LOCUS       NM_181782               6264 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens nuclear receptor coactivator 7 (NCOA7), transcript
            variant 1, mRNA.
ACCESSION   NM_181782
VERSION     NM_181782.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6264)
  AUTHORS   Wang,L., Wei,Z., Wu,Y., Hu,X., Zhou,L., Zhao,M., Sun,A., Shao,G.,
            Yang,W. and Lin,Q.
  TITLE     Nuclear receptor coactivator 7 (NCOA7) protects cancer cells from
            oxidative damage through its ERbd domain
  JOURNAL   Cell Signal 124, 111382 (2024)
   PUBMED   39243920
  REMARK    GeneRIF: Nuclear receptor coactivator 7 (NCOA7) protects cancer
            cells from oxidative damage through its ERbd domain.
REFERENCE   2  (bases 1 to 6264)
  AUTHORS   Guo,J., Ke,S., Chen,Q., Zhou,J., Guo,J. and Qiu,T.
  TITLE     NCOA7 Regulates Growth and Metastasis of Clear Cell Renal Cell
            Carcinoma via MAPK/ERK Signaling Pathway
  JOURNAL   Int J Mol Sci 24 (14), 11584 (2023)
   PUBMED   37511343
  REMARK    GeneRIF: NCOA7 Regulates Growth and Metastasis of Clear Cell Renal
            Cell Carcinoma via MAPK/ERK Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6264)
  AUTHORS   Tu,Y.X.I., Sydor,A.M., Coyaud,E., Laurent,E.M.N., Dyer,D.,
            Mellouk,N., St-Germain,J., Vernon,R.M., Forman-Kay,J.D., Li,T.,
            Hua,R., Zhao,K., Ridgway,N.D., Kim,P.K., Raught,B. and Brumell,J.H.
  TITLE     Global Proximity Interactome of the Human Macroautophagy Pathway
  JOURNAL   Autophagy 18 (5), 1174-1186 (2022)
   PUBMED   34524948
REFERENCE   4  (bases 1 to 6264)
  AUTHORS   Khan,H., Winstone,H., Jimenez-Guardeno,J.M., Graham,C.,
            Doores,K.J., Goujon,C., Matthews,D.A., Davidson,A.D., Rihn,S.J.,
            Palmarini,M., Neil,S.J.D. and Malim,M.H.
  TITLE     TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction
  JOURNAL   PLoS Pathog 17 (11), e1009820 (2021)
   PUBMED   34807954
  REMARK    GeneRIF: TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated
            restriction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6264)
  AUTHORS   Arnaud-Arnould,M., Tauziet,M., Moncorge,O., Goujon,C. and Blaise,M.
  TITLE     Crystal structure of the TLDc domain of human NCOA7-AS
  JOURNAL   Acta Crystallogr F Struct Biol Commun 77 (Pt 8), 230-237 (2021)
   PUBMED   34341188
  REMARK    GeneRIF: Crystal structure of the TLDc domain of human NCOA7-AS.
REFERENCE   6  (bases 1 to 6264)
  AUTHORS   Rushing,S.R. and Denison,M.S.
  TITLE     The silencing mediator of retinoic acid and thyroid hormone
            receptors can interact with the aryl hydrocarbon (Ah) receptor but
            fails to repress Ah receptor-dependent gene expression
  JOURNAL   Arch Biochem Biophys 403 (2), 189-201 (2002)
   PUBMED   12139968
REFERENCE   7  (bases 1 to 6264)
  AUTHORS   Shao,W., Halachmi,S. and Brown,M.
  TITLE     ERAP140, a conserved tissue-specific nuclear receptor coactivator
  JOURNAL   Mol Cell Biol 22 (10), 3358-3372 (2002)
   PUBMED   11971969
  REMARK    GeneRIF: ERAP140 may represent a distinct class of nuclear receptor
            coactivators.  ERAP140 is recruited by estrogen-bound ER alpha to
            the promoter region of endogenous ER alpha target genes in a cyclic
            pattern similar to that of other coactivators.
REFERENCE   8  (bases 1 to 6264)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 6264)
  AUTHORS   Nguyen,T.A., Hoivik,D., Lee,J.E. and Safe,S.
  TITLE     Interactions of nuclear receptor coactivator/corepressor proteins
            with the aryl hydrocarbon receptor complex
  JOURNAL   Arch Biochem Biophys 367 (2), 250-257 (1999)
   PUBMED   10395741
REFERENCE   10 (bases 1 to 6264)
  AUTHORS   Halachmi,S., Marden,E., Martin,G., MacKay,H., Abbondanza,C. and
            Brown,M.
  TITLE     Estrogen receptor-associated proteins: possible mediators of
            hormone-induced transcription
  JOURNAL   Science 264 (5164), 1455-1458 (1994)
   PUBMED   8197458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA770225.1, BC137094.1, AK294558.1, BX537385.1, AL834442.1 and
            AL035689.26.
            
            On Nov 22, 2018 this sequence version replaced NM_181782.4.
            
            Transcript Variant: This variant (1) and variants 3 and 4 encode
            the same longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537385.1, SRR1660807.23561.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392477.7/ ENSP00000376269.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               DA770225.1         198-565
            369-3066            BC137094.1         583-3280
            3067-3257           AK294558.1         2808-2998
            3258-5071           BX537385.1         3250-5063
            5072-6260           AL834442.1         4656-5844
            6261-6264           AL035689.26        139379-139382       c
FEATURES             Location/Qualifiers
     source          1..6264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31-q22.32"
     gene            1..6264
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /note="nuclear receptor coactivator 7"
                     /db_xref="GeneID:135112"
                     /db_xref="HGNC:HGNC:21081"
                     /db_xref="MIM:609752"
     exon            1..108
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            109..222
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..3001
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     estrogen receptor associated protein 140 kDa; putative
                     protein product of Nbla00052; putative protein product of
                     Nbla10993; estrogen nuclear receptor coactivator 1; 140
                     kDa estrogen receptor-associated protein;
                     TBC/LysM-associated domain containing 4"
                     /codon_start=1
                     /product="nuclear receptor coactivator 7 isoform 1"
                     /protein_id="NP_861447.3"
                     /db_xref="CCDS:CCDS5132.1"
                     /db_xref="GeneID:135112"
                     /db_xref="HGNC:HGNC:21081"
                     /db_xref="MIM:609752"
                     /translation="MDTKEEKKERKQSYFARLKKKKQAKQNAETASAVATRTHTGKED
                     NNTVVLEPDKCNIAVEEEYMTDEKKKRKSNQLKEIRRTELKRYYSIDDNQNKTHDKKE
                     KKMVVQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVPDA
                     NSPSSTLRLSSSSPGATVSPSSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGV
                     VKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVV
                     SIALYNDISHMKIKDALPSDLPQDLCPLYRPGEWEDLASEKDINPFSKFKSINKEKRQ
                     QNGEKIMTSDSRPIVPLEKSTGHTPTKPSGSSVSEKLKKLDSSRETSHGSPTVTKLSK
                     EPSDTSSAFESTAKENFLGEDDDFVDLEELSSQTGGGMHKKDTLKECLSLDPEERKKA
                     ESQINNSAVEMQVQSALAFLGTENDVELKGALDLETCEKQDIMPEVDKQSGSPESRVE
                     NTLNIHEDLDKVKLIEYYLTKNKEGPQVSENLQKTELSDGKSIEPGGIDITLSSSLSQ
                     AGDPITEGNKEPDKTWVKKGEPLPVKLNSSTEANVIKEALDSSLESTLDNSCQGAQMD
                     NKSEVQLWLLKRIQVPIEDILPSKEEKSKTPPMFLCIKVGKPMRKSFATHTAAMVQQY
                     GKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGKDAKEQGFVVVEKEELNMIDNFFS
                     EPTTKSWEIITVEEAKRRKSTCSYYEDEDEEVLPVLRPHSALLENMHIEQLARRLPAR
                     VQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDH
                     YYGTGETFLYTFSPHFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRS
                     NSCSTFNNDILSKKEDFIVQDLEVWAFD"
     exon            223..443
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..523
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            524..631
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            632..745
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            746..871
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1056
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..2099
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2268
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2416
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2542
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2695
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2791
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2865
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..6264
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5316..5321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /note="hexamer: AATAAA"
     polyA_site      5341
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /note="major polyA site"
     regulatory      6239..6244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
                     /note="hexamer: ATTAAA"
     polyA_site      6264
                     /gene="NCOA7"
                     /gene_synonym="dJ187J11.3; ERAP140; ESNA1; Nbla00052;
                     Nbla10993; NCOA7-AS; TLDC4"
ORIGIN      
        1 gagaggatgc gctccccggc gcccagcagc agaggccacc gctcccagaa atgcatgcga
       61 ccgatcccct tctcccggac cccaggagcc ggcgcccccg ccctgtaggg ttacgactca
      121 ctgattaaaa agagggactt tttcaaatac tttgcacttt tgattgtgta ttatggatac
      181 caaggaagag aagaaggaac ggaaacaaag ttattttgct cgactgaaaa agaaaaaaca
      241 agccaaacaa aatgcagaga cagcctcagc tgtagctaca aggactcata ctgggaagga
      301 agataataat acagtagttt tagagccaga caagtgcaac attgctgtgg aagaggaata
      361 tatgactgat gagaaaaaaa agagaaaaag taatcagtta aaggagatca ggcgtacaga
      421 actaaagaga tattatagta ttgatgacaa tcaaaacaaa acacatgata aaaaagagaa
      481 gaagatggtg gttcagaagc cccatgggac tatggaatac actgctggaa accaggacac
      541 cctaaactcc atagcactga aatttaacat cactcccaat aaattggtgg aactgaataa
      601 acttttcaca catactattg ttccaggcca ggtccttttt gtgccagatg ccaactctcc
      661 ttccagtacc ttaaggctat catcatccag tcctggtgct actgtctctc cttcatcatc
      721 agatgcagaa tatgataaat tgcctgatgc tgacttagca cgaaaggcct tgaaacccat
      781 tgaaagagtc ttatcgtcta cttctgaaga agatgagcca ggtgtggtga aatttttaaa
      841 aatgaattgt cgatacttca ccgatggaaa gggtgtggtt ggcggtgtta tgatagtgac
      901 tcctaacaac atcatgtttg accctcataa atctgatcct ctggttattg aaaatgggtg
      961 tgaggagtat ggtctcatct gccccatgga agaggttgtt tccattgcgc tctacaatga
     1021 catttctcac atgaagatca aagatgcctt gccatctgac ctacctcagg atctttgtcc
     1081 tctgtacagg cctggagaat gggaagacct ggcttcagaa aaggatatca acccattcag
     1141 taagttcaaa tctatcaaca aggaaaaacg acagcagaat ggagagaaaa ttatgacttc
     1201 ggattccaga ccaatagtac ctttggagaa gtccacagga catacaccta caaagccctc
     1261 aggcagctct gtgtcagaga aattaaagaa actggactcc tctagggaga catcccatgg
     1321 ttctcccaca gtgactaagc tcagcaagga accttccgac acttcttctg catttgaatc
     1381 tacagccaaa gaaaactttc taggggaaga tgatgatttt gttgacttgg aagaactttc
     1441 ttctcaaact ggtggtggaa tgcacaaaaa agacaccttg aaggagtgcc tttctcttga
     1501 cccagaggaa cgaaagaaag ctgagtcaca aataaacaat tctgccgtgg aaatgcaggt
     1561 gcagtcagcc ctagcctttt tgggaacaga gaatgatgtt gaactgaagg gggcgctaga
     1621 tttagaaacc tgtgagaagc aagatataat gccagaagtg gacaagcagt ctggttcgcc
     1681 agaaagccga gtagaaaaca cactgaacat acatgaagat ttagataaag ttaaactcat
     1741 tgaatattac ctgactaaga acaaagaagg gccacaggta tctgaaaatt tgcagaaaac
     1801 agaattaagt gatggaaaaa gtattgaacc agggggaata gacattaccc ttagtagttc
     1861 tctttcccag gcgggtgatc ccataactga gggcaataaa gagccagata agacctgggt
     1921 gaaaaaggga gagcccctcc cggtaaaact gaactcttct acagaagcaa atgtgattaa
     1981 agaggctcta gactcctctt tggaatctac tctggacaac agctgtcaag gtgcacaaat
     2041 ggataataaa tctgaagttc agttgtggct gttaaagaga attcaggtac ccattgaaga
     2101 tatacttcct tcaaaagaag aaaaaagcaa gaccccaccc atgttcctgt gcatcaaagt
     2161 gggaaaacca atgagaaaat cctttgccac tcacactgca gccatggtcc agcagtacgg
     2221 caaacggaga aagcagccag agtactggtt tgctgttcct cgggagaggg tggatcattt
     2281 gtacacattc tttgttcagt ggtctcccga tgtctatgga aaagatgcca aagagcaagg
     2341 ctttgtggtg gtggagaagg aagaactgaa catgattgac aacttcttca gtgagccaac
     2401 aaccaagagc tgggagatca tcactgttga agaggcaaag cgcaggaaga gcacatgcag
     2461 ctactatgaa gacgaggacg aagaggtgct gcctgtccta cggccccaca gcgcgctcct
     2521 ggagaatatg cacatcgagc agctggcccg acgccttcct gcaagggtgc aagggtatcc
     2581 atggagactg gcctatagca cgttagagca cgggaccagc ttaaagacgc tctaccggaa
     2641 atcggcatca ctagacagtc ctgtcctatt ggtcatcaaa gatatggata atcagatttt
     2701 tggagcatat gcaactcatc ctttcaagtt cagtgaccac tattatggca caggcgaaac
     2761 ttttctctac acattcagcc ctcattttaa ggtctttaag tggagtggag aaaattcata
     2821 ctttatcaat ggagacataa gttctttaga acttggtggt ggagggggac gatttggttt
     2881 atggctagat gctgatttat accacggacg aagcaactct tgcagcactt tcaataatga
     2941 tattctttcc aaaaaggaag acttcatagt tcaggatctg gaggtgtggg catttgattg
     3001 aaattcagac tgccttaaaa tataacatta aaaagactgg gttcgatcag ccctcctaaa
     3061 gctggctgga aaaagaagcc ccagcccagc ctgcctcatc ccaccccaat gcttcctttc
     3121 tgccatcatc tcagagcatg atcacattgc agaaagattc tggaaggtcc atgtagaggg
     3181 cagacattga agaaagaaac ttaaaatcca ggttgttgaa aagactttgt actcccactt
     3241 cctccaaatc catacagtga ggaatcagag tgtttataga tatatgagtt gaatgcaatt
     3301 tttatttttg gtaactgtga aaaataagat actgtggata tatacatgcc ttgtgtattt
     3361 atcagcataa ttttcattac caaaatgtac agctattatt tgccatggaa aaggttagtc
     3421 tcatttagaa aaatcgaaag tgcacagcac ttaaagggaa tatatgaggt tttttttttt
     3481 ttaaaaaaaa acttttattt attatttgta gtatattgtc tgaaatgtgt cggcagtttt
     3541 ttttctttta atgtgtcaaa tcttgaaata ttaaatgtat acattttgtg ctatgttttg
     3601 ggaacaaatc tgtttgattt atatagtttt atattgaatt ttttttgccc tgattgttta
     3661 gggtgatagg tcttaagcag catatatcta tatatctgta tgtgggtata tagagatata
     3721 tgtgtgtgtg tatgtatatg tacatataca tatatatgag tgtataattc taaatttcta
     3781 aaaactcatt atgaatgttc atcaatttga ctattatagg ccagctttcc atttagtcaa
     3841 taaaagcgta catttttagt tacttacctt gaacatattc gtgtgaaaaa gaatacatca
     3901 tttctcacag tcttaagttg atatttatag aaatgaatac ctttgtgaac ctagacttag
     3961 aacaaatcct gcttttgaaa aaaaatgttt tgcttcttac aaaatcattt gtgttaataa
     4021 caaaaacttt attttcggag tgttctttgt ataacttttc caagctttta cattaacgag
     4081 caggcctctg tcttaaaagg gactcagtat attaatttct gcatttttta aatcaaatga
     4141 aaaacgtcaa attggaccaa ttgtcttggt ttcttgattc atttatttga gaaaaaaaca
     4201 atacaaagaa atgcattcat atcaaaattg gaatagaaag gaaaacctat ttttaagata
     4261 tcaacctatt ttcacatcat aaaacatcta ttacataaaa taaaggtcca ggcatagtgg
     4321 ctcttgcctg taatcccagc actttgggag gccgaggcag gtggatcact caaggtcaca
     4381 agtttgagac cagtctggcc aacatggtga aaccccatct ctactaaaag tacaaatatt
     4441 agccgactat gtggcgggca cctgtaatcc cacctactcg ggaggctgag gcaggagaat
     4501 tgcttgaatc cgggaagcag aggttgtagt gagccaagat cgtgccactg cactctatcc
     4561 tgggtaacag cgagactctg tcttaaaaat aataacaata ataataataa taaagactta
     4621 cttaaccaat attattgatt accagacttt tatgaaagcc aaagactgct tgctagtagg
     4681 aaaaaatttc aaataataac caaagctgaa aaatggtctg tcataaatta tttccccggt
     4741 aatttttgaa aggaaaaatg tataacaagt actatttaca tatctgcatt taaaaaagca
     4801 attcttagaa tacttccttt acattattct cctattttag acattttgtg aaagagaaca
     4861 aattgtccag tggcctcctg tcagatcaac aattattata ctccttaatt ccatgcaaat
     4921 ttaaatgaat gctataaaat tttaaatctg tagcctgggt gtacgtttca ctcaagttct
     4981 cctactgagg actcttgact aacagcatac tggcagtttc accttaacct gctcgttaaa
     5041 taatgtgttg gtgtgagata tcaggaatgt ctcatgatat cacgtttacc atttacacca
     5101 tctgcaacca tatgctatta ataaaatgga aaaaaacaaa atggtcattt tgcatatact
     5161 tcactctgac ctagtttagt ccatgatact ataattgtga gagcatatcc agatgctgtg
     5221 ttctctatgt aaaacagtat tgtccattca gaaatgtgtg acccttcatt tatggatatt
     5281 gactatatgt aatgcagtgc tatcccaata ttttcaataa aggactttat gcattcagtg
     5341 attttctttc ccaaagattc attcatcagg tatttactgg gtaccagagt gtttattttt
     5401 gtgagaggat ggtgaaatat ccaagactaa acaaggtcca gagctcatgt tttcactgct
     5461 gccctggaaa ctccctcttc attccctgta gccaccctcc taattgtctc atcagttcac
     5521 ggaaactgct ctcattatgg ttaccagaga caactcttgg ctgtatctac cagtctcttc
     5581 taatctttct agctgtgcaa tgaatgacaa cctcctcctc ttaacatctg tcttaaccta
     5641 cttcataatt tccgtaaggg acactttact ctctgataaa ttttctttgg catcctgaca
     5701 cctagcccct agatgttggg ctagatgaag accccaagca gtcttcattg cttcataatt
     5761 cctcagttca taagtccata tcaaaggact tgggtgggag gaggcaacca aatgtttctt
     5821 cagactctac tgaaaatgat tagatgcatc cccgtgctac aagccaccag agacatcctg
     5881 cactattata agtatgtctt cccttaattt gatctccctc tccttgatgc cttttaaagt
     5941 tttagagaca cattgatatg gtttggctgt gtgtccccac caacatctca ttggaattat
     6001 aatccccaca tgttgaggga gggacctagt gggatgtgat tagaacatgg gggcggtttc
     6061 ccccatgctg ttctcatgat agtgagggag ttttcatgag atctgtttta aaatgtttgg
     6121 cagttccacc ctcaccctct cttctgctgc catgtaagat gtgccttgct tcccctttgc
     6181 cttctgccat gattgtaaat ttcctgacgc ctacccagcc atgtgaaact gtgagtccat
     6241 taaacctctt ttctttataa ataa
//
