LOCUS       XM_017012963            8720 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens nuclear receptor coactivator 2 (NCOA2),
            transcript variant X2, mRNA.
ACCESSION   XM_017012963
VERSION     XM_017012963.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000008.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017012963.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
     gene            1..8720
                     /gene="NCOA2"
                     /gene_synonym="bHLHe75; GRIP1; KAT13C; NCoA-2; SRC2; TIF2"
                     /note="nuclear receptor coactivator 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 20 ESTs, 1161 long SRA reads, 1 Protein, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 31 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:10499"
                     /db_xref="HGNC:HGNC:7669"
                     /db_xref="MIM:601993"
     CDS             269..4870
                     /gene="NCOA2"
                     /gene_synonym="bHLHe75; GRIP1; KAT13C; NCoA-2; SRC2; TIF2"
                     /codon_start=1
                     /product="nuclear receptor coactivator 2 isoform X1"
                     /protein_id="XP_016868452.1"
                     /db_xref="GeneID:10499"
                     /db_xref="HGNC:HGNC:7669"
                     /db_xref="MIM:601993"
                     /translation="MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENK
                     YIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDV
                     SSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVY
                     SILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQ
                     EAHQKYETMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDL
                     QGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFS
                     QIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMG
                     KPLNPISSNSPAHQALCSGNPGQDMTLSSNINFPINGPKEQMGMPMGRFGGSGGMNHV
                     SGMQATTPQGSNYALKMNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFS
                     PAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSP
                     VNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSE
                     RADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTS
                     LKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKK
                     ENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQ
                     PGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPV
                     GAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVI
                     PQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAM
                     NRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGGPQYSQQQAPP
                     NQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALR
                     NFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQG
                     SYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQQNRQ
                     PLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRT
                     LMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGTGLRSPPPFTSPFS
                     PVSPSVGSQLLSHSSLHGSQMNLANQGMIGNLGGQLGPVRSPQVQHSTFQALSSGISQ
                     QPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMF
                     SQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLS
                     SMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKYC"
ORIGIN      
        1 agtcacctct aggtcaccct ccctctacca cagtcaccca ttttgtcccc tgtcccctta
       61 ctcttcttca cctctccccg ggccgccttc tcagaggact ctgccgacgg agatgctgcg
      121 gaccccgcgg ccaggggctg ctccccggac aaccctgcgt ccacctttgc cccttcctcg
      181 ggggcgcgag agatttctct tggatttggc tacacactta tagatcttct gcactgttta
      241 caggcacagt tgctgatatg tgttcaagat gagtgggatg ggagaaaata cctctgaccc
      301 ctccagggca gagacaagaa agcgcaagga atgtcctgac caacttggac ccagccccaa
      361 aaggaacact gaaaaacgta atcgtgaaca ggaaaataaa tatatagaag aacttgcaga
      421 gttgattttt gcaaatttta atgatataga caactttaac ttcaaacctg acaaatgtgc
      481 aatcttaaaa gaaactgtga agcaaattcg tcagatcaaa gaacaagaga aagcagcagc
      541 tgccaacata gatgaagtgc agaagtcaga tgtatcctct acagggcagg gtgtcatcga
      601 caaggatgcg ctggggccta tgatgcttga ggcccttgat gggttcttct ttgtagtgaa
      661 cctggaaggc aacgttgtgt ttgtgtcaga gaatgtgaca cagtatctaa ggtataacca
      721 agaagagctg atgaacaaaa gtgtatatag catcttgcat gttggggacc acacggaatt
      781 tgtcaaaaac ctgctgccaa agtctatagt aaatggggga tcttggtctg gcgaacctcc
      841 gaggcggaac agccatacct tcaattgtcg gatgctggta aaacctttac ctgattcaga
      901 agaggagggt catgataacc aggaagctca tcagaaatat gaaactatgc agtgcttcgc
      961 tgtctctcaa ccaaagtcca tcaaagaaga aggagaagat ttgcagtcct gcttgatttg
     1021 cgtggcaaga agagttccca tgaaggaaag accagttctt ccctcatcag aaagttttac
     1081 tactcgccag gatctccaag gcaagatcac gtctctggat accagcacca tgagagcagc
     1141 catgaaacca ggctgggagg acctggtaag aaggtgtatt cagaagttcc atgcgcagca
     1201 tgaaggagaa tctgtgtcct atgctaagag gcatcatcat gaagtactga gacaaggatt
     1261 ggcattcagt caaatctatc gtttttcctt gtctgatggc actcttgttg ctgcacaaac
     1321 gaagagcaaa ctcatccgtt ctcagactac taatgaacct caacttgtaa tatctttaca
     1381 tatgcttcac agagagcaga atgtgtgtgt gatgaatccg gatctgactg gacaaacgat
     1441 ggggaagcca ctgaatccaa ttagctctaa cagccctgcc catcaggccc tgtgcagtgg
     1501 gaacccaggt caggacatga ccctcagtag caatataaat tttcccataa atggcccaaa
     1561 ggaacaaatg ggcatgccca tgggcaggtt tggtggttct gggggaatga accatgtgtc
     1621 aggcatgcaa gcaaccactc ctcagggtag taactatgca ctcaaaatga acagcccctc
     1681 acaaagcagc cctggcatga atccaggaca gcccacctcc atgctttcac caaggcatcg
     1741 catgagccct ggagtggctg gcagccctcg aatcccaccc agtcagtttt cccctgcagg
     1801 aagcttgcat tcccctgtgg gagtttgcag cagcacagga aatagccata gttataccaa
     1861 cagctccctc aatgcacttc aggccctcag cgaggggcac ggggtctcat tagggtcatc
     1921 gttggcttca ccagacctaa aaatgggcaa tttgcaaaac tccccagtta atatgaatcc
     1981 tcccccactc agcaagatgg gaagcttgga ctcaaaagac tgttttggac tatatgggga
     2041 gccctctgaa ggtacaactg gacaagcaga gagcagctgc catcctggag agcaaaagga
     2101 aacaaatgac cccaacctgc ccccggccgt gagcagtgag agagctgacg ggcagagcag
     2161 actgcatgac agcaaagggc agaccaaact cctgcagctg ctgaccacca aatctgatca
     2221 gatggagccc tcgcccttag ccagctcttt gtcggataca aacaaagact ccacaggtag
     2281 cttgcctggt tctgggtcta cacatggaac ctcgctcaag gagaagcata aaattttgca
     2341 cagactcttg caggacagca gttcccctgt ggacttggcc aagttaacag cagaagccac
     2401 aggcaaagac ctgagccagg agtccagcag cacagctcct ggatcagaag tgactattaa
     2461 acaagagccg gtgagcccca agaagaaaga gaatgcacta cttcgctatt tgctagataa
     2521 agatgatact aaagatattg gtttaccaga aataaccccc aaacttgaga gactggacag
     2581 taagacagat cctgccagta acacaaaatt aatagcaatg aaaactgaga aggaggagat
     2641 gagctttgag cctggtgacc agcctggcag tgagctggac aacttggagg agattttgga
     2701 tgatttgcag aatagtcaat taccacagct tttcccagac acgaggccag gcgcccctgc
     2761 tggatcagtt gacaagcaag ccatcatcaa tgacctcatg caactcacag ctgaaaacag
     2821 ccctgtcaca cctgttggag cccagaaaac agcactgcga atttcacaga gcacttttaa
     2881 taacccacga ccagggcaac tgggcaggtt attgccaaac cagaatttac cacttgacat
     2941 cacattgcaa agcccaactg gtgctggacc tttcccacca atcagaaaca gtagtcccta
     3001 ctcagtgata cctcagccag gaatgatggg taatcaaggg atgataggaa accaaggaaa
     3061 tttagggaac agtagcacag gaatgattgg taacagtgct tctcggccta ctatgccatc
     3121 tggagaatgg gcaccgcaga gttcggctgt gagagtcacc tgtgctgcta ccaccagtgc
     3181 catgaaccgg ccagtccaag gaggtatgat tcggaaccca gcagccagca tccccatgag
     3241 gcccagcagc cagcctggcc aaagacagac gcttcagtct caggtcatga atatagggcc
     3301 atctgaatta gagatgaaca tggggggacc tcagtatagc caacaacaag ctcctccaaa
     3361 tcagactgcc ccatggcctg aaagcatcct gcctatagac caggcgtctt ttgccagcca
     3421 aaacaggcag ccatttggca gttctccaga tgacttgcta tgtccacatc ctgcagctga
     3481 gtctccgagt gatgagggag ctctcctgga ccagctgtat ctggccttgc ggaattttga
     3541 tggcctggag gagattgata gagccttagg aatacccgaa ctggtcagcc agagccaagc
     3601 agtagatcca gaacagttct caagtcagga ttccaacatc atgctggagc agaaggcgcc
     3661 cgttttccca cagcagtatg catctcaggc acaaatggcc cagggtagct attctcccat
     3721 gcaagatcca aactttcaca ccatgggaca gcggcctagt tatgccacac tccgtatgca
     3781 gcccagaccg ggcctcaggc ccacgggcct agtgcagaac cagccaaatc aactaagact
     3841 tcaacttcag catcgcctcc aagcacagca gaatcgccag ccacttatga atcaaatcag
     3901 caatgtttcc aatgtgaact tgactctgag gcctggagta ccaacacagg cacctattaa
     3961 tgcacagatg ctggcccaga gacagaggga aatcctgaac cagcatcttc gacagagaca
     4021 aatgcatcag caacagcaag ttcagcaacg aactttgatg atgagaggac aagggttgaa
     4081 tatgacacca agcatggtgg ctcctagtgg tatgccagca actatgagca accctcggat
     4141 tccccaggca aatgcacagc agtttccatt tcctccaaac tacggtactg gacttagatc
     4201 cccaccacct ttcaccagtc ctttctcccc agtgtccccc agtgttgggt cacagctcct
     4261 ctctcacagc tctttgcatg gctcccagat gaatctggct aaccagggaa tgataggaaa
     4321 cctgggagga cagttggggc ctgtgaggag tccccaagtc cagcacagta ccttccaggc
     4381 tctcagctca ggaataagtc agcaacctga tccaggcttt actggggcta cgactcccca
     4441 gagcccactt atgtcacccc gaatggcaca tacacagagt cccatgatgc aacagtctca
     4501 ggccaaccca gcctatcagg ccccctccga cataaatgga tgggcgcagg ggaacatggg
     4561 cggaaacagc atgttttccc agcagtcccc accacacttt gggcagcaag caaacaccag
     4621 catgtacagt aacaacatga acatcaatgt gtccatggcg accaacacag gtggcatgag
     4681 cagcatgaac cagatgacag gacagatcag catgacctca gtgacctccg tgcctacgtc
     4741 agggctgtcc tccatgggtc ccgagcaggt taatgatcct gctctgaggg gaggcaacct
     4801 gttcccaaac cagctgcctg gaatggatat gattaagcag gagggagaca caacacggaa
     4861 atattgctga cactgctgaa gccagttgct tcttcagctg accgggctca cttgctcaaa
     4921 acacttccag tctggagagc tgtgtctatt tgtttcaacc caactgacct gccagccggt
     4981 tctgctagag cagacaggcc tggccctggt tcccagggtg gcgtccactc ggctgtggca
     5041 ggaggagctg cctcttctct tgacagtctg aagctcgcat ccagacagtc gctcagtctg
     5101 ttcactgcat tcaccttagt gcaacttaga tctctcctgc aaaagtaaat gttgacaggc
     5161 aaatttcata cccatgtcag attgaatgta tttaaatgta tgtatttaag gagaaccatg
     5221 ctcttgttct gttcctgttc ggttccagac actggtttct tgctttgttt tccctggcta
     5281 acagtctagt gcaaaagatt aagattttat ctgggggaaa gaaaagaatt ttttaaaaaa
     5341 ttaaactaaa gatgttttaa gctaaagcct gaatttggga tggaagcagg acagacaccg
     5401 tggacagcgc tgtatttaca gacacaccca gtgcgtgaag accaacaaag tcacagtcgt
     5461 atctctagaa agctctaaag accatgttgg aaagagtctc cagttactga acagatgaaa
     5521 aggagcctgt gagagggctg ttaacattag caaatatttt ttccttgttt tttctttgtt
     5581 aaaaccaaac tggttcacct gaatcatgaa ttgagaagaa ataattttca tttctaaatt
     5641 aagtcccttt tagtttgatc agacagcttg aatcagcatc tcttcttccc tgtcagcctg
     5701 actcttccct tcccctctct cattccccat actccctatt ttcattcctt ttttaaaaaa
     5761 taatataagc tacagaaacc aggtaagccc tttatttcct taaatgtttt gccagccact
     5821 taccaattgc taagtattga atttcagaaa aaaaaaatgc atttactggc aaggagaaga
     5881 gcaaagttaa ggcttgatac caatcgagct aaggatacct gctttggaag catgtttatt
     5941 ctgttcccca gcaactctgg cctccaaaat gggagaaaac gccagtgtgt ttaaattgat
     6001 agcagatatc acgacagatt taacctctgc catgtgtttt ttattttgtt ttttagcagt
     6061 gctgactaag ccgaagtttt gtaaggtaca taaaatccaa tttatatgta aacaagcaat
     6121 aatttaagtt gagaacttat gtgttttaat tgtataattt ttgtgaggta tacatattgt
     6181 ggaattgact caaaaatgag gtacttcagt attaaattag atatcttcat agcaatgtct
     6241 cctaaaggtg ttttgtaaag gatatcaatg ccttgattag acctaatttg tagacttaag
     6301 actttttatt ttctaaacct tgtgattctg cttataagtc atttatctaa tctatatgat
     6361 atgcagccgc tgtaggaacc aattcttgat ttttatatgt ttatattctt tcttaatgaa
     6421 ccttagaaag actacatgtt actaagcagg ccacttttat ggttgttttt cttgcccact
     6481 ctggtagggg aaaaatcttt tattaatagg tgtcagtttc agacaactcc aataccaaga
     6541 aactgatgac cttttttgag ctatttctcc ttaaccccta atacctttct tacctaaatt
     6601 tcagaatgat atctttttga tgtctaaaaa gcaaagcatt ttataatatc tcattagcca
     6661 ggctttttag gaacagagaa gtttttcctt gaaatttgat tgtttgttta tttgtggcag
     6721 ggtgaaaaat gtacaaacta cccctattta tacttatatc tctctctata tgtacgcatt
     6781 atggaaatat aggaagagat atagcccaaa gatagatggt aagtagacag tctgaaaatg
     6841 ttgctccata ctaaagaacc tttctggaaa tttgcatttc gctacttttt tccacttgag
     6901 aggggtctca atacagggag gtggccaagg aacaacactt ctcagtggcc accagttcat
     6961 atatcccctc aaaaggctct acttttctcc accaaaccat tgggttgccc aactgtgatg
     7021 gaaaaaacaa gcagatgttg gcccagaact ccaggacctc cccgtgggct gaggctcatg
     7081 tggcatacaa ttcagtgtga ccagttttaa tgttcagaaa tatgtgaatt agaatgactt
     7141 ttaacttcac acagcacaaa agagaaatgg agtttaaact ggatttgttt tgttttgagt
     7201 ttcaagtccc ttttcactac aacaccgtcc aaaactatct acctatctct tcttttttat
     7261 ccatctgccc gctgtatttt aatgtcaatc ctaattcaga caaatccgca acttcatgat
     7321 actggtaatt tataataatt cgtgatcatt gctgttttga aggaaaagag atgataaatt
     7381 ctcttacggt ttcaatcagg taatggattt tgttttacat ctagttagga gaagaaaagt
     7441 aagtgaagga atcctctgat catattgatc actatagaag caaaagccaa atcagttccc
     7501 ttcattatca gtatttctca tgctgtacac aataaatttg ttagactgag tacttggttt
     7561 ttgtttaata gaacaaataa tcagtgtttc acttatatta ctaaatgtga aaaacataat
     7621 gtgaaaagta tacatacatt aacttggttg taaaactcat tttaagtgtt catgtaatgt
     7681 ggtaagttta aaaagtgaag tgagctgttt tactacaatg aattcgtttg actcaaagat
     7741 taaaatgccc ctccccctat gtgtatctct tatggcctgt aataattgaa agcaatgttt
     7801 ttgcagttta tataatgcaa tttttaatct gtgttcaaaa atggagttca tatgggctta
     7861 acacatgaaa tgggtggcac agatccactt gcagaaccca aagatacaca atcagttttg
     7921 aaatgcaact taagccatta attgttggtg tgaatttaaa attttctagt gtttgtatgg
     7981 tggtatgctg cctaagagca aagcatcctc tgcacaaaag aaaattactg tagtggcttc
     8041 gattttaatt agaattttct ccctggtgtt tctttataga ctaaagcaaa atcttttaag
     8101 tttcttacta caggtaaaag ctatgtgcaa gaacctcaaa atgctaaaat ctagcataat
     8161 gccttagatc tgtttttaag tcttgtatat tcctacatag ctgtccgatg tattatattt
     8221 gtatagtgaa ttgtgtacaa tttttgaata agtgcatcat cacttaacct ttatgttgtt
     8281 tgaatagtga tgatgataca tttcttcaga catttaactg tcattttttt cctttgtcat
     8341 ttgtgagttt tatttgtaca gttcctcatg aagttgcatc tgagatgtgt gtatatgaaa
     8401 agattataca agggtaaaat taagcaatat attaactatg gttcttcagg agaaagctta
     8461 cagtgtttca ggttgtgatt tattttcaaa atggagttga ctctgaacat cactttgttc
     8521 acctgcattg atgtttgtat ttctagtgtg agcagtttat gcaaaggtag atatattcag
     8581 agaaatttta aatacattta tgcaagttaa tattgctttg ctgatgctat ttgcttattt
     8641 gatgttaaat aatgctattg taaataaaga attctgttgt tattgcatca tttaataaat
     8701 tttaatgcct tcgggtttta
//
