LOCUS       NM_003743               7381 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens nuclear receptor coactivator 1 (NCOA1), transcript
            variant 1, mRNA.
ACCESSION   NM_003743
VERSION     NM_003743.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7381)
  AUTHORS   Tong,Z., Zhang,Y., Guo,P., Wang,W., Chen,Q., Jin,J., Liu,S., Yu,C.,
            Mo,P., Zhang,L. and Huang,J.
  TITLE     Steroid receptor coactivator 1 promotes human hepatocellular
            carcinoma invasiveness through enhancing MMP-9
  JOURNAL   J Cell Mol Med 28 (7), e18171 (2024)
   PUBMED   38506084
  REMARK    GeneRIF: Steroid receptor coactivator 1 promotes human
            hepatocellular carcinoma invasiveness through enhancing MMP-9.
REFERENCE   2  (bases 1 to 7381)
  AUTHORS   Kurdi,M., Fadul,M.M., Addas,B.M.J., Faizo,E., Alkhayyat,S.,
            Bamaga,A.K., Alsinani,T., Katib,Y., Okal,F., Maghrabi,Y.,
            Sabbagh,A.J., Moshref,R., Albalawi,S., Alkhotani,A., Halawa,T.F.,
            Mulla,N., Hakamy,S. and Baeesa,S.
  TITLE     Dynamic interplay between corticosteroid treatment and the role of
            SRC-1 gene dysregulation in the progression of WHO-Grade 4
            Astrocytoma
  JOURNAL   J Neurooncol 163 (3), 693-705 (2023)
   PUBMED   37402091
  REMARK    GeneRIF: Dynamic interplay between corticosteroid treatment and the
            role of SRC-1 gene dysregulation in the progression of WHO-Grade 4
            Astrocytoma.
REFERENCE   3  (bases 1 to 7381)
  AUTHORS   Cacciottolo,T.M., Henning,E., Keogh,J.M., Bel Lassen,P., Lawler,K.,
            Bounds,R., Ahmed,R., Perdikari,A., Mendes de Oliveira,E., Smith,M.,
            Godfrey,E.M., Johnson,E., Hodson,L., Clement,K., van der
            Klaauw,A.A. and Farooqi,I.S.
  TITLE     Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is
            Associated With Endocrine and Metabolic Abnormalities
  JOURNAL   J Clin Endocrinol Metab 107 (6), e2532-e2544 (2022)
   PUBMED   35137184
  REMARK    GeneRIF: Obesity Due to Steroid Receptor Coactivator-1 Deficiency
            Is Associated With Endocrine and Metabolic Abnormalities.
REFERENCE   4  (bases 1 to 7381)
  AUTHORS   Guo,P., Chen,Q., Peng,K., Xie,J., Liu,J., Ren,W., Tong,Z., Li,M.,
            Xu,J., Zhang,Y., Yu,C. and Mo,P.
  TITLE     Nuclear receptor coactivator SRC-1 promotes colorectal cancer
            progression through enhancing GLI2-mediated Hedgehog signaling
  JOURNAL   Oncogene 41 (20), 2846-2859 (2022)
   PUBMED   35418691
  REMARK    GeneRIF: Nuclear receptor coactivator SRC-1 promotes colorectal
            cancer progression through enhancing GLI2-mediated Hedgehog
            signaling.
REFERENCE   5  (bases 1 to 7381)
  AUTHORS   Dermawan,J.K., Azzato,E.M., Jebastin Thangaiah,J.,
            Gjorgova-Gjeorgievski,S., Rubin,B.P., Folpe,A.L., Agaimy,A. and
            Fritchie,K.J.
  TITLE     PRRX1-NCOA1-rearranged fibroblastic tumour: a clinicopathological,
            immunohistochemical and molecular genetic study of six cases of a
            potentially under-recognised, distinctive mesenchymal tumour
  JOURNAL   Histopathology 79 (6), 997-1003 (2021)
   PUBMED   34272753
  REMARK    GeneRIF: PRRX1-NCOA1-rearranged fibroblastic tumour: a
            clinicopathological, immunohistochemical and molecular genetic
            study of six cases of a potentially under-recognised, distinctive
            mesenchymal tumour.
REFERENCE   6  (bases 1 to 7381)
  AUTHORS   Jeyakumar,M., Tanen,M.R. and Bagchi,M.K.
  TITLE     Analysis of the functional role of steroid receptor coactivator-1
            in ligand-induced transactivation by thyroid hormone receptor
  JOURNAL   Mol Endocrinol 11 (6), 755-767 (1997)
   PUBMED   9171239
REFERENCE   7  (bases 1 to 7381)
  AUTHORS   Takeshita,A., Yen,P.M., Misiti,S., Cardona,G.R., Liu,Y. and
            Chin,W.W.
  TITLE     Molecular cloning and properties of a full-length putative thyroid
            hormone receptor coactivator
  JOURNAL   Endocrinology 137 (8), 3594-3597 (1996)
   PUBMED   8754792
REFERENCE   8  (bases 1 to 7381)
  AUTHORS   Kamei,Y., Xu,L., Heinzel,T., Torchia,J., Kurokawa,R., Gloss,B.,
            Lin,S.C., Heyman,R.A., Rose,D.W., Glass,C.K. and Rosenfeld,M.G.
  TITLE     A CBP integrator complex mediates transcriptional activation and
            AP-1 inhibition by nuclear receptors
  JOURNAL   Cell 85 (3), 403-414 (1996)
   PUBMED   8616895
REFERENCE   9  (bases 1 to 7381)
  AUTHORS   Zhu,Y., Qi,C., Calandra,C., Rao,M.S. and Reddy,J.K.
  TITLE     Cloning and identification of mouse steroid receptor coactivator-1
            (mSRC-1), as a coactivator of peroxisome proliferator-activated
            receptor gamma
  JOURNAL   Gene Expr 6 (3), 185-195 (1996)
   PUBMED   9041124
REFERENCE   10 (bases 1 to 7381)
  AUTHORS   Onate,S.A., Tsai,S.Y., Tsai,M.J. and O'Malley,B.W.
  TITLE     Sequence and characterization of a coactivator for the steroid
            hormone receptor superfamily
  JOURNAL   Science 270 (5240), 1354-1357 (1995)
   PUBMED   7481822
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093798.3 and AC013459.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 5, 2018 this sequence version replaced NM_003743.4.
            
            Summary: The protein encoded by this gene acts as a transcriptional
            coactivator for steroid and nuclear hormone receptors. It is a
            member of the p160/steroid receptor coactivator (SRC) family and
            like other family members has histone acetyltransferase activity
            and contains a nuclear localization signal, as well as bHLH and PAS
            domains. The product of this gene binds nuclear receptors directly
            and stimulates the transcriptional activities in a
            hormone-dependent fashion. Alternatively spliced transcript
            variants encoding different isoforms have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as SRC1a, encodes
            the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.273062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348332.8/ ENSP00000320940.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AC093798.3         94528-94876
            350-485             AC093798.3         167569-167704
            486-570             AC093798.3         187750-187834
            571-727             AC013459.9         15363-15519
            728-833             AC013459.9         30058-30163
            834-1000            AC013459.9         37146-37312
            1001-1098           AC013459.9         44763-44860
            1099-1276           AC013459.9         54348-54525
            1277-1456           AC013459.9         62878-63057
            1457-1552           AC013459.9         64649-64744
            1553-1693           AC013459.9         69055-69195
            1694-1841           AC013459.9         76483-76630
            1842-3162           AC013459.9         77965-79285
            3163-3343           AC013459.9         82328-82508
            3344-3461           AC013459.9         97986-98103
            3462-3630           AC013459.9         99705-99873
            3631-3945           AC013459.9         100898-101212
            3946-4047           AC013459.9         110829-110930
            4048-4450           AC013459.9         113181-113583
            4451-4625           AC013459.9         123379-123553
            4626-4809           AC013459.9         129370-129553
            4810-4899           AC013459.9         134084-134173
            4900-7381           AC013459.9         139618-142099
FEATURES             Location/Qualifiers
     source          1..7381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..7381
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="nuclear receptor coactivator 1"
                     /db_xref="GeneID:8648"
                     /db_xref="HGNC:HGNC:7668"
                     /db_xref="MIM:602691"
     exon            1..349
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..485
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..570
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..727
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..833
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             745..5070
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     steroid receptor coactivator-1; Hin-2 protein; renal
                     carcinoma antigen NY-REN-52; class E basic
                     helix-loop-helix protein 74"
                     /codon_start=1
                     /product="nuclear receptor coactivator 1 isoform 1"
                     /protein_id="NP_003734.3"
                     /db_xref="CCDS:CCDS1712.1"
                     /db_xref="GeneID:8648"
                     /db_xref="HGNC:HGNC:7668"
                     /db_xref="MIM:602691"
                     /translation="MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLE
                     ELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSS
                     SQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSIL
                     HVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRY
                     EVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISID
                     TSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILND
                     GTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNP
                     SISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIV
                     ANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSF
                     PPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSS
                     QNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDRLSDGDS
                     KYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSS
                     LTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKK
                     KESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEE
                     IKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQS
                     ATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAINQSKSEDQCISSQLD
                     ELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSER
                     FPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGTMPVQVTPPRG
                     AFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGI
                     NMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSFGNNLPP
                     SSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSM
                     VSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPP
                     PQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVS
                     MAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLK
                     TEADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQ
                     QLLTE"
     exon            834..1000
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1098
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1276
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1456
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1552
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1693
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1841
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..3162
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3343
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3461
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3630
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3945
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4047
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4450
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4451..4625
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4626..4809
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4810..4899
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4900..7381
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5821..5826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="hexamer: ATTAAA"
     polyA_site      5841
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="major polyA site"
     regulatory      7182..7187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="hexamer: AATAAA"
     polyA_site      7206
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="major polyA site"
     regulatory      7247..7252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="hexamer: AATAGA"
     polyA_site      7270
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="major polyA site"
     regulatory      7359..7364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
                     /note="hexamer: AATAAA"
     polyA_site      7381
                     /gene="NCOA1"
                     /gene_synonym="bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160;
                     SRC1"
ORIGIN      
        1 ggcggcggtg gcggccgagg aggagaacat ggcggccgcg gagagcggct gaaatgcctg
       61 ttcttcaggc cgggcgagcg ggagtctgac gcgatttgct gagctctgtc ctccgacggc
      121 tgcctcgcgg ccttgagggc ctccgccgcc tgttcgctgc tgctccctcg agcggagcct
      181 gcgtcaggtt ccctctgcat ccccctgcgg ggggacccct gctccggagg agggggccgg
      241 agagccgcgg cgccgggccc gaggagcggc ggaggccggg gcggcgccgc cgccacggtc
      301 gcggacgagt gcggcgccgg tgagcggggc ccagaggcgg cggcggcaga tctatccata
      361 ctaatggaaa tgtaactgga actgactctg atgataaaat caaggaccat caagcaagat
      421 catgcagtag gcaactttgc ttccaaaaga agttaccaac atttagaatt tctacttatt
      481 ctgaggttcc agttacagct atatcagaga atgagttaat ctcctcagaa atcactaaat
      541 actactctga ggggcttaga aattaacagg ttgtttatat aattggcctt aaatgaggtg
      601 agagtgaaga gactagagcc atctctggaa aacatcatta tcccattccc cgggaagcta
      661 ccctctggaa ctcaagattt gaccatatct gttttgagga ttcattatga acaaagaagt
      721 ctcccaggtg tgaagttttt caacatgagt ggcctcgggg acagttcatc cgaccctgct
      781 aacccagact cacataagag gaaaggatcg ccatgtgaca cactggcatc aagcacggaa
      841 aagaggcgca gggagcaaga aaataaatat ttagaagaac tagctgagtt actgtctgcc
      901 aacattagtg acattgacag cttgagtgta aaaccagaca aatgcaagat tttgaagaaa
      961 acagtcgatc agatacagct aatgaagaga atggaacaag agaaatcaac aactgatgac
     1021 gatgtacaga aatcagacat ctcatcaagt agtcaaggag tgatagaaaa ggaatccttg
     1081 ggacctcttc ttttggaggc tttggatgga tttttctttg ttgtgaactg tgaagggaga
     1141 attgtatttg tgtcagagaa tgtaaccagc tacttaggtt acaatcagga ggaattaatg
     1201 aatacgagcg tctacagcat actgcacgtg ggggatcatg cagaatttgt gaagaatctg
     1261 ctaccaaaat cactagtaaa tggagttcct tggcctcaag aggcaacacg acgaaatagc
     1321 cataccttta actgcaggat gctaattcac cctccagatg agccagggac cgagaaccaa
     1381 gaagcttgcc agcgttatga agtaatgcag tgtttcactg tgtcacagcc aaaatcaatt
     1441 caagaggatg gagaagattt ccagtcatgt ctgatttgta ttgcacggcg attacctcgg
     1501 cctccagcta ttacgggtgt agaatccttt atgaccaagc aagatactac aggtaaaatc
     1561 atctctattg atactagttc cctgagagct gctggcagaa ctggttggga agatttagtg
     1621 aggaagtgca tttatgcttt tttccaacct cagggcagag aaccatctta tgccagacag
     1681 ctgttccaag aagtgatgac tcgtggcact gcctccagcc cctcctatag attcatattg
     1741 aatgatggga caatgcttag cgcccacacc aagtgtaaac tttgctaccc tcaaagtcca
     1801 gacatgcaac ctttcatcat gggaattcat atcatcgaca gggagcacag tgggctttct
     1861 cctcaagatg acactaattc tggaatgtca attccccgag taaatccctc ggtcaatcct
     1921 agtatctctc cagctcatgg tgtggctcgt tcatccacat tgccaccatc caacagcaac
     1981 atggtatcca ccagaataaa ccgccagcag agctcagacc ttcatagcag cagtcatagt
     2041 aattctagca acagccaagg aagtttcgga tgctcacccg gaagtcagat tgtagccaat
     2101 gttgccttaa accaaggaca ggccagttca cagagcagta atccctcttt aaacctcaat
     2161 aattctccta tggaaggtac aggaatatcc ctagcacagt tcatgtctcc aaggagacag
     2221 gttacttctg gattggcaac aaggcccagg atgccaaaca attcctttcc tcctaatatt
     2281 tcgacattaa gctctcccgt tggcatgaca agtagtgcct gtaataataa taaccgatct
     2341 tattcaaaca tcccagtaac atctttacag ggtatgaatg aaggacccaa taactccgtt
     2401 ggcttctctg ccagttctcc agtcctcagg cagatgagct cacagaattc acctagcaga
     2461 ttaaatatac aaccagcaaa agctgagtcc aaagataaca aagagattgc ctcaatttta
     2521 aatgaaatga ttcaatctga caacagctct agtgatggca aacctctgga ttcagggctt
     2581 ctgcataaca atgacagact ttcagatgga gacagtaaat actctcaaac cagtcacaaa
     2641 ctagtgcagc ttttgacaac aactgccgaa cagcagttac ggcatgctga tatagacaca
     2701 agctgcaaag atgtcctgtc ttgcacaggc acttccaact ctgcctctgc taactcttca
     2761 ggaggttctt gtccctcttc tcatagctca ttgacagaac ggcataaaat tctacaccgg
     2821 ctcttacagg agggtagccc ctcagatatc accactttgt ctgtcgagcc tgataaaaag
     2881 gacagtgcat ctacttctgt gtcagtgact ggacaggtac aaggaaactc cagtataaaa
     2941 ctagaactgg atgcttcaaa gaaaaaagaa tcaaaagacc atcagctcct acgctatctt
     3001 ttagataaag atgagaaaga tttaagatca actccaaacc tgagcctgga tgatgtaaag
     3061 gtgaaagtgg aaaagaaaga acagatggat ccatgtaata caaacccaac cccaatgacc
     3121 aaacccactc ctgaggaaat aaaactggag gcccagagcc agtttacagc tgaccttgac
     3181 cagtttgatc agttactgcc cacgctggag aaggcagcac agttgccagg cttatgtgag
     3241 acagacagga tggatggtgc ggtcaccagt gtaaccatca aatcggagat cctgccagct
     3301 tcacttcagt ccgccactgc cagacccact tccaggctaa atagattacc tgagctggaa
     3361 ttggaagcaa ttgataacca atttggacaa ccaggaacag gcgatcagat tccatggaca
     3421 aataatacag tgacagctat aaatcagagt aaatcagaag accagtgtat tagctcacaa
     3481 ttagatgagc ttctctgtcc acccacaaca gtagaaggga gaaatgatga gaaggctctt
     3541 cttgaacagc tggtatcctt ccttagtggc aaagatgaaa ctgagctagc tgaactagac
     3601 agagctctgg gaattgacaa acttgttcag gggggtggat tagatgtatt atcagagaga
     3661 tttccaccac aacaagcaac gccacctttg atcatggaag aaagacccaa cctttattcc
     3721 cagccttact cttctccttc tcctactgcc aatctcccta gccctttcca aggcatggtc
     3781 aggcaaaaac cttcactggg gacgatgcct gttcaagtaa cacctccccg aggtgctttt
     3841 tcacctggca tgggcatgca gcccaggcaa actctaaaca gacctccggc tgcacctaac
     3901 cagcttcgac ttcaactaca gcagcgatta cagggacaac agcagttgat acaccaaaat
     3961 cggcaagcta tcttaaacca gtttgcagca actgctcctg ttggcatcaa tatgagatca
     4021 ggcatgcaac agcaaattac acctcagcca cccctgaatg ctcaaatgtt ggcacaacgt
     4081 cagcgggaac tgtacagtca acagcaccga cagaggcagc taatacagca gcaaagagcc
     4141 atgcttatga ggcagcaaag ctttgggaac aacctccctc cctcatctgg actaccagtt
     4201 caaatgggga acccccgtct tcctcagggt gctccacagc aattccccta tccaccaaac
     4261 tatggtacaa atccaggaac cccacctgct tctaccagcc cgttttcaca actagcagca
     4321 aatcctgaag catccttggc caaccgcaac agcatggtga gcagaggcat gacaggaaac
     4381 ataggaggac agtttggcac tggaatcaat cctcagatgc agcagaatgt cttccagtat
     4441 ccaggagcag gaatggttcc ccaaggtgag gccaactttg ctccatctct aagccctggg
     4501 agctccatgg tgccgatgcc aatccctcct cctcagagtt ctcttctcca gcaaactcca
     4561 cctgcctccg ggtatcagtc accagacatg aaggcctggc agcaaggagc gataggaaac
     4621 aacaatgtgt tcagtcaagc tgtccagaac cagcccacgc ctgcacagcc aggagtatac
     4681 aacaacatga gcatcaccgt ttccatggca ggtggaaata cgaatgttca gaacatgaac
     4741 ccaatgatgg cccagatgca gatgagctct ttgcagatgc caggaatgaa cactgtgtgc
     4801 cctgagcaga taaatgatcc cgcactgaga cacacaggcc tctactgcaa ccagctctca
     4861 tccactgacc ttctcaaaac agaagcagat ggaacccagc aggtgcaaca ggttcaggtg
     4921 tttgctgacg tccagtgtac agtgaatctg gtaggcgggg acccttacct gaaccagcct
     4981 ggtccactgg gaactcaaaa gcccacgtca ggaccacaga ccccccaggc ccagcagaag
     5041 agcctccttc agcagctact gactgaataa ccacttttaa aggaatgtga aatttaaata
     5101 atagacatac agagatatac aaatatatta tatatttttc tgagattttt gatatctcaa
     5161 tctgcagcca ttcttcaggt cgtagcattt ggagcaaaaa aaaaaaaaaa aaaaaaaaaa
     5221 ggagtttgct tttgtcggga gattgaaaga tgtttttgtt tctttctttg taaaggcctt
     5281 ggatattgaa aaaataccaa ggcagaacag ttggacaatc tatttcttga gccaaattta
     5341 attattctta tttttgtaat cagtcattgg cttcttatct ggatgaaggc ttttggagga
     5401 gaaccaaaac gacaagttcc aagaagaaga tgaagctccg cctccgccgc ttagtcccaa
     5461 ccctgcccag gaagaagggc ccgtggggct ttgcctgtgc ccgtccacca aaggctgtca
     5521 tgtgtctcga aatcagcagc cctccccatc ccaatcccag gcagcttgtg tgtacaatca
     5581 gcttctctag caactctgta tctgttggct tcaagagaat attttgcctc cacatatgta
     5641 ccccttctcc tttttttaaa gatggattta aaccaagatg cctccaggaa agaggacgaa
     5701 atgagtatat tcacagagga atccaaaaaa tacagtttgg gggaaaatgc aataattttt
     5761 gatgagatgg gtgaaggaca agaagtgagt tgtgtcaatt attgtagata caattttctg
     5821 attaaatctg gaaaaataaa aggcagcctg ttttttctgc ttttattgta ttaacagctg
     5881 aggtagctaa agttatttaa aataaaatta aatttatgat ccaagtagct tatttttccc
     5941 tttaaatctc attgtaaata tatttgattt cttgtagaaa ttgatttcct tctgtttaat
     6001 tttatgcttt tattatactc ttgatttttc taaatttgtg tgtgaaatat aacattgatt
     6061 gaattgcagt tacatttggt tagtaatatt tcattatttt aataactgtg atgtcatgta
     6121 tggatttact ttggggttca aatcaaaatg tcactgccag aaagagctgt tccagctgat
     6181 ctagagcata ctgccctaga gtgtccctgg gatcatctga acagaagtgc acaggctact
     6241 tgtacagaga aaaaattaat actcaaagga aatcttcatt ttttagattg actttgggaa
     6301 tttgaatttt catcagtgca aatataaatt tctctatcct gctctgaggc taattggtac
     6361 catattttcc ctttgtgtct tgtgactctg ccacatccca tctcatcctg gcctctgagt
     6421 caagaaccca gtgaactgac tttctagttc tagaagttcc gctgcaaggc caggaaagct
     6481 tgagaaaggt attgtggaag aagcaaaggt agacccccat cactcacctt tgtctgcatc
     6541 cctgggcctg tgaatgatga cagcacctga cattctgcac cagctacctc tgcctccatg
     6601 gcagagaaaa ggccataaga acagtggaag aggagcatgg actcagactt caaggaagaa
     6661 gccatttccc caggtccttc cttctgcatc tcaccacccc tagttacaaa taactccatt
     6721 gaacagcatc tattcagaaa ctatgccgaa taaaaagatt ggtggaaggg ctcatgtggt
     6781 tagcaactat gaaacagaaa taggacactc agttacaaac attatctcct ttagtttttc
     6841 agaaaatgca tccctgattt cattcatttc cagcttgaaa gccagccata ttactctagt
     6901 ccctaccaaa ctgctctaga aggtcatttc cattttgttt gtgatattta gacgcgcaga
     6961 cttcaggaag ttcaccttta acttcagcat tccagatgaa gtttcctgac tcagtgcttt
     7021 tgcataagga actagaaaaa aaaagtaagg aaaattggag atgctaacat cctcccccat
     7081 cccaactgca ccttaaaata tgcatgtcac cttcaaggtt ttataattgc actgtttgtt
     7141 ttatgtatgt acagattaaa attattgcta catttgagga aaataaaatt gcttgcttct
     7201 atgtaattcc tgtcattcca caggaaattc acttttccag ctactgaata gaatttgttt
     7261 aacaacctca tgggttgcct cttcatttac agggaagaaa tgaaatgtac atctgcagaa
     7321 attgccaaag cccaaattaa cgagtattat aaaaggataa taaagcatcc ctgaagccaa
     7381 a
//
