S. and Banci,L.
  TITLE     Anamorsin/Ndor1 Complex Reduces [2Fe-2S]-MitoNEET via a Transient
            Protein-Protein Interaction
  JOURNAL   J Am Chem Soc 139 (28), 9479-9482 (2017)
   PUBMED   28648056
REFERENCE   5  (bases 1 to 4817)
  AUTHORS   Frey,A.G., Palenchar,D.J., Wildemann,J.D. and Philpott,C.C.
  TITLE     A Glutaredoxin.BolA Complex Serves as an Iron-Sulfur Cluster
            Chaperone for the Cytosolic Cluster Assembly Machinery
  JOURNAL   J Biol Chem 291 (43), 22344-22356 (2016)
   PUBMED   27519415
REFERENCE   6  (bases 1 to 4817)
  AUTHORS   Finn,R.D., Wilkie,M., Smith,G. and Paine,M.J.
  TITLE     Identification of a functionally impaired allele of human novel
            oxidoreductase 1 (NDOR1), NDOR1*1
  JOURNAL   Pharmacogenet Genomics 15 (6), 381-386 (2005)
   PUBMED   15900210
REFERENCE   7  (bases 1 to 4817)
  AUTHORS   Kwasnicka,D.A., Krakowiak,A., Thacker,C., Brenner,C. and
            Vincent,S.R.
  TITLE     Coordinate expression of NADPH-dependent flavin reductase, Fre-1,
            and Hint-related 7meGMP-directed hydrolase, DCS-1
  JOURNAL   J Biol Chem 278 (40), 39051-39058 (2003)
   PUBMED   12871939
REFERENCE   8  (bases 1 to 4817)
  AUTHORS   Olteanu,H. and Banerjee,R.
  TITLE     Redundancy in the pathway for redox regulation of mammalian
            methionine synthase: reductive activation by the dual flavoprotein,
            novel reductase 1
  JOURNAL   J Biol Chem 278 (40), 38310-38314 (2003)
   PUBMED   12871938
  REMARK    GeneRIF: NR1 may represent a minor pathway in the cell for redox
            regulation of methionine synthase
REFERENCE   9  (bases 1 to 4817)
  AUTHORS   Finn,R.D., Basran,J., Roitel,O., Wolf,C.R., Munro,A.W., Paine,M.J.
            and Scrutton,N.S.
  TITLE     Determination of the redox potentials and electron transfer
            properties of the FAD- and FMN-binding domains of the human
            oxidoreductase NR1
  JOURNAL   Eur J Biochem 270 (6), 1164-1175 (2003)
   PUBMED   12631275
  REMARK    GeneRIF: characterized in detail the redox and electron transfer
            properties of the component flavin-binding domains of protein NR1
REFERENCE   10 (bases 1 to 4817)
  AUTHORS   Paine,M.J., Garner,A.P., Powell,D., Sibbald,J., Sales,M., Pratt,N.,
            Smith,T., Tew,D.G. and Wolf,C.R.
  TITLE     Cloning and characterization of a novel human dual flavin reductase
  JOURNAL   J Biol Chem 275 (2), 1471-1478 (2000)
   PUBMED   10625700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA858250.1, BC015735.1,
            BX255925.17 and KF458948.1.
            
            On Aug 14, 2020 this sequence version replaced NM_014434.3.
            
            Summary: This gene encodes an NADPH-dependent diflavin reductase
            that contains both flavin mononucleotide (FMN) and flavin adenine
            dinucleotide (FAD) binding domains. The encoded protein catalyzes
            the transfer of electrons from NADPH through FAD and FMN cofactors
            to potential redox partners. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform b) compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.235072.1,
                                           SRR18074969.2516771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684003.1/ ENSP00000507194.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA858250.1         34-64
            32-1641             BC015735.1         1-1610
            1642-1642           BX255925.17        11483-11483
            1643-2465           BC015735.1         1612-2434
            2466-3990           BX255925.17        12390-13914
            3991-4384           KF458948.1         1-394
            4385-4817           BX255925.17        14309-14741
FEATURES             Location/Qualifiers
     source          1..4817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..4817
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /note="NADPH dependent diflavin oxidoreductase 1"
                     /db_xref="GeneID:27158"
                     /db_xref="HGNC:HGNC:29838"
                     /db_xref="MIM:606073"
     exon            1..213
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1872
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /EC_number="1.6.-.-"
                     /note="isoform b is encoded by transcript variant 2;
                     NADPH-dependent FMN and FAD-containing oxidoreductase"
                     /codon_start=1
                     /product="NADPH-dependent diflavin oxidoreductase 1
                     isoform b"
                     /protein_id="NP_055249.1"
                     /db_xref="CCDS:CCDS7036.1"
                     /db_xref="GeneID:27158"
                     /db_xref="HGNC:HGNC:29838"
                     /db_xref="MIM:606073"
                     /translation="MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYP
                     VVNLINEPLVIFVCATTGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSY
                     AKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPP
                     PGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQR
                     VTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFML
                     QPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFS
                     SAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLT
                     HPSRLQILVAVVQFQTRLKEPRRGLCSSWLASLDPGQGPVRVPLWVRPGSLAFPETPD
                     TPVIMVGPGTGVAPFRAAIQERVAQGQTGNFLFFGCRWRDQDFYWEAEWQELEKRDCL
                     TLIPAFSREQEQKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSI
                     FQEEGGLCSPDAAAYLARLQQTRRFQTETWA"
     exon            214..291
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..389
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..488
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..590
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..800
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..922
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1143
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1251
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1366
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1513
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1632
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1727
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..4817
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4798..4803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /note="hexamer: AATAAA"
     polyA_site      4817
                     /gene="NDOR1"
                     /gene_synonym="bA350O14.9; CIAE1; NR1"
                     /note="major polyA site"
ORIGIN      
        1 ggagcggtcc ctgcaacccg gccggcggga actgccttct agtttttagt ctcagaccag
       61 accaccgggc gcaccccgat gccgagcccg cagcttctgg tgctcttcgg cagccagaca
      121 ggcacggctc aggatgtgtc ggagagactg ggtcgcgagg cccggcgccg gcggcttggc
      181 tgccgggtgc aggccctgga ctcctacccg gtggtgaatc tgattaacga gcccctggtg
      241 atatttgttt gtgcaactac aggccaagga gacccccctg acaacatgaa gaacttctgg
      301 aggtttatat tccggaagaa cctgccctcc actgccctct gtcagatgga ctttgccgtc
      361 ctgggcctcg gggactcctc atacgccaag ttcaacttcg tggccaagaa gctgcaccga
      421 cggctactgc agcttggggg cagcgccctc ctgcccgtgt gcctgggcga tgaccagcat
      481 gagctggggc ccgacgctgc tgtggacccc tggctgcgag acttgtggga cagggttctg
      541 gggctgtacc cgccgcctcc gggcctcact gagatccctc ccggagtccc cctgccctcc
      601 aagttcaccc tgctgttcct ccaagaggca cccagcacgg gctctgaggg gcagcgggta
      661 gctcaccccg gctctcagga gcccccgtca gagtcgaagc ccttcctagc acccatgatc
      721 tccaaccaga gagtcaccgg cccctcccac ttccaggacg ttcggctgat tgagtttgac
      781 atcttgggct ctggcatcag ctttgctgct ggtgatgtgg tgctgattca gccctccaac
      841 tcggctgccc atgtccagcg gttctgccag gtgctgggcc tggaccctga ccagctcttc
      901 atgctgcagc cgcgggagcc agatgtctcc tcccccacga ggctgcccca gccctgctcc
      961 atgcggcacc tcgtgtccca ctacctggac atcgccagcg tgcctcgccg ctccttcttc
     1021 gaactcctgg cctgtctatc cctccatgag ctggagcggg agaagctgct ggagttcagt
     1081 tctgcccaag gccaggagga gctctttgaa tactgcaacc ggccccgcag gaccatcctg
     1141 gaggtgctct gtgacttccc gcacacagct gccgccatcc ctcccgacta cctgttggac
     1201 ctcatccccg ttatccggcc gagggccttc tccatcgcct cctcgctgct gactcacccc
     1261 tcacggctgc agatcctcgt ggctgtagtg cagttccaga ctcgcctcaa ggagccccgc
     1321 cggggcctct gctcctcctg gctggcatcc ctggaccctg ggcaaggacc tgtccgggtg
     1381 cccctctggg tgcggcctgg gagtctggcc ttcccagaga caccagacac acctgtgatc
     1441 atggtggggc ctggcactgg ggtagccccc ttccgagcag ccatccagga gcgtgtggcc
     1501 cagggccaga ctggaaactt cttgtttttt ggctgccgct ggcgggacca agacttctac
     1561 tgggaggctg agtggcagga gctggagaag cgggactgtc tgaccctcat ccctgccttc
     1621 tcccgggaac aggagcagaa agtatatgtg cagcaccggc tccgggagct ggggtcgctt
     1681 gtgtgggaac tgctggaccg ccagggtgca tacttctacc tggcaggcaa cgccaagtcc
     1741 atgccagcgg acgtctcgga agccctgatg tccatcttcc aggaggaggg tggactctgc
     1801 agcccggacg cagccgcgta tctagccagg ctccagcaga cacggcgctt ccagacagag
     1861 acgtgggcct gaggcccgcg gctgcccgtg ccccctctga cagccatcct cctgggagcc
     1921 caggaaggca tccacgaggg agctcctggc cagcagccgt catcctctcg gaccagccag
     1981 ctggtcctct gggaacagcc agctcccgag cacagccgca ctcctgttga ccctggatcc
     2041 caccctttga gcctgacccc actgcagcct ctgcccagcc agccctgcgc tcccccaccc
     2101 tgacagtgag ctgtgtcctc gtccccccac ccccttccca gtcaaggtgg tggcctgggc
     2161 cgctccacct caccggtgca gtgacccagg acggcatcag cagcccagtg agcaccaggg
     2221 gtggcatagg gcacccatga ggctgcgctg cactcctctg ccctggggcc acctcggctg
     2281 ctgcagcctg cccagcagca cattccagtc actgcccccg cactcccaca gggctcaggc
     2341 tgggctcaga ggccactgag atgccagctc cttgagagca gtgggggtgt cccaggccag
     2401 agcagcctct tcctctcctg gtcccagaaa aacccttgca gtaaatggtg gcctctgggt
     2461 ggttacttct agcgcaggct tccttccttc ctctagctcc tcccggtgcc ctgggtgctg
     2521 ggtgctggat ggatgggcgt cctctagctc ctcccggtgc cctgggtgct gggtgctgga
     2581 tgggtgggcg tcctctagct cctcccggtg ccctgggtgc tgggtgctgg atgggtgggc
     2641 gccacggtgc acccttgttg ggctgcctgt gcccgagtgg cctctgcagc tcttatgtct
     2701 gcctctaatg ggatgtgcgc cctgactgcc tcgttcttaa gggcatagtg ggtcggctaa
     2761 gatctgatcg ccaggactgc gttctgggca ggtgctggga aggcggaacc aagccgtccg
     2821 tgccgctagg gagccgagac tgccggaaag aggagcggca ggagggggcg tggttgtgca
     2881 gccccacccc cgggaggggc tttaggcact gggaaggaaa gtcctgttgg aggagttcgg
     2941 tggctgttca cacccgcctc gctgtcttgg agtcttgatc tgtcgtcggc gggtcgctgg
     3001 cacaggacta aacatggctg aggctgggct ccagccagat ctggctgggg acagcaccgc
     3061 gtgggcccag gatccaccca gagcaggcag gccttgctgg ggccccagtc aagtccactt
     3121 ccagtgagga gagccagccg ggaggtcagt gccagagctc tggtggagcc cagaccctgc
     3181 cttccctgag ggccgcccct gtcgccgccc tggggtccct gtcctcctat cctgactcct
     3241 gccccagggc caccacccct gaactgtgcc ctggggcccc caccctccac ctggccgact
     3301 ccagctctgg gcctgtcagt ccacctgggt cctctctggg ccctgagtgc ctggaccctc
     3361 tgtgccaagc accagcaagc aaaggggatg accttgggca cccccaaggt gctgagacta
     3421 cagccagtga gcccctgctg ggggccaaag ccatggaggg tgcctgggcc cttccaacct
     3481 ggaaggagga ggggagagag caggcagcag ggcaggggga agaggaggag tgcccgatct
     3541 gcacagagcc ctacgggccc agagagcgcc gcctggccct gctgaactgt agccacggcc
     3601 tgtgtgtggg ctgcctgcac aggctgctgg gctcggcctc cagtgccgac ctgggccggg
     3661 tgcgctgccc gctgtgccgc cagaagacgc ccgtgctgga atgggagatc tgccggctac
     3721 aggaggagct gctacaggcc gacgggccct cacgccagcc ccgccgagag gcccctgcat
     3781 cctatcaccg caaccctggg ccctggggct ccctggagca ccgctaccag ctgcgcttcc
     3841 tggcagggcc cgtgggcggc cggggctgcc tgcccttcct gccctgtcca ccctgcctgg
     3901 gtgcccggct ctggaccctg cgggagcggg gaccctgtgc ccgccgcctg gcgctgctga
     3961 gcctgctggc ccttgagctt ctggggctgc tgctggtctt cacgccgctc ctgctgctgg
     4021 gactgctctt cgtgctcctg gaccgctctg gccgctgagc agagcccagg acagccccgc
     4081 cgccaacagg ccagggggcc cagactggcc cacgtcccca tgcctgggtg ctgtgaggcc
     4141 tgatgaccag gctggaaaaa cccaaggttg ggtccagggc agtggccttc aatcaagacc
     4201 tcccattgct gaacccacaa ccagggctac ccagaggcct gaccctgcca gagtccatgg
     4261 ctgcactgct gcccagacac tagctgaacc caaggacacc agcgcccaag gacagctcct
     4321 ggaggaggcc agcccagcag gaaagtctgt gagcaggacc ccattcaccc tgcggcagac
     4381 gggcaccgta ctggccacgg gctgacgccg gccacacttc ccctccgagg gccagctgag
     4441 cacagcaggc atgaaagcaa acagagatac agcagtgagt cagttccttg gagagggcag
     4501 ggactccgcc caccctgtgt tcagataagg gccagtgtgt gtccctgaag gtcaggccag
     4561 ccgggggagg ggtccatgct gcgaaaattc agcctgcaaa ggctcctctc cccacttgat
     4621 caggcccaga ccaggtgggg gttggcgctg gcctgtgttg caggggacaa gggcccaccc
     4681 aggccttgga acataagctc tgcccctgca caccctcatg tcaccacacc tgggatggag
     4741 acatcaggtg gcccagcgag agatggagga ctgatcctgg aacgtgaagc agctttcaat
     4801 aaaccagctc ctgggga
//
