LOCUS       NM_002487               1906 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens necdin, MAGE family member (NDN), mRNA.
ACCESSION   NM_002487
VERSION     NM_002487.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Sanderson,M.R., Badior,K.E., Fahlman,R.P. and Wevrick,R.
  TITLE     The necdin interactome: evaluating the effects of amino acid
            substitutions and cell stress using proximity-dependent
            biotinylation (BioID) and mass spectrometry
  JOURNAL   Hum Genet 139 (12), 1513-1529 (2020)
   PUBMED   32529326
  REMARK    GeneRIF: The necdin interactome: evaluating the effects of amino
            acid substitutions and cell stress using proximity-dependent
            biotinylation (BioID) and mass spectrometry.
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   Polvora-Brandao,D., Joaquim,M., Godinho,I., Aprile,D., Alvaro,A.R.,
            Onofre,I., Raposo,A.C., Pereira de Almeida,L., Duarte,S.T. and da
            Rocha,S.T.
  TITLE     Loss of hierarchical imprinting regulation at the
            Prader-Willi/Angelman syndrome locus in human iPSCs
  JOURNAL   Hum Mol Genet 27 (23), 3999-4011 (2018)
   PUBMED   30102380
  REMARK    GeneRIF: We focused on three important regulatory DNA elements
            which are all differentially methylated regions (DMRs), methylated
            on the maternal allele: the PWS imprinting center (PWS-IC), which
            is a germline DMR and the somatic NDN and MKRN3 DMRs,
            hierarchically controlled by PWS-IC.
REFERENCE   5  (bases 1 to 1906)
  AUTHORS   Lau,J.C., Hanel,M.L. and Wevrick,R.
  TITLE     Tissue-specific and imprinted epigenetic modifications of the human
            NDN gene
  JOURNAL   Nucleic Acids Res 32 (11), 3376-3382 (2004)
   PUBMED   15247330
  REMARK    GeneRIF: Tissue-specific gene expression regulation and imprinted
            epigenetic modifications of the human NDN gene.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1906)
  AUTHORS   Nakada,Y., Taniura,H., Uetsuki,T., Inazawa,J. and Yoshikawa,K.
  TITLE     The human chromosomal gene for necdin, a neuronal growth
            suppressor, in the Prader-Willi syndrome deletion region
  JOURNAL   Gene 213 (1-2), 65-72 (1998)
   PUBMED   9630521
REFERENCE   7  (bases 1 to 1906)
  AUTHORS   Taniura,H., Taniguchi,N., Hara,M. and Yoshikawa,K.
  TITLE     Necdin, a postmitotic neuron-specific growth suppressor, interacts
            with viral transforming proteins and cellular transcription factor
            E2F1
  JOURNAL   J Biol Chem 273 (2), 720-728 (1998)
   PUBMED   9422723
REFERENCE   8  (bases 1 to 1906)
  AUTHORS   Jay,P., Rougeulle,C., Massacrier,A., Moncla,A., Mattei,M.G.,
            Malzac,P., Roeckel,N., Taviaux,S., Lefranc,J.L., Cau,P., Berta,P.,
            Lalande,M. and Muscatelli,F.
  TITLE     The human necdin gene, NDN, is maternally imprinted and located in
            the Prader-Willi syndrome chromosomal region
  JOURNAL   Nat Genet 17 (3), 357-361 (1997)
   PUBMED   9354807
REFERENCE   9  (bases 1 to 1906)
  AUTHORS   MacDonald,H.R. and Wevrick,R.
  TITLE     The necdin gene is deleted in Prader-Willi syndrome and is
            imprinted in human and mouse
  JOURNAL   Hum Mol Genet 6 (11), 1873-1878 (1997)
   PUBMED   9302265
  REMARK    GeneRIF: The necdin gene is imprinted, with preferential expression
            from the paternal allele in human and mouse.
REFERENCE   10 (bases 1 to 1906)
  AUTHORS   Aizawa,T., Maruyama,K., Kondo,H. and Yoshikawa,K.
  TITLE     Expression of necdin, an embryonal carcinoma-derived nuclear
            protein, in developing mouse brain
  JOURNAL   Brain Res Dev Brain Res 68 (2), 265-274 (1992)
   PUBMED   1394972
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124309.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002487.2.
            
            Summary: This intronless gene is located in the Prader-Willi
            syndrome deletion region. It is an imprinted gene and is expressed
            exclusively from the paternal allele. Studies in mouse suggest that
            the protein encoded by this gene may suppress growth in postmitotic
            neurons. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR3476690.434425.1, DRR138527.509882.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 9302265
            MANE Ensembl match     :: ENST00000649030.2/ ENSP00000497916.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1906              AC124309.7         55964-57869
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q11.2"
     gene            1..1906
                     /gene="NDN"
                     /gene_synonym="HsT16328; PWCR"
                     /note="necdin, MAGE family member"
                     /db_xref="GeneID:4692"
                     /db_xref="HGNC:HGNC:7675"
                     /db_xref="MIM:602117"
     exon            1..1906
                     /gene="NDN"
                     /gene_synonym="HsT16328; PWCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1054
                     /gene="NDN"
                     /gene_synonym="HsT16328; PWCR"
                     /note="necdin homolog; Prader-Willi syndrome chromosome
                     region; necdin, melanoma antigen (MAGE) family member;
                     necdin-like protein"
                     /codon_start=1
                     /product="necdin"
                     /protein_id="NP_002478.1"
                     /db_xref="CCDS:CCDS10014.1"
                     /db_xref="GeneID:4692"
                     /db_xref="HGNC:HGNC:7675"
                     /db_xref="MIM:602117"
                     /translation="MSEQSKDLSDPNFAAEAPNSEVHSSPGVSEGVPPSATLAEPQSP
                     PLGPTAAPQAAPPPQAPNDEGDPKALQQAAEEGRAHQAPSAAQPGPAPPAPAQLVQKA
                     HELMWYVLVKDQKKMIIWFPDMVKDVIGSYKKWCRSILRRTSLILARVFGLHLRLTSL
                     HTMEFALVKALEPEELDRVALSNRMPMTGLLLMILSLIYVKGRGARESAVWNVLRILG
                     LRPWKKHSTFGDVRKLITEEFVQMNYLKYQRVPYVEPPEYEFFWGSRASREITKMQIM
                     EFLARVFKKDPQAWPSRYREALEEARALREANPTAHYPRSSVSED"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDN"
                     /gene_synonym="HsT16328; PWCR"
                     /note="hexamer: ATTAAA"
     polyA_site      1627
                     /gene="NDN"
                     /gene_synonym="HsT16328; PWCR"
                     /note="major polyA site"
     regulatory      1831..1836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDN"
                     /gene_synonym="HsT16328; PWCR"
                     /note="hexamer: AATATA"
     polyA_site      1856
                     /gene="NDN"
                     /gene_synonym="HsT16328; PWCR"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDN"
                     /gene_synonym="HsT16328; PWCR"
                     /note="hexamer: AATAAA"
     polyA_site      1906
                     /gene="NDN"
                     /gene_synonym="HsT16328; PWCR"
ORIGIN      
        1 gcacttcctc tccaggaatc cgcggaggga gcgcaggctc gaagagctcc tggacgcaga
       61 ggccctgccc ttgccagacg gcgcagacat gtcagaacaa agtaaggatc tgagcgaccc
      121 taactttgca gccgaggccc ccaactccga ggtgcacagc agccctgggg tttcggaggg
      181 ggttcctccg tccgcgaccc tggcagagcc gcagagccct cctctaggcc cgacggccgc
      241 tccgcaggcc gcgccgcctc cccaggcccc gaacgacgag ggcgacccga aggccctgca
      301 gcaggctgcg gaggagggcc gcgcccacca ggccccgagc gcggcccagc cgggcccggc
      361 accgccagcc ccggcgcagc tggtgcagaa ggcgcacgag ctcatgtggt acgtgctggt
      421 caaggaccag aagaagatga tcatctggtt tccagacatg gtgaaagatg tcatcggcag
      481 ctacaagaag tggtgcagga gcatcctccg gcgcaccagc ctcatcctcg cccgggtgtt
      541 cgggctgcac ctgaggctaa ccagcctgca caccatggag tttgcgctgg tcaaagcgct
      601 ggagcccgag gagctggaca gggtggcgct gagcaaccgc atgcccatga caggcctcct
      661 gctcatgatc ctgagcctca tctacgtgaa gggccgcggc gccagagaga gcgccgtctg
      721 gaacgtgctg cgcatcctgg ggctgcggcc ctggaagaag cactccacct tcggggacgt
      781 gcggaagctc atcactgagg agttcgtcca aatgaattac ctgaagtacc agcgcgtccc
      841 atacgtggag ccgcccgaat acgagttctt ttggggctcc cgggccagcc gcgaaatcac
      901 caagatgcaa atcatggagt tcctggccag ggtctttaag aaagaccccc aggcctggcc
      961 ctcccgatac agagaagctc tggaggaggc cagagctctg cgggaggcta atcccactgc
     1021 ccactaccct cgcagcagtg tctctgagga ctagcaaagt ctggaggcag atgaatggtt
     1081 tctgaccctc accagggctg tggaagggtg ggggtgggtc attatagtat tcaggattta
     1141 cagtgcagta ttcacgtgta acttttaagt tttcagtaca gtgcttttat acctttaatg
     1201 caatgttgta ttcatttggg tactattgtg tagtatttag gatgtatgca tgtttgttta
     1261 tatgtaagct tggttggtgc tttcgctttt gtgctacctt tcttggattt ttgtaccaga
     1321 gatgtgctaa actgatgaaa tacattgaga aagtttccat cttattcttt tatatgggac
     1381 tgatgatgtg tgttggggta gactgctcct gcagagtttg gaagaagtca ccagcaaagc
     1441 cggcctaacc aagaaaagtc aaggcccttc atgaccttgc tgggcacaga aaacaccctc
     1501 gtggagtaca ctaatttgaa ctggactggt ctcagtgtga gcacttggca cactttacta
     1561 aacacatata caaccccacc gtgagtcaac tttaaagtaa acattaaaga ttcttgtgat
     1621 acaatcattt ttggaaaagt gtactttatc attttaacaa agcagtatgg ttgggaatga
     1681 gacaattctc tattttacag tgtatacaga tacaactatt tcccctaata gggtgggaaa
     1741 aatcgctact catgattact cctaaatttg tgaagtttat agttctattg tctttaaatg
     1801 taactcatgt ttatttcaaa aacattcaca aatatagaaa agtatacaaa acaaaacagt
     1861 aagattgtct gtaatcacat catatgggaa taaaaaacaa aaataa
//
