LOCUS       NM_020967               3224 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens nuclear receptor coactivator 5 (NCOA5), transcript
            variant 1, mRNA.
ACCESSION   NM_020967
VERSION     NM_020967.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3224)
  AUTHORS   Zhang,Y., Luo,Y., Liu,X., Kiupel,M., Li,A., Wang,H., Mi,Q.S. and
            Xiao,H.
  TITLE     NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently
            Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma
  JOURNAL   Cell Mol Gastroenterol Hepatol 17 (1), 1-27 (2024)
   PUBMED   37734594
  REMARK    GeneRIF: NCOA5 Haploinsufficiency in Myeloid-Lineage Cells
            Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular
            Carcinoma.
REFERENCE   2  (bases 1 to 3224)
  AUTHORS   Rustemoglu,H., Arslan,E., Atasever,S., Cevik,B., Taspinar,F.,
            Turhan,A.B. and Rustemoglu,A.
  TITLE     Could NCOA5 a novel candidate gene for multiple sclerosis
            susceptibility?
  JOURNAL   Mol Biol Rep 50 (11), 9335-9341 (2023)
   PUBMED   37817021
  REMARK    GeneRIF: Could NCOA5 a novel candidate gene for multiple sclerosis
            susceptibility?
REFERENCE   3  (bases 1 to 3224)
  AUTHORS   Koptan,D.M.T., Rasheed Bahgat,D.M., Abdelrasool,A.A.,
            Allam,R.S.H.M., Elgengehy,F.T., Abdel Baki,N.M. and Medhat,B.M.
  TITLE     Analysis of Nuclear Receptor Coactivator 5 (NCOA5) Messenger RNA
            Expression and rs2903908 Single Nucleotide Polymorphism of NCOA5 in
            an Egyptian Cohort with Behcet's Disease: A Single-Center
            Case-control Study
  JOURNAL   Ocul Immunol Inflamm 30 (6), 1436-1446 (2022)
   PUBMED   34255592
  REMARK    GeneRIF: Analysis of Nuclear Receptor Coactivator 5 (NCOA5)
            Messenger RNA Expression and rs2903908 Single Nucleotide
            Polymorphism of NCOA5 in an Egyptian Cohort with Behcet's Disease:
            A Single-Center Case-control Study.
REFERENCE   4  (bases 1 to 3224)
  AUTHORS   Xia,E., Hu,W., Bhandari,A., Sindan,N. and Huang,D.
  TITLE     Nuclear Receptor Coactivator 5 is Correlated with Progression in
            Breast Carcinoma
  JOURNAL   Anticancer Agents Med Chem 21 (18), 2520-2524 (2021)
   PUBMED   33573580
  REMARK    GeneRIF: Nuclear Receptor Coactivator 5 is Correlated with
            Progression in Breast Carcinoma.
REFERENCE   5  (bases 1 to 3224)
  AUTHORS   Liang,Y., Zhang,T., Shi,M., Zhang,S., Guo,Y., Gao,J. and Yang,X.
  TITLE     Low expression of NCOA5 predicts poor prognosis in human cervical
            cancer and promotes proliferation, migration, and invasion of
            cervical cancer cell lines by regulating notch3 signaling pathway
  JOURNAL   J Cell Biochem 120 (4), 6237-6249 (2019)
   PUBMED   30335900
  REMARK    GeneRIF: Results found the expression levels of NCOA5 mRNA and
            protein significantly decreased in cervical cancer (CC) tissues and
            correlated with poor overall survival. Its upregulation might
            suppress cancer cell proliferation, migration, and invasion by
            inactivating NOTCH3 signaling pathway. These findings suggest that
            NCOA5 acts as a tumor suppressor and represents a potential novel
            prognostic marker for overall survival in CC.
REFERENCE   6  (bases 1 to 3224)
  AUTHORS   Lewis,J.P., Palmer,N.D., Ellington,J.B., Divers,J., Ng,M.C., Lu,L.,
            Langefeld,C.D., Freedman,B.I. and Bowden,D.W.
  TITLE     Analysis of candidate genes on chromosome 20q12-13.1 reveals
            evidence for BMI mediated association of PREX1 with type 2 diabetes
            in European Americans
  JOURNAL   Genomics 96 (4), 211-219 (2010)
   PUBMED   20650312
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 3224)
  AUTHORS   Tao,W.A., Wollscheid,B., O'Brien,R., Eng,J.K., Li,X.J.,
            Bodenmiller,B., Watts,J.D., Hood,L. and Aebersold,R.
  TITLE     Quantitative phosphoproteome analysis using a dendrimer conjugation
            chemistry and tandem mass spectrometry
  JOURNAL   Nat Methods 2 (8), 591-598 (2005)
   PUBMED   16094384
REFERENCE   8  (bases 1 to 3224)
  AUTHORS   Jiang,C., Ito,M., Piening,V., Bruck,K., Roeder,R.G. and Xiao,H.
  TITLE     TIP30 interacts with an estrogen receptor alpha-interacting
            coactivator CIA and regulates c-myc transcription
  JOURNAL   J Biol Chem 279 (26), 27781-27789 (2004)
   PUBMED   15073177
REFERENCE   9  (bases 1 to 3224)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 3224)
  AUTHORS   Sauve,F., McBroom,L.D., Gallant,J., Moraitis,A.N., Labrie,F. and
            Giguere,V.
  TITLE     CIA, a novel estrogen receptor coactivator with a bifunctional
            nuclear receptor interacting determinant
  JOURNAL   Mol Cell Biol 21 (1), 343-353 (2001)
   PUBMED   11113208
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035662.65, CN369226.1,
            AF230533.1 and AL162458.10.
            
            On Nov 22, 2018 this sequence version replaced NM_020967.2.
            
            Summary: This gene encodes a coregulator for the alpha and beta
            estrogen receptors and the orphan nuclear receptor NR1D2. The
            protein localizes to the nucleus, and is thought to have both
            coactivator and corepressor functions. Its interaction with nuclear
            receptors is independent of the AF2 domain on the receptors, which
            is known to regulate interaction with other coreceptors. Several
            alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.56634.1,
                                           SRR1803616.24017.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290231.11/ ENSP00000290231.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AL035662.65        25667-25687         c
            22-159              CN369226.1         2-139
            160-1946            AF230533.1         111-1897
            1947-3224           AL162458.10        147407-148684       c
FEATURES             Location/Qualifiers
     source          1..3224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..3224
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /note="nuclear receptor coactivator 5"
                     /db_xref="GeneID:57727"
                     /db_xref="HGNC:HGNC:15909"
                     /db_xref="MIM:616825"
     exon            1..146
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            147..213
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1915
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coactivator independent of AF-2; NCoA-5"
                     /codon_start=1
                     /product="nuclear receptor coactivator 5 isoform 1"
                     /protein_id="NP_066018.1"
                     /db_xref="CCDS:CCDS13392.1"
                     /db_xref="GeneID:57727"
                     /db_xref="HGNC:HGNC:15909"
                     /db_xref="MIM:616825"
                     /translation="MNTAPSRPSPTRRDPYGFGDSRDSRRDRSPIRGSPRREPRDGRN
                     GRDARDSRDIRDPRDLRDHRHSRDLRDHRDSRSVRDVRDVRDLRDFRDLRDSRDFRDQ
                     RDPMYDRYRDMRDSRDPMYRREGSYDRYLRMDDYCRRKDDSYFDRYRDSFDGRGPPGP
                     ESQSRAKERLKREERRREELYRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGR
                     KVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQ
                     EHRNMPQADAMVLVARNYERYKNECREKEREEIARQAAKMADEAILQERERGGPEEGV
                     RGGHPPAIQSLINLLADNRYLTAEETDKIINYLRERKERLMRSSTDSLPGPISRQPLG
                     ATSGASLKTQPSSQPLQSGQVLPSATPTPSAPPTSQQELQAKILSLFNSGTVTANSSS
                     ASPSVAAGNTPNQNFSTAANSQPQQRSQASGNQPPSILGQGGSAQNMGPRPGAPSQGL
                     FGQPSSRLAPASNMTSQRPVSSTGINFDNPSVQKALDTLIQSGPALSHLVSQTTAQMG
                     QPQAPMGSYQRHY"
     exon            214..540
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            541..677
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            678..804
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1004
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1325
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..3224
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2144..2149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /note="hexamer: AATAAA"
     polyA_site      2166
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
     regulatory      3190..3195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /note="hexamer: AATGAA"
     polyA_site      3224
                     /gene="NCOA5"
                     /gene_synonym="bA465L10.6; CIA"
                     /note="major polyA site"
ORIGIN      
        1 actctccgcc cggccgccat tgcctcgtgc ccgcgccggt cggttggtgg cgcctttgtc
       61 ctacggcggg caggtgggcc gacgcggagg cggcagcggc gggcctgagg cgaaggagcg
      121 gccgggagcc cgccgcgctg gtagcgatat taataaggca gcggaaagaa gaaatatgaa
      181 tacggctcca tcaagaccca gccccacacg aagggatcca tatggctttg gagacagtcg
      241 agattcaagg cgtgatcgat ccccaattcg aggaagtcca aggagagagc ccagggatgg
      301 cagaaatggc cgggatgccc gggacagcag agacattcga gacccccgag acttgcggga
      361 ccacagacat agtagagatt tgcgggatca cagagacagc aggagtgtgc gcgacgttcg
      421 ggacgtgagg gatcttagag actttcgtga tctaagagac tctagggatt ttcgagatca
      481 gcgagacccc atgtacgaca gatacagaga catgagagac tcccgagatc ctatgtacag
      541 gagagaaggc tcttatgacc gatacctacg aatggatgac tattgcagga gaaaggatga
      601 ctcttatttt gaccgttaca gagatagctt tgatggacgg ggccctccag gcccagaaag
      661 tcagtctcgt gcaaaagagc gtttgaaacg tgaggaacgg cgtagagaag agctttatcg
      721 tcaatatttt gaggaaatcc agagacgctt tgatgccgaa aggcccgttg attgttctgt
      781 gattgtggtc aacaaacaga caaaagacta tgctgagtct gtggggcgga aggtgcgaga
      841 cctgggcatg gtagtggact tgatcttcct taacacagaa gtgtcactgt cacaagcctt
      901 ggaggatgtt agcaggggag gttctccttt tgctattgtc atcacccagc aacaccagat
      961 tcaccgctcc tgcacagtca acatcatgtt tggaaccccg caagagcatc gcaacatgcc
     1021 ccaagcagat gccatggtgc tggtggccag aaattatgag cgttacaaga atgagtgccg
     1081 ggagaaggaa cgtgaggaga ttgccagaca ggcagccaag atggccgatg aagccatcct
     1141 gcaggaaaga gagagaggag gccctgagga gggagtgcgt gggggccacc ctccagccat
     1201 ccagagcctc atcaacctgc tggcagacaa caggtacctc actgctgaag agactgacaa
     1261 gatcatcaac tacctgcgag agcggaagga gcggctgatg aggagcagca ccgactctct
     1321 gcctggcccg atttcccgcc aaccactcgg ggcgacctcg ggtgcctcgc tgaagacaca
     1381 gccaagctcc caaccgctcc agagcggcca agtgctcccc tctgctacac ccactccatc
     1441 tgcacccccc acctcccagc aagagcttca ggccaaaatc ctcagcctct tcaatagtgg
     1501 cacagtgacg gccaatagca gctctgcatc cccctcggtt gctgccggaa acaccccaaa
     1561 ccagaatttt tccacagcag caaacagcca gcctcaacaa agatcacagg cttctggcaa
     1621 tcagcctcca agcattttgg gacagggagg atctgctcag aacatgggcc ccagacctgg
     1681 ggctccttcc caagggcttt ttggccagcc ttccagtcgc ctggcacctg ctagcaacat
     1741 gactagccag aggcctgtgt cttccacagg tatcaacttt gacaatccaa gtgtacagaa
     1801 ggctctggat accctgatcc agagtggccc tgctctctcc cacctggtta gccagaccac
     1861 agcacagatg gggcagccac aggcccccat gggatcttac cagaggcatt actgaagcta
     1921 aatctttcaa ctctccccag tcccctcatc ccctggcctc ctcccactta cttgttctaa
     1981 atagagctgt ttggaggatg ttctctgcgc tcccaggccg gcatcgagtg tcatcaattt
     2041 ctaccacctg ctctctcttc tgcccaaggc tgtgttgctt attccttaca aagtttatac
     2101 tgcatttggg gctgtatctt tttttgtttt ttgttttgta gaaaataaat atctccgggg
     2161 gcagtacagg tgtctgggct tgtatttgat ggggtttctc cggtccctgt ttctactgga
     2221 tttggagcca ggcccagcta gccaagtttg gaatggcatt tgtcatgtca gtagccacca
     2281 cctttgttca ttgtgaacct accaaggctt tccagcttca tacacattga ccagagctca
     2341 agctcctgcc tgcaactcct gcctagagtt gaagaaaagc aaactggcct tggcaggcac
     2401 agtgtcatca taccctcacc ccatatgttt ggggtctgct tgaggattca taaatcagcc
     2461 actctggatt gttgaggaat ggccatggca gccacagaaa aaagaatttt tctctctgag
     2521 ccaaggttgt tttttgtttt tttctctttt cttttttgtt ttcatttcat tggaagatct
     2581 ccaatggact gaacagctcc agtcagcagc agttaccaca aactgtgaat ctgggcccca
     2641 ccactcttcc ctgttaacca gttctgtcag catccccctc tccagcagca cttccatgaa
     2701 gttggttctg agactctggc cgtgaacacc cgtttcttca gtgatttgtt ttgggctttt
     2761 ggctcaaaac cccaggctct tgtttttgtc tagactctta ttctgtttcc tgagcagcag
     2821 gaggtaggga ccactttgat gtcagacttc tggtagctgg acatgttctc gagatgggtg
     2881 gctgttcgcg acttttgtac cagagtgaaa ttgttagaag gagggtttct ggctgtggtt
     2941 ctaaatggag ccccaggaag ctgccctctc cccagggttt gtgctcagta gagccctgtg
     3001 gatcacagtc ttgaggtcct ctagcagggg tgagggagag cagcgacttc agctgagtcc
     3061 ctgccagtgg ttaagcaaac aatggtttca aaattcaagg tccccaaatg gcagcatttt
     3121 atgttctgac ctgtttgtgt tatatagtgg tttttttttt cctctttgga actcttgtgt
     3181 tgttaataaa atgaaatgat tactttttaa ttaaaatgaa aaaa
//
