LOCUS       NM_207363               7608 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens NCK associated protein 5 (NCKAP5), transcript variant
            1, mRNA.
ACCESSION   NM_207363
VERSION     NM_207363.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7608)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7608)
  AUTHORS   Khor,S.S., Miyagawa,T., Toyoda,H., Yamasaki,M., Kawamura,Y.,
            Tanii,H., Okazaki,Y., Sasaki,T., Lin,L., Faraco,J., Rico,T.,
            Honda,Y., Honda,M., Mignot,E. and Tokunaga,K.
  TITLE     Genome-wide association study of HLA-DQB1*06:02 negative essential
            hypersomnia
  JOURNAL   PeerJ 1, e66 (2013)
   PUBMED   23646285
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7608)
  AUTHORS   Gourraud,P.A., Sdika,M., Khankhanian,P., Henry,R.G., Beheshtian,A.,
            Matthews,P.M., Hauser,S.L., Oksenberg,J.R., Pelletier,D. and
            Baranzini,S.E.
  TITLE     A genome-wide association study of brain lesion distribution in
            multiple sclerosis
  JOURNAL   Brain 136 (Pt 4), 1012-1024 (2013)
   PUBMED   23412934
REFERENCE   4  (bases 1 to 7608)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   5  (bases 1 to 7608)
  AUTHORS   Osman,W., Low,S.K., Takahashi,A., Kubo,M. and Nakamura,Y.
  TITLE     A genome-wide association study in the Japanese population confirms
            9p21 and 14q23 as susceptibility loci for primary open angle
            glaucoma
  JOURNAL   Hum Mol Genet 21 (12), 2836-2842 (2012)
   PUBMED   22419738
REFERENCE   6  (bases 1 to 7608)
  AUTHORS   Smith,E.N., Bloss,C.S., Badner,J.A., Barrett,T., Belmonte,P.L.,
            Berrettini,W., Byerley,W., Coryell,W., Craig,D., Edenberg,H.J.,
            Eskin,E., Foroud,T., Gershon,E., Greenwood,T.A., Hipolito,M.,
            Koller,D.L., Lawson,W.B., Liu,C., Lohoff,F., McInnis,M.G.,
            McMahon,F.J., Mirel,D.B., Murray,S.S., Nievergelt,C.,
            Nurnberger,J., Nwulia,E.A., Paschall,J., Potash,J.B., Rice,J.,
            Schulze,T.G., Scheftner,W., Panganiban,C., Zaitlen,N., Zandi,P.P.,
            Zollner,S., Schork,N.J. and Kelsoe,J.R.
  TITLE     Genome-wide association study of bipolar disorder in European
            American and African American individuals
  JOURNAL   Mol Psychiatry 14 (8), 755-763 (2009)
   PUBMED   19488044
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 7608)
  AUTHORS   Baranzini,S.E., Wang,J., Gibson,R.A., Galwey,N., Naegelin,Y.,
            Barkhof,F., Radue,E.W., Lindberg,R.L., Uitdehaag,B.M.,
            Johnson,M.R., Angelakopoulou,A., Hall,L., Richardson,J.C.,
            Prinjha,R.K., Gass,A., Geurts,J.J., Kragt,J., Sombekke,M.,
            Vrenken,H., Qualley,P., Lincoln,R.R., Gomez,R., Caillier,S.J.,
            George,M.F., Mousavi,H., Guerrero,R., Okuda,D.T., Cree,B.A.,
            Green,A.J., Waubant,E., Goodin,D.S., Pelletier,D., Matthews,P.M.,
            Hauser,S.L., Kappos,L., Polman,C.H. and Oksenberg,J.R.
  TITLE     Genome-wide association analysis of susceptibility and clinical
            phenotype in multiple sclerosis
  JOURNAL   Hum Mol Genet 18 (4), 767-778 (2009)
   PUBMED   19010793
REFERENCE   8  (bases 1 to 7608)
  AUTHORS   Lasky-Su,J., Neale,B.M., Franke,B., Anney,R.J., Zhou,K.,
            Maller,J.B., Vasquez,A.A., Chen,W., Asherson,P., Buitelaar,J.,
            Banaschewski,T., Ebstein,R., Gill,M., Miranda,A., Mulas,F.,
            Oades,R.D., Roeyers,H., Rothenberger,A., Sergeant,J.,
            Sonuga-Barke,E., Steinhausen,H.C., Taylor,E., Daly,M., Laird,N.,
            Lange,C. and Faraone,S.V.
  TITLE     Genome-wide association scan of quantitative traits for attention
            deficit hyperactivity disorder identifies novel associations and
            confirms candidate gene associations
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1345-1354 (2008)
   PUBMED   18821565
REFERENCE   9  (bases 1 to 7608)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   10 (bases 1 to 7608)
  AUTHORS   Matuoka,K., Miki,H., Takahashi,K. and Takenawa,T.
  TITLE     A novel ligand for an SH3 domain of the adaptor protein Nck bears
            an SH2 domain and nuclear signaling motifs
  JOURNAL   Biochem Biophys Res Commun 239 (2), 488-492 (1997)
   PUBMED   9344857
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011243.8, AK057980.1, AK092189.1, AY946008.1, AK124659.1,
            CA438539.1 and AC010974.9.
            
            On Nov 22, 2018 this sequence version replaced NM_207363.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409261.6/ ENSP00000387128.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC011243.8         83301-83303         c
            4-584               AK057980.1         1-581
            585-956             AK092189.1         257-628
            957-6090            AY946008.1         376-5509
            6091-7100           AK124659.1         960-1969
            7101-7597           CA438539.1         18-514              c
            7598-7608           AC010974.9         18572-18582         c
FEATURES             Location/Qualifiers
     source          1..7608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.2"
     gene            1..7608
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /note="NCK associated protein 5"
                     /db_xref="GeneID:344148"
                     /db_xref="HGNC:HGNC:29847"
                     /db_xref="MIM:608789"
     exon            1..248
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            249..316
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            317..446
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..6107
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peripheral clock protein 2; NAP-5; nck-associated protein
                     5"
                     /codon_start=1
                     /product="nck-associated protein 5 isoform 1"
                     /protein_id="NP_997246.2"
                     /db_xref="CCDS:CCDS46418.1"
                     /db_xref="GeneID:344148"
                     /db_xref="HGNC:HGNC:29847"
                     /db_xref="MIM:608789"
                     /translation="MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHR
                     SLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNR
                     IQMRSLQQQFSRMEETVRNLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDL
                     HMVVDEDSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVA
                     NQVVQALLTQKDLREECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLL
                     DLSSGDLLSEVERNRSLTQSRTDAEVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSS
                     SSELSLSSTCSEYSSGSSYTWHDGKNLRKRQSSQNWDKRLSIDSSLPSGFASPTNELP
                     PTRIKESHILEGLRKLQKRKVLLEPPSVITKWGYKDCMNSNEGIYSPGIKSSSLKEYP
                     PCKTADLGSPCKEPHKTFVYDLDSHVDADDDPSTLALLQAVPNQSCRPHGSKLTHSVS
                     DSLFGWETNRKHFLEGTSSVYPKERPEKLTSCASSCPLEMKLCPSVQTPQVQRERGPQ
                     GQGHGRMALNLQLSDTDDNETFDELHIESSDEKSPSDVSLAADTDKSVENLDVLVGFG
                     KSLCGSPEEEEKQVPIPSETRPKTFSFIKQQRVVKRTSSEECVTVIFDAEDGEPIEFS
                     SHQTGVVTVTRNEISINSTPAGPKAEHTELLPQGIACLQPRAAARDYTFFKRSEEDTE
                     KNIPKDNVDNVPRVSTESFSSRTVTQNPQQQKLVKPTHNISCQSNSRSSAPMGIYQKQ
                     NLTKIPPRGKSSPQKSKLMEPEATTLLPSSGLVTLEKSPALAPGKLSRFMKTESSGPL
                     FELRSDPHIPKHSAQLPHSSRMPSRRDWVQCPKSQTPGSRSRPAIESSDSGEPPTRDE
                     HCGSGPEAGVKSPSPPPPPGRSVSLLARPSYDYSPAPSSTKSETRVPSETARTPFKSP
                     LLKGISAPVISSNPATTEVQRKKPSVAFKKPIFTHPMPSPEAVIQTRCPAHAPSSSFT
                     VMALGPPKVSPKRGVPKTSPRQTLGTPQRDIGLQTPRISPSTHEPLEMTSSKSVSPGR
                     KGQLNDSASTPPKPSFLGVNESPSSQVSSSSSSSSPAKSHNSPHGCQSAHEKGLKTRL
                     PVGLKVLMKSPQLLRKSSTVPGKHEKDSLNEASKSSVAVNKSKPEDSKNPASMEITAG
                     ERNVTLPDSQAQGSLADGLPLETALQEPLESSIPGSDGRDGVDNRSMRRSLSSSKPHL
                     KPALGMNGAKARSHSFSTHSGDKPSTPPIEGSGKVRTQIITNTAERGNSLTRQNSSTE
                     SSPNKAPSAPMLESLPSVGRPSGHPSSGKGSLGSSGSFSSQHGSPSKLPLRIPPKSEG
                     LLIPPGKEDQQAFTQGECPSANVAVLGEPGSDRRSCPPTPTDCPEALQSPGRTQHPST
                     FETSSTSKLETSGRHPDASATATDAVSSEAPLSPTIEEKVMLCIQENVEKGQVQTKPT
                     SVEAKQKPGPSFASWFGFRKSRLPALSSRKMDISKTKVEKKDAKVLGFGNRQLKSERK
                     KEKKKPELQCETENELIKDTKSADNPDGGLQSKNNRRTPQDIYNQLKIEPRNRHSPVA
                     CSTKDTFMTELLNRVDKKAAPQTESGSSNASCRNVLKGSSQGSCLIGSSISTQGNHKK
                     NMKIKADMEVPKDSLVKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFP
                     LPDSGNRSTGRYLCQPDSPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPAD
                     SAIVHSTSDPIMTARGMRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPM
                     ASQPLPDWGSEVAATGTQDKAPRMCTYSASGGSNSDSDLDYGDNGFGAGRGQLVKALK
                     SAAPEIETT"
     exon            447..520
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            521..584
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            585..718
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            719..806
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            807..956
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1025
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1064
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1184
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1286
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1469
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..5248
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..5426
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5427..5505
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5506..5820
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5821..5957
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            5958..6090
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            6091..7608
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6163..6168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /note="hexamer: AATAAA"
     polyA_site      6201
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /note="major polyA site"
     regulatory      7232..7237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /note="hexamer: AATAAA"
     polyA_site      7257
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /note="major polyA site"
     regulatory      7574..7579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /note="hexamer: AATAAA"
     polyA_site      7608
                     /gene="NCKAP5"
                     /gene_synonym="ERIH1; ERIH2; NAP5"
                     /note="major polyA site"
ORIGIN      
        1 gaagcaacta cggagccgca gcccagggag caagtctccg caaacttgct ccgcattcac
       61 ggcaggactt cccagccgct gtggatgttc aggaaaaccg agtctgttct gttagcgtgg
      121 cctttgaatg cttcaaaaat aaacagagga taaccaaccg cgggaggaaa tttttagctg
      181 gagagagttg tagttcctgt gtctgtctcc aggactgtga tatgtgttga ctgaagagct
      241 aactacaagt tcatcgtgaa gaataaatga gataagctac ctcaagtgcc tgtaccaaaa
      301 tagactcaca atacattgac cctggaaaca gacgggggat tcttataagt cacaaaagaa
      361 aataaataac ttcatccatg gagggaaaga gacagcttga gaaaagggac tttggaaaaa
      421 ggctgtctct agacagcagt cttgtggaat acatggactc caataaatac attgagcatc
      481 tgctgactca gcttgaggag caacacagga gtctctggag ggagaagttg gcagtggccc
      541 gactacagcg agaagttgcc caaagaacaa gtgagggggc catgcatgag aagctgatac
      601 atgaactgga agaggagaga cacttacgtc ttcaaagcga gaagcggttg caggaggtga
      661 ccctagagtc tgaacgcaac agaattcaga tgcgtagctt gcagcagcag ttctccagga
      721 tggaagaaac agtacgaaat ctattgcaga gtcaaggatc tccagagcag aaaaaagaag
      781 aaactgttaa tataatggtc tatcaggaaa agctgtcaga ggaagagaga aaacataagg
      841 aagctttgga agatcttcac atggtggttg atgaggattc gaggagtgaa agcagcagta
      901 cagatgaggg aaaagaaaag accaaattgc tattagagag attgaaagct ctagaggcag
      961 agaattcagc gttggctttg gagaatgaaa atcaaaggga acaatatgag cgatgtcttg
     1021 atgaggtagc caaccaagtt gttcaagctc tgcttactca aaaggatcta agagaggaat
     1081 gtgtgaagtt gaaaacaaga gtgtttgatt tggaacagca gaatcgaaca ctaagcatcc
     1141 tattccaaca gcgagtcaga cccacttctg atctgctcct ccagaaactt cactcacgtc
     1201 tcttggatct ttcatctgga gatttgcttt cagaggtgga aagaaaccga agtctgacac
     1261 agtcacgaac tgatgctgag gtgcacgaac accaactaaa tacaaaatcg gccttgaaat
     1321 gccctggctt gggggctgtc atccctggtc atctctgtcc tcgaaacagc tacagtagca
     1381 gcagtgaact gtctctttca agcacctgca gcgagtactc cagtggctcc tcctacacgt
     1441 ggcacgatgg gaagaacctc aggaaaaggc aatcatcaca aaactgggat aaaaggctaa
     1501 gtattgattc ttcgctccca agtggctttg ctagtcctac aaatgaacta cctccaactc
     1561 gtatcaagga aagccacatt ttggaagggc taagaaagct acagaagcga aaagtgttac
     1621 ttgaaccccc atcagtgata accaaatggg gttataaaga ttgcatgaac tcgaatgaag
     1681 gaatatattc tcctggaatt aaaagtagca gcctcaagga gtatcccccc tgcaaaacag
     1741 ctgacctggg gagcccctgc aaggaacccc acaagacatt tgtttatgat ctagattccc
     1801 acgttgatgc ggacgatgac ccttccacct tagcattgct ccaagcagtt ccaaaccaga
     1861 gctgcaggcc acatggcagt aaattaaccc acagtgtttc cgacagtctg tttggctggg
     1921 agacaaacag aaaacacttt ctggaaggca catcctcagt ttatcccaag gaaaggcctg
     1981 aaaagctgac aagttgcgcc agcagctgtc ccttagagat gaagctgtgc ccaagtgtgc
     2041 agacgcctca ggtacagagg gagaggggcc cacagggcca aggccatggc cgcatggctc
     2101 tcaacctcca gctttcagac actgatgaca atgaaacgtt tgatgagctg cacatagaga
     2161 gcagtgatga gaaaagtcct tcagacgtgt cattggctgc cgacaccgat aagtccgtgg
     2221 agaacctgga tgtccttgtg gggtttggaa aatctctatg tgggtctcct gaagaggagg
     2281 aaaaacaagt gcccatccct tcagagacta ggccaaagac ttttagtttc attaagcagc
     2341 aaagagttgt aaaaaggact tcttcagaag aatgtgtgac tgtgatattt gatgcggaag
     2401 acggtgagcc cattgaattc agctctcacc agactggggt tgtcactgtt accagaaatg
     2461 agatttccat caattcaact cctgctggac ccaaggcaga acatactgag cttttacctc
     2521 agggaattgc ttgtttacag ccaagagctg ctgcaagaga ctatactttc tttaaaaggt
     2581 ctgaagagga cactgagaaa aacattccaa aagataatgt agataatgtt cccagggtgt
     2641 ccactgaatc tttcagctcc aggacagtga cacaaaatcc tcagcagcaa aagctggtca
     2701 aaccaacaca caatatatca tgccagagta attccaggtc ttcggcaccc atgggcatct
     2761 atcaaaagca aaatctgaca aaaatacctc ccaggggcaa gtcttcacct cagaaatcaa
     2821 aactaatgga gcccgaagcc accacactac tcccttcatc tggcctggtg actcttgaaa
     2881 aatcaccagc cttagctcct gggaaactct cacgattcat gaagactgag agctcagggc
     2941 ccctctttga attacgatca gatccacaca ttccaaaaca ttccgcccaa cttccgcaca
     3001 gctccaggat gcccagcagg agggactggg tccagtgccc caagagtcag actccagggt
     3061 cacggtcaag gcctgccatt gagtctagtg acagtggaga gccccccacg agggatgaac
     3121 actgtggctc tgggccggag gcaggggtga aatccccttc ccctccgccc cctccaggca
     3181 ggtccgtctc cctgctggcc aggcccagct atgactattc accagcacct tcatccacca
     3241 agtccgaaac cagggtcccc agtgaaacag caaggacccc attcaaatcc ccgctgctga
     3301 aaggaatttc tgctccagtt atttcttcta atccggccac gacagaagtg cagaggaaga
     3361 aaccttctgt ggccttcaaa aagcctatct tcactcaccc tatgccctcc ccagaagcag
     3421 tcattcaaac ccgatgccct gctcatgccc cctccagctc cttcaccgta atggctctgg
     3481 ggcctccaaa ggtctctccg aagagaggtg tccccaaaac ctctcctcgc caaacacttg
     3541 ggaccccaca aagggacata ggattacaga ctcccaggat ctctccttca acccatgagc
     3601 cactggaaat gacgtcctcc aaaagtgtat ctccagggag aaaaggacaa ttgaatgata
     3661 gcgcctccac accccccaag ccttccttct taggggtaaa tgagtcacca tcatctcagg
     3721 tcagcagttc ctcatcatcc tcatcacccg ccaaaagcca taacagccct catggttgtc
     3781 aaagtgctca tgagaaagga ctgaaaactc gccttccagt gggactcaaa gtgctcatga
     3841 agtctcccca gctgctcagg aaaagttcca ccgtgccagg gaaacatgaa aaagacagtt
     3901 taaatgaagc ctccaaaagt tccgtggctg tgaacaagtc taagccagag gactccaaga
     3961 atccagcaag catggagatc acagcgggtg aaagaaatgt gaccctaccg gattcacaag
     4021 cacagggcag tttagctgat gggcttcccc tggaaacagc actacaagag ccattggaaa
     4081 gtagcatccc tgggagtgat ggaagggatg gggtagataa tagatccatg agaagatccc
     4141 tttcctccag caaaccacac ctaaaaccag ctctgggtat gaatggcgcc aaagcccgca
     4201 gccacagctt cagtacacac tcaggagaca agccttctac gccccccatc gaagggtcag
     4261 gcaaagtccg cactcagatc attaccaata ccgccgagag aggcaattct cttacccggc
     4321 agaactcttc cacggaaagc tctcccaaca aggccccttc tgctcccatg ttggagagtc
     4381 tccccagtgt tgggaggccc tcggggcacc cctcctccgg gaagggctcc ctggggagct
     4441 caggcagctt cagcagtcag catgggagcc caagtaagtt gcctttgagg atccctccaa
     4501 agtctgaggg actcctcatc ccacctggaa aggaagacca gcaggccttc acccagggag
     4561 agtgccccag tgccaatgtg gctgtacttg gggaaccagg cagtgaccgc cgcagttgcc
     4621 cacccacccc aacagactgc cctgaagccc tgcagagccc agggaggact cagcatccaa
     4681 gcacttttga aacaagcagt acatccaagc tagaaacttc tggaaggcat ccagatgcct
     4741 ctgcaaccgc gactgatgct gtgagttcag aagcccccct ctcacccaca atcgaagaaa
     4801 aggtcatgtt gtgcattcag gaaaatgtgg aaaagggcca agtgcaaaca aagcccacct
     4861 ctgtggaagc aaagcagaag cctgggcctt cttttgccag ctggtttggt tttcggaaga
     4921 gtagacttcc agctctgagt agcaggaaaa tggacatctc caaaaccaaa gtagaaaaga
     4981 aagatgcaaa agtcttgggg tttggaaaca gacaactaaa atcagaaaga aaaaaagaga
     5041 aaaagaagcc tgaactacag tgtgagacag aaaatgagct tatcaaggac accaagtcag
     5101 cagataatcc agatggcggt ttacaaagca aaaataatcg gagaacacca caagacattt
     5161 acaaccaact gaagattgaa ccaaggaata gacacagccc tgttgcatgt tcaacgaaag
     5221 acaccttcat gacggaactc ttgaacagag ttgataagaa agcagctcca cagacagaaa
     5281 gtggatcaag taatgcttcc tgcaggaatg tgttaaaggg cagttctcag ggctcctgtc
     5341 tcatcggcag ctctatcagt actcaaggaa accacaagaa aaacatgaaa atcaaagccg
     5401 atatggaagt accaaaagac tccctggtaa aagaggcaaa tgaaaacttg caagaggatg
     5461 aagacgatgc agttgcagat tctgtatttc agagccacat catagaatcc aactgccaga
     5521 tgagaacatt ggacagtggg atcggaacct ttccactccc agactcggga aatcgctcga
     5581 caggacgcta cctatgccag ccagactccc cagaggacgc tgagcctctc ctgcctctcc
     5641 agtcagccct ttctgcagtt tcttccatga gagcccaaac ccttgaacgt gaagtgcctt
     5701 cctccacaga cggccagcgc cctgcagata gcgccattgt tcattccaca tccgacccca
     5761 tcatgaccgc cagagggatg aggcctcttc agagccgcct ccccaaacca gcttcctcag
     5821 gaaaagtcag ttcccaaaag cagaatgaag cagagccaag gcctcagaca tgctcatcat
     5881 tcggatatgc tgaagaccca atggcaagcc agccgcttcc agactggggg agtgaagttg
     5941 ctgccaccgg gacccaggac aaggcaccca gaatgtgtac gtactctgcc agcggtggca
     6001 gtaatagtga cagtgacctg gactatggag ataatggttt tggagctgga aggggacagt
     6061 tagtgaaagc actgaagagc gctgccccag aaattgagac aacttgaaga aacaaaagac
     6121 gatcccgaga atagattatc gaaaatttcc ctagagtcat tcaataaatt taacagcaat
     6181 actgtgattt tattagaaaa agagaagaac tctctgaaca aggttgaagg acagaaggaa
     6241 gaaaaagaaa aaaatgaaga gacatctttg agtagttcag ataggcctgg ggtagacaac
     6301 ttggaatctt tgagtgattc tttatatgat agcttctctt cctgtgccag tcaaggttca
     6361 aatgatgtat aaaggacatc tcttccctta gtgagctggg actggagcgc ttaagaaatg
     6421 atgggtgggg ggtggggggt gcaccgcttg atagagataa caataaacta ttgcagtacc
     6481 agagccttcc ttgtcaaatt cacagcaggc aacccaccag agcttatttc tctgacaggg
     6541 caataaagat agactccatt tattgtgttt caagaggatt aagcgtaaac acatctatga
     6601 tacagaatcc ttaattttgc actttttttg aatatttgta cagaagttgt aaattttttg
     6661 gaagagaaat tatatttgta gcaaaaaaag acagcaataa atggaatcag tgccatgctc
     6721 ttgaaataat gtactaagtc ttagaagttg atgataatat atatttttta aaatcccaac
     6781 tgaagttttt gtgaagttcg ttgtcctggt cctcaaattg tttgtgggta cactctgtaa
     6841 acctacaaca gggcctgcca aaaaatcgga gggttcctcc tcatctccat ctcacaaatc
     6901 tcaatttgat ggaaatgttc attttagtgt aatttcagat tcgttgccag agattcaggt
     6961 gatagtaata agtgtcattc tgcttctgct gaaaaatgaa aagggtcctg aagtgtggac
     7021 actgattggg agtgtgacat tgtatcagaa atgaccgaat tctattccca ataccagttt
     7081 ttccttccag acatttcttt agattgtctt ttacttagtg cttctctatg atcctgaata
     7141 ttatttgatt tttatcttct tgctcttttt attaaaatct gggcactcta aaaatgaaaa
     7201 caaatttcta tttgcaatgt tcacttttaa aaataaaatt aatggtgcta cgaagaattc
     7261 tttttaatat cctttttttt ctacaaagac tgtttatatg taaggataaa ttctatttta
     7321 aaggttatgt gtattttttc tagatgtgaa ctatttataa ttacttatgt acaggagctt
     7381 gtaaactagg cccaatagaa atatttttag gatctatatg gctactttag cacataattg
     7441 tttctttaaa gagtattgta tgatcagtgt tatttggtta atttgtgcaa tttgttttat
     7501 tttatcttaa atgaaaatta tgtaaaatgt ccttgtcttt cagactttaa aaaatctttt
     7561 tgtttccttt ctgaataaaa gttatatcac atttgcaccc tctgaaaa
//
