LOCUS       NM_001001414            1975 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens NCCRP1, F-box associated domain containing (NCCRP1),
            mRNA.
ACCESSION   NM_001001414
VERSION     NM_001001414.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1975)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1975)
  AUTHORS   Miwa,T., Kanda,M., Tanaka,H., Tanaka,C., Kobayashi,D., Umeda,S.,
            Iwata,N., Hayashi,M., Yamada,S., Fujii,T., Fujiwara,M. and
            Kodera,Y.
  TITLE     FBXO50 Enhances the Malignant Behavior of Gastric Cancer Cells
  JOURNAL   Ann Surg Oncol 24 (12), 3771-3779 (2017)
   PUBMED   28560594
  REMARK    GeneRIF: High FBXO50 expression is associated with Gastric Cancer.
REFERENCE   3  (bases 1 to 1975)
  AUTHORS   Kallio,H., Tolvanen,M., Janis,J., Pan,P.W., Laurila,E.,
            Kallioniemi,A., Kilpinen,S., Tuominen,V.J., Isola,J., Valjakka,J.,
            Pastorekova,S., Pastorek,J. and Parkkila,S.
  TITLE     Characterization of non-specific cytotoxic cell receptor protein 1:
            a new member of the lectin-type subfamily of F-box proteins
  JOURNAL   PLoS One 6 (11), e27152 (2011)
   PUBMED   22087255
  REMARK    GeneRIF: to characterize human NCCRP1 and to elucidate its
            relationship to carbonic anhydrase IX
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK123941.1 and AC011443.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001001414.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067874.1, BC092493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339852.5/ ENSP00000342137.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1973              AK123941.1         1-1973
            1974-1975           AC011443.6         139755-139756
FEATURES             Location/Qualifiers
     source          1..1975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1975
                     /gene="NCCRP1"
                     /gene_synonym="FBXO50; NCCRP-1"
                     /note="NCCRP1, F-box associated domain containing"
                     /db_xref="GeneID:342897"
                     /db_xref="HGNC:HGNC:33739"
                     /db_xref="MIM:615901"
     exon            1..356
                     /gene="NCCRP1"
                     /gene_synonym="FBXO50; NCCRP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..847
                     /gene="NCCRP1"
                     /gene_synonym="FBXO50; NCCRP-1"
                     /note="nonspecific cytotoxic cell receptor protein 1
                     homolog; NCC receptor protein 1 homolog; non-specific
                     cytotoxic cell receptor protein 1 homolog"
                     /codon_start=1
                     /product="F-box only protein 50"
                     /protein_id="NP_001001414.1"
                     /db_xref="CCDS:CCDS12529.1"
                     /db_xref="GeneID:342897"
                     /db_xref="HGNC:HGNC:33739"
                     /db_xref="MIM:615901"
                     /translation="MEEVREGHALGGGMEADGPASLQELPPSPRSPSPPPSPPPLPSP
                     PSLPSPAAPEAPELPEPAQPSEAHARQLLLEEWGPLSGGLELPQRLTWKLLLLRRPLY
                     RNLLRSPNPEGINIYEPAPPTGPTQRPLETLGNFRGWYIRTEKLQQNQSWTVKQQCVD
                     LLAEGLWEELLDDEQPAITVMDWFEDSRLDACVYELHVWLLAADRRTVIAQHHVAPRT
                     SGRGPPGRWVQVSHVFRHYGPGVRFIHFLHKAKNRMEPGGLRRTRVTDSSVSVQLRE"
     exon            357..419
                     /gene="NCCRP1"
                     /gene_synonym="FBXO50; NCCRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..471
                     /gene="NCCRP1"
                     /gene_synonym="FBXO50; NCCRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..567
                     /gene="NCCRP1"
                     /gene_synonym="FBXO50; NCCRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..706
                     /gene="NCCRP1"
                     /gene_synonym="FBXO50; NCCRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..1975
                     /gene="NCCRP1"
                     /gene_synonym="FBXO50; NCCRP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCCRP1"
                     /gene_synonym="FBXO50; NCCRP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1975
                     /gene="NCCRP1"
                     /gene_synonym="FBXO50; NCCRP-1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgcag cctcgaggga tggaggaggt gcgtgaggga cacgcgctcg gtggcgggat
       61 ggaagccgat gggcccgcga gcctccagga gctgcctccc tcgccacggt cgccttcacc
      121 gccgccgtcg ccgccaccac tgccctcgcc gccgtcgctg ccatcgcccg cagccccgga
      181 ggcccccgag ctccccgagc cggcgcagcc gtccgaggct cacgcccggc agctgctgct
      241 ggaggagtgg gggccgctga gcgggggcct ggagctgccc cagcgcctca cctggaagct
      301 gctcctgttg cggcggccgc tctaccgcaa cctgctgcgc tcgcccaacc ccgaaggcat
      361 caacatttat gagccagcac cccctactgg tcccacccag cgacccctgg aaactctggg
      421 caatttccgt ggctggtaca ttagaactga aaagctccag cagaaccaaa gctggacagt
      481 gaagcagcag tgtgtggacc ttctggccga gggcctgtgg gaggagctgc tggatgacga
      541 acaaccagcc attacggtca tggactggtt cgaggacagc cggctggatg cgtgcgtcta
      601 tgagctgcat gtctggctgc tggcggccga ccgccgcacg gtcattgctc agcaccacgt
      661 ggccccccga acttctggga gaggaccccc tggccgctgg gtccaggtgt cccacgtatt
      721 ccgccattat ggtcccggtg tgcgctttat ccacttcctg cacaaggcca agaaccgcat
      781 ggagcctggt gggctgcggc ggacacgggt gaccgactcc tccgtgtctg tgcagctccg
      841 ggagtgactg gctggctcct ctgtcctgac cccacagcac ctccctgacc tttaggagcc
      901 ccaactctta gtcacctcct aggcctctta tttctccctg gcccttggct tctcacttga
      961 tggacagctt cacacaccct taagcggtgg actccagcat tttcccagca ctgtctgagc
     1021 cccatgaggg cggagccact ccttgtaaat tcagtgcccg acagatgctc tggcacagat
     1081 gctttgtaga tctctgttga gagaatgcat agacacctgt gcccaaggat gctgagggct
     1141 ggtctctgct tctttgaact tcactgaaac tgaatgctca ctgctgtgtt gccagcacca
     1201 cccagcccag ggctgtgaac ggagtgggtg gcagcaaatg tgtgttgaaa ggggaatgaa
     1261 gccattcact tcactcagtt cctgtcccat ttaaccgccc cgatccttga tcttccatta
     1321 ccttcacatc ccggggtcct tctgaactga ccttgacctc tgatctcttc acacatctcc
     1381 ccttagcatc tccacttacc tacttttttt tttttttttg agatggcatc tcactctgtc
     1441 acccaggctg gagtgtagtg acacgatctc gactcactgc aatttccacc tctcaggttc
     1501 aagtggttct cctgcctcag cctctcaagt agctgggatt acaggtgcac agcacctccc
     1561 ccgactaatt tttatatttt tagtagagac gggatttcgc catgttggcc aggctggtct
     1621 caaactcctg acctcaagtg atctgcccac cttggcttcc caaagtgctg ggattgcaga
     1681 cgtgagtcac tgcgcccagc cattccatgt ctcttaagtc tcagaatctc ccctagctcc
     1741 ctccaggtgt ctgcagtggt tgtcccctca aagctgtccc acaccctcct ccgaggaccc
     1801 tttgtgtatc tcctccagct accgcagagc ccacaaaccc aggcatctat caaagtccct
     1861 cattcatgag ggtggtgagg acacagactg cgaccagaac agaaatatga aaatgtgaat
     1921 gacagcgtcc cccgtgtgtg gaatgtgggg attaaaagca tttatcaacc tctaa
//
