LOCUS       NM_147233               6892 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens nuclear receptor coactivator 1 (NCOA1), transcript
            variant 3, mRNA.
ACCESSION   NM_147233
VERSION     NM_147233.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6892)
  AUTHORS   Tong,Z., Zhang,Y., Guo,P., Wang,W., Chen,Q., Jin,J., Liu,S., Yu,C.,
            Mo,P., Zhang,L. and Huang,J.
  TITLE     Steroid receptor coactivator 1 promotes human hepatocellular
            carcinoma invasiveness through enhancing MMP-9
  JOURNAL   J Cell Mol Med 28 (7), e18171 (2024)
   PUBMED   38506084
  REMARK    GeneRIF: Steroid receptor coactivator 1 promotes human
            hepatocellular carcinoma invasiveness through enhancing MMP-9.
REFERENCE   2  (bases 1 to 6892)
  AUTHORS   Kurdi,M., Fadul,M.M., Addas,B.M.J., Faizo,E., Alkhayyat,S.,
            Bamaga,A.K., Alsinani,T., Katib,Y., Okal,F., Maghrabi,Y.,
            Sabbagh,A.J., Moshref,R., Albalawi,S., Alkhotani,A., Halawa,T.F.,
            Mulla,N., Hakamy,S. and Baeesa,S.
  TITLE     Dynamic interplay between corticosteroid treatment and the role of
            SRC-1 gene dysregulation in the progression of WHO-Grade 4
            Astrocytoma
  JOURNAL   J Neurooncol 163 (3), 693-705 (2023)
   PUBMED   37402091
  REMARK    GeneRIF: Dynamic interplay between corticosteroid treatment and the
            role of SRC-1 gene dysregulation in the progression of WHO-Grade 4
            Astrocytoma.
REFERENCE   3  (bases 1 to 6892)
  AUTHORS   Cacciottolo,T.M., Henning,E., Keogh,J.M., Bel Lassen,P., Lawler,K.,
            Bounds,R., Ahmed,R., Perdikari,A., Mendes de Oliveira,E., Smith,M.,
            Godfrey,E.M., Johnson,E., Hodson,L., Clement,K., van der
            Klaauw,A.A. and Farooqi,I.S.
  TITLE     Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is
            Associated With Endocrine and Metabolic Abnormalities
  JOURNAL   J Clin Endocrinol Metab 107 (6), e2532-e2544 (2022)
   PUBMED   35137184
  REMARK    GeneRIF: Obesity Due to Steroid Receptor Coactivator-1 Deficiency
            Is Associated With Endocrine and Metabolic Abnormalities.
REFERENCE   4  (bases 1 to 6892)
  AUTHORS   Guo,P., Chen,Q., Peng,K., Xie,J., Liu,J., Ren,W., Tong,Z., Li,M.,
            Xu,J., Zhang,Y., Yu,C. and Mo,P.
  TITLE     Nuclear receptor coactivator SRC-1 promotes colorectal cancer
            progression through enhancing GLI2-mediated Hedgehog signaling
  JOURNAL   Oncogene 41 (20), 2846-2859 (2022)
   PUBMED   35418691
  REMARK    GeneRIF: Nuclear receptor coactivator SRC-1 promotes colorectal
            cancer progression through enhancing GLI2-mediated Hedgehog
            signaling.
REFERENCE   5  (bases 1 to 6892)
  AUTHORS   Dermawan,J.K., Azzato,E.M., Jebastin Thangaiah,J.,
            Gjorgova-Gjeorgievski,S., Rubin,B.P., Folpe,A.L., Agaimy,A. and
            Fritchie,K.J.
  TITLE     PRRX1-NCOA1-rearranged fibroblastic tumour: a clinicopathological,
            immunohistochemical and molecular genetic study of six cases of a
            potentially under-recognised, distinctive mesenchymal tumour
  JOURNAL   Histopathology 79 (6), 997-1003 (2021)
   PUBMED   34272753
  REMARK    GeneRIF: PRRX1-NCOA1-rearranged fibroblastic tumour: a
            clinicopathological, immunohistochemical and molecular genetic
            study of six cases of a potentially under-recognised, distinctive
            mesenchymal tumour.
REFERENCE   6  (bases 1 to 6892)
  AUTHORS   Jeyakumar,M., Tanen,M.R. and Bagchi,M.K.
  TITLE     Analysis of the functional role of steroid receptor coactivator-1
            in ligand-induced transactivation by thyroid hormone receptor
  JOURNAL   Mol Endocrinol 11 (6), 755-767 (1997)
   PUBMED   9171239
REFERENCE   7  (bases 1 to 6892)
  AUTHORS   Takeshita,A., Yen,P.M., Misiti,S., Cardona,G.R., Liu,Y. and
            Chin,W.W.
  TITLE     Molecular cloning and properties of a full-length putative thyroid
            hormone receptor coactivator
  JOURNAL   Endocrinology 137 (8), 3594-3597 (1996)
   PUBMED   8754792
REFERENCE   8  (bases 1 to 6892)
  AUTHORS   Kamei,Y., Xu,L., Heinzel,T., Torchia,J., Kurokawa,R., Gloss,B.,
            Lin,S.C., Heyman,R.A., Rose,D.W., Glass,C.K. and Rosenfeld,M.G.
  TITLE     A CBP integrator complex mediates transcriptional activation and
            AP-1 inhibition by nuclear receptors
  JOURNAL   Cell 85 (3), 403-414 (1996)
   PUBMED   8616895
REFERENCE   9  (bases 1 to 6892)
  AUTHORS   Zhu,Y., Qi,C., Calandra,C., Rao,M.S. and Reddy,J.K.
  TITLE     Cloning and identification of mouse steroid receptor coactivator-1
            (mSRC-1), as a coactivator of peroxisome proliferator-activated
            receptor gamma
  JOURNAL   Gene Expr 6 (3), 185-195 (1996)
   PUBMED   9041124
REFERENCE   10 (bases 1 to 6892)
  AUTHORS   Onate,S.A., Tsai,S.Y., Tsai,M.J. and O'Malley,B.W.
  TITLE     Sequence and characterization of a coactivator for the steroid
            hormone receptor superfamily
  JOURNAL   Science 270 (5240), 1354-1357 (1995)
   PUBMED   7481822
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE675986.1, AJ000881.1,
            U90661.2, BF975824.1, CB047008.1 and AC013459.9.
            
            On Feb 18, 2005 this sequence version replaced NM_147233.1.
            
            Summary: The protein encoded by this gene acts as a transcriptional
            coactivator for steroid and nuclear hormone receptors. It is a
            member of the p160/steroid receptor coactivator (SRC) family and
            like other family members has histone acetyltransferase activity
            and contains a nuclear localization signal, as well as bHLH and PAS
            domains. The product of this gene binds nuclear receptors directly
            and stimulates the transcriptional activities in a
            hormone-dependent fashion. Alternatively spliced transcript
            variants encoding different isoforms have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3), also known as SRC(-Q), uses
            an alternate in-frame splice site in the 3' coding region, compared
            to variant 1, resulting in a protein (isoform 3) that lacks a
            single amino acid, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U59302.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                BE675986.1         395-478
            85-239              AJ000881.1         27-181
            240-719             AJ000881.1         183-662
            720-1626            U90661.2           468-1374
            1627-4058           AJ000881.1         1570-4001
            4059-4061           BF975824.1         333-335
            4062-4413           AJ000881.1         4005-4356
            4414-4718           AJ000881.1         4360-4664
            4719-5237           CB047008.1         53-571
            5238-6892           AC013459.9         140445-142099
FEATURES             Location/Qualifiers
     source          1..6892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..6892
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="nuclear receptor coactivator 1"
                     /db_xref="GeneID:8648"
                     /db_xref="HGNC:HGNC:7668"
                     /db_xref="MIM:602691"
     exon            1..84
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            85..241
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..347
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..4581
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /EC_number="2.3.1.48"
                     /note="isoform 3 is encoded by transcript variant 3;
                     steroid receptor coactivator-1; Hin-2 protein; renal
                     carcinoma antigen NY-REN-52; class E basic
                     helix-loop-helix protein 74"
                     /codon_start=1
                     /product="nuclear receptor coactivator 1 isoform 3"
                     /protein_id="NP_671766.1"
                     /db_xref="CCDS:CCDS42660.1"
                     /db_xref="GeneID:8648"
                     /db_xref="HGNC:HGNC:7668"
                     /db_xref="MIM:602691"
                     /translation="MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLE
                     ELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSS
                     SQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSIL
                     HVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRY
                     EVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISID
                     TSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILND
                     GTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNP
                     SISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIV
                     ANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSF
                     PPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSS
                     QNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDRLSDGDS
                     KYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSS
                     LTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKK
                     KESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEE
                     IKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQS
                     ATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAINQSKSEDQCISSQLD
                     ELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSER
                     FPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGTMPVQVTPPRG
                     AFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGI
                     NMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSFGNNLPP
                     SSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSM
                     VSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPP
                     PQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
                     MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLK
                     TEADGTQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQ
                     LLTE"
     exon            348..514
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..612
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..790
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..970
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1066
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1207
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1355
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..2676
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2857
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2975
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3144
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3459
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3561
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3964
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4139
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4140..4323
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4324..4413
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4414..6892
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5332..5337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="hexamer: ATTAAA"
     polyA_site      5352
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="major polyA site"
     regulatory      6693..6698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="hexamer: AATAAA"
     polyA_site      6717
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="major polyA site"
     regulatory      6758..6763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="hexamer: AATAGA"
     polyA_site      6781
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="major polyA site"
     regulatory      6870..6875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="hexamer: AATAAA"
     polyA_site      6892
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
ORIGIN      
        1 ttccagttac agctatatca gagaatgagt taatctcctc agaaatcact aaatactact
       61 ctgaggggct tagaaattaa caggttgttt atataattgg ccttaaatga ggtgagagtg
      121 aagagactag agccatctct ggaaaacatc attatcccat tccccgggaa gctaccctct
      181 ggaactcaag atttgaccat atctgttttg aggattcatt atgaacaaag aagtctccca
      241 ggtgtgaagt ttttcaacat gagtggcctc ggggacagtt catccgaccc tgctaaccca
      301 gactcacata agaggaaagg atcgccatgt gacacactgg catcaagcac ggaaaagagg
      361 cgcagggagc aagaaaataa atatttagaa gaactagctg agttactgtc tgccaacatt
      421 agtgacattg acagcttgag tgtaaaacca gacaaatgca agattttgaa gaaaacagtc
      481 gatcagatac agctaatgaa gagaatggaa caagagaaat caacaactga tgacgatgta
      541 cagaaatcag acatctcatc aagtagtcaa ggagtgatag aaaaggaatc cttgggacct
      601 cttcttttgg aggctttgga tggatttttc tttgttgtga actgtgaagg gagaattgta
      661 tttgtgtcag agaatgtaac cagctactta ggttacaatc aggaggaatt aatgaatacg
      721 agcgtctaca gcatactgca cgtgggggat catgcagaat ttgtgaagaa tctgctacca
      781 aaatcactag taaatggagt tccttggcct caagaggcaa cacgacgaaa tagccatacc
      841 tttaactgca ggatgctaat tcaccctcca gatgagccag ggaccgagaa ccaagaagct
      901 tgccagcgtt atgaagtaat gcagtgtttc actgtgtcac agccaaaatc aattcaagag
      961 gatggagaag atttccagtc atgtctgatt tgtattgcac ggcgattacc tcggcctcca
     1021 gctattacgg gtgtagaatc ctttatgacc aagcaagata ctacaggtaa aatcatctct
     1081 attgatacta gttccctgag agctgctggc agaactggtt gggaagattt agtgaggaag
     1141 tgcatttatg cttttttcca acctcagggc agagaaccat cttatgccag acagctgttc
     1201 caagaagtga tgactcgtgg cactgcctcc agcccctcct atagattcat attgaatgat
     1261 gggacaatgc ttagcgccca caccaagtgt aaactttgct accctcaaag tccagacatg
     1321 caacctttca tcatgggaat tcatatcatc gacagggagc acagtgggct ttctcctcaa
     1381 gatgacacta attctggaat gtcaattccc cgagtaaatc cctcggtcaa tcctagtatc
     1441 tctccagctc atggtgtggc tcgttcatcc acattgccac catccaacag caacatggta
     1501 tccaccagaa taaaccgcca gcagagctca gaccttcata gcagcagtca tagtaattct
     1561 agcaacagcc aaggaagttt cggatgctca cccggaagtc agattgtagc caatgttgcc
     1621 ttaaaccaag gacaggccag ttcacagagc agtaatccct ctttaaacct caataattct
     1681 cctatggaag gtacaggaat atccctagca cagttcatgt ctccaaggag acaggttact
     1741 tctggattgg caacaaggcc caggatgcca aacaattcct ttcctcctaa tatttcgaca
     1801 ttaagctctc ccgttggcat gacaagtagt gcctgtaata ataataaccg atcttattca
     1861 aacatcccag taacatcttt acagggtatg aatgaaggac ccaataactc cgttggcttc
     1921 tctgccagtt ctccagtcct caggcagatg agctcacaga attcacctag cagattaaat
     1981 atacaaccag caaaagctga gtccaaagat aacaaagaga ttgcctcaat tttaaatgaa
     2041 atgattcaat ctgacaacag ctctagtgat ggcaaacctc tggattcagg gcttctgcat
     2101 aacaatgaca gactttcaga tggagacagt aaatactctc aaaccagtca caaactagtg
     2161 cagcttttga caacaactgc cgaacagcag ttacggcatg ctgatataga cacaagctgc
     2221 aaagatgtcc tgtcttgcac aggcacttcc aactctgcct ctgctaactc ttcaggaggt
     2281 tcttgtccct cttctcatag ctcattgaca gaacggcata aaattctaca ccggctctta
     2341 caggagggta gcccctcaga tatcaccact ttgtctgtcg agcctgataa aaaggacagt
     2401 gcatctactt ctgtgtcagt gactggacag gtacaaggaa actccagtat aaaactagaa
     2461 ctggatgctt caaagaaaaa agaatcaaaa gaccatcagc tcctacgcta tcttttagat
     2521 aaagatgaga aagatttaag atcaactcca aacctgagcc tggatgatgt aaaggtgaaa
     2581 gtggaaaaga aagaacagat ggatccatgt aatacaaacc caaccccaat gaccaaaccc
     2641 actcctgagg aaataaaact ggaggcccag agccagttta cagctgacct tgaccagttt
     2701 gatcagttac tgcccacgct ggagaaggca gcacagttgc caggcttatg tgagacagac
     2761 aggatggatg gtgcggtcac cagtgtaacc atcaaatcgg agatcctgcc agcttcactt
     2821 cagtccgcca ctgccagacc cacttccagg ctaaatagat tacctgagct ggaattggaa
     2881 gcaattgata accaatttgg acaaccagga acaggcgatc agattccatg gacaaataat
     2941 acagtgacag ctataaatca gagtaaatca gaagaccagt gtattagctc acaattagat
     3001 gagcttctct gtccacccac aacagtagaa gggagaaatg atgagaaggc tcttcttgaa
     3061 cagctggtat ccttccttag tggcaaagat gaaactgagc tagctgaact agacagagct
     3121 ctgggaattg acaaacttgt tcaggggggt ggattagatg tattatcaga gagatttcca
     3181 ccacaacaag caacgccacc tttgatcatg gaagaaagac ccaaccttta ttcccagcct
     3241 tactcttctc cttctcctac tgccaatctc cctagccctt tccaaggcat ggtcaggcaa
     3301 aaaccttcac tggggacgat gcctgttcaa gtaacacctc cccgaggtgc tttttcacct
     3361 ggcatgggca tgcagcccag gcaaactcta aacagacctc cggctgcacc taaccagctt
     3421 cgacttcaac tacagcagcg attacaggga caacagcagt tgatacacca aaatcggcaa
     3481 gctatcttaa accagtttgc agcaactgct cctgttggca tcaatatgag atcaggcatg
     3541 caacagcaaa ttacacctca gccacccctg aatgctcaaa tgttggcaca acgtcagcgg
     3601 gaactgtaca gtcaacagca ccgacagagg cagctaatac agcagcaaag agccatgctt
     3661 atgaggcagc aaagctttgg gaacaacctc cctccctcat ctggactacc agttcaaatg
     3721 gggaaccccc gtcttcctca gggtgctcca cagcaattcc cctatccacc aaactatggt
     3781 acaaatccag gaaccccacc tgcttctacc agcccgtttt cacaactagc agcaaatcct
     3841 gaagcatcct tggccaaccg caacagcatg gtgagcagag gcatgacagg aaacatagga
     3901 ggacagtttg gcactggaat caatcctcag atgcagcaga atgtcttcca gtatccagga
     3961 gcaggaatgg ttccccaagg tgaggccaac tttgctccat ctctaagccc tgggagctcc
     4021 atggtgccga tgccaatccc tcctcctcag agttctcttc tccagcaaac tccacctgcc
     4081 tccgggtatc agtcaccaga catgaaggcc tggcagcaag gagcgatagg aaacaacaat
     4141 gtgttcagtc aagctgtcca gaaccagccc acgcctgcac agccaggagt atacaacaac
     4201 atgagcatca ccgtttccat ggcaggtgga aatacgaatg ttcagaacat gaacccaatg
     4261 atggcccaga tgcagatgag ctctttgcag atgccaggaa tgaacactgt gtgccctgag
     4321 cagataaatg atcccgcact gagacacaca ggcctctact gcaaccagct ctcatccact
     4381 gaccttctca aaacagaagc agatggaacc caggtgcaac aggttcaggt gtttgctgac
     4441 gtccagtgta cagtgaatct ggtaggcggg gacccttacc tgaaccagcc tggtccactg
     4501 ggaactcaaa agcccacgtc aggaccacag accccccagg cccagcagaa gagcctcctt
     4561 cagcagctac tgactgaata accactttta aaggaatgtg aaatttaaat aatagacata
     4621 cagagatata caaatatatt atatattttt ctgagatttt tgatatctca atctgcagcc
     4681 attcttcagg tcgtagcatt tggagcaaaa aaaaaaaaaa aaaaaaaaaa aggagtttgc
     4741 ttttgtcggg agattgaaag atgtttttgt ttctttcttt gtaaaggcct tggatattga
     4801 aaaaatacca aggcagaaca gttggacaat ctatttcttg agccaaattt aattattctt
     4861 atttttgtaa tcagtcattg gcttcttatc tggatgaagg cttttggagg agaaccaaaa
     4921 cgacaagttc caagaagaag atgaagctcc gcctccgccg cttagtccca accctgccca
     4981 ggaagaaggg cccgtggggc tttgcctgtg cccgtccacc aaaggctgtc atgtgtctcg
     5041 aaatcagcag ccctccccat cccaatccca ggcagcttgt gtgtacaatc agcttctcta
     5101 gcaactctgt atctgttggc ttcaagagaa tattttgcct ccacatatgt accccttctc
     5161 ctttttttaa agatggattt aaaccaagat gcctccagga aagaggacga aatgagtata
     5221 ttcacagagg aatccaaaaa atacagtttg ggggaaaatg caataatttt tgatgagatg
     5281 ggtgaaggac aagaagtgag ttgtgtcaat tattgtagat acaattttct gattaaatct
     5341 ggaaaaataa aaggcagcct gttttttctg cttttattgt attaacagct gaggtagcta
     5401 aagttattta aaataaaatt aaatttatga tccaagtagc ttatttttcc ctttaaatct
     5461 cattgtaaat atatttgatt tcttgtagaa attgatttcc ttctgtttaa ttttatgctt
     5521 ttattatact cttgattttt ctaaatttgt gtgtgaaata taacattgat tgaattgcag
     5581 ttacatttgg ttagtaatat ttcattattt taataactgt gatgtcatgt atggatttac
     5641 tttggggttc aaatcaaaat gtcactgcca gaaagagctg ttccagctga tctagagcat
     5701 actgccctag agtgtccctg ggatcatctg aacagaagtg cacaggctac ttgtacagag
     5761 aaaaaattaa tactcaaagg aaatcttcat tttttagatt gactttggga atttgaattt
     5821 tcatcagtgc aaatataaat ttctctatcc tgctctgagg ctaattggta ccatattttc
     5881 cctttgtgtc ttgtgactct gccacatccc atctcatcct ggcctctgag tcaagaaccc
     5941 agtgaactga ctttctagtt ctagaagttc cgctgcaagg ccaggaaagc ttgagaaagg
     6001 tattgtggaa gaagcaaagg tagaccccca tcactcacct ttgtctgcat ccctgggcct
     6061 gtgaatgatg acagcacctg acattctgca ccagctacct ctgcctccat ggcagagaaa
     6121 aggccataag aacagtggaa gaggagcatg gactcagact tcaaggaaga agccatttcc
     6181 ccaggtcctt ccttctgcat ctcaccaccc ctagttacaa ataactccat tgaacagcat
     6241 ctattcagaa actatgccga ataaaaagat tggtggaagg gctcatgtgg ttagcaacta
     6301 tgaaacagaa ataggacact cagttacaaa cattatctcc tttagttttt cagaaaatgc
     6361 atccctgatt tcattcattt ccagcttgaa agccagccat attactctag tccctaccaa
     6421 actgctctag aaggtcattt ccattttgtt tgtgatattt agacgcgcag acttcaggaa
     6481 gttcaccttt aacttcagca ttccagatga agtttcctga ctcagtgctt ttgcataagg
     6541 aactagaaaa aaaaagtaag gaaaattgga gatgctaaca tcctccccca tcccaactgc
     6601 accttaaaat atgcatgtca ccttcaaggt tttataattg cactgtttgt tttatgtatg
     6661 tacagattaa aattattgct acatttgagg aaaataaaat tgcttgcttc tatgtaattc
     6721 ctgtcattcc acaggaaatt cacttttcca gctactgaat agaatttgtt taacaacctc
     6781 atgggttgcc tcttcattta cagggaagaa atgaaatgta catctgcaga aattgccaaa
     6841 gcccaaatta acgagtatta taaaaggata ataaagcatc cctgaagcca aa
//
