LOCUS       NM_001145263            3461 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript
            variant 4, mRNA.
ACCESSION   NM_001145263
VERSION     NM_001145263.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3461)
  AUTHORS   He,X., Wang,Z., Ge,Q., Sun,S., Li,R. and Wang,B.
  TITLE     Lactylation of nuclear receptor coactivator 4 promotes
            ferritinophagy and glycolysis of neuronal cells after cerebral
            ischemic injury
  JOURNAL   Neuroreport 35 (14), 895-903 (2024)
   PUBMED   39166386
  REMARK    GeneRIF: Lactylation of nuclear receptor coactivator 4 promotes
            ferritinophagy and glycolysis of neuronal cells after cerebral
            ischemic injury.
REFERENCE   2  (bases 1 to 3461)
  AUTHORS   Zhao,H., Lu,Y., Zhang,J., Sun,Z., Cheng,C., Liu,Y., Wu,L.,
            Zhang,M., He,W., Hao,S. and Li,K.
  TITLE     NCOA4 requires a [3Fe-4S] to sense and maintain the iron
            homeostasis
  JOURNAL   J Biol Chem 300 (2), 105612 (2024)
   PUBMED   38159858
  REMARK    GeneRIF: NCOA4 requires a [3Fe-4S] to sense and maintain the iron
            homeostasis.
REFERENCE   3  (bases 1 to 3461)
  AUTHORS   Lin,Y., Gong,H., Liu,J., Hu,Z., Gao,M., Yu,W. and Liu,J.
  TITLE     HECW1 induces NCOA4-regulated ferroptosis in glioma through the
            ubiquitination and degradation of ZNF350
  JOURNAL   Cell Death Dis 14 (12), 794 (2023)
   PUBMED   38049396
  REMARK    GeneRIF: HECW1 induces NCOA4-regulated ferroptosis in glioma
            through the ubiquitination and degradation of ZNF350.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3461)
  AUTHORS   Khonrak,T., Watcharadetwittaya,S., Chamgramol,Y., Intarawichian,P.
            and Deenonpoe,R.
  TITLE     RET rearrangements are relevant to histopathologic subtypes and
            clinicopathological features in Thai papillary thyroid carcinoma
            patients
  JOURNAL   Pathol Oncol Res 29, 1611138 (2023)
   PUBMED   37188126
  REMARK    GeneRIF: RET rearrangements are relevant to histopathologic
            subtypes and clinicopathological features in Thai papillary thyroid
            carcinoma patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3461)
  AUTHORS   Bongarzone,I., Butti,M.G., Fugazzola,L., Pacini,F., Pinchera,A.,
            Vorontsova,T.V., Demidchik,E.P. and Pierotti,M.A.
  TITLE     Comparison of the breakpoint regions of ELE1 and RET genes involved
            in the generation of RET/PTC3 oncogene in sporadic and in
            radiation-associated papillary thyroid carcinomas
  JOURNAL   Genomics 42 (2), 252-259 (1997)
   PUBMED   9192845
REFERENCE   6  (bases 1 to 3461)
  AUTHORS   Yeh,S. and Chang,C.
  TITLE     Cloning and characterization of a specific coactivator, ARA70, for
            the androgen receptor in human prostate cells
  JOURNAL   Proc Natl Acad Sci U S A 93 (11), 5517-5521 (1996)
   PUBMED   8643607
REFERENCE   7  (bases 1 to 3461)
  AUTHORS   Minoletti,F., Butti,M.G., Coronelli,S., Miozzo,M., Sozzi,G.,
            Pilotti,S., Tunnacliffe,A., Pierotti,M.A. and Bongarzone,I.
  TITLE     The two genes generating RET/PTC3 are localized in chromosomal band
            10q11.2
  JOURNAL   Genes Chromosomes Cancer 11 (1), 51-57 (1994)
   PUBMED   7529046
REFERENCE   8  (bases 1 to 3461)
  AUTHORS   Bongarzone,I., Butti,M.G., Coronelli,S., Borrello,M.G., Santoro,M.,
            Mondellini,P., Pilotti,S., Fusco,A., Della Porta,G. and
            Pierotti,M.A.
  TITLE     Frequent activation of ret protooncogene by fusion with a new
            activating gene in papillary thyroid carcinomas
  JOURNAL   Cancer Res 54 (11), 2979-2985 (1994)
   PUBMED   8187085
REFERENCE   9  (bases 1 to 3461)
  AUTHORS   Jhiang,S.M., Smanik,P.A. and Mazzaferri,E.L.
  TITLE     Development of a single-step duplex RT-PCR detecting different
            forms of ret activation, and identification of the third form of in
            vivo ret activation in human papillary thyroid carcinoma
  JOURNAL   Cancer Lett 78 (1-3), 69-76 (1994)
   PUBMED   8180971
REFERENCE   10 (bases 1 to 3461)
  AUTHORS   Santoro,M., Dathan,N.A., Berlingieri,M.T., Bongarzone,I.,
            Paulin,C., Grieco,M., Pierotti,M.A., Vecchio,G. and Fusco,A.
  TITLE     Molecular characterization of RET/PTC3; a novel rearranged version
            of the RETproto-oncogene in a human thyroid papillary carcinoma
  JOURNAL   Oncogene 9 (2), 509-516 (1994)
   PUBMED   8290261
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312325.1, AK292480.1 and
            BC012736.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001145263.1.
            
            Summary: This gene encodes an androgen receptor coactivator. The
            encoded protein interacts with the androgen receptor in a
            ligand-dependent manner to enhance its transcriptional activity.
            Chromosomal translocations between this gene and the ret tyrosine
            kinase gene, also located on chromosome 10, have been associated
            with papillary thyroid carcinoma. Alternatively spliced transcript
            variants have been described. Pseudogenes are present on
            chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon in the 5' coding region and uses a downstream start codon,
            compared to variant 1. This variant (4) also lacks an exon in the
            3' coding region, which results in a frameshift and use of a
            downstream stop codon, compared to variant 1. The encoded isoform
            (3) has a shorter N-terminus and a shorter, distinct C-terminus
            compared to isoform 1. Variants 3, 4, and 5 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X77548.1, AK129911.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000581486.6/ ENSP00000462943.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-661               AK312325.1         38-698
            662-2254            AK292480.1         779-2371
            2255-3461           BC012736.2         2087-3293
FEATURES             Location/Qualifiers
     source          1..3461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..3461
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /note="nuclear receptor coactivator 4"
                     /db_xref="GeneID:8031"
                     /db_xref="HGNC:HGNC:7671"
                     /db_xref="MIM:601984"
     exon            1..98
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /inference="alignment:Splign:2.1.0"
     exon            99..253
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1957
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /note="isoform 3 is encoded by transcript variant 4;
                     RET-activating gene ELE1; ret fused; NCoA-4; 70 kDa
                     AR-activator; 70 kDa androgen receptor coactivator;
                     androgen receptor-associated protein of 70 kDa; ferritin
                     cargo receptor NCOA4"
                     /codon_start=1
                     /product="nuclear receptor coactivator 4 isoform 3"
                     /protein_id="NP_001138735.1"
                     /db_xref="CCDS:CCDS73092.1"
                     /db_xref="GeneID:8031"
                     /db_xref="HGNC:HGNC:7671"
                     /db_xref="MIM:601984"
                     /translation="MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDN
                     LREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCL
                     THQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTI
                     QIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPY
                     IPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHS
                     TTSSFSIEMEKVGDQELPDQDEMDLSDWLVTPQESHKLRKPENGSRETSEKFKLLFQS
                     YNVNDWLVKTDSCTNCQGNQPKGVEIENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQ
                     NHQDPCKVEEVCRANEPCTSFAECVCDENCEKEALYKWLLKKEGKDKNGMPVEPKPEP
                     EKHKDSLNMWLCPRKEVIEQTKAPKAMTPSRIADSFQVIKNSPLSEWLIRPPYKEGSP
                     KEVPGTEDRAGKQKFKSPMNTSWCSFNTADWVLPGKKMGNLSQLSSGEDKWLLRKKAQ
                     EVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLKVDKEKWLYRTPLQM"
     exon            254..394
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /inference="alignment:Splign:2.1.0"
     exon            395..483
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /inference="alignment:Splign:2.1.0"
     exon            484..592
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /inference="alignment:Splign:2.1.0"
     exon            593..682
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /inference="alignment:Splign:2.1.0"
     exon            683..826
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1810
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1951
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..3461
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3441..3446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /note="hexamer: ATTAAA"
     polyA_site      3461
                     /gene="NCOA4"
                     /gene_synonym="ARA70; ELE1; PTC3; RFG"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcgagaa ctctgccttt gggccgtagg ttagtgtggg gccgtgtctc agtccaccca
       61 aggtctcctc ggatcgcctg gagaggcact cggacctgga gcagtgagga gaatgaatac
      121 cttccaagac cagagtggca gctccagtaa tagagaaccc cttttgaggt gtagtgatgc
      181 acggagggac ttggagcttg ctattggtgg agttctccgg gctgaacagc aaattaaaga
      241 taacttgcga gaggtcaaag ctcagattca cagttgcata agccgtcacc tggaatgtct
      301 tagaagccgt gaggtatggc tgtatgaaca ggtggacctt atttatcagc ttaaagagga
      361 gacacttcaa cagcaggctc agcagctcta ctcgttattg ggccagttca attgtcttac
      421 tcatcaactg gagtgtaccc aaaacaaaga tctagccaat caagtctctg tgtgcctgga
      481 gagactgggc agtttgaccc ttaagcctga agattcaact gtcctgctct ttgaagctga
      541 cacaattact ctgcgccaga ccatcaccac atttgggtct ctcaaaacca ttcaaattcc
      601 tgagcacttg atggctcatg ctagttcagc aaatattggg cccttcctgg agaagagagg
      661 ctgtatctcc atgccagagc agaagtcagc atccggtatt gtagctgtcc ctttcagcga
      721 atggctcctt ggaagcaaac ctgccagtgg ttatcaagct ccttacatac ccagcaccga
      781 cccccaggac tggcttaccc aaaagcagac cttggagaac agtcagactt cttccagagc
      841 ctgcaatttc ttcaataatg tcgggggaaa cctaaagggc ttagaaaact ggctcctcaa
      901 gagtgaaaaa tcaagttatc aaaagtgtaa cagccattcc actactagtt ctttctccat
      961 tgaaatggaa aaggttggag atcaagagct tcctgatcaa gatgagatgg acctatcaga
     1021 ttggctagtg actccccagg aatcccataa gctgcggaag cctgagaatg gcagtcgtga
     1081 aaccagtgag aagtttaagc tcttattcca gtcctataat gtgaatgatt ggcttgtcaa
     1141 gactgactcc tgtaccaact gtcagggaaa ccagcccaaa ggtgtggaga ttgaaaacct
     1201 gggcaatctg aagtgcctga atgaccactt ggaggccaag aaaccattgt ccacccccag
     1261 catggttaca gaggattggc ttgtccagaa ccatcaggac ccatgtaagg tagaggaggt
     1321 gtgcagagcc aatgagccct gcacaagctt tgcagagtgt gtgtgtgatg agaattgtga
     1381 gaaggaggct ctgtataagt ggcttctgaa gaaagaagga aaggataaaa atgggatgcc
     1441 tgtggaaccc aaacctgagc ctgagaagca taaagattcc ctgaatatgt ggctctgtcc
     1501 tagaaaagaa gtaatagaac aaactaaagc accaaaggca atgactcctt ctagaattgc
     1561 tgattccttc caagtcataa agaacagccc cttgtcggag tggcttatca ggcccccata
     1621 caaagaagga agtcccaagg aagtgcctgg tactgaagac agagctggca aacagaagtt
     1681 taaaagcccc atgaatactt cctggtgttc ctttaacaca gctgactggg tcctgccagg
     1741 aaagaagatg ggcaacctca gccagttatc ttctggagaa gacaagtggc tgcttcgaaa
     1801 gaaggcccag gaagtattac ttaattcacc tctacaggag gaacataact tccccccaga
     1861 ccattatggc ctccctgcag tttgtgatct ctttgcctgt atgcagctta aagttgataa
     1921 agagaagtgg ttatatcgaa ctcctctaca gatgtgaagg aatggacaag agttgagcag
     1981 cctttctgct gattatcaca catcatgagc tgagtgactg cagcttgcca aatctttgtg
     2041 tttctgggtc tgaccaatta gcttagttct tctcctgcct aattttgaac tagtaaagca
     2101 aagtgagtca tcagattatg agttactgtt taaaagaaaa atgctgttta ttcatgctga
     2161 ggtgattcag ttccctcctt cttacagaag tattttaatt caccccacac tagaaatgca
     2221 gcatctttgt ggacgtcttt ttcacaagcc tccaaggctc cttagattgg gtcgttacta
     2281 aaagtacatt aaaacactct tgtttatcga agtatattga tgtattctaa agctagtaaa
     2341 cttccctaac gtttaattgc cctacagatg cttctcttgc tgtgggtttt cttttgttag
     2401 tggtctgaaa taattatttt cctgttctat taatacatag tgtattttgc acaaaaaaat
     2461 taacctggtc aatagtgatt accaaaatat atattaataa tcttggcaat ttttgacatt
     2521 aattatgaaa cattttagcc cacgttagtt ctacattatt cttcacttaa actcagctac
     2581 tgcaaatttt gtctttctgt aaatgttatt aaaatatcca gtgagctctt tagaaggact
     2641 cagtattatt tcaagactat ttttgaggta attctagcct tttaaaatat tctacagacc
     2701 tacggggctt aaaagaaccc cagtaccgac taagcaaata ggcaaaagac atgttggaaa
     2761 tgtagtatag tacttgaaac agtcactatc atagggataa ttggtgcatc ctgtgtaaat
     2821 ggaagctgag cttgacacct ggtgctttta agtagggata aagtcatcct ctcactgcaa
     2881 gcacagcata cctgtacctc caaaagtgac gttttagtga acaggccgtt ttcaacactt
     2941 gtgccttggg gtgttcattg aagctttgtg aaaactactg atgttttctc agtctcctta
     3001 aagttacgtc catgctttaa aatgtctgtg taggagagaa gtggggttta taatgttttc
     3061 tctaagatat ctttgctgct ttccagactt tgaaactatt aagcttctta actgcctctt
     3121 accggaaata cttctgggga aacttcatgg tcccaaaatg tcattgccat acagcttcac
     3181 tagagttctt tgaaccacag ctgaaaagag ctttgtatta ttttttaatt ccctccccag
     3241 atatcattta ggagtattat ataaaggtgg tgggcaaaaa caatgtaagg agcctttcca
     3301 gttatcttga gttgcagctc tgtagtttct tgaggccaaa cacactgtat tttacaagtc
     3361 aaaatataat ttacattaat cactatgtta atgagtatgt aaaacattct tttgcattga
     3421 tgaattttgt atctgcttcc attaaaagca taacagccat a
//
