LOCUS       NM_030571               3574 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens Nedd4 family interacting protein 1 (NDFIP1), mRNA.
ACCESSION   NM_030571
VERSION     NM_030571.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3574)
  AUTHORS   Fu,X., Qu,L., Xu,H. and Xie,J.
  TITLE     Ndfip1 protected dopaminergic neurons via regulating mitochondrial
            function and ferroptosis in Parkinson's disease
  JOURNAL   Exp Neurol 375, 114724 (2024)
   PUBMED   38365133
  REMARK    GeneRIF: Ndfip1 protected dopaminergic neurons via regulating
            mitochondrial function and ferroptosis in Parkinson's disease.
REFERENCE   2  (bases 1 to 3574)
  AUTHORS   Cheng,Y., Lu,X., Li,F., Chen,Z., Zhang,Y., Han,Q., Zeng,Q., Wu,T.,
            Li,Z., Lu,S., Williams,C. and Xia,W.
  TITLE     NDFIP1 limits cellular TAZ accumulation via exosomal sorting to
            inhibit NSCLC proliferation
  JOURNAL   Protein Cell 14 (2), 123-136 (2023)
   PUBMED   36929005
  REMARK    GeneRIF: NDFIP1 limits cellular TAZ accumulation via exosomal
            sorting to inhibit NSCLC proliferation.
REFERENCE   3  (bases 1 to 3574)
  AUTHORS   Tang,Y.L., Zhu,L., Yang,H.F., Tao,Y., Lu,W. and Cheng,H.
  TITLE     Research progress on the role of Ndfip1 (Nedd4 family interacting
            protein 1) in immune cells
  JOURNAL   Allergol Immunopathol (Madr) 51 (1), 77-83 (2023)
   PUBMED   36617825
  REMARK    GeneRIF: Research progress on the role of Ndfip1 (Nedd4 family
            interacting protein 1) in immune cells.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3574)
  AUTHORS   Traeger,L., Wiegand,S.B., Sauer,A.J., Corman,B.H.P., Peneyra,K.M.,
            Wunderer,F., Fischbach,A., Bagchi,A., Malhotra,R., Zapol,W.M. and
            Bloch,D.B.
  TITLE     UBA6 and NDFIP1 regulate the degradation of ferroportin
  JOURNAL   Haematologica 107 (2), 478-488 (2022)
   PUBMED   34320783
  REMARK    GeneRIF: UBA6 and NDFIP1 regulate the degradation of ferroportin.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3574)
  AUTHORS   Lopez-Cotarelo,P., Gonzalez-Jimenez,A., Agudo-Jimenez,T.,
            Abarca-Zabalia,J., Aladro,Y., Pilo,B., Comabella,M.,
            Espino-Paisan,L. and Urcelay,E.
  TITLE     Genetic variation in NDFIP1 modifies the metabolic patterns in
            immune cells of multiple sclerosis patients
  JOURNAL   Sci Rep 11 (1), 21371 (2021)
   PUBMED   34725369
  REMARK    GeneRIF: Genetic variation in NDFIP1 modifies the metabolic
            patterns in immune cells of multiple sclerosis patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3574)
  AUTHORS   Putz,U., Howitt,J., Lackovic,J., Foot,N., Kumar,S., Silke,J. and
            Tan,S.S.
  TITLE     Nedd4 family-interacting protein 1 (Ndfip1) is required for the
            exosomal secretion of Nedd4 family proteins
  JOURNAL   J Biol Chem 283 (47), 32621-32627 (2008)
   PUBMED   18819914
  REMARK    GeneRIF: Ndfip1 is required for the exosomal secretion of Nedd4
            family proteins
REFERENCE   7  (bases 1 to 3574)
  AUTHORS   Foot,N.J., Dalton,H.E., Shearwin-Whyatt,L.M., Dorstyn,L., Tan,S.S.,
            Yang,B. and Kumar,S.
  TITLE     Regulation of the divalent metal ion transporter DMT1 and iron
            homeostasis by a ubiquitin-dependent mechanism involving Ndfips and
            WWP2
  JOURNAL   Blood 112 (10), 4268-4275 (2008)
   PUBMED   18776082
REFERENCE   8  (bases 1 to 3574)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   9  (bases 1 to 3574)
  AUTHORS   Harvey,K.F., Shearwin-Whyatt,L.M., Fotia,A., Parton,R.G. and
            Kumar,S.
  TITLE     N4WBP5, a potential target for ubiquitination by the Nedd4 family
            of proteins, is a novel Golgi-associated protein
  JOURNAL   J Biol Chem 277 (11), 9307-9317 (2002)
   PUBMED   11748237
REFERENCE   10 (bases 1 to 3574)
  AUTHORS   Jolliffe,C.N., Harvey,K.F., Haines,B.P., Parasivam,G. and Kumar,S.
  TITLE     Identification of multiple proteins expressed in murine embryos as
            binding partners for the WW domains of the ubiquitin-protein ligase
            Nedd4
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 557-565 (2000)
   PUBMED   11042109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA236494.1, AB097010.1,
            AL832993.1 and AA496123.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030571.3.
            
            Summary: The protein encoded by this gene belongs to a small group
            of evolutionarily conserved proteins with three transmembrane
            domains. It is a potential target for ubiquitination by the Nedd4
            family of proteins. This protein is thought to be part of a family
            of integral Golgi membrane proteins. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.136458.1,
                                           SRR1660803.45873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253814.6/ ENSP00000253814.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DA236494.1         21-64
            45-1908             AB097010.1         1-1864
            1909-3571           AL832993.1         1410-3072
            3572-3574           AA496123.1         6-8                 c
FEATURES             Location/Qualifiers
     source          1..3574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..3574
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /note="Nedd4 family interacting protein 1"
                     /db_xref="GeneID:80762"
                     /db_xref="HGNC:HGNC:17592"
                     /db_xref="MIM:612050"
     exon            1..259
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..862
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /note="Nedd4 WW domain-binding protein 5; putative
                     MAPK-activating protein PM13; breast cancer-associated
                     protein SGA-1M; putative NFKB and MAPK-activating protein;
                     putative NF-kappa-B-activating protein 164"
                     /codon_start=1
                     /product="NEDD4 family-interacting protein 1"
                     /protein_id="NP_085048.1"
                     /db_xref="CCDS:CCDS4273.1"
                     /db_xref="GeneID:80762"
                     /db_xref="HGNC:HGNC:17592"
                     /db_xref="MIM:612050"
                     /translation="MALALAALAAVEPACGSRYQQLQNEEESGEPEQAAGDAPPPYSS
                     ISAESAAYFDYKDESGFPKPPSYNVATTLPSYDEAERTKAEATIPLVPGRDEDFVGRD
                     DFDDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKW
                     ILIVRFSTYFPGYFDGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPETFSNLPRTRVL
                     FIY"
     exon            260..347
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            348..478
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            479..566
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            567..691
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            692..758
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            759..864
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            865..3574
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      982..987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /note="hexamer: AATAAA"
     polyA_site      1002
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
     regulatory      1888..1893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /note="hexamer: AATAAA"
     polyA_site      1909
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /note="major polyA site"
     regulatory      2308..2313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /note="hexamer: ATTAAA"
     polyA_site      2332
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
     regulatory      3309..3314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /note="hexamer: AATAAA"
     polyA_site      3330
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
     regulatory      3549..3554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
                     /note="hexamer: ATTAAA"
     polyA_site      3574
                     /gene="NDFIP1"
                     /gene_synonym="N4WBP5"
ORIGIN      
        1 aggggccgcg tcggagcctc ggcggcggcg gcggtgctta cagcctgaga agagcgtctc
       61 gcccgggagc ggcggcggcc atcgagaccc acccaaggcg cgtccccctc ggcctcccag
      121 cgctcccaag ccgcagcggc cgcgcccctt cagctagctc gctcgctcgc tctgcttccc
      181 tgctgccggc tgcgccatgg cgttggcgtt ggcggcgctg gcggcggtcg agccggcctg
      241 cggcagccgg taccagcagt tgcagaatga agaagagtct ggagaacctg aacaggctgc
      301 aggtgatgct cctccacctt acagcagcat ttctgcagag agcgcagcat attttgacta
      361 caaggatgag tctgggtttc caaagccccc atcttacaat gtagctacaa cactgcccag
      421 ttatgatgaa gcggagagga ccaaggctga agctactatc cctttggttc ctgggagaga
      481 tgaggatttt gtgggtcggg atgattttga tgatgctgac cagctgagga taggaaatga
      541 tgggattttc atgttaactt ttttcatggc attcctcttt aactggattg ggtttttcct
      601 gtctttttgc ctgaccactt cagctgcagg aaggtatggg gccatttcag gatttggtct
      661 ctctctaatt aaatggatcc tgattgtcag gttttccacc tatttccctg gatattttga
      721 tggtcagtac tggctctggt gggtgttcct tgttttaggc tttctcctgt ttctcagagg
      781 atttatcaat tatgcaaaag ttcggaagat gccagaaact ttctcaaatc tccccaggac
      841 cagagttctc tttatttatt aaagatgttt tctggcaaag gccttcctgc atttatgaat
      901 tctctctcaa gaagcaagag aacacctgca ggaagtgaat caagatgcag aacacagagg
      961 aataatcacc tgctttaaaa aaataaagta ctgttgaaaa gatcatttct ctctatttgt
     1021 tcctaggtgt aaaattttaa tagttaatgc agaattctgt aatcattgaa tcattagtgg
     1081 ttaatgtttg aaaaagctct tgcaatcaag tctgtgatgt attaataatg ccttatatat
     1141 tgtttgtagt cattttaagt agcatgagcc atgtccctgt agtcggtagg gggcagtctt
     1201 gctttattca tcctccatct caaaatgaac ttggaattaa atattgtaag atatgtataa
     1261 tgctggccat tttaaagggg ttttctcaaa agttaaactt ttgctatgac tgtgtttttg
     1321 cacataatcc atatttgctg ttcaagttaa tctagaaatt tattcaattc tgtatgaaca
     1381 cctggaagca aaatcatagt gcaaaaatac atttaaggtg tggtcaaaaa taagtcttta
     1441 attggtaaat aataagcatt aattttttat agcctgtatt cacaattctg cggtacctta
     1501 ttgtacctaa gggattctaa aggtgttgtc actgtataaa acagaaagca ctaggataca
     1561 aatgaagctt aattactaaa atgtaattct tgacactctt tctataatta gcgttcttca
     1621 cccccacccc cacccccacc ccccttattt tccttttgtc tcctggtgat taggccaaag
     1681 tctgggagta aggagaggat taggtactta ggagcaaaga aagaagtagc ttggaacttt
     1741 tgagatgatc cctaacatac tgtactactt gcttttacaa tgtgttagca gaaaccagtg
     1801 ggttataatg tagaatgatg tgctttctgc ccaagtggta attcatcttg gtttgctatg
     1861 ttaaaactgt aaatacaaca gaacattaat aaatatctct tgtgtagcac cttttactgt
     1921 agattagtgc ttaatttctt ggcttgcatt tgttgattgc taaggcaatt ttttctaatc
     1981 ttagggaatc attcagtaga tgcgattaaa aaactaatgt tgggtcaatt tttttcttca
     2041 ttttcagcac aagaagtcct cttatatcct actaaataca ttcctaaaaa tgtatttgaa
     2101 cattggttct gtaaaagata atggactaaa aaagtagaga ggagttgtag agatcttaaa
     2161 tcattctgga attcctaatt atgcttcaat ttttagacat aattttagat aatttatttc
     2221 cagtgttttc tgcatgttct catttgttct ttttctcagt tgaatgcacc aactggtttg
     2281 agtcctgtga gcattcagtc agttgaaatt aaagattcct catttctcct gatttctatt
     2341 cttgtctcaa tcttaaattt agagaccagt tgtttttatg atatcagcca tttgattttt
     2401 ttcattttct atttaagaaa tatgaagaaa aaatacacca agatggtcaa attactacac
     2461 aaatcagcac cagcacagtc tgatagctgc aaatgtccat tcatctgctg tgtatgtata
     2521 tccagaatca gcataggaag tcgttcagga tatcagtata taatgcacag aagtgtgggt
     2581 tgtttgaaag ccaaacagga aaattaggag cctcctggat tgacatttca atgatccctc
     2641 taaccagttt atggattatt atgaataata gtgtagtgtg ttctttttca gaagttatat
     2701 ttgataatag agaagggagt tttatggaag tttctttgaa gatttttttt tttccatttc
     2761 gaatcagatt atagcaacaa tggagtttgg aagtttgtat ggcctataat gttctaagtt
     2821 ccagaatgaa aagatctgta acaatctgaa tagatgtgga cacatatagc agagagaact
     2881 atgtaaatta tcttgcagaa caaaatagaa gggtcctaaa tcacgttaac tcaaacattg
     2941 tagactagct ttgtgtttat tcttcaggtc cttgcgcctt atttggtttt gtatattcaa
     3001 cgaactgaaa tatttggaat tcctatttct acgtatttgg tggtccataa gactttgtca
     3061 aatgtaaacc tacagtttga tacgctttaa aatacctagt taagaggatg atttctcttt
     3121 aatcgtttaa atgttctgaa aattaaaatc ttttgaggca catgaagtgg gcaccatata
     3181 tcatctagag tccttactgg tattcaggat gaaaatgttc acgctgcatt aattgtcatt
     3241 tttctctccc atgttctttc tcactttgat acgttaatac tgataatgga taaagagtga
     3301 gtttttataa taaatggttt tggaaaggta ttcataggaa ccgcggttat ttacttaagg
     3361 ttatggagta aactagcttg gaccttgggc tgcaggacga ctaggattca cccataacga
     3421 cacagtgccc tatgtttctt aacttcttgt tgccatttga aactctgtac tcttatgttt
     3481 aaagggttct gtatagccat tttttttttc agaaagttac attgctttgt atagaaataa
     3541 aaggcattat taaaatttgc ttgttaaaaa atga
//
