LOCUS       NM_004829               1157 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens natural cytotoxicity triggering receptor 1 (NCR1),
            transcript variant 1, mRNA.
ACCESSION   NM_004829
VERSION     NM_004829.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1157)
  AUTHORS   Biniaris-Georgallis,S.I., Aschman,T., Stergioula,K., Schreiber,F.,
            Jafari,V., Taranko,A., Karmalkar,T., Kasapi,A., Lenac Rovis,T.,
            Jelencic,V., Bejarano,D.A., Fabry,L., Papacharalampous,M.,
            Mattiola,I., Molgora,M., Hou,J., Hublitz,K.W., Heinrich,F.,
            Guerra,G.M., Durek,P., Patone,G., Lindberg,E.L., Maatz,H.,
            Holsken,O., Kronke,G., Mortha,A., Voll,R.E., Clarke,A.J.,
            Hauser,A.E., Colonna,M., Thurley,K., Schlitzer,A., Schneider,C.,
            Stamatiades,E.G., Mashreghi,M.F., Jonjic,S., Hubner,N.,
            Diefenbach,A., Kanda,M. and Triantafyllopoulou,A.
  TITLE     Amplification of autoimmune organ damage by NKp46-activated ILC1s
  JOURNAL   Nature 634 (8035), 952-960 (2024)
   PUBMED   39137897
  REMARK    GeneRIF: Amplification of autoimmune organ damage by
            NKp46-activated ILC1s.
REFERENCE   2  (bases 1 to 1157)
  AUTHORS   Sen Santara,S., Lee,D.J., Crespo,A., Hu,J.J., Walker,C., Ma,X.,
            Zhang,Y., Chowdhury,S., Meza-Sosa,K.F., Lewandrowski,M., Zhang,H.,
            Rowe,M., McClelland,A., Wu,H., Junqueira,C. and Lieberman,J.
  TITLE     The NK cell receptor NKp46 recognizes ecto-calreticulin on
            ER-stressed cells
  JOURNAL   Nature 616 (7956), 348-356 (2023)
   PUBMED   37020026
  REMARK    GeneRIF: The NK cell receptor NKp46 recognizes ecto-calreticulin on
            ER-stressed cells.
            Erratum:[Nature. 2023 Jun;618(7964):E17. doi:
            10.1038/s41586-023-06151-z.. PMID: 37198495]
REFERENCE   3  (bases 1 to 1157)
  AUTHORS   Mai,C., Fukui,A., Takeyama,R., Yamamoto,M., Saeki,S., Yamaya,A.,
            Kato,T., Ukita,Y., Wakimoto,Y. and Shibahara,H.
  TITLE     NK cells that differ in expression of NKp46 might play different
            roles in endometrium
  JOURNAL   J Reprod Immunol 147, 103367 (2021)
   PUBMED   34464905
  REMARK    GeneRIF: NK cells that differ in expression of NKp46 might play
            different roles in endometrium.
REFERENCE   4  (bases 1 to 1157)
  AUTHORS   Takeyama,R., Fukui,A., Mai,C., Yamamoto,M., Saeki,S., Yamaya,A. and
            Shibahara,H.
  TITLE     Co-expression of NKp46 with activating or inhibitory receptors on,
            and cytokine production by, uterine endometrial NK cells in
            recurrent pregnancy loss
  JOURNAL   J Reprod Immunol 145, 103324 (2021)
   PUBMED   33930666
  REMARK    GeneRIF: Co-expression of NKp46 with activating or inhibitory
            receptors on, and cytokine production by, uterine endometrial NK
            cells in recurrent pregnancy loss.
REFERENCE   5  (bases 1 to 1157)
  AUTHORS   Dons'koi,B.V., Osypchuk,D.V., Chernyshov,V.P. and Khazhylenko,K.G.
  TITLE     Expression of natural cytotoxicity receptor NKp46 on peripheral
            blood natural killer cells in women with a history of recurrent
            implantation failures
  JOURNAL   J Obstet Gynaecol Res 47 (3), 1009-1015 (2021)
   PUBMED   33368832
  REMARK    GeneRIF: Expression of natural cytotoxicity receptor NKp46 on
            peripheral blood natural killer cells in women with a history of
            recurrent implantation failures.
REFERENCE   6  (bases 1 to 1157)
  AUTHORS   Vankayalapati,R., Wizel,B., Weis,S.E., Safi,H., Lakey,D.L.,
            Mandelboim,O., Samten,B., Porgador,A. and Barnes,P.F.
  TITLE     The NKp46 receptor contributes to NK cell lysis of mononuclear
            phagocytes infected with an intracellular bacterium
  JOURNAL   J Immunol 168 (7), 3451-3457 (2002)
   PUBMED   11907104
  REMARK    GeneRIF: The NKp46 receptor participates in NK cell-mediated lysis
            of cells infected with the intracellular pathogen Mycobacterium
            tuberculosis, an activity that is reduced in tuberculosis patients
            compared with findings in healthy donors.
REFERENCE   7  (bases 1 to 1157)
  AUTHORS   Cantoni,C., Bottino,C., Vitale,M., Pessino,A., Augugliaro,R.,
            Malaspina,A., Parolini,S., Moretta,L., Moretta,A. and Biassoni,R.
  TITLE     NKp44, a triggering receptor involved in tumor cell lysis by
            activated human natural killer cells, is a novel member of the
            immunoglobulin superfamily
  JOURNAL   J Exp Med 189 (5), 787-796 (1999)
   PUBMED   10049942
REFERENCE   8  (bases 1 to 1157)
  AUTHORS   Pessino,A., Sivori,S., Bottino,C., Malaspina,A., Morelli,L.,
            Moretta,L., Biassoni,R. and Moretta,A.
  TITLE     Molecular cloning of NKp46: a novel member of the immunoglobulin
            superfamily involved in triggering of natural cytotoxicity
  JOURNAL   J Exp Med 188 (5), 953-960 (1998)
   PUBMED   9730896
REFERENCE   9  (bases 1 to 1157)
  AUTHORS   Vitale,M., Bottino,C., Sivori,S., Sanseverino,L., Castriconi,R.,
            Marcenaro,E., Augugliaro,R., Moretta,L. and Moretta,A.
  TITLE     NKp44, a novel triggering surface molecule specifically expressed
            by activated natural killer cells, is involved in non-major
            histocompatibility complex-restricted tumor cell lysis
  JOURNAL   J Exp Med 187 (12), 2065-2072 (1998)
   PUBMED   9625766
REFERENCE   10 (bases 1 to 1157)
  AUTHORS   Sivori,S., Vitale,M., Morelli,L., Sanseverino,L., Augugliaro,R.,
            Bottino,C., Moretta,L. and Moretta,A.
  TITLE     p46, a novel natural killer cell-specific surface molecule that
            mediates cell activation
  JOURNAL   J Exp Med 186 (7), 1129-1136 (1997)
   PUBMED   9314561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245128.3, AJ001383.1 and AC011476.8.
            
            On May 17, 2019 this sequence version replaced NM_004829.6.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2144333,
                              SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291890.9/ ENSP00000291890.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC245128.3         207772-207773
            3-20                AJ001383.1         1-18
            21-283              AJ001383.1         20-282
            284-284             AC245128.3         208320-208320
            285-592             AJ001383.1         284-591
            593-593             AC245128.3         211066-211066
            594-1155            AJ001383.1         593-1154
            1156-1157           AC011476.8         15818-15819
FEATURES             Location/Qualifiers
     source          1..1157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1157
                     /gene="NCR1"
                     /gene_synonym="CD335; LY94; NK-p46; NKP46"
                     /note="natural cytotoxicity triggering receptor 1"
                     /db_xref="GeneID:9437"
                     /db_xref="HGNC:HGNC:6731"
                     /db_xref="MIM:604530"
     exon            1..74
                     /gene="NCR1"
                     /gene_synonym="CD335; LY94; NK-p46; NKP46"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..955
                     /gene="NCR1"
                     /gene_synonym="CD335; LY94; NK-p46; NKP46"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; lymphocyte antigen 94 homolog (activating
                     NK-receptor; NK-p46); natural killer cell p46-related
                     protein; NK cell-activating receptor"
                     /codon_start=1
                     /product="natural cytotoxicity triggering receptor 1
                     isoform a precursor"
                     /protein_id="NP_004820.2"
                     /db_xref="CCDS:CCDS12911.1"
                     /db_xref="GeneID:9437"
                     /db_xref="HGNC:HGNC:6731"
                     /db_xref="MIM:604530"
                     /translation="MSSTLPALLCVGLCLSQRISAQQQTLPKPFIWAEPHFMVPKEKQ
                     VTICCQGNYGAVEYQLHFEGSLFAVDRPKPPERINKVQFYIPDMNSRMAGQYSCIYRV
                     GELWSEPSNLLDLVVTEMYDTPTLSVHPGPEVISGEKVTFYCRLDTATSMFLLLKEGR
                     SSHVQRGYGKVQAEFPLGPVTTAHRGTYRCFGSYNNHAWSFPSEPVKLLVTGDIENTS
                     LAPEDPTFPADTWGTYLLTTETGLQKDHALWDHTAQNLLRMGLAFLVLVALVWFLVED
                     WLSRKRTRERASRASTWEGRRRLNTQTL"
     exon            75..110
                     /gene="NCR1"
                     /gene_synonym="CD335; LY94; NK-p46; NKP46"
                     /inference="alignment:Splign:2.1.0"
     exon            111..395
                     /gene="NCR1"
                     /gene_synonym="CD335; LY94; NK-p46; NKP46"
                     /inference="alignment:Splign:2.1.0"
     exon            396..674
                     /gene="NCR1"
                     /gene_synonym="CD335; LY94; NK-p46; NKP46"
                     /inference="alignment:Splign:2.1.0"
     exon            675..722
                     /gene="NCR1"
                     /gene_synonym="CD335; LY94; NK-p46; NKP46"
                     /inference="alignment:Splign:2.1.0"
     exon            723..773
                     /gene="NCR1"
                     /gene_synonym="CD335; LY94; NK-p46; NKP46"
                     /inference="alignment:Splign:2.1.0"
     exon            774..1157
                     /gene="NCR1"
                     /gene_synonym="CD335; LY94; NK-p46; NKP46"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccccact gctcagcact aggccggcag aatctgagcg atgtcttcca cactccctgc
       61 cctgctctgc gtcgggctgt gtctgagtca gaggatcagc gcccagcagc agactctccc
      121 aaaaccgttc atctgggccg agccccattt catggttcca aaggaaaagc aagtgaccat
      181 ctgttgccag ggaaattatg gggctgttga ataccagctg cactttgaag gaagcctttt
      241 tgccgtggac agaccaaaac cccctgagcg gattaacaaa gtccaattct acatcccgga
      301 catgaactcc cgcatggcag ggcaatacag ctgcatctat cgggttgggg agctctggtc
      361 agagcccagc aacttgctgg atctggtggt aacagaaatg tatgacacac ccaccctctc
      421 ggttcatcct ggacccgaag tgatctcggg agagaaggtg accttctact gccgtctaga
      481 cactgcaaca agcatgttct tactgctcaa ggagggaaga tccagccacg tacagcgcgg
      541 atacgggaag gtccaggcgg agttccccct gggccctgtg accacagccc acagagggac
      601 ataccgatgt tttggctcct ataacaacca tgcctggtct ttccccagtg agccagtgaa
      661 gctcctggtc acaggcgaca ttgagaacac cagccttgca cctgaagacc ccacctttcc
      721 tgcagacact tggggcacct accttttaac cacagagacg ggactccaga aagaccatgc
      781 cctctgggat cacactgccc agaatctcct tcggatgggc ctggcctttc tagtcctggt
      841 ggctctagtg tggttcctgg ttgaagactg gctcagcagg aagaggacta gagagcgagc
      901 cagcagagct tccacttggg aaggcaggag aaggctgaac acacagactc tttgaagaat
      961 gaccatgaga cacagtggcc atgggtggat ctgaaagctg gtgttgagcc tgggcggcgt
     1021 gagctctgtg ttggacccac ggaggaggga gtcactgcag ggaaagaggg acactggcat
     1081 tccatttgtc agagcatccc ggacgatgca gagggtggga gaactacatg ctaaatttct
     1141 tttttttttt ttttgag
//
