LOCUS       NM_004828               1125 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens natural cytotoxicity triggering receptor 2 (NCR2),
            transcript variant 1, mRNA.
ACCESSION   NM_004828
VERSION     NM_004828.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1125)
  AUTHORS   Padoan,B., Casar,C., Krause,J., Schultheiss,C., Baumdick,M.E.,
            Niehrs,A., Zecher,B.F., Pujantell,M., Yuki,Y., Martin,M.,
            Remmerswaal,E.B.M., Dekker,T., van der Bom-Baylon,N.D., Noble,J.A.,
            Carrington,M., Bemelman,F.J., van Lier,R.A.W., Binder,M.,
            Gagliani,N., Bunders,M.J. and Altfeld,M.
  TITLE     NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK
            cells
  JOURNAL   Cell Rep 43 (4), 114089 (2024)
   PUBMED   38615318
  REMARK    GeneRIF: NKp44/HLA-DP-dependent regulation of CD8 effector T cells
            by NK cells.
REFERENCE   2  (bases 1 to 1125)
  AUTHORS   Ikeda,A., Ogino,T., Kayama,H., Okuzaki,D., Nishimura,J., Fujino,S.,
            Miyoshi,N., Takahashi,H., Uemura,M., Matsuda,C., Yamamoto,H.,
            Takeda,K., Mizushima,T., Mori,M. and Doki,Y.
  TITLE     Human NKp44+ Group 3 Innate Lymphoid Cells Associate with
            Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer
  JOURNAL   Cancer Immunol Res 8 (6), 724-731 (2020)
   PUBMED   32229590
  REMARK    GeneRIF: Human NKp44(+) Group 3 Innate Lymphoid Cells Associate
            with Tumor-Associated Tertiary Lymphoid Structures in Colorectal
            Cancer.
REFERENCE   3  (bases 1 to 1125)
  AUTHORS   McQuaid,S.L., Loughran,S.T., Power,P.A., Maguire,P., Szczygiel,A.
            and Johnson,P.A.
  TITLE     Low-dose IL-2 induces CD56bright NK regulation of T cells via NKp44
            and NKp46
  JOURNAL   Clin Exp Immunol 200 (3), 228-241 (2020)
   PUBMED   31989589
  REMARK    GeneRIF: Low-dose IL-2 induces CD56(bright) NK regulation of T
            cells via NKp44 and NKp46.
REFERENCE   4  (bases 1 to 1125)
  AUTHORS   Barrow,A.D., Martin,C.J. and Colonna,M.
  TITLE     The Natural Cytotoxicity Receptors in Health and Disease
  JOURNAL   Front Immunol 10, 909 (2019)
   PUBMED   31134055
  REMARK    GeneRIF: The Natural Cytotoxicity Receptors in Health and Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1125)
  AUTHORS   Parodi,M., Favoreel,H., Candiano,G., Gaggero,S., Sivori,S.,
            Mingari,M.C., Moretta,L., Vitale,M. and Cantoni,C.
  TITLE     NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer
            Cells and Other Innate Lymphoid Cells in Humans
  JOURNAL   Front Immunol 10, 719 (2019)
   PUBMED   31024551
  REMARK    GeneRIF: NKp44-NKp44 Ligand Interactions in the Regulation of
            Natural Killer Cells and Other Innate Lymphoid Cells in Humans.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1125)
  AUTHORS   Augugliaro,R., Parolini,S., Castriconi,R., Marcenaro,E.,
            Cantoni,C., Nanni,M., Moretta,L., Moretta,A. and Bottino,C.
  TITLE     Selective cross-talk among natural cytotoxicity receptors in human
            natural killer cells
  JOURNAL   Eur J Immunol 33 (5), 1235-1241 (2003)
   PUBMED   12731048
  REMARK    GeneRIF: Selective cross-talk among natural cytotoxicity receptors
            (NKp46, NKp30 and NKp44) in human natural killer cells.
REFERENCE   7  (bases 1 to 1125)
  AUTHORS   Eapen,B.R.
  TITLE     A new insight into the pathogenesis of Reiter's syndrome using
            bioinformatics tools
  JOURNAL   Int J Dermatol 42 (3), 242-243 (2003)
   PUBMED   12653925
  REMARK    GeneRIF: homology of the gene on chromosome 6, close to MHC class I
            loci to the most common bacterium in postdiarrheal Reiter's
            syndrome may be significan
REFERENCE   8  (bases 1 to 1125)
  AUTHORS   Allcock,R.J., Barrow,A.D., Forbes,S., Beck,S. and Trowsdale,J.
  TITLE     The human TREM gene cluster at 6p21.1 encodes both activating and
            inhibitory single IgV domain receptors and includes NKp44
  JOURNAL   Eur J Immunol 33 (2), 567-577 (2003)
   PUBMED   12645956
  REMARK    GeneRIF: The human TREM gene cluster at 6p21.1 encodes both
            activating and inhibitory single IgV domain receptors and includes
            NKp44.
REFERENCE   9  (bases 1 to 1125)
  AUTHORS   Cantoni,C., Ponassi,M., Biassoni,R., Conte,R., Spallarossa,A.,
            Moretta,A., Moretta,L., Bolognesi,M. and Bordo,D.
  TITLE     Crystallization and preliminary crystallographic characterization
            of the extracellular Ig-like domain of human natural killer cell
            activating receptor NKp44
  JOURNAL   Acta Crystallogr D Biol Crystallogr 58 (Pt 10 Pt 2), 1843-1845
            (2002)
   PUBMED   12351833
  REMARK    GeneRIF: crystallization and preliminary crystallographic
            characterization of the extracellular Ig-like domain of human
            natural killer cell activating receptor
REFERENCE   10 (bases 1 to 1125)
  AUTHORS   Cantoni,C., Bottino,C., Vitale,M., Pessino,A., Augugliaro,R.,
            Malaspina,A., Parolini,S., Moretta,L., Moretta,A. and Biassoni,R.
  TITLE     NKp44, a triggering receptor involved in tumor cell lysis by
            activated human natural killer cells, is a novel member of the
            immunoglobulin superfamily
  JOURNAL   J Exp Med 189 (5), 787-796 (1999)
   PUBMED   10049942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136967.5.
            
            On Nov 23, 2018 this sequence version replaced NM_004828.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1968540
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000373089.10/
                                                ENSP00000362181.5
            RefSeq Select criteria           :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AL136967.5         22343-22663
            322-663             AL136967.5         22822-23163
            664-799             AL136967.5         28529-28664
            800-913             AL136967.5         28771-28884
            914-1125            AL136967.5         37413-37624
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1125
                     /gene="NCR2"
                     /gene_synonym="CD336; dJ149M18.1; LY95; NK-p44; NKP44"
                     /note="natural cytotoxicity triggering receptor 2"
                     /db_xref="GeneID:9436"
                     /db_xref="HGNC:HGNC:6732"
                     /db_xref="MIM:604531"
     exon            1..321
                     /gene="NCR2"
                     /gene_synonym="CD336; dJ149M18.1; LY95; NK-p44; NKP44"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1100
                     /gene="NCR2"
                     /gene_synonym="CD336; dJ149M18.1; LY95; NK-p44; NKP44"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lymphocyte antigen 95 homolog (activating
                     NK-receptor; NK-p44); lymphocyte antigen 95 (activating
                     NK-receptor; NK-p44); NK cell activating receptor (NKp44);
                     NK cell-activating receptor; natural killer cell
                     p44-related protein"
                     /codon_start=1
                     /product="natural cytotoxicity triggering receptor 2
                     isoform 1 precursor"
                     /protein_id="NP_004819.2"
                     /db_xref="CCDS:CCDS4855.1"
                     /db_xref="GeneID:9436"
                     /db_xref="HGNC:HGNC:6732"
                     /db_xref="MIM:604531"
                     /translation="MAWRALHPLLLLLLLFPGSQAQSKAQVLQSVAGQTLTVRCQYPP
                     TGSLYEKKGWCKEASALVCIRLVTSSKPRTMAWTSRFTIWDDPDAGFFTVTMTDLREE
                     DSGHYWCRIYRPSDNSVSKSVRFYLVVSPASASTQTSWTPRDLVSSQTQTQSCVPPTA
                     GARQAPESPSTIPVPSQPQNSTLRPGPAAPIALVPVFCGLLVAKSLVLSALLVWWGDI
                     WWKTMMELRSLDTQKATCHLQQVTDLPWTSVSSPVEREILYHTVARTKISDDDDEHTL
                     "
     exon            322..663
                     /gene="NCR2"
                     /gene_synonym="CD336; dJ149M18.1; LY95; NK-p44; NKP44"
                     /inference="alignment:Splign:2.1.0"
     exon            664..799
                     /gene="NCR2"
                     /gene_synonym="CD336; dJ149M18.1; LY95; NK-p44; NKP44"
                     /inference="alignment:Splign:2.1.0"
     exon            800..913
                     /gene="NCR2"
                     /gene_synonym="CD336; dJ149M18.1; LY95; NK-p44; NKP44"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1125
                     /gene="NCR2"
                     /gene_synonym="CD336; dJ149M18.1; LY95; NK-p44; NKP44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1103..1108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCR2"
                     /gene_synonym="CD336; dJ149M18.1; LY95; NK-p44; NKP44"
                     /note="hexamer: AATAAA"
     polyA_site      1125
                     /gene="NCR2"
                     /gene_synonym="CD336; dJ149M18.1; LY95; NK-p44; NKP44"
                     /note="major polyA site"
ORIGIN      
        1 aggcatcttc tacagaggcc tgggaagctg tgtgccagac agcgccgagc ccaccagacc
       61 cagactcacc tacagctgga gatccccact tccctgtgcc cacagaatct gccctttgca
      121 gtctcccatc tccccaaccc aggcctcagc ctgtctcatt tttctatcag acgtgctgga
      181 agagcagcag aatcaggccc agctcccaat tccctctccc cagtcttctc caggtgtccc
      241 ctcccatgag cgcacaggaa aaggaccaca tggcctggcg agccctacac ccactgctac
      301 tgctgctgct gctgttccca ggctctcagg cacaatccaa ggctcaggta cttcaaagtg
      361 tggcagggca gacgctaacc gtgagatgcc agtacccgcc cacgggcagt ctctacgaga
      421 agaaaggctg gtgtaaggag gcttcagcac ttgtgtgcat caggttagtc accagctcca
      481 agcccaggac gatggcttgg acctctcgat tcacaatctg ggacgaccct gatgctggct
      541 tcttcactgt caccatgact gatctgagag aggaagactc aggacattac tggtgtagaa
      601 tctaccgccc ttctgacaac tctgtctcta agtccgtcag attctatctg gtggtatctc
      661 cagcctctgc ctccacacag acctcctgga ctccccgcga cctggtctct tcacagaccc
      721 agacccagag ctgtgtgcct cccactgcag gagccagaca agcccctgag tctccatcta
      781 ccatccctgt cccttcacag ccacagaact ccacgctccg ccctggccct gcagccccca
      841 ttgccctggt gcctgtgttc tgtggactcc tcgtagccaa gagcctggtg ctgtcagccc
      901 tgctcgtctg gtggggggac atatggtgga aaaccatgat ggagctcagg agcctggata
      961 cccaaaaagc cacctgccac cttcaacagg tcacggacct tccctggacc tcagtttcct
     1021 cacctgtaga gagagaaata ttatatcaca ctgttgcaag gactaagata agcgatgatg
     1081 atgatgaaca cactttgtga ataataaaat tatctgaatg tttta
//
