LOCUS       NM_001128826            5052 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens neuronal calcium sensor 1 (NCS1), transcript variant
            2, mRNA.
ACCESSION   NM_001128826
VERSION     NM_001128826.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5052)
  AUTHORS   Sanchez,J.C., Aleman,A., Henao,J.F., Olaya,J.C. and Ehrlich,B.E.
  TITLE     NCS-1 protein regulates TRPA1 channel through the PI3K pathway in
            breast cancer and neuronal cells
  JOURNAL   J Physiol Biochem 80 (2), 451-463 (2024)
   PUBMED   38564162
  REMARK    GeneRIF: NCS-1 protein regulates TRPA1 channel through the PI3K
            pathway in breast cancer and neuronal cells.
REFERENCE   2  (bases 1 to 5052)
  AUTHORS   Baksheeva,V.E., Zamyatnin,A.A. Jr. and Zernii,E.Y.
  TITLE     [Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of
            Nervous System Signaling Pathways]
  JOURNAL   Mol Biol (Mosk) 57 (6), 1098-1129 (2023)
   PUBMED   38062964
  REMARK    GeneRIF: [Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein
            of Nervous System Signaling Pathways].
            Review article
REFERENCE   3  (bases 1 to 5052)
  AUTHORS   Baksheeva,V.E., Baldin,A.V., Zalevsky,A.O., Nazipova,A.A.,
            Kazakov,A.S., Vladimirov,V.I., Gorokhovets,N.V., Devred,F.,
            Philippov,P.P., Bazhin,A.V., Golovin,A.V., Zamyatnin,A.A. Jr.,
            Zinchenko,D.V., Tsvetkov,P.O., Permyakov,S.E. and Zernii,E.Y.
  TITLE     Disulfide Dimerization of Neuronal Calcium Sensor-1: Implications
            for Zinc and Redox Signaling
  JOURNAL   Int J Mol Sci 22 (22), 12602 (2021)
   PUBMED   34830487
  REMARK    GeneRIF: Disulfide Dimerization of Neuronal Calcium Sensor-1:
            Implications for Zinc and Redox Signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5052)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5052)
  AUTHORS   Staby,L., Kemplen,K.R., Stein,A., Ploug,M., Clarke,J., Skriver,K.,
            Heidarsson,P.O. and Kragelund,B.B.
  TITLE     Disorder in a two-domain neuronal Ca2+-binding protein regulates
            domain stability and dynamics using ligand mimicry
  JOURNAL   Cell Mol Life Sci 78 (5), 2263-2278 (2021)
   PUBMED   32936312
  REMARK    GeneRIF: Disorder in a two-domain neuronal Ca(2+)-binding protein
            regulates domain stability and dynamics using ligand mimicry.
REFERENCE   6  (bases 1 to 5052)
  AUTHORS   Chen,C., Yu,L., Zhang,P., Jiang,J., Zhang,Y., Chen,X., Wu,Q., Wu,Q.
            and Zhao,S.
  TITLE     Human neuronal calcium sensor-1 shows the highest expression level
            in cerebral cortex
  JOURNAL   Neurosci Lett 319 (2), 67-70 (2002)
   PUBMED   11825672
REFERENCE   7  (bases 1 to 5052)
  AUTHORS   Zhao,X., Varnai,P., Tuymetova,G., Balla,A., Toth,Z.E.,
            Oker-Blom,C., Roder,J., Jeromin,A. and Balla,T.
  TITLE     Interaction of neuronal calcium sensor-1 (NCS-1) with
            phosphatidylinositol 4-kinase beta stimulates lipid kinase activity
            and affects membrane trafficking in COS-7 cells
  JOURNAL   J Biol Chem 276 (43), 40183-40189 (2001)
   PUBMED   11526106
REFERENCE   8  (bases 1 to 5052)
  AUTHORS   Nakamura,T.Y., Pountney,D.J., Ozaita,A., Nandi,S., Ueda,S., Rudy,B.
            and Coetzee,W.A.
  TITLE     A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4
            K+-currents
  JOURNAL   Proc Natl Acad Sci U S A 98 (22), 12808-12813 (2001)
   PUBMED   11606724
REFERENCE   9  (bases 1 to 5052)
  AUTHORS   Bourne,Y., Dannenberg,J., Pollmann,V., Marchot,P. and Pongs,O.
  TITLE     Immunocytochemical localization and crystal structure of human
            frequenin (neuronal calcium sensor 1)
  JOURNAL   J Biol Chem 276 (15), 11949-11955 (2001)
   PUBMED   11092894
REFERENCE   10 (bases 1 to 5052)
  AUTHORS   Burgoyne,R.D. and Weiss,J.L.
  TITLE     The neuronal calcium sensor family of Ca2+-binding proteins
  JOURNAL   Biochem J 353 (Pt 1), 1-12 (2001)
   PUBMED   11115393
  REMARK    Review article
            Erratum:[Biochem J 2001 Mar 15;354(Pt 3):727]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL360004.22, BQ880305.1,
            DA092531.1, AF134479.1, AL161981.1, BM011362.1, BU150740.1,
            AI564128.1, AI521726.1, CF453730.1, AI768193.1 and CK301145.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001128826.1.
            
            Summary: This gene is a member of the neuronal calcium sensor gene
            family, which encode calcium-binding proteins expressed
            predominantly in neurons. The protein encoded by this gene
            regulates G protein-coupled receptor phosphorylation in a
            calcium-dependent manner and can substitute for calmodulin. The
            protein is associated with secretory granules and modulates
            synaptic transmission and synaptic plasticity. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains a distinct 5' UTR and
            5' coding region, compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus when compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.152277.1,
                                           SRR1803615.222109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AL360004.22        71830-72022
            194-194             BQ880305.1         1-1
            195-663             DA092531.1         1-469
            664-1162            AF134479.1         583-1081
            1163-1926           AL161981.1         394-1157
            1927-3244           AF134479.1         1846-3163
            3245-3671           BM011362.1         300-726
            3672-4026           BU150740.1         300-654
            4027-4313           AI564128.1         62-348              c
            4314-4376           AI521726.1         4-66                c
            4377-4879           CF453730.1         275-777
            4880-5037           AI768193.1         12-169              c
            5038-5052           CK301145.1         20-34               c
FEATURES             Location/Qualifiers
     source          1..5052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..5052
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /note="neuronal calcium sensor 1"
                     /db_xref="GeneID:23413"
                     /db_xref="HGNC:HGNC:3953"
                     /db_xref="MIM:603315"
     exon            1..212
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..721
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /note="isoform 2 is encoded by transcript variant 2;
                     frequenin-like ubiquitous protein; frequenin-like protein;
                     frequenin homolog"
                     /codon_start=1
                     /product="neuronal calcium sensor 1 isoform 2"
                     /protein_id="NP_001122298.1"
                     /db_xref="CCDS:CCDS78448.1"
                     /db_xref="GeneID:23413"
                     /db_xref="HGNC:HGNC:3953"
                     /db_xref="MIM:603315"
                     /translation="MATITEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPT
                     KFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNE
                     MLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPS
                     IVQALSLYDGLV"
     exon            213..237
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /inference="alignment:Splign:2.1.0"
     exon            238..376
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /inference="alignment:Splign:2.1.0"
     exon            377..455
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /inference="alignment:Splign:2.1.0"
     exon            456..544
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /inference="alignment:Splign:2.1.0"
     exon            545..622
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /inference="alignment:Splign:2.1.0"
     exon            623..738
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /inference="alignment:Splign:2.1.0"
     exon            739..5052
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4353..4358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /note="hexamer: AATAAA"
     polyA_site      4376
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /note="major polyA site"
     regulatory      5023..5028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
                     /note="hexamer: ATTAAA"
     polyA_site      5052
                     /gene="NCS1"
                     /gene_synonym="FLUP; FREQ"
ORIGIN      
        1 gttcatgtct tgccagtgaa agagcccggg ctgaccacag agaggggctg cagggacagg
       61 ctgacaggga gggtggtcca cccttctgct gagagctgcc ccttttcagc ctagctcccc
      121 ccaccccccc acataggtgg ggcagccgag tgcctgggga agccagggcc ttccctgaca
      181 tcccgtcccc agggattgag agatggcaac gattaccgag aaggaggtcc agcagtggta
      241 caaaggcttc atcaaggact gccccagtgg gcagctggat gcggcaggct tccagaagat
      301 ctacaagcaa ttcttcccgt tcggagaccc caccaagttt gccacatttg ttttcaacgt
      361 ctttgatgaa aacaaggacg ggcgaattga gttctccgag ttcatccagg cgctgtcggt
      421 gacctcacgg ggaaccctgg atgagaagct acggtgggcc ttcaagctct acgacttgga
      481 caatgatggc tacatcacca ggaatgagat gctggacatt gtggatgcca tttaccagat
      541 ggtggggaat accgtggagc tcccagagga ggagaacact cctgagaaga gggtggaccg
      601 gatctttgcc atgatggata agaatgccga cgggaagctg accctgcagg agttccagga
      661 gggttccaag gcagacccgt ccattgtgca ggcgctgtcc ctctacgacg ggctggtata
      721 gtcccaggct ggagctggat gcctgggaac cactcacctc cttctgtgcc atgaggccac
      781 ctcagccctg acaccaaccc cgtgcgtcca cccagccttc ttccgcatcc acacacagcc
      841 ggctgccctt gacccgggag gccccggctc tcctctcccc tgtcctgcac ccatcccccg
      901 cctgaagcca ccggctccaa ttgccagcaa cctctgcttg tccggaaaac gacaacacga
      961 aatggaaaag gctacagccc tctgcataaa ccaaggactt ggctgcctcg caggcagcct
     1021 ccgttcctcc cgctctcttg cgcgtgtgct tttgtttttt attttgaaca gacgttttaa
     1081 aagaaaaaaa aacaactacc ttctgtccta gaagacacag actgacagat ggggtgaagg
     1141 cctggggacc tcagagaact ctgccttgcc ctcgtccctc gtccttcggc agccggagag
     1201 gctgtgggtg ggccgagggt gtctaggggt tctgcctggt caacgttatt tgtcgtccca
     1261 tcttttggca gcaaaaccac ctgcgtggct aggatgatta attatgagga tgatgatttt
     1321 ttttgtgata acagtattgt gctttttgtg gggaaagtga ggtttttttt tatatacata
     1381 tataattgat atctttaatt tattggttgt taactgttgc tgctgcctgg tgtgtcctca
     1441 gctcccaggg ctgcgggccc accgtttaca tgtgcacgcc ctgacccacc tgcccacgcc
     1501 gacttgggag gatggtggcc tgcagcggcc aagaagccaa aaaaaatttt ttttttttca
     1561 gatactgtgc ttgatttttg gagaggggag aggtggaaat tcctaaatgg ctaatgcact
     1621 gttccctcca gcccgaatgc ctcctgccaa accccttttc cctgctgcct ctgtccccgc
     1681 atccttgttc tcccctgggt ccgtaacatt ttttccgagg atgaacaggg gacatcttta
     1741 ggtttctcaa ctcttgcttt ggtgtttgcc gcagcatgga aaacagggcg cctaaggctg
     1801 ggagctggaa gaaggggcat tgggtaccca ggcagagtca ggagaggtgg tctttgaagt
     1861 aagttagcag aaatcaaggg gacccccgcc tccttgggct ggggagggga tttcaagata
     1921 gttcatgact ctctcccgct ctgccttccc tccttcctat ctgctttttc cagtaaactg
     1981 catggtgtcc ttccctggcc ttctcttggc tcaaaggctg ggagggaggg aaggagagaa
     2041 gagttccagg caatcccatc aatatagtcc ctacacctgg ggctgcggcc cacatgtctt
     2101 cacggaggct tccagcggtg cctgccactg aggcaggtgc ggccccagga ccatcaccag
     2161 gaatgcgagg ccaccctgga ccagaggtag gagcccaagg tccggccctt gctctttgat
     2221 tgtgggcagc ctcctgccct ctctgggtct cagttgcccc atctgcagag cgaggaggcc
     2281 cgggctggtt ggtcttgaag gcccttttcc atgccgacat catgtcactc taggcctggg
     2341 gttcagtttc ctgtggctgg tgatgctgtg gttaagtttg cttgacccca gcagcccgag
     2401 ggactgtctg agtcacagca cagcccctat tgcgtggctg ctggtgtgtg gggtcagttc
     2461 cagcagatga atgtgtcatg tggcacacct tgtcccttcc cgcagcattt cctggttccc
     2521 cccagaccct tgagcgctct ttgggaccca gaaggagtcc ttgcacaggg aaggcttgag
     2581 gtgagaagcc gcttcccaga ctgtcagggc caggcctggg tctagaattc ttgctgctgc
     2641 tttgcagagt caacagccca tcagcccatg ttttagaggg gacactttgg tcctcggttc
     2701 ccaccctcag caagcaggcc tccagcccga ggaaggcctc tgccgtagtg acgttgccgt
     2761 gtggggctgc gtggctgttc cccttggctg gagcattcag ccaaccccag cgtcccccct
     2821 gaggcgttca ttggcagccc cctaggactg cacgctggcc ccacggtaac cccccctccc
     2881 ccaccaacat cctgcaggga tggggtcagt ggttccacct tcacaggcca ctttgaaggg
     2941 tggattcttt gaggcccctg ccagtcggct ccctgctcag ctgctggccc gggcgacctg
     3001 ggactcagca ccaacggctg aagtttctca gctgggctct gacctggggt ctggggcagg
     3061 gaacgaacat ggtggctttg ggctgagagg atgagggagg tctttcccag gtcaaattac
     3121 tttcctttgg cctctgcctg aggctcgatt tgcctctctg gtccaatggg actgacactg
     3181 ttgtacaacc tgacctgtgg ctgagggtgt ctgggcttaa gcatgtggac cccttcggtg
     3241 tgtccggcct tcctccatcg tcctgccctt tggccttttg gtttgaagcc acaggtgtgg
     3301 cttctggcct tagcagatgg tatgcttgcg gaccgcagcc cagcatgccg gtgggcccac
     3361 agcccgagcc agcccagagc tgccggaagg gccgcccttc ccggccctgg cggggtgctg
     3421 gacactggcc attttcacta gagtttgcct ggcagggacc gatctctgcc ccctcctctc
     3481 cccaggcctc tggctgcagt gatgccgcag aatcctgagc caggtgcctc ctgagcagcc
     3541 cgtgcgcctc tccacagcgg cgtttgccac ccaatgcggc tcgcttcaga tgctctgatg
     3601 cagagggcac gcccatagtc cctctgcaga gcctcgcact ggggccaggg caggcaccag
     3661 ccccaggcgg ccagtcggcc acggcctgtc ctcttcctcg tagcgtctgc tcctcacttt
     3721 gtgttgatgg tgacttagga gaatgttccg attttccatg atctaagcag gccacgttta
     3781 aaataacatc aaggcaagcg tacgtgtcac cctctgtact gacatctctt cccctgaaat
     3841 gcttttcagt ttgacagccc gtttcctaga caagtgcacc tggggtttca ggaactttgt
     3901 gttttttcgg agggggttgg tggggaggtc gggatgcctg ggatcccttc ctggagaggc
     3961 aggctgtctc tggaaaaagc ctccattgcc cacccgccag gcggaaagtc accctgttcc
     4021 cagcgcggtt tcagcattta attttaaggg agctaaggaa gcgcggcgcg ccccctggtg
     4081 gtggtaagcc gccaacgcac ctgggggctg caaccccacc ggacgggtgg tccggaggga
     4141 ggctggagcg gggaggcgag gagggggctg tgagtcctca gaggccctgg gccaccacat
     4201 ttctggcagc gtttcccaga cacccctctg ctaggccatc cctggatagc aagtgaatta
     4261 acttaagggc actgtgatgg gaagccttgc ccccctcttt tttttttttt tttaatatct
     4321 gcggaataaa cccaatggtt aatttttgaa tgaataaaag gcttttgttg aataaacagc
     4381 tggtcccatc ttctgtcttg gcatcttagc atccaggctc aggctctgcc ccttctccag
     4441 gatggggtag ccccgagtcg ccctccccag tctgcacatt ccctgttgtc cctgttcctg
     4501 cagtggctcc cggccccagg gaggcccacc tcactcccag cctgactcgg tggctggctt
     4561 ccttcaggac tttgcgcaag tcagttctgc tcattgggtc tcaatttccc catcccttgg
     4621 atgggagcaa gagtctctgc tgggcctgcc tcgcaggggc ctggtgagac ccaaatgtga
     4681 gtgtcatcat caaagcccct cacagaagtg gaggacggtg cccaagagta gcggtttgga
     4741 ctgctgctgc ctcccacccg gagcctgcca cttgggggag aaattggtat aatgcttgca
     4801 aaaacaaaca aacaaaaggc aatgtcttct ggttgtggtt atttcctttc ctgcttgcct
     4861 ccccagcccc ctttgagtct ctttttgggg tgccgtcctg tctgaacctg ccggtgtgtg
     4921 tctctggggc cagggtcagg gcgaggccca ggggtggaca ggggccgtgt agcatgcccc
     4981 agcctcccca agctcctgct gtatgtcgtc catgtcacgc caattaaaca cgcttcctgg
     5041 acttgtcctc gc
//
