LOCUS       NM_024574               2902 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens neuron derived neurotrophic factor (NDNF), mRNA.
ACCESSION   NM_024574
VERSION     NM_024574.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2902)
  AUTHORS   Liu,Y., Ren,J., Bai,R., He,S., Peng,Z., Yin,W., Guo,R., Niu,J.,
            Zhang,W., Xia,Z., Fan,X., Yang,K., Li,B., Yang,H., Song,H. and
            Xie,J.
  TITLE     Overexpression of NDNF Improves the Cytoprotective Effects of Aged
            Human Bone Marrow Mesenchymal Stem Cells by Modulating Oxidative
            Stress and Apoptosis
  JOURNAL   Stem Cells Dev 33 (15-16), 432-437 (2024)
   PUBMED   38801165
  REMARK    GeneRIF: Overexpression of NDNF Improves the Cytoprotective Effects
            of Aged Human Bone Marrow Mesenchymal Stem Cells by Modulating
            Oxidative Stress and Apoptosis.
REFERENCE   2  (bases 1 to 2902)
  AUTHORS   Yang,S., Wu,X., Daoutidou,E.I., Zhang,Y., Shimell,M., Chuang,K.H.,
            Peterson,A.J., O'Connor,M.B. and Zheng,X.
  TITLE     The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP
            modulator that regulates Drosophila wing patterning and growth
  JOURNAL   Elife 11, e73357 (2022)
   PUBMED   35037619
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2902)
  AUTHORS   Messina,A., Pulli,K., Santini,S., Acierno,J., Kansakoski,J.,
            Cassatella,D., Xu,C., Casoni,F., Malone,S.A., Ternier,G., Conte,D.,
            Sidis,Y., Tommiska,J., Vaaralahti,K., Dwyer,A., Gothilf,Y.,
            Merlo,G.R., Santoni,F., Niederlander,N.J., Giacobini,P., Raivio,T.
            and Pitteloud,N.
  TITLE     Neuron-Derived Neurotrophic Factor Is Mutated in Congenital
            Hypogonadotropic Hypogonadism
  JOURNAL   Am J Hum Genet 106 (1), 58-70 (2020)
   PUBMED   31883645
  REMARK    GeneRIF: Neuron-Derived Neurotrophic Factor Is Mutated in
            Congenital Hypogonadotropic Hypogonadism.
REFERENCE   4  (bases 1 to 2902)
  AUTHORS   Zhang,Y., Wu,X., Kai,Y., Lee,C.H., Cheng,F., Li,Y., Zhuang,Y.,
            Ghaemmaghami,J., Chuang,K.H., Liu,Z., Meng,Y., Keswani,M.,
            Gough,N.R., Wu,X., Zhu,W., Tzatsos,A., Peng,W., Seto,E.,
            Sotomayor,E.M. and Zheng,X.
  TITLE     Secretome profiling identifies neuron-derived neurotrophic factor
            as a tumor-suppressive factor in lung cancer
  JOURNAL   JCI Insight 4 (24), 129344 (2019)
   PUBMED   31852841
  REMARK    GeneRIF: Secretome profiling identifies neuron-derived neurotrophic
            factor as a tumor-suppressive factor in lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2902)
  AUTHORS   Ohashi,K., Enomoto,T., Joki,Y., Shibata,R., Ogura,Y., Kataoka,Y.,
            Shimizu,Y., Kambara,T., Uemura,Y., Yuasa,D., Matsuo,K.,
            Hayakawa,S., Hiramatsu-Ito,M., Murohara,T. and Ouchi,N.
  TITLE     Neuron-derived neurotrophic factor functions as a novel modulator
            that enhances endothelial cell function and revascularization
            processes
  JOURNAL   J Biol Chem 289 (20), 14132-14144 (2014)
   PUBMED   24706764
  REMARK    GeneRIF: NDNF acts as an endogenous modulator that promotes
            endothelial cell function and ischemia-induced revascularization
            through eNOS-dependent mechanisms
REFERENCE   6  (bases 1 to 2902)
  AUTHORS   Kuang,X.L., Zhao,X.M., Xu,H.F., Shi,Y.Y., Deng,J.B. and Sun,G.T.
  TITLE     Spatio-temporal expression of a novel neuron-derived neurotrophic
            factor (NDNF) in mouse brains during development
  JOURNAL   BMC Neurosci 11, 137 (2010)
   PUBMED   20969804
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2902)
  AUTHORS   Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
            Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
            Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
            Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
            Riley,B.P.
  TITLE     A systematic gene-based screen of chr4q22-q32 identifies
            association of a novel susceptibility gene, DKK2, with the
            quantitative trait of alcohol dependence symptom counts
  JOURNAL   Hum Mol Genet 19 (12), 2497-2506 (2010)
   PUBMED   20332099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
            Victor [added]; Tischfield, Jay A [added]]
REFERENCE   8  (bases 1 to 2902)
  AUTHORS   Utine,G.E. and Aktas,D.
  TITLE     Mosaicism for terminal deletion of 4q
  JOURNAL   Genet Couns 17 (2), 205-209 (2006)
   PUBMED   16970039
  REMARK    GeneRIF: direct duplication of chromosome 4q27q31.3 de novo results
            in partial trisomy of its long arm.
REFERENCE   9  (bases 1 to 2902)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105254.3, BX359842.2, BC019351.1, AY358821.1, DA807168.1 and
            AK026844.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024574.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019351.1, SRR1803615.220308.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379692.9/ ENSP00000369014.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC105254.3         42433-42449         c
            18-121              BX359842.2         1-104
            122-445             BC019351.1         1-324
            446-729             AY358821.1         1-284
            730-1104            DA807168.1         197-571
            1105-1935           AY358821.1         660-1490
            1936-2886           AK026844.1         1006-1956
            2887-2888           BC019351.1         2766-2767
            2889-2902           AC105254.3         5527-5540           c
FEATURES             Location/Qualifiers
     source          1..2902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q27"
     gene            1..2902
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /note="neuron derived neurotrophic factor"
                     /db_xref="GeneID:79625"
                     /db_xref="HGNC:HGNC:26256"
                     /db_xref="MIM:616506"
     exon            1..543
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /inference="alignment:Splign:2.1.0"
     exon            544..732
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /inference="alignment:Splign:2.1.0"
     CDS             545..2251
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /note="fibronectin type-III domain-containing protein
                     C4orf31; protein NDNF"
                     /codon_start=1
                     /product="protein NDNF precursor"
                     /protein_id="NP_078850.3"
                     /db_xref="CCDS:CCDS3717.2"
                     /db_xref="GeneID:79625"
                     /db_xref="HGNC:HGNC:26256"
                     /db_xref="MIM:616506"
                     /translation="MVLLHWCLLWLLFPLSSRTQKLPTRDEELFQMQIRDKAFFHDSS
                     VIPDGAEISSYLFRDTPKRYFFVVEEDNTPLSVTVTPCDAPLEWKLSLQELPEDRSGE
                     GSGDLEPLEQQKQQIINEEGTELFSYKGNDVEYFISSSSPSGLYQLDLLSTEKDTHFK
                     VYATTTPESDQPYPELPYDPRVDVTSLGRTTVTLAWKPSPTASLLKQPIQYCVVINKE
                     HNFKSLCAVEAKLSADDAFMMAPKPGLDFSPFDFAHFGFPSDNSGKERSFQAKPSPKL
                     GRHVYSRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVVNINSNMSTAYVGTFART
                     KEEAKQKTVELKDGKITDVFVKRKGAKFLRFAPVSSHQKVTFFIHSCLDAVQIQVRRD
                     GKLLLSQNVEGIQQFQLRGKPKAKYLVRLKGNKKGASMLKILATTRPTKQSFPSLPED
                     TRIKAFDKLRTCSSATVAWLGTQERNKFCIYKKEVDDNYNEDQKKREQNQCLGPDIRK
                     KSEKVLCKYFHSQNLQKAVTTETIKGLQPGKSYLLDVYVIGHGGHSVKYQSKVVKTRK
                     FC"
     exon            733..857
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /inference="alignment:Splign:2.1.0"
     exon            858..2902
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2693..2698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /note="hexamer: ATTAAA"
     polyA_site      2714
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /note="major polyA site"
     regulatory      2862..2867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /note="hexamer: ATTAAA"
     regulatory      2876..2881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /note="hexamer: ATTATA"
     polyA_site      2888
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /note="major polyA site"
     polyA_site      2902
                     /gene="NDNF"
                     /gene_synonym="C4orf31; HH25; NORD"
                     /note="major polyA site"
ORIGIN      
        1 acactcccca cttccagccg cgagagagtg gagctaactg agcagcgcac ccgccacggc
       61 cgctgccgcc ccgtgcgccc ggctctccca gcaccccgcg cggcgctcca gccaggcgcc
      121 tgtgcgacta gcggcggccg gcgaagcccg cgccagcccc gcgggtcgct gcggcatcct
      181 cccgccgccc agcccccgca cgctccctgc agtttaaaag gacctcccgc cgcttctcgg
      241 cgctgccccg ggattcccca gccccgcgcg gctccctact ccacttcgca gcaacttcgg
      301 cgaccgcgcg ccgcccgccc tcgcccgcct ttgaagtttg ctgtgccgac cgcaaagttg
      361 ggacacttca gcggattgaa tttttctctt ttatctgcct ccgtccccgc cctccaggct
      421 tctcgttcct ggatattggt gcttagcatc ttggcagggt ccggggacgt ggactatttc
      481 gcacaccaca ccacggggag ggattttttt ctattttccc tacgaaaaac agatcttttt
      541 aaggatggtg ctgctccact ggtgcctgct gtggctcctg tttccactca gctcaaggac
      601 ccagaagtta cccacccggg atgaggaact ttttcagatg cagatccggg acaaggcatt
      661 ttttcatgat tcgtcagtaa ttccagatgg agctgaaatt agcagttatc tctttagaga
      721 tacacctaag aggtatttct ttgtggttga agaagacaat actccattat cagtcacagt
      781 gacgccctgt gatgcgcctt tggagtggaa gctgagcctc caggagctgc cagaggacag
      841 gagcggggaa ggctcaggtg atctggaacc tcttgagcag cagaagcagc agatcattaa
      901 tgaggaaggc actgagttat tctcctacaa aggcaatgat gttgagtatt ttatatcgtc
      961 tagttcccca tccggtttat atcagttgga tcttctttca acagagaaag acacacattt
     1021 caaagtatat gccaccacaa ctccagaatc tgatcagcca taccctgagt taccctatga
     1081 cccaagagta gatgtgacct cactggggcg caccacggtc actttggcct ggaaaccaag
     1141 ccccactgcc tctttgctga aacaacccat tcagtactgt gtggtcatca acaaagagca
     1201 caatttcaaa agtctctgtg cagtggaagc aaaactgagt gcagatgatg cttttatgat
     1261 ggcaccgaaa cctggtctgg acttcagccc ctttgacttt gcccactttg gatttccttc
     1321 tgataattca ggtaaagaac gcagtttcca ggcaaagcct tctccaaaac tggggcgtca
     1381 tgtctactcc aggcccaagg ttgatattca gaaaatctgc ataggaaaca agaacatctt
     1441 caccgtctct gatctgaaac ccgacacgca gtactacttt gatgtatttg tggtcaacat
     1501 caacagcaac atgagcaccg cttatgtagg tacctttgcc aggaccaagg aagaagccaa
     1561 acagaagaca gtcgagctaa aagatgggaa gataacagat gtatttgtta aaaggaaggg
     1621 agcaaagttt ctacggtttg ctccagtctc ttctcaccaa aaagtcacct tctttattca
     1681 ctcttgtctg gatgctgtcc aaatccaagt gagaagagat gggaaacttc ttctgtctca
     1741 gaatgtggaa ggcattcagc agtttcagct tagaggaaaa cctaaagcta aatacctcgt
     1801 tcgactgaaa ggaaacaaga aaggagcatc tatgttgaaa attctagcta ccacaaggcc
     1861 tactaagcag tcatttccct ctcttcctga agacacaaga atcaaagcct ttgacaagct
     1921 ccgtacctgt tcctcagcca ccgtggcttg gctaggcact caggaaagga acaagttttg
     1981 catctacaaa aaagaagtgg atgataacta caatgaagac cagaagaaaa gagagcaaaa
     2041 ccaatgtcta ggaccagata taaggaagaa gtcagaaaag gtcctctgta aatatttcca
     2101 cagtcaaaac ctgcagaaag cagtgaccac agaaacaatt aaaggtcttc agcctggcaa
     2161 atcttacctg ctggatgttt atgtcatagg acatgggggg cactctgtaa agtatcagag
     2221 taaggttgtg aaaactagaa agttctgtta gttaccttct tatagagata tattatgtag
     2281 aactccagga gggacattaa atcactttaa gtataaactg actactccca cagttgagag
     2341 aagttgtgac ctgtacttgt actatggaag gaaggatatc aacgtgtgta tattgatgtt
     2401 tatataagta actcttgaag gagacttgtt ctagcgtgcc ccatggtacc tagtgtgtgt
     2461 ctgatgccgg ttggtgtcaa agatagaggg cttcttgaag gaacttgcca ttccttgctt
     2521 tgaccactgc atgaactgct tctaaattat tttattacct aaaaatttaa aatatgccat
     2581 tcattgcaca cacccacaaa tgcaaatcat tcctctctgt agatgctagg atatatataa
     2641 attattttat aaattcttgt tttaaatgtc agtgtttcta tgattgtaaa ctattaaatt
     2701 cttttcctat taaagtacag atctaatcta agtattatta agttgatagc cctctagtca
     2761 gttatattgc tattgtaaat tcttgtttgt tgagtaaaat gtttaaatac tatatgtatc
     2821 tcatgtacaa agttgacata cattatattc atgtacataa aattaaagag attagattat
     2881 atactgttca ttttcccaag ca
//
