LOCUS       NM_014071               7083 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nuclear receptor coactivator 6 (NCOA6), transcript
            variant 1, mRNA.
ACCESSION   NM_014071
VERSION     NM_014071.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7083)
  AUTHORS   Lee,K.G., Hong,B.K., Lee,S., Lee,N., Kim,S.W., Kim,D. and Kim,W.U.
  TITLE     Nuclear receptor coactivator 6 is a critical regulator of NLRP3
            inflammasome activation and gouty arthritis
  JOURNAL   Cell Mol Immunol 21 (3), 227-244 (2024)
   PUBMED   38195836
  REMARK    GeneRIF: Nuclear receptor coactivator 6 is a critical regulator of
            NLRP3 inflammasome activation and gouty arthritis.
REFERENCE   2  (bases 1 to 7083)
  AUTHORS   Fang,Y., Xu,Y., Liao,W., Ji,T., Yu,L., Li,L., Pan,M. and Yang,D.
  TITLE     Multiomics analyses and machine learning of nuclear receptor
            coactivator 6 reveal its essential role in hepatocellular carcinoma
  JOURNAL   Cancer Sci 114 (1), 75-90 (2023)
   PUBMED   36086920
  REMARK    GeneRIF: Multiomics analyses and machine learning of nuclear
            receptor coactivator 6 reveal its essential role in hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 7083)
  AUTHORS   Watanabe,N., Kawagoe,J., Sugiyama,A., Takehara,I., Ohta,T. and
            Nagase,S.
  TITLE     Nuclear receptor coactivator-6 is essential for the morphological
            change of human uterine stromal cell decidualization via regulating
            actin fiber reorganization
  JOURNAL   Mol Reprod Dev 89 (4), 165-174 (2022)
   PUBMED   35384116
  REMARK    GeneRIF: Nuclear receptor coactivator-6 is essential for the
            morphological change of human uterine stromal cell decidualization
            via regulating actin fiber reorganization.
REFERENCE   4  (bases 1 to 7083)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 7083)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 7083)
  AUTHORS   Caira,F., Antonson,P., Pelto-Huikko,M., Treuter,E. and
            Gustafsson,J.A.
  TITLE     Cloning and characterization of RAP250, a novel nuclear receptor
            coactivator
  JOURNAL   J Biol Chem 275 (8), 5308-5317 (2000)
   PUBMED   10681503
REFERENCE   7  (bases 1 to 7083)
  AUTHORS   Lee,S.K., Anzick,S.L., Choi,J.E., Bubendorf,L., Guan,X.Y.,
            Jung,Y.K., Kallioniemi,O.P., Kononen,J., Trent,J.M., Azorsa,D.,
            Jhun,B.H., Cheong,J.H., Lee,Y.C., Meltzer,P.S. and Lee,J.W.
  TITLE     A nuclear factor, ASC-2, as a cancer-amplified transcriptional
            coactivator essential for ligand-dependent transactivation by
            nuclear receptors in vivo
  JOURNAL   J Biol Chem 274 (48), 34283-34293 (1999)
   PUBMED   10567404
REFERENCE   8  (bases 1 to 7083)
  AUTHORS   Guan,X.Y., Xu,J., Anzick,S.L., Zhang,H., Trent,J.M. and
            Meltzer,P.S.
  TITLE     Hybrid selection of transcribed sequences from microdissected DNA:
            isolation of genes within amplified region at 20q11-q13.2 in breast
            cancer
  JOURNAL   Cancer Res 56 (15), 3446-3450 (1996)
   PUBMED   8758910
REFERENCE   9  (bases 1 to 7083)
  AUTHORS   Carney,J.P., McKnight,C., VanEpps,S. and Kelley,M.R.
  TITLE     Random rapid amplification of cDNA ends (RRACE) allows for cloning
            of multiple novel human cDNA fragments containing (CAG)n repeats
  JOURNAL   Gene 155 (2), 289-292 (1995)
   PUBMED   7536696
REFERENCE   10 (bases 1 to 7083)
  AUTHORS   Estey,A., Kemp,M., Allison,S. and Lamb,C.
  TITLE     Evaluation of a patient information booklet
  JOURNAL   J Nurs Staff Dev 9 (6), 278-282 (1993)
   PUBMED   8263591
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049709.18, CR749037.1,
            BC069829.1, AL109824.24 and AI498955.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014071.4.
            
            Summary: The protein encoded by this gene is a transcriptional
            coactivator that can interact with nuclear hormone receptors to
            enhance their transcriptional activator functions. This protein has
            been shown to be involved in the hormone-dependent coactivation of
            several receptors, including prostanoid, retinoid, vitamin D3,
            thyroid hormone, and steroid receptors. Alternatively spliced
            transcript variants encoding different isoforms have been described
            for this gene. [provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1 and 3 encode the same isoform (1, also
            known as NCOA6-alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069829.1, SRR14038193.623769.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359003.7/ ENSP00000351894.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL049709.18        31753-31754         c
            3-80                CR749037.1         12-89
            81-2589             BC069829.1         1-2509
            2590-2590           AL109824.24        48147-48147         c
            2591-4775           BC069829.1         2511-4695
            4776-4776           AL109824.24        40023-40023         c
            4777-6857           BC069829.1         4696-6776
            6858-6860           AL109824.24        13197-13199         c
            6861-7057           BC069829.1         6777-6973
            7058-7083           AI498955.1         10-35               c
FEATURES             Location/Qualifiers
     source          1..7083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..7083
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /note="nuclear receptor coactivator 6"
                     /db_xref="GeneID:23054"
                     /db_xref="HGNC:HGNC:15936"
                     /db_xref="MIM:605299"
     exon            1..180
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            181..294
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            295..578
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..6535
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amplified in breast cancer-3 protein; activating signal
                     cointegrator-2; nuclear receptor coactivator RAP250;
                     peroxisome proliferator-activated receptor interacting
                     protein; thyroid hormone receptor binding protein; NRC
                     RAP250; PPAR-interacting protein; amplified in breast
                     cancer protein 3; nuclear receptor-activating protein, 250
                     kDa; cancer-amplified transcriptional coactivator ASC-2"
                     /codon_start=1
                     /product="nuclear receptor coactivator 6 isoform 1"
                     /protein_id="NP_054790.2"
                     /db_xref="CCDS:CCDS13241.1"
                     /db_xref="GeneID:23054"
                     /db_xref="HGNC:HGNC:15936"
                     /db_xref="MIM:605299"
                     /translation="MVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDTKSDSILE
                     DSTIFVAFKGNIDDKDFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPR
                     EAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSVR
                     MEAGFPMASGPGIIRMNNPATVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMD
                     PLLSGLHIQQQSHPSGSLAPPHHPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQ
                     QQQQQQQQQLQARPPQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGS
                     LGTMTANQGWKKAPLPGPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQ
                     MSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQ
                     QQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGL
                     GGMPKRLPPGFSAGQANPNFMQGQVPSTTATTPGNSGAPQLQANQNVQHAGGQGAGPP
                     QNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSGVPQVNLSNMQGQPQQGPPSQLMGM
                     HQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQNLGPSPQRMTPPKQ
                     MLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQSNVMPGP
                     AQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPHMA
                     QQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNSASGNHFSGHGMSFNAP
                     FSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKP
                     KKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGINLDNSGPKLPEFSNRPPG
                     YPSQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQPQSQQQQQQQ
                     QQMMMMLMMQQDPKSVRLPVSQNVHPPRGPLNPDSQRMPMQQSGSVPVMVSLQGPASV
                     PPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEASGSEAPSVPGG
                     PNNMPSHVVLPQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPT
                     QTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPLPP
                     RPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGA
                     TKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSP
                     TPLANPPVPGSFPNNSGLNPQNSTVSVAAVGGVVEDNKESLNVPQDSDCQNSQSRKEQ
                     VNIELKAVPAQEVKMVVPEDQSKKDGQPSDPNKLPSVEENKNLVSPAMREAPTSLSQL
                     LDNSGAPNVTIKPPGLTDLEVTPPVVSGEDLKKASVIPTLQDLSSSKEPSNSLNLPHS
                     NELCSSLVHPELSEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSA
                     NTSAALPTHLQSALMSTVVTMPNAGSKVMVSEGQSAAQSNARPQFITPVFINSSSIIQ
                     VMKGSQPSTIPAAPLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVPPNALSSSPAPNI
                     QTGRPLVLSSRATPVQLPSPPCTSSPVVPSHPPVQQVKELNPDEASPQVNTSADQNTL
                     PSSQSTTMVSPLLTNSPGSSGNRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKG
                     EEQYGADGETEGQGLDTTAPGLMGTEQLSTELDSKTPTPPAPTLLKMTSSPVGPGTAS
                     AGPSLPGGALPTSVRSIVTTLVPSELISAVPTTKSNHGGIASESLAGGLVEEKVGSHP
                     ELLPSIAPSQNLVSKETSTTALQASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRR
                     NSRTEEPTVASESVENGHRKRSSRPASASSSTKDITSAVQSKRRKSK"
     exon            579..734
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            735..857
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            858..986
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1871
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2018
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..3135
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3257
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..6236
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            6237..6305
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            6306..6342
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            6343..6491
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            6492..7083
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6991..6996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /note="hexamer: AATAAA"
     polyA_site      7025
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /note="major polyA site"
     regulatory      7036..7041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /note="hexamer: AATAAA"
     polyA_site      7057
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /note="major polyA site"
     regulatory      7058..7063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
                     /note="hexamer: CATAAA"
     polyA_site      7083
                     /gene="NCOA6"
                     /gene_synonym="AIB3; ASC2; NRC; PRIP; RAP250; TRBP"
ORIGIN      
        1 atccccctcc ccgccggctc cgtgaggccc tgccgggtcg ggctgcgggc ggccgggcgc
       61 gggcggcggg acagacgggc gcacgcgagg actgacggac ggacgcaccg agggcggcgg
      121 gcacgcacgg cccgggccgg cgctccaagg cccgcccggg agggccgggg ccgcgctcag
      181 aattttgatt tggctgctgg gctgctacct tgaaatccaa gccctaaaaa tgccagcttc
      241 tttggactta gaagatgacc tggataaatg ataaaaatta agaaagagat tttgaagttt
      301 tcttattgtc ctcttggcat atgcttctgg aataatattc accatggttt tggatgacct
      361 tccaaactta gaagacatct atacttcctt gtgttcatca acaatggaag actcagagat
      421 ggattttgac tctggactag aagatgatga cacaaaaagt gatagtattt tggaggattc
      481 cacaattttt gtggccttca aaggaaatat agatgataaa gacttcaaat ggaaattaga
      541 tgcaatattg aaaaacgtgc ccaatttgtt acacatggag tccagcaagc taaaagtaca
      601 gaaggtggag ccctggaaca gcgtgcgtgt gacattcaac atcccccggg aagcagcgga
      661 gcggctacgg atccttgctc agagcaacaa ccagcagctt cgggatttag ggattctctc
      721 cgttcagatt gaaggggaag gtgctattaa cctggctttg gctcagaacc gaagccaaga
      781 tgtgagaatg aatggaccca tgggagctgg aaattcagtt aggatggagg cgggatttcc
      841 tatggcaagt ggtccaggaa taataaggat gaacaaccct gccactgtta tgataccccc
      901 gggtggaaat gtgtcatctt ccatgatggc accaggcccc aatccagagc tgcagcccag
      961 gactcctcgc cctgcttctc agtcagatgc aatggatcca ctcctctctg ggctccatat
     1021 acagcagcaa agtcatccct caggatcttt agctccccca catcacccaa tgcagcctgt
     1081 ctctgtgaac agacaaatga acccagctaa ttttccccag ctgcagcagc agcagcaaca
     1141 acaacaacag cagcagcagc agcagcagca gcaacaacag caacagcagc aacaacagtt
     1201 gcaggcaaga cccccacagc aacatcagca gcaacagcca cagggaattc gaccccagtt
     1261 tactgcccca actcaggtgc ctgttcctcc aggctggaac cagctgcctt ctggagccct
     1321 tcaacctcct ccagcccagg gttctctggg cacaatgact gcaaaccaag ggtggaagaa
     1381 ggctcccttg cccggcccaa tgcaacagca actccaggca agaccatcct tagccacggt
     1441 acagacgcct tcccaccctc cccctccata tccctttggc agccagcaag cctcacaagc
     1501 ccacacaaac tttcctcaga tgagcaaccc aggccagttc acagctcctc agatgaagag
     1561 tttgcaggga gggccctcta gggtcccaac tcccttgcag cagccccacc tcaccaacaa
     1621 gtctcctgcc tcctcaccct cctccttcca gcagggatcc cctgcatcct ccccaacggt
     1681 taaccaaact cagcagcaga tgggaccaag gccacctcaa aataacccac ttccccaggg
     1741 atttcagcag cctgtcagct ctccgggtcg gaatcctatg gttcaacagg gaaatgtgcc
     1801 acctaacttc atggtgatgc agcagcaacc accaaaccag gggccacaga gtttacatcc
     1861 aggcctagga ggaatgccta aacgcctccc acctggcttc tcagcaggac aggccaatcc
     1921 gaactttatg caaggtcagg tgccttcgac cacagcaacc acccctggga attcaggagc
     1981 ccctcagctg caagcaaatc aaaatgtcca gcatgcaggt ggtcaaggag ctggtcctcc
     2041 tcaaaaccag atgcaggtgt cccacgggcc gccaaatatg atgcagccca gcctcatggg
     2101 aattcatggc aacatgaaca atcagcaggc tggtacttct ggggttcctc aagtgaacct
     2161 cagcaacatg caaggccagc cccagcaggg cccaccatct cagctgatgg gcatgcacca
     2221 gcaaatcgtg ccctcccagg gccagatggt ccagcaacaa ggaaccttga accctcagaa
     2281 ccctatgatc ctttcaaggg cccagcttat gccacagggc cagatgatgg tgaacccccc
     2341 gagccaaaat cttgggccct cgccccaaag gatgacccca cccaagcaga tgctttccca
     2401 gcagggccca caaatgatgg cgccacataa ccagatgatg gggcctcagg ggcaggtttt
     2461 gctccaacag aacccaatga tagagcagat tatgaccaat caaatgcagg ggaataagca
     2521 gcagtttaac actcagaacc agtccaatgt catgccggga ccagcccaga taatgagggg
     2581 accaactcca aacatgcaag gaaatatggt gcagtttacg ggacagatgt caggacagat
     2641 gctgccccag caagggcctg tgaacaacag tccatctcag gttatgggca ttcagggaca
     2701 ggtcctgcgg ccaccagggc ccagcccaca catggcccag cagcatggtg atcctgctac
     2761 tacagcaaat aacgatgtca gtttatctca gatgatgcct gatgttagca ttcaacaaac
     2821 caacatggtc ccccctcatg tgcaggccat gcagggaaac agtgcctcgg gaaaccactt
     2881 ctcaggccat gggatgtctt tcaatgcacc tttcagtgga gctcccaatg gaaatcagat
     2941 gtcctgtggt caaaatccag gcttcccagt caataaggat gtcacgctaa cgagcccatt
     3001 gttggtcaac ttattgcaga gtgacatatc tgcaggccat tttggggtaa acaataagca
     3061 aaataatacc aacgcaaata aaccgaagaa gaagaaaccc cctcggaaga agaaaaatag
     3121 tcagcaagat ctaaacaccc cagatactcg cccagctggt ctggaagagg ctgatcagcc
     3181 accgttgcct ggagaacaag gaattaactt ggataactca ggccctaaac tgccagaatt
     3241 ttcaaaccgg ccaccaggtt atccttctca accagttgaa cagaggccac ttcagcagat
     3301 gcctcctcaa ctcatgcagc atgtggcacc cccaccacag ccaccacagc agcagccaca
     3361 gccacaactg cctcagcagc agcagccacc acctcccagt cagccacagt ctcagcagca
     3421 gcagcagcag cagcaacaaa tgatgatgat gctcatgatg cagcaggatc ccaaatcagt
     3481 taggcttcca gtctctcaaa atgtccatcc tccaaggggc cccctgaacc ccgactccca
     3541 gagaatgccc atgcaacaga gtggcagtgt gcctgtcatg gtcagtctgc aaggacctgc
     3601 ctccgtgcca ccatcacctg ataaacaaag aatgccaatg cctgtgaata ctcccttggg
     3661 aagcaattca aggaaaatgg tctatcagga gagcccgcag aatccttcca gctcgccact
     3721 ggcggagatg gcctcactcc ctgaagcaag tggcagtgaa gcaccatctg tcccaggagg
     3781 cccaaacaac atgccttcac atgtagtact tccccagaat cagttaatga tgacagggcc
     3841 aaaacctgga ccatcgcccc tttcagcaac tcaaggtgca actccccagc aaccccctgt
     3901 aaattccctg cccagctctc acggccacca cttcccaaat gtggctgcgc caacccagac
     3961 atctaggccc aaaacaccaa acagagccag ccccagaccc tattatcctc agacacccaa
     4021 caaccgccct cccagcacag aaccttcaga aatcagtctg tcaccagaaa gactcaatgc
     4081 ctccatagca ggactcttcc ctccacagat taatattcct ttacctccta ggccaaattt
     4141 aaacaggggc tttgatcaac aaggcctaaa tccaacaact ttgaaggcca tcgggcaagc
     4201 accttcaaat cttaccatga atccttccaa ttttgctacc ccacaaactc acaaattaga
     4261 ttctgtggta gtgaattctg gaaagcagtc taattctgga gcaacaaaac gggcaagtcc
     4321 aagcaacagt cgcaggtcta gtcctgggtc cagtaggaaa accactccaa gccctgggag
     4381 gcaaaattca aaagccccta aacttactct ggcctctcag acaaatgcag ccctattgca
     4441 gaatgtggag ttgccgagaa atgtattggt cagtcccact cctctggcca atccccctgt
     4501 acctgggagc tttcctaaca acagtgggct gaatcctcag aattctactg tgtctgtggc
     4561 tgcagttggg ggtgttgttg aggataacaa ggagagcttg aatgtgcctc aggacagtga
     4621 ttgccagaat tcccagagta ggaaggaaca ggtaaacatt gaactaaaag cagtccctgc
     4681 ccaagaagtt aaaatggttg tccctgaaga tcagtccaaa aaggatgggc agccttcgga
     4741 tcctaacaaa cttcccagtg tcgaagagaa caaaaatttg gtgtctcctg ctatgaggga
     4801 agcaccaaca tcgttaagtc aacttcttga caactctgga gctcccaatg tgacaattaa
     4861 accccctggg cttacagatc tggaagtaac acctccagta gtttctgggg aggacctcaa
     4921 aaaagcatct gtcattccca cactgcagga tctgtcttct tctaaagaac cttctaattc
     4981 cctaaactta cctcacagta atgagctgtg ttcatccctt gtgcatcccg aattgagtga
     5041 ggtcagttct aacgttgcac caagcatccc tccagtaatg tcaagacctg ttagctcttc
     5101 ctccatttcc actcccttgc ccccaaatca aataactgta tttgtcactt ccaatcccat
     5161 cacaacttca gctaacacat cagcagcttt gccaactcac ttgcagtctg cattgatgtc
     5221 aacagttgtc acaatgccca atgcgggtag caaggttatg gtttctgagg gacagtcagc
     5281 tgctcagtct aatgcccggc ctcagttcat tacacctgtc tttatcaatt catcctcaat
     5341 aattcaggtt atgaaaggat cacagccaag cacaattcct gcagccccac tgacaaccaa
     5401 ctctggcctg atgcctccct ctgttgcagt tgttggccct ttacacatac ctcagaacat
     5461 aaaattttct tctgctcctg taccgcctaa tgccctctcc agtagtcctg ctccaaacat
     5521 ccagacaggt cgacctttgg tccttagctc acgagccacc cctgttcagc ttccttcccc
     5581 tccttgtacg tcttctccag ttgtcccttc tcatccccct gtgcagcaag tgaaagaatt
     5641 gaatccagat gaggctagcc ctcaggtgaa cacctcagca gatcagaaca ctcttccctc
     5701 ttcacagtca accacaatgg tttctcccct tttgaccaat agtccagggt cctctggcaa
     5761 ccggcgaagc ccagtctcgt ctagtaaggg caaaggaaaa gtggacaaaa ttggccaaat
     5821 tttgttgacc aaggcatgta agaaagttac aggctctctt gagaaagggg aagaacaata
     5881 tggtgcagat ggagagactg aaggccaagg gctagacacc acagctccgg ggctcatggg
     5941 aacagagcag ttatccacag agctggacag taaaacccca acgcccccag cacccactct
     6001 gctaaaaatg acctctagcc ctgtgggccc gggcactgcc tcagcaggac ccagcttacc
     6061 tggcggtgct ctccccacca gtgtacgctc gatagtaacc actctggtac cctccgagct
     6121 catctccgcc gtaccgacca caaaaagcaa tcatggtggc atagcatctg agtcacttgc
     6181 gggtggccta gtggaggaga aggtgggatc ccatccagaa cttctaccca gcatagcccc
     6241 gtcgcagaat ttagtctcaa aggaaacttc aaccacagca ctgcaggcct ctgttgccag
     6301 accagagctg gaggtaaatg ctgccatagt ctctggacaa agcagtgagc ccaaagagat
     6361 agttgaaaag tccaaaatcc caggccgaag aaactcccga actgaagagc caactgtggc
     6421 ctctgaaagt gtggaaaatg gacatcgtaa acgatcttct cgacctgctt cagcctccag
     6481 ctctactaaa gacataacca gtgcggtgca atccaagcga agaaaatcca agtaaacaag
     6541 caggactgcg acttgatact tggaaatgtg tgtgactttt acaaagagca attttgagct
     6601 gtgacttttt taaatcaatt tctgtacagt tagtaatttt aataatgtgg cccttttcct
     6661 agtccctgca acctgtttca taaagtgcaa tggggaaagc aggactgttg agcccttttg
     6721 gtgttgcgag ttgaagttca aggtttctaa aatgttgtct tgtattgaaa ggagctaatg
     6781 ccattataaa tgttactagt tttcacattt cctaagcagc ctagagtaca gggtgagcat
     6841 ttttagatct cctaatgatg tattgtgccg tggaagtact gtgtgtgaat agcagtagtg
     6901 ggggcaaaag caatcttctc atttggaaat gttgtaaata attttattat atagtgtttt
     6961 ggatgtattt gttgtagaaa tggaccagtg aataaagaga atctaaggat ttgtacaatg
     7021 tgaaataacg tgttaaataa atgtcattgt catagaacat aaagttatgt tattggtaag
     7081 gga
//
