LOCUS       NM_001202439            6364 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens natural killer cell cytotoxicity receptor 3 ligand 1
            (NCR3LG1), mRNA.
ACCESSION   NM_001202439
VERSION     NM_001202439.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6364)
  AUTHORS   Mohammadi,A., Najafi,S., Amini,M., Baradaran,B. and Firouzamandi,M.
  TITLE     B7H6 silencing increases chemosensitivity to dacarbazine and
            suppresses cell survival and migration in cutaneous melanoma
  JOURNAL   Melanoma Res 33 (3), 173-183 (2023)
   PUBMED   37053079
  REMARK    GeneRIF: B7H6 silencing increases chemosensitivity to dacarbazine
            and suppresses cell survival and migration in cutaneous melanoma.
REFERENCE   2  (bases 1 to 6364)
  AUTHORS   Fan,J., Wang,Y., Liang,X., Peng,Y., Li,S., Li,X., Zhou,F. and Li,Y.
  TITLE     B7-H6 enhances F-actin rearrangement by targeting c-MYC activation
            to promote medulloblastoma migration and invasion
  JOURNAL   Med Oncol 40 (3), 85 (2023)
   PUBMED   36692844
  REMARK    GeneRIF: B7-H6 enhances F-actin rearrangement by targeting c-MYC
            activation to promote medulloblastoma migration and invasion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6364)
  AUTHORS   Liu,X., Guo,R. and Xu,Y.
  TITLE     B7-H6 as a Diagnostic Biomarker for Cervical Squamous Cell
            Carcinoma
  JOURNAL   Genet Test Mol Biomarkers 25 (7), 463-470 (2021)
   PUBMED   34280008
  REMARK    GeneRIF: B7-H6 as a Diagnostic Biomarker for Cervical Squamous Cell
            Carcinoma.
REFERENCE   4  (bases 1 to 6364)
  AUTHORS   Cherif,B., Triki,H., Charfi,S., Bouzidi,L., Kridis,W.B.,
            Khanfir,A., Chaabane,K., Sellami-Boudawara,T. and Rebai,A.
  TITLE     Immune checkpoint molecules B7-H6 and PD-L1 co-pattern the tumor
            inflammatory microenvironment in human breast cancer
  JOURNAL   Sci Rep 11 (1), 7550 (2021)
   PUBMED   33824367
  REMARK    GeneRIF: Immune checkpoint molecules B7-H6 and PD-L1 co-pattern the
            tumor inflammatory microenvironment in human breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6364)
  AUTHORS   Ponath,V., Hoffmann,N., Bergmann,L., Mader,C., Alashkar Alhamwe,B.,
            Preusser,C. and Pogge von Strandmann,E.
  TITLE     Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in
            Contrast to BAG6 Only Marginally Released via Extracellular
            Vesicles
  JOURNAL   Int J Mol Sci 22 (4), 2189 (2021)
   PUBMED   33671836
  REMARK    GeneRIF: Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is
            in Contrast to BAG6 Only Marginally Released via Extracellular
            Vesicles.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6364)
  AUTHORS   Hartmann,J., Tran,T.V., Kaudeer,J., Oberle,K., Herrmann,J.,
            Quagliano,I., Abel,T., Cohnen,A., Gatterdam,V., Jacobs,A.,
            Wollscheid,B., Tampe,R., Watzl,C., Diefenbach,A. and Koch,J.
  TITLE     The stalk domain and the glycosylation status of the activating
            natural killer cell receptor NKp30 are important for ligand binding
  JOURNAL   J Biol Chem 287 (37), 31527-31539 (2012)
   PUBMED   22807449
REFERENCE   7  (bases 1 to 6364)
  AUTHORS   Kaifu,T., Escaliere,B., Gastinel,L.N., Vivier,E. and Baratin,M.
  TITLE     B7-H6/NKp30 interaction: a mechanism of alerting NK cells against
            tumors
  JOURNAL   Cell Mol Life Sci 68 (21), 3531-3539 (2011)
   PUBMED   21877119
  REMARK    Review article
REFERENCE   8  (bases 1 to 6364)
  AUTHORS   Joyce,M.G., Tran,P., Zhuravleva,M.A., Jaw,J., Colonna,M. and
            Sun,P.D.
  TITLE     Crystal structure of human natural cytotoxicity receptor NKp30 and
            identification of its ligand binding site
  JOURNAL   Proc Natl Acad Sci U S A 108 (15), 6223-6228 (2011)
   PUBMED   21444796
REFERENCE   9  (bases 1 to 6364)
  AUTHORS   Li,Y., Wang,Q. and Mariuzza,R.A.
  TITLE     Structure of the human activating natural cytotoxicity receptor
            NKp30 bound to its tumor cell ligand B7-H6
  JOURNAL   J Exp Med 208 (4), 703-714 (2011)
   PUBMED   21422170
  REMARK    GeneRIF: The NKp30-B7-H6 structure revealed that this NK cell
            activating complex is distinct from the CTLA4-B7 and PD-1-PD-L T
            cell inhibitory complexes in both overall organization and detailed
            atomic interactions that mediate binding and specificity.
REFERENCE   10 (bases 1 to 6364)
  AUTHORS   Brandt,C.S., Baratin,M., Yi,E.C., Kennedy,J., Gao,Z., Fox,B.,
            Haldeman,B., Ostrander,C.D., Kaifu,T., Chabannon,C., Moretta,A.,
            West,R., Xu,W., Vivier,E. and Levin,S.D.
  TITLE     The B7 family member B7-H6 is a tumor cell ligand for the
            activating natural killer cell receptor NKp30 in humans
  JOURNAL   J Exp Med 206 (7), 1495-1503 (2009)
   PUBMED   19528259
  REMARK    GeneRIF: DKFZp686O24166 was designated the gene B7-H6;
            identification as a tumor cell surface molecule that binds NKp30, a
            receptor which triggers antitumor NK cell cytotoxicity and cytokine
            secretion
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124798.5 and KC877395.1.
            
            On May 17, 2019 this sequence version replaced NM_001202439.2.
            
            Summary: B7H6 belongs to the B7 family (see MIM 605402) and is
            selectively expressed on tumor cells. Interaction of B7H6 with
            NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell
            activation and cytotoxicity (Brandt et al., 2009 [PubMed
            19528259]).[supplied by OMIM, Jan 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537685.1, CR749521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338965.9/ ENSP00000341637.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC124798.5         1657-1896
            241-591             AC124798.5         6508-6858
            592-930             AC124798.5         16866-17204
            931-1028            AC124798.5         18724-18821
            1029-3358           AC124798.5         21863-24192
            3359-3868           KC877395.1         1-510               c
            3869-6364           AC124798.5         24703-27198
FEATURES             Location/Qualifiers
     source          1..6364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..6364
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
                     /note="natural killer cell cytotoxicity receptor 3 ligand
                     1"
                     /db_xref="GeneID:374383"
                     /db_xref="HGNC:HGNC:42400"
                     /db_xref="MIM:613714"
     exon            1..240
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1535
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
                     /note="putative Ig-like domain-containing protein
                     DKFZp686O24166/DKFZp686I21167; B7 homolog 6; natural
                     cytotoxicity triggering receptor 3 ligand 1"
                     /codon_start=1
                     /product="natural cytotoxicity triggering receptor 3
                     ligand 1 precursor"
                     /protein_id="NP_001189368.1"
                     /db_xref="CCDS:CCDS55748.1"
                     /db_xref="GeneID:374383"
                     /db_xref="HGNC:HGNC:42400"
                     /db_xref="MIM:613714"
                     /translation="MTWRAAASTCAALLILLWALTTEGDLKVEMMAGGTQITPLNDNV
                     TIFCNIFYSQPLNITSMGITWFWKSLTFDKEVKVFEFFGDHQEAFRPGAIVSPWRLKS
                     GDASLRLPGIQLEEAGEYRCEVVVTPLKAQGTVQLEVVASPASRLLLDQVGMKENEDK
                     YMCESSGFYPEAINITWEKQTQKFPHPIEISEDVITGPTIKNMDGTFNVTSCLKLNSS
                     QEDPGTVYQCVVRHASLHTPLRSNFTLTAARHSLSETEKTDNFSIHWWPISFIGVGLV
                     LLIVLIPWKKICNKSSSAYTPLKCILKHWNSFDTQTLKKEHLIFFCTRAWPSYQLQDG
                     EAWPPEGSVNINTIQQLDVFCRQEGKWSEVPYVQAFFALRDNPDLCQCCRIDPALLTV
                     TSGKSIDDNSTKSEKQTPREHSDAVPDAPILPVSPIWEPPPATTSTTPVLSSQPPTLL
                     LPLQ"
     exon            241..591
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
                     /inference="alignment:Splign:2.1.0"
     exon            592..930
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1028
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..6364
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1664
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
                     /note="major polyA site"
     regulatory      5210..5215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
                     /note="hexamer: AATAAA"
     polyA_site      5229
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
     regulatory      5606..5611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
                     /note="hexamer: ATTAAA"
     polyA_site      5633
                     /gene="NCR3LG1"
                     /gene_synonym="B7-H6; B7H6; DKFZp686O24166"
ORIGIN      
        1 gcagttgccg aagggatctg aagaagtggg atgtgcaaaa gcgccggctg gaaatcccgg
       61 ctgtgtctcc gtcaactctt tacgcaacag aggtctcccc ctgcccttgg tttctaccgg
      121 gccgcctgct cccactcggc gaaaaaaatt acacaacagc agccgcggcg atgacgtgga
      181 gggctgccgc ctccacgtgc gcggcgctcc tgattctgct gtgggcgctg acgaccgaag
      241 gtgatctgaa agtagagatg atggcagggg ggactcagat cacacccctg aatgacaatg
      301 tcaccatatt ctgcaatatc ttttattccc aacccctcaa catcacgtct atgggtatca
      361 cctggttttg gaagagtctg acgtttgaca aagaagtcaa agtctttgaa ttttttggag
      421 atcaccaaga ggcattccga cctggagcca ttgtgtctcc atggaggctg aagagtgggg
      481 acgcctcact gcggctgcct ggaatccagc tggaggaagc aggagagtac cgatgtgagg
      541 tggtggtcac ccctctgaag gcacagggaa cagtccagct tgaagttgtg gcttccccag
      601 ccagcagatt gttgctggat caagtgggca tgaaagagaa tgaagacaaa tatatgtgtg
      661 agtcaagtgg gttctaccca gaggctatta atataacatg ggagaagcag acccagaagt
      721 ttccccatcc catagagatt tctgaggatg tcatcactgg tcccaccatc aagaatatgg
      781 atggcacatt taatgtcact agctgcttga agctgaactc ctctcaggaa gaccctggga
      841 ctgtctacca gtgtgtggta cggcatgcgt ccttgcatac ccccttgagg agcaacttta
      901 ccctgactgc tgctcggcac agtctttctg aaactgagaa gacagataat ttttccattc
      961 attggtggcc tatttcattc attggtgttg gactggtttt attaattgtt ttgattcctt
     1021 ggaaaaagat atgtaacaaa tcatcttcag cctatactcc tctcaagtgc attctgaaac
     1081 actggaactc ctttgacact cagactctga agaaagagca cctcatattc ttttgcactc
     1141 gggcatggcc gtcttaccag ctgcaggatg gggaggcttg gcctcctgag ggaagtgtta
     1201 atattaatac tattcaacaa ctagatgttt tctgcagaca ggagggcaaa tggtccgagg
     1261 ttccttatgt gcaagccttc tttgccttgc gagacaaccc agatctttgt cagtgttgta
     1321 gaattgaccc tgctctccta acagttacat caggcaagtc catagatgat aattccacaa
     1381 agtctgagaa acaaacccct agggaacact cggatgcagt tccggatgcc ccaatccttc
     1441 ctgtctcccc tatctgggaa cctcctccag ccacaacatc aacaactcca gttctatcct
     1501 cccaaccccc aactttactg ttacccctac agtaaatgcc tgatggacct ggtgccacta
     1561 gggtccaagt tcccttttca ttacaggacc ttgggcaaat aagaggggac ctgggcaagt
     1621 tctctgatga cctgatagat atatagaggc tttccaaaac ctaactcagg tgtttgacct
     1681 tacttggggt gatgttatgt tgctcttaaa ctcttaacta ctacagagaa acaggtagcc
     1741 ctgcaggcag cagaaaaatt cagagatgaa caacatgtct tctatagcca ctcaataagg
     1801 aaagaaggtg agaaacaacc agcattcaca tacccaatag gaagcgaggc agtgcccctt
     1861 gaacaacata attcggaccc cagtggtacc ttagatgagt ggcaaagaaa acattttcaa
     1921 atgtgcttat tagagggcct acagaggacc agagccaagc ctcttaatta ccccaaactc
     1981 tccatgatag atcaaaaact agatgaaaat ccctcagcct ttttggaaag gctgagagag
     2041 gctgtagtga aacacacttc cttgtctcct gttaggtatg tttatacctc acataaataa
     2101 ttcaattgag ggacagctaa ttttgaaaga caagtttatt actcagacag cccctgatat
     2161 cagaaggaag ctagagaaac aggccatggg attagatagc accttacaaa acctcctgaa
     2221 ggtagccacc tcggtctttt ataataggga ccaggaggag gcccagggga aggagaggaa
     2281 acacaagaaa aaggcagaga ctctggtggc cactttgtat aaaacccagt atccccaagg
     2341 tacacctgct agttgctacc aatgtggcaa actagggcac ttcaaaaggg actgcccagg
     2401 cagcaagaag aagccacctc aaccctgtcc agtatacaat ggggaccact ggaaggcaga
     2461 ctgtcctggg aagcataggt cactgagtcc agagccagtc tcacaaatgg tccagcagga
     2521 ctgatgggtc ctggggctca actccctggc tccagtggct cagactgctg ttactacccg
     2581 ggagcaccag gtgattctgg agttcgaagg gaggaaggta gacttctttc tggacactgg
     2641 agccaggctt ctgttttcct ctccaattca ggccttcgtt cctcccatag cacaaccatg
     2701 atgggcatct caggaaagac tttaacttga tatttttctc aacctattag ttgcagtcag
     2761 agggacctac tgtttacaca ggccttttta gtcatgcctg aaagtcccac tcctttatta
     2821 gatagagata ttccagcacg tatgggggcc accatcctta tggctccagg acaaactccg
     2881 cctcccctta gtggaaacca gtattaaccc agaggtttgg gcaactcagg gaagaagtgg
     2941 ccggactata accactatac cagtctggat ccacctcaag gatcccactt tttttcctaa
     3001 ccagagacaa taccctctga agccagaaag tagaaaaggg ctagacgcca gcattgataa
     3061 cctaaaggca caaggcctcc ttaggccttg cagtagccct tgaaacaccc caatattagg
     3121 ggtgcaaaaa tccaatgggg aagggagact agttcaggac ctctgcctta ttcatgaggc
     3181 tgtgattacg attcatccag tagatcccag tccctatact ttgctaactc aaatatccaa
     3241 gggaactaaa tggttcacag ttctgggcct aaaggatgcc tttttctgta tacctttata
     3301 ccctgactcc caatacttgt ttacctttga agacccctcc aatcaaacca cccagttaac
     3361 ctggactgta ctgcctcagg gatttagaga tagcccccac ctatttgggc aagtattgtc
     3421 aagagatctc ttcgaattct tccattctca ggttaaagtt ttacaatatg tagatgacat
     3481 tctcctctgt gccccaactg aggaagtttc ttgagacggc actgaggctc tccttaattt
     3541 cctagctgga aagggatata aggcttcaaa atctaaggct cagctctatc agactttggt
     3601 aaagtaccta ggtctggtct tgtcagaagg gaacaagagc actaggcgag gagaggatta
     3661 atcccatttc ctcccttcct ctccccagaa ccctcaagca gctgagggat gcttgggcat
     3721 tacaggtttt tgtaggttat agatacccag gtatgataaa ataggttgcc ctttatatca
     3781 ccttataaaa gaaattcaag tggctaaaac tcacttcctg acctgggaac ctgaaggtca
     3841 aaaggccatt aatcagttaa aacaagcctt gcttaaagca ccagccccca gtctttctgt
     3901 agggaagtcc tttaatcttt atgtatcata aaggaaagga atgaccctgg gagttttaat
     3961 tcaagttcaa ggcccagctc aacagccagt aggttactta agtagagagc ttgacttgga
     4021 ggctaaagga tggccagctt gcctctgagc agttacagta gtggccctgc tagtcccaga
     4081 ggccaccaag ttaaccctgg ggaataacct gtttatgcct cacataaata atgtggcagg
     4141 cttgctgtcc tctaaagcga gtctctggct aacagacagc tgcctcctca agtatcagac
     4201 tttgctgcta gaggaatctg cagtccagtt aaaaacctga ccttgcctga tcccagacac
     4261 tttcctccca gaggaaactg gagaaactga acataattgt gaacagactg tagtacaacc
     4321 tatgccgcta gggaggatct caaagaaatt cccctagaaa atccagactg gacccacttt
     4381 atggatggga gctcttttgt aggacaggga gtctgaaaag tgggatatgc agtagtcacc
     4441 ctaaataaca ttgaaaatgt gcctctctca ccaggcacac acactcaatc agttgagctg
     4501 atccctctca caagagcact tgaactaagc aaaggaaaga cagctaacat ttatactgac
     4561 tccaagtgta cctttctagt tctccttgcc catgctgcca tctgaaagga aaggcacttc
     4621 ctcaccgcta atgggtcttg cattaaatac catcaagaca tcaacaggct attatcctca
     4681 gtgttcctcc catgagaatt agtggtcaga cattgcagag ggcatcagaa gcgggtagat
     4741 gaaatagcga aaggaaacag gctagcagac caaagagcta agtcagcagt aagaaggccc
     4801 caaggtccca aaacacttga ggcccctctg atttgggagg gctacataag ggaaataaag
     4861 cctcagtatt cccctacaga gatagaatgg gccacctctc gaggtatact tttcaaccct
     4921 caggatggtt acaatcagaa gattgcaaag tacgcttgcc agcctccagc caatggaaga
     4981 ttcttaaaat cctccactga gcctttcact taggaaagca taagacatca gtgcatccaa
     5041 agattgttct caggagaaaa tctactaaaa atggtcaaat aggttgttaa tactcgtgaa
     5101 accctcttaa aaataatccc tttaacagat gacttcttcc ccaccacaat caaaggatgg
     5161 gaagttactc aggggaggac tggcagatag acttcaccca tatgcccaaa ataaatggca
     5221 ttcaatgtct tttggtgtgg gtgcatacct tcattaactg ggtagaggca ttcccatgcc
     5281 caacagaaaa ggcctctgag gtggtgagaa tactaattag ttaaataatt cctcactttg
     5341 ggctccctaa gtacttccaa aacaacaatg gtccctcatt taaagaagcc tctacccagt
     5401 agggccgagt ctgctaggac tttttattgg gtttggtaat acgtcacacc ctttagcctc
     5461 tactgtgtca gccatgtccc atttatacaa gacaaattgc tgggtctgtc ctgagcggtt
     5521 tgctcagttc agtaacacta aggaacctct tgatgacttg gtatttactg tcttagcatt
     5581 ccctttgtta gctttacctt tagccattaa agacttgtca ggcataaatg gaacatggta
     5641 tgggaacact ttcaactgag taactaactc ctcccaggaa agcatttcct ccctggtgcc
     5701 agaaaacact ttccccaaag ataagcctca caccctcagg ctaggaaaag ttggccgggt
     5761 aatagcaaat gcctcctcct gttttaaaag cagaggaaaa ggaccatacc tgggagatct
     5821 caaatattat aacaccatac ttgtaattgc tgaaagctcg gaagtttgga gaaaaagaca
     5881 taagaaggat gatctaagaa aattggaagc catatggagg ggaggctttc agaattcagc
     5941 gtctcctcct ggttgaaagt cctgctggga atggcaggct ctgggtaacc accctgacac
     6001 atggcactat aatgtaaaaa acaacacata ggccttccca gacatgcacc ctcatgggat
     6061 tccagacccc ctgtatgatg cttagtagta gtggcctaca aatctgtggg tgaacagaac
     6121 aggagacttc tggactgaca gcccctgtca caagggggca ttatctgaga tattggccag
     6181 ggcatatcgt gtccctggtc ttttgaaact ccatttgtcg gccaggtgtg gtggcttacg
     6241 actgtaatcc cagcactttg ggaggctgag gcaggtagat gatgaggtca ggagttcaag
     6301 actagcctgg acaatatggt gaaaccccgt ctgtactaat aatacaaaaa aaaaaaaaaa
     6361 aaaa
//
