LOCUS       NM_019080               4624 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens Nedd4 family interacting protein 2 (NDFIP2),
            transcript variant 1, mRNA.
ACCESSION   NM_019080 XM_041162
VERSION     NM_019080.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4624)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4624)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4624)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4624)
  AUTHORS   Kang,Y., Guo,J., Yang,T., Li,W. and Zhang,S.
  TITLE     Regulation of the human ether-a-go-go-related gene (hERG) potassium
            channel by Nedd4 family interacting proteins (Ndfips)
  JOURNAL   Biochem J 472 (1), 71-82 (2015)
   PUBMED   26363003
  REMARK    GeneRIF: Data show that membrane protein Ndfip1 recruits E3
            ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target
            ether-a-go-go-related gene (hERG) channel for degradation while
            membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG
            in the Golgi.
REFERENCE   5  (bases 1 to 4624)
  CONSRTM   GENDEP Investigators; MARS Investigators; STAR*D Investigators
  TITLE     Common genetic variation and antidepressant efficacy in major
            depressive disorder: a meta-analysis of three genome-wide
            pharmacogenetic studies
  JOURNAL   Am J Psychiatry 170 (2), 207-217 (2013)
   PUBMED   23377640
REFERENCE   6  (bases 1 to 4624)
  AUTHORS   Shearwin-Whyatt,L.M., Brown,D.L., Wylie,F.G., Stow,J.L. and
            Kumar,S.
  TITLE     N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to
            multivesicular bodies and the Golgi, and has a potential role in
            protein trafficking
  JOURNAL   J Cell Sci 117 (Pt 16), 3679-3689 (2004)
   PUBMED   15252135
  REMARK    GeneRIF: N4WBP5A acts as an adaptor to recruit Nedd4 family
            ubiquitin-protein ligases to the protein trafficking machinery
REFERENCE   7  (bases 1 to 4624)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   8  (bases 1 to 4624)
  AUTHORS   Cristillo,A.D., Nie,L., Macri,M.J. and Bierer,B.E.
  TITLE     Cloning and characterization of N4WBP5A, an inducible,
            cyclosporine-sensitive, Nedd4-binding protein in human T
            lymphocytes
  JOURNAL   J Biol Chem 278 (36), 34587-34597 (2003)
   PUBMED   12796489
  REMARK    GeneRIF: N4WBP5A may play a regulatory role in modulating Nedd4
            activity at the level of the Golgi apparatus in T lymphocytes
REFERENCE   9  (bases 1 to 4624)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   10 (bases 1 to 4624)
  AUTHORS   Konstas,A.A., Shearwin-Whyatt,L.M., Fotia,A.B., Degger,B.,
            Riccardi,D., Cook,D.I., Korbmacher,C. and Kumar,S.
  TITLE     Regulation of the epithelial sodium channel by N4WBP5A, a novel
            Nedd4/Nedd4-2-interacting protein
  JOURNAL   J Biol Chem 277 (33), 29406-29416 (2002)
   PUBMED   12050153
  REMARK    GeneRIF: role in regulating epithelial sodium channel
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355603.17 and AL136442.12.
            
            On May 1, 2021 this sequence version replaced NM_019080.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032991.1, SRR14038193.3593135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000218652.12/ ENSP00000218652.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               AL355603.17        58021-58390
            371-536             AL355603.17        97676-97841
            537-670             AL136442.12        147145-147278       c
            671-764             AL136442.12        140826-140919       c
            765-889             AL136442.12        136919-137043       c
            890-956             AL136442.12        132207-132273       c
            957-1062            AL136442.12        129479-129584       c
            1063-4624           AL136442.12        124524-128085       c
FEATURES             Location/Qualifiers
     source          1..4624
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q31.1"
     gene            1..4624
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="Nedd4 family interacting protein 2"
                     /db_xref="GeneID:54602"
                     /db_xref="HGNC:HGNC:18537"
                     /db_xref="MIM:610041"
     exon            1..370
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1060
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="isoform 1 is encoded by transcript variant 1; NEDD4
                     WW domain-binding protein 5A; NF-kappa-B-activating
                     protein 413; MAPK-activating protein PM04 PM05 PM06 PM07;
                     NEDD4 family-interacting protein 2; putative
                     NF-kappa-B-activating protein 413; putative
                     MAPK-activating protein PM04/PM05/PM06/PM07"
                     /codon_start=1
                     /product="NEDD4 family-interacting protein 2 isoform 1"
                     /protein_id="NP_061953.2"
                     /db_xref="CCDS:CCDS31998.1"
                     /db_xref="GeneID:54602"
                     /db_xref="HGNC:HGNC:18537"
                     /db_xref="MIM:610041"
                     /translation="MARRRSQRVCASGPSMLNSARGAPELLRGTATNAEVSAAAAGAT
                     GSEELPPGDRGCRNGGGRGPAATTSSTGVAVGAEHGEDSLSRKPDPEPGRMDHHQPGT
                     GRYQVLLNEEDNSESSAIEQPPTSNPAPQIVQAASSAPALETDSSPPPYSSITVEVPT
                     TSDTEVYGEFYPVPPPYSVATSLPTYDEAEKAKAAAMAAAAAETSQRIQEEECPPRDD
                     FSDADQLRVGNDGIFMLAFFMAFIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWI
                     LIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFF
                     LL"
     exon            371..536
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /inference="alignment:Splign:2.1.0"
     exon            537..670
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /inference="alignment:Splign:2.1.0"
     exon            671..764
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /inference="alignment:Splign:2.1.0"
     exon            765..889
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /inference="alignment:Splign:2.1.0"
     exon            890..956
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1062
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..4624
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1445..1450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="hexamer: AATAAA"
     polyA_site      1469
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="major polyA site"
     regulatory      2549..2554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="hexamer: AATAAA"
     polyA_site      2572
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="major polyA site"
     regulatory      2612..2617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="hexamer: AATAAA"
     polyA_site      2635
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="major polyA site"
     regulatory      4371..4376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="hexamer: AATAAA"
     polyA_site      4400
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
     regulatory      4598..4603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="hexamer: AACAAA"
     polyA_site      4624
                     /gene="NDFIP2"
                     /gene_synonym="N4WBP5A"
                     /note="major polyA site"
ORIGIN      
        1 acttttccat ctcctcccac ccagctatac cctcccactg gcggcgcgga tggcacgccg
       61 gcggagccag cgagtctgcg cgagcggtcc gagcatgctc aatagcgcgc gcggcgcccc
      121 ggagcttctc cgcggaaccg cgaccaacgc ggaggtctcg gcggccgctg cgggagccac
      181 aggaagtgaa gagcttccgc cgggagaccg cggctgcagg aacggaggcg gaaggggccc
      241 tgcggcgacg acgtcgtcga cgggggtggc cgtgggagct gagcacggag aagactccct
      301 ctctcggaag ccggatcccg agccgggcag gatggatcac caccagccgg ggactgggcg
      361 ctaccaggtg cttcttaatg aagaggataa ctcagaatca tcggctatag agcagccacc
      421 tacttcaaac ccagcaccgc agattgtgca ggctgcgtct tcagcaccag cacttgaaac
      481 tgactcttcc cctccaccat atagtagtat tactgtggaa gtacctacaa cttcagatac
      541 agaagtttac ggtgagtttt atcccgtgcc acctccctat agcgttgcta cctctcttcc
      601 tacatacgat gaagctgaga aggctaaagc tgctgcaatg gcagctgcag cagcagaaac
      661 atctcaaaga attcaggagg aagagtgtcc accaagagat gacttcagtg atgcagacca
      721 gctcagagtg gggaatgatg gcattttcat gctggcattt ttcatggcat ttattttcaa
      781 ctggcttgga ttttgtttat ccttctgtat caccaatacc atagctggaa ggtatggtgc
      841 tatctgcgga tttggccttt ccttgatcaa atggatcctt attgtcaggt tttctgatta
      901 ttttactgga tatttcaatg gacagtattg gctttggtgg atatttcttg tacttggcct
      961 gctccttttc ttcagaggat ttgttaatta tctaaaagtc agaaacatgt ctgaaagtat
     1021 ggcagctgct catagaacaa ggtatttctt cttattgtag agactgcatc aacccgacat
     1081 tcctttctta taccaatgtg aaatttccag atcatctgta aacctacaac tttaatagaa
     1141 gactactaat aacagaagac aaattagtga agaaaagacg gagtttcgaa attgaatggc
     1201 agggtggttt ttgcttacaa gccatttctg ttcattcttt aagtatctat atttcatttg
     1261 ttttgcacat atgcatatgt gcccatttaa gatatttgca tatacttgat agaaaccata
     1321 aagttgtagc agttaagtcc agtcacattt ggttaatcag tgtttgatat aattgaaaga
     1381 gttgagtgga taaacagtct tccagcttgt aaatgccatt gacttctgac ctgacattta
     1441 gtataataaa aatgaaattc ttaaccatgt caaatgattt agtttctggc tcttagactc
     1501 atctggcagt tctacacatg aaacatcttt tgttatataa ggtgtattga aacctgcagt
     1561 gctgattatt agaaaggatt tgtcagattt ttgaacatga tatttacatt attatttagg
     1621 aaaactcttc ctgtaaataa ccatgcataa cttactttct gcaatgtttt cttagaaatt
     1681 gtgtccagat agctttcact aattttaaat taagtgaact aaatatatat gtgtatatgt
     1741 atacacatat atatacacac acacatatat atatttagaa acgtgagtgt taaagataga
     1801 atttgtttta ggacaaattt taagaaaatg tgggaatacc aaatgtcctt tataagaaaa
     1861 ataaatttta ttttaaggga catactagtt ttagggattt tcagatggga agctgcattt
     1921 ttaggattgc ccatcttaag agatcttgca ggaagagatt gtattagata ttatatttat
     1981 ttcatttaag ataattttca aagttaattt tctaaataag ataattctca tttgtgtttg
     2041 tcttttaaaa ggccaataaa atatctttca gtatcattgt aataattttt tagagtttaa
     2101 tttgtaaagc ttagcaaata aaatcttgta ctatgaatag cttcttgctt tatgacttta
     2161 ggattaactt gtaaaaaaca tatcctgaac tgagatatgc aaaatactca ttttcaagtt
     2221 atggaaatgt gtttgtggca tataggactg tggggtctgt gtgtgtagtg agagtgtgta
     2281 gccactatta taactggaat ttaatttaca ttcataaact actatatttc ccatcttgca
     2341 aatcatttta tgtctcatct gtttttcctt tcggttatat ctttggtttt gaataccaac
     2401 atttaaaatg atggtatttt atcttttaaa cttaaaaatt atttaataca gctatatgga
     2461 ccttataaaa ttgatttctt atttattatt agacattact actaaaaggt acatctaact
     2521 attcagggac atttttccat ttccaaaaaa taaaatttat tatgctttat aacctcttct
     2581 gtattttcta attttttcat tgtctttgat aaataaaaca gttttgtttt gctaatatag
     2641 cctatttttt gttttgtctc attcagttta ctttcctgcg tagaattttt attgttatat
     2701 taaaattttt attgttgtat taaagtacct gtgttacacc ccttgaagta agacagtagc
     2761 atggggtaaa gaaaaaatat ttagtttagt tgcctaattt ggaagttaat taaaattaaa
     2821 ctgtactaat aacatattca aactcatgct ggatctcttt catattaatt tcttatagac
     2881 ctgtacttta ttctttcaat aatttttaaa tgaaattaag ctttgctaca tggtaattaa
     2941 ataattacta ggaagcttag ctatcaaaca tcgacttact aaaatttcat tttagctttt
     3001 atggtatatg tgcttgtttt ctgaatatgg atacatgtta cttttgatcc agcatcaaaa
     3061 cttcactttt tgttttgact tttcccccca aatctgtaag gttcaagtat acatattact
     3121 gaatcctcta taattggcat aattcaatgg tagccttaaa tctcatcatg taagcagggg
     3181 aatcagaatg ttattttcaa gaacttaatg ttcccttcag atatataaaa tcctgcatac
     3241 ttcatttcct gtgagcttga acagctgctg ttgtgttttg gggatgcttg atcatctttg
     3301 cactctgcct taaagattga aaaatcaaaa ctcttgttag ggtatctaaa catttttgag
     3361 tgtgaactgg ggattggaag ttaatacaaa aaaatttcaa attatttcta ttgtaaatga
     3421 ataagctagt catggctagg ataatccatt ttcatgtatt tatgcaataa actgaatttt
     3481 aaggcaaaaa caacactttt ctatatagtg tatgcaggac agattttaga aacttagatt
     3541 aaaatacaaa tcccattaca tttggttaaa atgaaaatct ctgcttaatg gaaaaaatac
     3601 taatctttag cctattttga gtctataaga tatatttcat tttagacatg ccttctaagt
     3661 tgttcacaga tttttacctg ctaaaacaat attatttcca gtaaaacctc tcctaacagg
     3721 aaaagtggag ttcaaaatat ccaattggag aaaaattcag agttccttca ttaaatataa
     3781 tttttttcat ctagtatgta ctatttcaag aagtgcaaaa agtaatgata gtgaatgtga
     3841 taccatactt aactaaggta atatatatcc ttagtttgct caaaagagtc ctggttattc
     3901 ctgttttctc agcttaatag tgcctcatcg tactctcaaa agtgttctaa tttggaggat
     3961 aagttatatg atcatcctgt gtataattgt agactgtacc aagaagcaac taccttagct
     4021 ccactgccct ttgagggatg gaactggggt aagggcagga gccagttatt attgccacag
     4081 tgttttctaa tgaaccattt ggcctgtaga agaggaatag tatttttttt aatagttgta
     4141 tttgaatgat tccagcttat cgtaaatact aaactgaatg gcttttatat ttttaactgc
     4201 tgttaaatgt tattttagca tttattagtt gtttattatt taattcttca aatagtcata
     4261 tgaaaacata tatttgataa aggtcaattg ttagatgata atgtgccatt cattatcata
     4321 ggaatgtcct tgcccatata taaaacatgc tggcatgtat tttacttgtt aataaagttg
     4381 tatagatgtg gaagtgtgaa cctgtgatgc atccttttca aaatcagttt aagattcgca
     4441 tattatcatg actgtgacct cactaaactg tttatgtgac aaacctttca agattggaga
     4501 tgaaaacaac acttgtgaaa ttaggttggg gttgcaacat cttttaactt ctcagttatt
     4561 tgtatgtcag gagacagatt gtggtttaat tttaataaac aaaatatcat ctttttgaaa
     4621 ataa
//
