LOCUS       NM_181659               7961 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript
            variant 1, mRNA.
ACCESSION   NM_181659
VERSION     NM_181659.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7961)
  AUTHORS   Xie,Y., Yuan,Q., Cao,X., Qiu,Y., Zeng,J., Cao,Y., Xie,Y., Meng,X.,
            Huang,K., Yi,F. and Zhang,C.
  TITLE     Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic
            Kidney Disease by Impairing Podocyte Autophagy
  JOURNAL   Adv Sci (Weinh) 11 (19), e2308378 (2024)
   PUBMED   38483947
  REMARK    GeneRIF: Deficiency of Nuclear Receptor Coactivator 3 Aggravates
            Diabetic Kidney Disease by Impairing Podocyte Autophagy.
REFERENCE   2  (bases 1 to 7961)
  AUTHORS   Xiang,P., Ge,T., Zhou,J. and Zhang,Y.
  TITLE     Protective role of circRNA CCND1 in ulcerative colitis via
            miR-142-5p/NCOA3 axis
  JOURNAL   BMC Gastroenterol 23 (1), 18 (2023)
   PUBMED   36658474
  REMARK    GeneRIF: Protective role of circRNA CCND1 in ulcerative colitis via
            miR-142-5p/NCOA3 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7961)
  AUTHORS   Han,R., Dermawan,J.K., Demicco,E.G., Ferguson,P.C., Griffin,A.M.,
            Swanson,D., Antonescu,C.R. and Dickson,B.C.
  TITLE     ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell
            rhabdomyosarcoma
  JOURNAL   Genes Chromosomes Cancer 61 (11), 645-652 (2022)
   PUBMED   35521817
  REMARK    GeneRIF: ZFP64::NCOA3 gene fusion defines a novel subset of spindle
            cell rhabdomyosarcoma.
REFERENCE   4  (bases 1 to 7961)
  AUTHORS   Yang,M. and Jing,F.
  TITLE     FBXL16 modulates the proliferation and autophagy in breast cancer
            cells via activating SRC-3-AKT signaling pathway
  JOURNAL   Reprod Biol 21 (3), 100538 (2021)
   PUBMED   34333223
  REMARK    GeneRIF: FBXL16 modulates the proliferation and autophagy in breast
            cancer cells via activating SRC-3-AKT signaling pathway.
REFERENCE   5  (bases 1 to 7961)
  AUTHORS   Tesolin,P., Morgan,A., Notarangelo,M., Ortore,R.P., Concas,M.P.,
            Notarangelo,A. and Girotto,G.
  TITLE     Non-Syndromic Autosomal Dominant Hearing Loss: The First Italian
            Family Carrying a Mutation in the NCOA3 Gene
  JOURNAL   Genes (Basel) 12 (7), 1043 (2021)
   PUBMED   34356059
  REMARK    GeneRIF: Non-Syndromic Autosomal Dominant Hearing Loss: The First
            Italian Family Carrying a Mutation in the NCOA3 Gene.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7961)
  AUTHORS   Anzick,S.L., Kononen,J., Walker,R.L., Azorsa,D.O., Tanner,M.M.,
            Guan,X.Y., Sauter,G., Kallioniemi,O.P., Trent,J.M. and Meltzer,P.S.
  TITLE     AIB1, a steroid receptor coactivator amplified in breast and
            ovarian cancer
  JOURNAL   Science 277 (5328), 965-968 (1997)
   PUBMED   9252329
REFERENCE   7  (bases 1 to 7961)
  AUTHORS   Li,H., Gomes,P.J. and Chen,J.D.
  TITLE     RAC3, a steroid/nuclear receptor-associated coactivator that is
            related to SRC-1 and TIF2
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8479-8484 (1997)
   PUBMED   9238002
REFERENCE   8  (bases 1 to 7961)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
REFERENCE   9  (bases 1 to 7961)
  AUTHORS   Guan,X.Y., Xu,J., Anzick,S.L., Zhang,H., Trent,J.M. and
            Meltzer,P.S.
  TITLE     Hybrid selection of transcribed sequences from microdissected DNA:
            isolation of genes within amplified region at 20q11-q13.2 in breast
            cancer
  JOURNAL   Cancer Res 56 (15), 3446-3450 (1996)
   PUBMED   8758910
REFERENCE   10 (bases 1 to 7961)
  AUTHORS   Liu,F., Ventura,F., Doody,J. and Massague,J.
  TITLE     Human type II receptor for bone morphogenic proteins (BMPs):
            extension of the two-kinase receptor model to the BMPs
  JOURNAL   Mol Cell Biol 15 (7), 3479-3486 (1995)
   PUBMED   7791754
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353777.18, AL021394.10 and
            AL034418.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_181659.2.
            
            Summary: The protein encoded by this gene is a nuclear receptor
            coactivator that interacts with nuclear hormone receptors to
            enhance their transcriptional activator functions. The encoded
            protein has histone acetyltransferase activity and recruits
            p300/CBP-associated factor and CREB binding protein as part of a
            multisubunit coactivation complex. This protein is initially found
            in the cytoplasm but is translocated into the nucleus upon
            phosphorylation. Several transcript variants encoding different
            isoforms have been found for this gene. In addition, a polymorphic
            repeat region is found in the C-terminus of the encoded protein.
            [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.128781.1,
                                           SRR1803613.237496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371998.8/ ENSP00000361066.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL353777.18        49049-49181
            134-212             AL021394.10        67634-67712
            213-314             AL034418.5         38191-38292
            315-487             AL034418.5         39873-40045
            488-588             AL034418.5         41343-41443
            589-763             AL034418.5         42964-43138
            764-952             AL034418.5         43523-43711
            953-1054            AL034418.5         43884-43985
            1055-1195           AL034418.5         49458-49598
            1196-1343           AL034418.5         50010-50157
            1344-1735           AL034418.5         51284-51675
            1736-2607           AL034418.5         51853-52724
            2608-2743           AL034418.5         53610-53745
            2744-2938           AL034418.5         54970-55164
            2939-3184           AL034418.5         55539-55784
            3185-3311           AL034418.5         55887-56013
            3312-3483           AL034418.5         58175-58346
            3484-3777           AL034418.5         63035-63328
            3778-3882           AL034418.5         64967-65071
            3883-4177           AL034418.5         66944-67238
            4178-4352           AL034418.5         68368-68542
            4353-4494           AL034418.5         68893-69034
            4495-7961           AL034418.5         69368-72834
FEATURES             Location/Qualifiers
     source          1..7961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..7961
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /note="nuclear receptor coactivator 3"
                     /db_xref="GeneID:8202"
                     /db_xref="HGNC:HGNC:7670"
                     /db_xref="MIM:601937"
     exon            1..133
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..212
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..314
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..4506
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /EC_number="2.3.1.48"
                     /note="isoform a is encoded by transcript variant 1;
                     thyroid hormone receptor activator molecule 1;
                     receptor-associated coactivator 3; steroid receptor
                     coactivator protein 3; CBP-interacting protein; amplified
                     in breast cancer 1 protein; class E basic helix-loop-helix
                     protein 42"
                     /codon_start=1
                     /product="nuclear receptor coactivator 3 isoform a"
                     /protein_id="NP_858045.1"
                     /db_xref="CCDS:CCDS13407.1"
                     /db_xref="GeneID:8202"
                     /db_xref="HGNC:HGNC:7670"
                     /db_xref="MIM:601937"
                     /translation="MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKY
                     IEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSS
                     TGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNI
                     LHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMR
                     QRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGK
                     VVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYR
                     FSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMA
                     GCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQS
                     PSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMA
                     SSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQD
                     SKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQL
                     LTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKH
                     RILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKKENNALLRY
                     LLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLD
                     NLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLKSSQSVQSIRPPYNRAV
                     SLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMGGPNRNVTVTQT
                     PSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPTLPLRSNSIPGAR
                     PVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLL
                     RNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQAL
                     EPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMNQMNQQG
                     NFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTAGGAA
                     VMRPMMQPQVSSQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQ
                     QQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQ
                     PDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQ
                     QQFAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC"
     exon            315..487
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..588
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..763
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..952
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1054
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1195
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1343
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1735
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..2607
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2743
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2938
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3184
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3311
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3483
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3777
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3882
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4177
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4178..4352
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4353..4494
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..7961
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7941..7946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /note="hexamer: AATAAA"
     polyA_site      7961
                     /gene="NCOA3"
                     /gene_synonym="ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26;
                     KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1"
                     /note="major polyA site"
ORIGIN      
        1 agctgctgct gtctcagccg ctccacagcg acggcagcgg ctgcggctta gtcggtggcg
       61 gccggcggcg gctgcgggct gagcggcgag tttccgattt aaagctgagc tgcgaggaaa
      121 atggcggcgg gaggatcaaa atacttgctg gatggtggac tcagagacca ataaaaataa
      181 actgcttgaa catcctttga ctggttagcc agttgctgat gtatattcaa gatgagtgga
      241 ttaggagaaa acttggatcc actggccagt gattcacgaa aacgcaaatt gccatgtgat
      301 actccaggac aaggtcttac ctgcagtggt gaaaaacgga gacgggagca ggaaagtaaa
      361 tatattgaag aattggctga gctgatatct gccaatctta gtgatattga caatttcaat
      421 gtcaaaccag ataaatgtgc gattttaaag gaaacagtaa gacagatacg tcaaataaaa
      481 gagcaaggaa aaactatttc caatgatgat gatgttcaaa aagccgatgt atcttctaca
      541 gggcagggag ttattgataa agactcctta ggaccgcttt tacttcaggc attggatggt
      601 ttcctatttg tggtgaatcg agacggaaac attgtatttg tatcagaaaa tgtcacacaa
      661 tacctgcaat ataagcaaga ggacctggtt aacacaagtg tttacaatat cttacatgaa
      721 gaagacagaa aggattttct taagaattta ccaaaatcta cagttaatgg agtttcctgg
      781 acaaatgaga cccaaagaca aaaaagccat acatttaatt gccgtatgtt gatgaaaaca
      841 ccacatgata ttctggaaga cataaacgcc agtcctgaaa tgcgccagag atatgaaaca
      901 atgcagtgct ttgccctgtc tcagccacga gctatgatgg aggaagggga agatttgcaa
      961 tcttgtatga tctgtgtggc acgccgcatt actacaggag aaagaacatt tccatcaaac
     1021 cctgagagct ttattaccag acatgatctt tcaggaaagg ttgtcaatat agatacaaat
     1081 tcactgagat cctccatgag gcctggcttt gaagatataa tccgaaggtg tattcagaga
     1141 ttttttagtc taaatgatgg gcagtcatgg tcccagaaac gtcactatca agaagcttat
     1201 cttaatggcc atgcagaaac cccagtatat cgattctcgt tggctgatgg aactatagtg
     1261 actgcacaga caaaaagcaa actcttccga aatcctgtaa caaatgatcg acatggcttt
     1321 gtctcaaccc acttccttca gagagaacag aatggatata gaccaaaccc aaatcctgtt
     1381 ggacaaggga ttagaccacc tatggctgga tgcaacagtt cggtaggcgg catgagtatg
     1441 tcgccaaacc aaggcttaca gatgccgagc agcagggcct atggcttggc agaccctagc
     1501 accacagggc agatgagtgg agctaggtat gggggttcca gtaacatagc ttcattgacc
     1561 cctgggccag gcatgcaatc accatcttcc taccagaaca acaactatgg gctcaacatg
     1621 agtagccccc cacatgggag tcctggtctt gccccaaacc agcagaatat catgatttct
     1681 cctcgtaatc gtgggagtcc aaagatagcc tcacatcagt tttctcctgt tgcaggtgtg
     1741 cactctccca tggcatcttc tggcaatact gggaaccaca gcttttccag cagctctctc
     1801 agtgccctgc aagccatcag tgaaggtgtg gggacttccc ttttatctac tctgtcatca
     1861 ccaggcccca aattggataa ctctcccaat atgaatatta cccaaccaag taaagtaagc
     1921 aatcaggatt ccaagagtcc tctgggcttt tattgcgacc aaaatccagt ggagagttca
     1981 atgtgtcagt caaatagcag agatcacctc agtgacaaag aaagtaagga gagcagtgtt
     2041 gagggggcag agaatcaaag gggtcctttg gaaagcaaag gtcataaaaa attactgcag
     2101 ttacttacct gttcttctga tgaccggggt cattcctcct tgaccaactc ccccctagat
     2161 tcaagttgta aagaatcttc tgttagtgtc accagcccct ctggagtctc ctcctctaca
     2221 tctggaggag tatcctctac atccaatatg catgggtcac tgttacaaga gaagcaccgg
     2281 attttgcaca agttgctgca gaatgggaat tcaccagctg aggtagccaa gattactgca
     2341 gaagccactg ggaaagacac cagcagtata acttcttgtg gggacggaaa tgttgtcaag
     2401 caggagcagc taagtcctaa gaagaaggag aataatgcac ttcttagata cctgctggac
     2461 agggatgatc ctagtgatgc actctctaaa gaactacagc cccaagtgga aggagtggat
     2521 aataaaatga gtcagtgcac cagctccacc attcctagct caagtcaaga gaaagaccct
     2581 aaaattaaga cagagacaag tgaagaggga tctggagact tggataatct agatgctatt
     2641 cttggtgatc tgactagttc tgacttttac aataattcca tatcctcaaa tggtagtcat
     2701 ctggggacta agcaacaggt gtttcaagga actaattctc tgggtttgaa aagttcacag
     2761 tctgtgcagt ctattcgtcc tccatataac cgagcagtgt ctctggatag ccctgtttct
     2821 gttggctcaa gtcctccagt aaaaaatatc agtgctttcc ccatgttacc aaagcaaccc
     2881 atgttgggtg ggaatccaag aatgatggat agtcaggaaa attatggctc aagtatgggt
     2941 gggccaaacc gaaatgtgac tgtgactcag actccttcct caggagactg gggcttacca
     3001 aactcaaagg ccggcagaat ggaacctatg aattcaaact ccatgggaag accaggagga
     3061 gattataata cttctttacc cagacctgca ctgggtggct ctattcccac attgcctctt
     3121 cggtctaata gcataccagg tgcgagacca gtattgcaac agcagcagca gatgcttcaa
     3181 atgaggcctg gtgaaatccc catgggaatg ggggctaatc cctatggcca agcagcagca
     3241 tctaaccaac tgggttcctg gcccgatggc atgttgtcca tggaacaagt ttctcatggc
     3301 actcaaaata ggcctcttct taggaattcc ctggatgatc ttgttgggcc accttccaac
     3361 ctggaaggcc agagtgacga aagagcatta ttggaccagc tgcacactct tctcagcaac
     3421 acagatgcca caggcctgga agaaattgac agagctttgg gcattcctga acttgtcaat
     3481 cagggacagg cattagagcc caaacaggat gctttccaag gccaagaagc agcagtaatg
     3541 atggatcaga aggcaggatt atatggacag acatacccag cacaggggcc tccaatgcaa
     3601 ggaggctttc atcttcaggg acaatcacca tcttttaact ctatgatgaa tcagatgaac
     3661 cagcaaggca attttcctct ccaaggaatg cacccacgag ccaacatcat gagaccccgg
     3721 acaaacaccc ccaagcaact tagaatgcag cttcagcaga ggctgcaggg ccagcagttt
     3781 ttgaatcaga gccgacaggc acttgaattg aaaatggaaa accctactgc tggtggtgct
     3841 gcggtgatga ggcctatgat gcagccccag gtgagctccc agcagggttt tcttaatgct
     3901 caaatggtcg cccaacgcag cagagagctg ctaagtcatc acttccgaca acagagggtg
     3961 gctatgatga tgcagcagca gcagcagcag caacagcagc agcagcagca gcagcagcag
     4021 caacagcaac agcaacagca acagcagcaa cagcagcaaa cccaggcctt cagcccacct
     4081 cctaatgtga ctgcttcccc cagcatggat gggcttttgg caggacccac aatgccacaa
     4141 gctcctccgc aacagtttcc atatcaacca aattatggaa tgggacaaca accagatcca
     4201 gcctttggtc gagtgtctag tcctcccaat gcaatgatgt cgtcaagaat gggtccctcc
     4261 cagaatccca tgatgcaaca cccgcaggct gcatccatct atcagtcctc agaaatgaag
     4321 ggctggccat caggaaattt ggccaggaac agctcctttt cccagcagca gtttgcccac
     4381 caggggaatc ctgcagtgta tagtatggtg cacatgaatg gcagcagtgg tcacatggga
     4441 cagatgaaca tgaaccccat gcccatgtct ggcatgccta tgggtcctga tcagaaatac
     4501 tgctgacatc tctgcaccag gacctcttaa ggaaaccact gtacaaatga cactgcacta
     4561 ggattattgg gaaggaatca ttgttccagg catccatctt ggaagaaagg accagctttg
     4621 agctccatca agggtatttt aagtgatgtc atttgagcag gactggattt taagccgaag
     4681 ggcaatatct acgtgttttt cccccctcct tctgctgtgt atcatggtgt tcaaaacaga
     4741 aatgtttttt ggcattccac ctcctaggga tataattctg gagacatgga gtgttactga
     4801 tcataaaact tttgtgtcac ttttttctgc cttgctagcc aaaatctctt aaatacacgt
     4861 aggtgggcca gagaacattg gaagaatcaa gagagattag aatatctggt ttctctagtt
     4921 gcagtattgg acaaagagca tagtcccagc cttcaggtgt agtagttctg tgttgaccct
     4981 ttgtccagtg gaattggtga ttctgaattg tcctttacta atggtgttga gttgctctgt
     5041 ccctattatt tgccctaggc tttctcctaa tgaaggtttt catttgccat tcatgtcctg
     5101 taatacttca cctccaggaa ctgtcatgga tgtccaaatg gctttgcaga aaggaaatga
     5161 gatgacagta tttaatcgca gcagtagcaa acttttcaca tgctaatgtg cagctgagtg
     5221 cactttattt aaaaagaatg gataaatgca atattcttga ggtcttgagg gaatagtgaa
     5281 acacattcct ggtttttgcc tacacttacg tgttagacaa gaactatgat tttttttttt
     5341 aaagtactgg tgtcaccctt tgcctatatg gtagagcaat aatgcttttt aaaaataaac
     5401 ttctgaaaac ccaaggccag gtactgcatt ctgaatcaga atctcgcagt gtttctgtga
     5461 atagattttt ttgtaaatat gacctttaag atattgtatt atgtaaaata tgtatatacc
     5521 tttttttgta ggtcacaaca actcattttt acagagtttg tgaagctaaa tatttaacat
     5581 tgttgatttc agtaagctgt gtggtgaggc taccagtgga agagacatcc cttgactttt
     5641 gtggcctggg ggaggggtag tgctccacag cttttccttc cccacccccc agccttagat
     5701 gcctcgctct tttcaatctc ttaatctaaa tgctttttaa agagattatt tgtttagatg
     5761 taggcatttt aattttttaa aaattcctct accagaacta agcactttgt taatttgggg
     5821 ggaaagaata gatatgggga aataaactta aaaaaaaatc aggaatttaa aaaaacgagc
     5881 aatttgaaga gaatcttttg gattttaagc agtccgaaat aatagcaatt catgggctgt
     5941 gtgtgtgtgt gtatgtgtgt gtgtgtgtgt gtatgtttaa ttatgttacc ttttcatccc
     6001 ctttaggagc gttttcagat tttggttgct aagacctgaa tcccatattg agatctcgag
     6061 tagaatcctt ggtgtggttt ctggtgtctg ctcagctgtc ccctcattct actaatgtga
     6121 tgctttcatt atgtccctgt ggattagaat agtgtcagtt atttcttaag taactcagta
     6181 cccagaacag ccagttttac tgtgattcag agccacagtc taactgagca ccttttaaac
     6241 ccctccctct tctgccccct accacttttc tgctgttgcc tctctttgac acctgtttta
     6301 gtcagttggg aggaagggaa aaatcaagtt taattccctt tatctgggtt aattcatttg
     6361 gttcaaatag ttgacggaat tgggtttctg aatgtctgtg aatttcagag gtctctgcta
     6421 gccttggtat cattttctag caataactga gagccagtta attttaagaa tttcacacat
     6481 ttagccaatc tttctagatg tctctgaagg taagatcatt taatatcttt gatatgctta
     6541 cgagtaagtg aatcctgatt atttccagac ccaccaccag agtggatctt attttcaaag
     6601 cagtatagac aattatgagt ttgccctctt tcccctacca agttcaaaat atatctaaga
     6661 aagattgtaa atccgaaaac ttccattgta gtggcctgtg cttttcagat agtatactct
     6721 cctgtttgga gacagaggaa gaaccaggtc agtctgtctc tttttcagct caattgtatc
     6781 tgacccttct ttaagttatg tgtgtgggga gaaatagaat ggtgctctta tctttcttga
     6841 ctttaaaaaa attattaaaa acaaaaaaaa aataaatttt tttgcaatcc tttcctcaga
     6901 cctggctcca ggctaactgg aaggcagcac tccctttttt atatagtaga aaaatgaagt
     6961 ttattataag tttttatatt ttctacttgt tcatttggtg caaactcaag atttctttta
     7021 ataggtgcag tctttgagat aatttgtttt tacctgtatt gccctttatc ttttttaggt
     7081 aattctttgt actcctgctg tctacctctc ctcacacccc agcacccccc attttttcaa
     7141 accttggtat ctgttgggtg aacagtataa tcttttcatc tgcttttaga atgtgggata
     7201 tttccagtac ctactttttt tttttttttt tgctgaatcc aaagatatat aaataaaata
     7261 tatatatttt ataaagatca gaatgatata aaggagatac atgtttcttc ctttaaaaaa
     7321 taaacggaag ttacattgtt aatgttcata ttatgatgcc acttttctaa actgcatctg
     7381 gattgaaagg tgtaaatatc aataacagtg ctacttagtt atcagtattt aatatctgag
     7441 gtgagttggg ggtatctata ttaggggtag ggtattacag aagataattg gcttgatgtc
     7501 ctagaagttc tttgatccag aggtgggtgc agctgaaagt aaacagaatg gattgccagt
     7561 tacatgtatg cctgcccagt tcccttttta tttgcagaag ctgtgagttt tgttcacaat
     7621 taggttccta ggagcaaaac ctcaaggatt gatttattgt tttcaactcc aaggcacact
     7681 gttaataaac gagcagggtg ttttctctct tcctttctaa tatatggagt ttcgaagaat
     7741 aaaatatgag agcaatattt aaattctcag gaattgactt atactcttga gaatgaattc
     7801 agtttcaatc aagtttacat tatgttgctt aaaaaaatag aaattattct ttatcttgca
     7861 aagaattgaa accacatgaa atgacttatg ggggatggtg agctgtgact gctttgctga
     7921 ccattttgga tgtcattgta aataaaggtt tctatttaaa a
//
