LOCUS       NM_147130               1063 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens natural cytotoxicity triggering receptor 3 (NCR3),
            transcript variant 1, mRNA.
ACCESSION   NM_147130
VERSION     NM_147130.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1063)
  AUTHORS   Wang,X., Huang,L., Wen,X., Li,D., Yang,G. and Zheng,J.
  TITLE     Altered NCR3 Splice Variants May Result in Deficient NK Cell
            Function in Renal Cell Carcinoma Patients
  JOURNAL   In Vivo 38 (1), 174-183 (2024)
   PUBMED   38148073
  REMARK    GeneRIF: Altered NCR3 Splice Variants May Result in Deficient NK
            Cell Function in Renal Cell Carcinoma Patients.
REFERENCE   2  (bases 1 to 1063)
  AUTHORS   Onyango,C.O., Cheng,Q., Munde,E.O., Raballah,E., Anyona,S.B.,
            McMahon,B.H., Lambert,C.G., Onyango,P.O., Schneider,K.A.,
            Perkins,D.J. and Ouma,C.
  TITLE     Human NCR3 gene variants rs2736191 and rs11575837 alter
            longitudinal risk for development of pediatric malaria episodes and
            severe malarial anemia
  JOURNAL   BMC Genomics 24 (1), 542 (2023)
   PUBMED   37704951
  REMARK    GeneRIF: Human NCR3 gene variants rs2736191 and rs11575837 alter
            longitudinal risk for development of pediatric malaria episodes and
            severe malarial anemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1063)
  AUTHORS   Klausz,K., Pekar,L., Boje,A.S., Gehlert,C.L., Krohn,S., Gupta,T.,
            Xiao,Y., Krah,S., Zaynagetdinov,R., Lipinski,B., Toleikis,L.,
            Poetzsch,S., Rabinovich,B., Peipp,M. and Zielonka,S.
  TITLE     Multifunctional NK Cell-Engaging Antibodies Targeting EGFR and
            NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory
            Cytokine Release
  JOURNAL   J Immunol 209 (9), 1724-1735 (2022)
   PUBMED   36104113
  REMARK    GeneRIF: Multifunctional NK Cell-Engaging Antibodies Targeting EGFR
            and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory
            Cytokine Release.
REFERENCE   4  (bases 1 to 1063)
  AUTHORS   Ponath,V., Hoffmann,N., Bergmann,L., Mader,C., Alashkar Alhamwe,B.,
            Preusser,C. and Pogge von Strandmann,E.
  TITLE     Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in
            Contrast to BAG6 Only Marginally Released via Extracellular
            Vesicles
  JOURNAL   Int J Mol Sci 22 (4), 2189 (2021)
   PUBMED   33671836
  REMARK    GeneRIF: Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is
            in Contrast to BAG6 Only Marginally Released via Extracellular
            Vesicles.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1063)
  AUTHORS   Djeu,J.Y., Jiang,K. and Wei,S.
  TITLE     A view to a kill: signals triggering cytotoxicity
  JOURNAL   Clin Cancer Res 8 (3), 636-640 (2002)
   PUBMED   11895890
  REMARK    Review article
REFERENCE   6  (bases 1 to 1063)
  AUTHORS   Sato,M., Ohashi,J., Tsuchiya,N., Tadokoro,K., Juji,T., Hanaoka,K.,
            Tokunaga,K. and Yabe,T.
  TITLE     Identification of novel single nucleotide substitutions in the
            NKp30 gene expressed in human natural killer cells
  JOURNAL   Tissue Antigens 58 (4), 255-258 (2001)
   PUBMED   11782277
REFERENCE   7  (bases 1 to 1063)
  AUTHORS   Sivakamasundari,R., Raghunathan,A., Zhang,C.Y., Chowdhury,R.R. and
            Weissman,S.M.
  TITLE     Expression and cellular localization of the protein encoded by the
            1C7 gene: a recently described component of the MHC
  JOURNAL   Immunogenetics 51 (8-9), 723-732 (2000)
   PUBMED   10941844
REFERENCE   8  (bases 1 to 1063)
  AUTHORS   Pende,D., Parolini,S., Pessino,A., Sivori,S., Augugliaro,R.,
            Morelli,L., Marcenaro,E., Accame,L., Malaspina,A., Biassoni,R.,
            Bottino,C., Moretta,L. and Moretta,A.
  TITLE     Identification and molecular characterization of NKp30, a novel
            triggering receptor involved in natural cytotoxicity mediated by
            human natural killer cells
  JOURNAL   J Exp Med 190 (10), 1505-1516 (1999)
   PUBMED   10562324
REFERENCE   9  (bases 1 to 1063)
  AUTHORS   Neville,M.J. and Campbell,R.D.
  TITLE     A new member of the Ig superfamily and a V-ATPase G subunit are
            among the predicted products of novel genes close to the TNF locus
            in the human MHC
  JOURNAL   J Immunol 162 (8), 4745-4754 (1999)
   PUBMED   10202016
REFERENCE   10 (bases 1 to 1063)
  AUTHORS   Nalabolu,S.R., Shukla,H., Nallur,G., Parimoo,S. and Weissman,S.M.
  TITLE     Genes in a 220-kb region spanning the TNF cluster in human MHC
  JOURNAL   Genomics 31 (2), 215-222 (1996)
   PUBMED   8824804
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662801.7, AF031137.1 and
            BC052582.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_147130.2.
            
            Summary: The protein encoded by this gene is a natural cytotoxicity
            receptor (NCR) that may aid NK cells in the lysis of tumor cells.
            The encoded protein interacts with CD3-zeta (CD247), a T-cell
            receptor. A single nucleotide polymorphism in the 5' untranslated
            region of this gene has been associated with mild malaria
            suceptibility. Three transcript variants encoding different
            isoforms have been found for this gene.[provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031137.1, SRR1163658.10119.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340027.10/ ENSP00000342156.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL662801.7         65657-65677         c
            22-77               AF031137.1         1-56
            78-1063             BC052582.1         1-986
FEATURES             Location/Qualifiers
     source          1..1063
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1063
                     /gene="NCR3"
                     /gene_synonym="1C7; CD337; LY117; MALS; NKp30"
                     /note="natural cytotoxicity triggering receptor 3"
                     /db_xref="GeneID:259197"
                     /db_xref="HGNC:HGNC:19077"
                     /db_xref="MIM:611550"
     exon            1..328
                     /gene="NCR3"
                     /gene_synonym="1C7; CD337; LY117; MALS; NKp30"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..891
                     /gene="NCR3"
                     /gene_synonym="1C7; CD337; LY117; MALS; NKp30"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; lymphocyte antigen 117; activating NK-A1
                     receptor; activating natural killer receptor p30; natural
                     killer cell p30-related protein; NK-p30"
                     /codon_start=1
                     /product="natural cytotoxicity triggering receptor 3
                     isoform a precursor"
                     /protein_id="NP_667341.1"
                     /db_xref="CCDS:CCDS34397.1"
                     /db_xref="GeneID:259197"
                     /db_xref="HGNC:HGNC:19077"
                     /db_xref="MIM:611550"
                     /translation="MAWMLLLILIMVHPGSCALWVSQPPEIRTLEGSSAFLPCSFNAS
                     QGRLAIGSVTWFRDEVVPGKEVRNGTPEFRGRLAPLASSRFLHDHQAELHIRDVRGHD
                     ASIYVCRVEVLGLGVGTGNGTRLVVEKEHPQLGAGTVLLLRAGFYAVSFLSVAVGSTV
                     YYQGKCLTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG"
     exon            329..673
                     /gene="NCR3"
                     /gene_synonym="1C7; CD337; LY117; MALS; NKp30"
                     /inference="alignment:Splign:2.1.0"
     exon            674..781
                     /gene="NCR3"
                     /gene_synonym="1C7; CD337; LY117; MALS; NKp30"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1063
                     /gene="NCR3"
                     /gene_synonym="1C7; CD337; LY117; MALS; NKp30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1024..1029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCR3"
                     /gene_synonym="1C7; CD337; LY117; MALS; NKp30"
                     /note="hexamer: AATAAA"
     polyA_site      1063
                     /gene="NCR3"
                     /gene_synonym="1C7; CD337; LY117; MALS; NKp30"
                     /note="major polyA site"
ORIGIN      
        1 ctcacacgct tagctagcct gccacaagct ggccccttgg cctcctagag accctgacat
       61 ctcctccagc agcatctgtc ctctctcctc agggaggcaa gcatttgatg ctcgaggtcc
      121 ctggcagttg tggtccttgg caagtgatgt gtgagtcccg tgtgtcatag gaagctcccc
      181 atccccatct ggtgaccaaa ggcctggcta caagtagtga gtccttcctc ctccacccag
      241 acctcactgc tcagatcccc ttcgccaact gggacatctt ccgacatggc ctggatgctg
      301 ttgctcatct tgatcatggt ccatccagga tcctgtgctc tctgggtgtc ccagccccct
      361 gagattcgta ccctggaagg atcctctgcc ttcctgccct gctccttcaa tgccagccaa
      421 gggagactgg ccattggctc cgtcacgtgg ttccgagatg aggtggttcc agggaaggag
      481 gtgaggaatg gaaccccaga gttcaggggc cgcctggccc cacttgcttc ttcccgtttc
      541 ctccatgacc accaggctga gctgcacatc cgggacgtgc gaggccatga cgccagcatc
      601 tacgtgtgca gagtggaggt gctgggcctt ggtgtcggga cagggaatgg gactcggctg
      661 gtggtggaga aagaacatcc tcagctaggg gctggtacag tcctcctcct tcgggctgga
      721 ttctatgctg tcagctttct ctctgtggcc gtgggcagca ccgtctatta ccagggcaaa
      781 tgtctgacct ggaaaggtcc aagaaggcag ctgccggctg tggtcccagc gcccctccca
      841 ccaccatgtg ggagctcagc acatctgctt cccccagtcc caggaggctg agcctgattg
      901 tcctgagaaa tgggaaggat cagatatgac tcctccttgg caactgccct ttcctgccag
      961 gcccacacat accctcttct ggctgttagg ggagcttggg tccctgaaca ctgtcattca
     1021 cccaataaat tactatttga ccccagagtg ggtggaaggg tga
//
