LOCUS       NM_001114118           12772 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens nuclear cap binding subunit 3 (NCBP3), transcript
            variant 1, mRNA.
ACCESSION   NM_001114118
VERSION     NM_001114118.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12772)
  AUTHORS   Li,X., Zhang,F., Ma,J., Ruan,X., Liu,X., Zheng,J., Liu,Y., Cao,S.,
            Shen,S., Shao,L., Cai,H., Li,Z. and Xue,Y.
  TITLE     NCBP3/SNHG6 inhibits GBX2 transcription in a histone modification
            manner to facilitate the malignant biological behaviour of glioma
            cells
  JOURNAL   RNA Biol 18 (1), 47-63 (2021)
   PUBMED   32618493
  REMARK    GeneRIF: NCBP3/SNHG6 inhibits GBX2 transcription in a histone
            modification manner to facilitate the malignant biological
            behaviour of glioma cells.
REFERENCE   2  (bases 1 to 12772)
  AUTHORS   Dou,Y., Barbosa,I., Jiang,H., Iasillo,C., Molloy,K.R.,
            Schulze,W.M., Cusack,S., Schmid,M., Le Hir,H., LaCava,J. and
            Jensen,T.H.
  TITLE     NCBP3 positively impacts mRNA biogenesis
  JOURNAL   Nucleic Acids Res 48 (18), 10413-10427 (2020)
   PUBMED   32960271
  REMARK    GeneRIF: NCBP3 positively impacts mRNA biogenesis.
REFERENCE   3  (bases 1 to 12772)
  AUTHORS   Dou,Y., Kalmykova,S., Pashkova,M., Oghbaie,M., Jiang,H.,
            Molloy,K.R., Chait,B.T., Rout,M.P., Fenyo,D., Jensen,T.H.,
            Altukhov,I. and LaCava,J.
  TITLE     Affinity proteomic dissection of the human nuclear cap-binding
            complex interactome
  JOURNAL   Nucleic Acids Res 48 (18), 10456-10469 (2020)
   PUBMED   32960270
  REMARK    GeneRIF: Affinity proteomic dissection of the human nuclear
            cap-binding complex interactome.
REFERENCE   4  (bases 1 to 12772)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 12772)
  AUTHORS   Gebhardt,A., Habjan,M., Benda,C., Meiler,A., Haas,D.A., Hein,M.Y.,
            Mann,A., Mann,M., Habermann,B. and Pichlmair,A.
  TITLE     mRNA export through an additional cap-binding complex consisting of
            NCBP1 and NCBP3
  JOURNAL   Nat Commun 6, 8192 (2015)
   PUBMED   26382858
  REMARK    GeneRIF: NCBP3 binds mRNA, associates with components of the mRNA
            processing machinery and contributes to poly(A) RNA export. Study
            proposes the existence of an alternative cap-binding complex
            involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12772)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 12772)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 12772)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   9  (bases 1 to 12772)
  AUTHORS   Robinson,P.W., Green,S.J., Carter,C., Coadwell,J. and Kilshaw,P.J.
  TITLE     Studies on transcriptional regulation of the mucosal T-cell
            integrin alphaEbeta7 (CD103)
  JOURNAL   Immunology 103 (2), 146-154 (2001)
   PUBMED   11412301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA815746.1, DA403386.1, BP344033.1, AJ277841.1, AC116914.5,
            BM974475.1, KC877636.1 and KC877633.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001114118.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. This RefSeq lacks full-length human
            transcript support, but is supported by partial transcript
            alignments and by full-length homologous transcripts.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.6998.1,
                                           SRR1660805.49996.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389005.6/ ENSP00000373657.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-565               DA815746.1         6-570
            566-718             DA403386.1         111-263
            719-790             DA403386.1         265-336
            791-988             BP344033.1         45-242
            989-3407            AJ277841.1         291-2709
            3408-7490           AC116914.5         101878-105960       c
            7491-8182           BM974475.1         11-702              c
            8183-8997           AC116914.5         100371-101185       c
            8998-9531           KC877636.1         1-534
            9532-11667          AC116914.5         97701-99836         c
            11668-12225         KC877633.1         1-558               c
            12226-12772         AC116914.5         96596-97142         c
FEATURES             Location/Qualifiers
     source          1..12772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..12772
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /note="nuclear cap binding subunit 3"
                     /db_xref="GeneID:55421"
                     /db_xref="HGNC:HGNC:24612"
                     /db_xref="MIM:616624"
     exon            1..206
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1886
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CTD-3195I5.1; CTD-3195I5.5; nuclear cap-binding protein
                     subunit 3"
                     /codon_start=1
                     /product="nuclear cap-binding protein subunit 3 isoform 1"
                     /protein_id="NP_001107590.1"
                     /db_xref="CCDS:CCDS45578.1"
                     /db_xref="GeneID:55421"
                     /db_xref="HGNC:HGNC:24612"
                     /db_xref="MIM:616624"
                     /translation="MAAVRGLRVSVKAEAPAGPALGLPSPEAESGVDRGEPEPMEVEE
                     GELEIVPVRRSLKELIPDTSRRYENKAGSFITGIDVTSKEAIEKKEQRAKRFHFRSEV
                     NLAQRNVALDRDMMKKAIPKVRLETIYICGVDEMSTQDVFSYFKEYPPAHIEWLDDTS
                     CNVVWLDEMTATRALINMSSLPAQDKIRSRDASEDKSAEKRKKDKQEDSSDDDEAEEG
                     EVEDENSSDVELDTLSQVEEESLLRNDLRPANKLAKGNRLFMRFATKDDKKELGAARR
                     SQYYMKYGNPNYGGMKGILSNSWKRRYHSRRIQRDVIKKRALIGDDVGLTSYKHRHSG
                     LVNVPEEPIEEEEEEEEEEEEEEEEDQDMDADDRVVVEYHEELPALKQPRERSASRRS
                     SASSSDSDEMDYDLELKMISTPSPKKSMKMTMYADEVESQLKNIRNSMRADSVSSSNI
                     KNRIGNKLPPEKFADVRHLLDEKRQHSRPRPPVSSTKSDIRQRLGKRPHSPEKAFSSN
                     PVVRREPSSDVHSRLGVPRQDSKGLYADTREKKSGNLWTRLGSAPKTKEKNTKKVDHR
                     APGAEEDDSELQRAWGALIKEKEQSRQKKSRLDNLPSLQIEVSRESSSGSEAES"
     exon            207..272
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            273..378
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            379..504
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            505..633
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            634..710
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            711..819
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            820..919
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1023
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1333
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1488
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1650
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..12772
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3199..3204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /note="hexamer: AATAAA"
     polyA_site      3222
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /note="major polyA site"
     regulatory      3371..3376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /note="hexamer: AGTAAA"
     polyA_site      3407
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
     regulatory      8163..8168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /note="hexamer: AATAAA"
     polyA_site      8182
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
     regulatory      12748..12753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
                     /note="hexamer: AATAAA"
     polyA_site      12772
                     /gene="NCBP3"
                     /gene_synonym="C17orf85; ELG; HSA277841"
ORIGIN      
        1 agtggtgcgg ccggcaggca gcgatggcgg ccgtacgggg cctgcgggtg tcggtgaagg
       61 cggaggcccc ggcggggccg gccctggggc tcccgtcccc tgaggcggag tccggtgttg
      121 accgtggcga gccggagccc atggaggtgg aggagggcga gctggaaatc gtgcctgtgc
      181 ggcgctcgct caaggaactg atcccggaca cgagcagaag atatgaaaac aaggctggca
      241 gcttcatcac tggaattgat gtcacctcca aggaagcaat tgaaaagaaa gagcagcgag
      301 ccaagcgctt ccattttcga tcggaagtaa atcttgccca aagaaatgta gccttggacc
      361 gagacatgat gaagaaagca atccccaagg tgagactgga gacaatctat atttgcggag
      421 tagatgagat gagcacccaa gatgtctttt cctattttaa agaatatcct ccagctcaca
      481 tcgaatggtt ggatgatacc tcctgtaatg tagtttggct ggatgaaatg acagccacac
      541 gagcacttat caatatgagc tccctgcctg cacaggataa gatcagaagc agggatgcca
      601 gtgaggacaa gtcagctgag aaaaggaaaa aagacaagca ggaagacagt tcagatgatg
      661 atgaagctga agaaggagag gttgaagatg agaactcaag tgatgtagag ttggatacgt
      721 tgtctcaggt agaagaggag tctttgttaa gaaacgatct tcgtccagct aacaaacttg
      781 ctaaaggaaa taggttattc atgagatttg ctacaaaaga tgacaaaaag gaacttggag
      841 cagccagaag aagtcagtat tacatgaaat atgggaatcc aaattatgga ggcatgaaag
      901 gaattcttag caattcatgg aagcgaagat atcattcccg tcgtattcag cgggacgtga
      961 tcaagaagag agccctgatt ggggatgacg ttggcttgac gtcgtataaa catcgacatt
     1021 ctgggctagt gaatgttccc gaggaaccca ttgaagagga ggaagaggag gaggaggagg
     1081 aagaggaaga ggaagaagaa gaccaggaca tggatgcaga tgacagagtg gtggtagagt
     1141 accacgagga gctcccggct ctcaagcagc cccgggagcg gagcgcgtct agacgatcca
     1201 gtgccagcag ctcagactca gatgaaatgg actatgatct agaactgaaa atgatttcca
     1261 cgccttcacc aaagaaaagc atgaaaatga ctatgtatgc tgacgaagtg gaatctcagt
     1321 tgaaaaatat taggaactcc atgagggcag atagtgtatc ttcaagcaat atcaaaaacc
     1381 gaattggtaa caaattacca cctgagaaat ttgcagatgt ccgacatcta ttagatgaga
     1441 aacgtcagca ctcccgtcca cggccaccag tcagcagtac taaatcagat atacgccagc
     1501 ggttaggaaa aagaccacat tctccggaaa aggcttttag tagtaacccc gtcgttcgga
     1561 gagagccctc ttctgatgtg catagtaggc taggtgttcc caggcaggat agtaaaggcc
     1621 tctacgccga tactcgggag aagaaatcag gtaatttatg gactcgccta ggatctgcac
     1681 ccaagaccaa agaaaagaat acgaagaaag tggatcacag ggcgcctggc gctgaggaag
     1741 acgactctga gctgcaaagg gcatgggggg ctctgattaa ggagaaagag cagtctcgcc
     1801 aaaagaagag ccggttagat aacttaccat ctctccagat tgaagttagt cgggaaagca
     1861 gctctggttc agaggcagag tcctgatgcc cctggggcct atggcagctg ccctaaagcc
     1921 tgacattctt gcacagggtg gggcgcgcag taggaacctc ccccgcagga gctggcgccc
     1981 tctcgctcct gctcacacag tcaccctccg ctcttgctac ttcggcaaga catcttaaga
     2041 atgtgacaca ttttcaaggg catctctatc tttcgctgca gagttgtagt tctgggccct
     2101 cgattccttt cccaccaccc cacaggcttt accctttgag aaaaaggcag ccctccagat
     2161 tttgtagaca tttttcttaa tatttttaac attgtgtctt ttaaaagaaa tgttttacac
     2221 agttcatcca aagagcagag aactgaactt ctcactattg ccttggccct gacagctgtt
     2281 accagcaccc ttttcccaag aaaagtcaat tcccaggtgc ttattggaca tccttcgagg
     2341 gggaagagga gggaagcggc cagctcaccc ttccgggacc ctagtgtggg gcgaatctca
     2401 cggacctgac ctcagaggtg caccagtgcc gcccaggtag ataagagctg cagcattgac
     2461 tgtgcttccg ttcttccctc ggggattgct catggcatgg gcctcttacg tgctgtcagc
     2521 ttgatgtgaa gatcaagttc agtgctgtgg gatttttagg aacaaaaaac tgtgacgtct
     2581 ggatttgggg ttgatttttg tgctggggtg ggattatggg tcaatgttga agaattttta
     2641 agtctgtatt atgtttaaaa catgaatgat ttgaaagttt aaatttttaa tttttatatg
     2701 tggaaattct tcctgttggc taaaggggaa gctcaagtgg tgtcgtcttt tgtgctgtta
     2761 aatatatatt ctattctttg gaagaaggca gagagaggag tcttattatt tttaaatgct
     2821 cctagttgta tagtctgtct gttgtacata gagttcagct tgttttttgg ctccagtagg
     2881 aaaaaaaatc catccatctg agatggggtc ctgttgttta ttatcactct agaagttata
     2941 cattgatatt tattctttct gtccccacgt tgtggcacct gaagacatct tcaaaattgg
     3001 cagaaaagat aatagttata aaaattttag ttcatttatt tttaaactcc tttcagatta
     3061 ttttaccatt aggaggaggt agattgtttc gtcttcctgt ctgatttttg ttttgtagta
     3121 tttaattttg tattcctctg cagttttaag aaacagtgtt tttcttcggt ttgctggaac
     3181 atgggcgtta gagatggtaa taaaccgtgg tcctttttgc gatgtcacga ctcttcacct
     3241 gcctgggctg ttgtgcacac agtgcagcct ggatcctgtc gatctttact tgtggcggag
     3301 ctaatggtca cattgatagt tgattacact gtggcacgaa ttaatgcaga acactgttat
     3361 taataaagga agtaaagggc tgcaagattt gagagctgca acaaaaactg tattgtccca
     3421 tattttgttg attaaccttg ctttttctcc ctccctttag agagattaga ggatataacc
     3481 atgatatatt tcagcttctt attaggattc taggaaagag atggttctgg tttctctgcc
     3541 agttgagact taagacatct gagatttctc agcttttctt tccctgtgaa gcatacagct
     3601 gagagccagg ttcttaggaa gggtcagggt ttggggagtt ggtagagtga ggagtgcggg
     3661 ggcctgagaa tcggacacct ggatgccaac ccctggctct gctccatgga cctgggcctc
     3721 agttttcccg tctagcagtt gagtgggctg ttaccagaat tcctggcttt gttggtgcat
     3781 ctcagtggcg gtttactctt cccaagctgt gacggcagtg ggctcgccag catgaatttc
     3841 tactgcaggt ggaggaggcg ccagggagac aactgagggc gcgcatgagg tgtagacagg
     3901 ggcttattcc catcccagca cagtctctgc ttctactgac ggggcaaaga tgtcttgtgg
     3961 tcagcgtccc agctggcatg cctctgcagg gtttagaata tgctccttca cagactttcc
     4021 ttttggtttt acaccagcag ctcaggtcca tttgttccac ggcctttcag cactcagcag
     4081 tctcctgcta cagatcagcg aagccattct ggaaggaggt ggtgtgcagt caaaactggg
     4141 tctttgatgt aaccaagaga aatacacact cgagtaacct tacagttttc acagacacac
     4201 agagagaacc cagaaaggca gctttaaaga tttttacttc tcggagttac tggccttatt
     4261 agtttctcta accctcctgc ccactctcag tcactcagat cttgcaacat cttgagtgtg
     4321 tcctgaatga tgaggccttt tctttggagt ttaagagtaa gaatggatag tcaggacagg
     4381 cccgtggcag gcagctgggc gtgattttac cctggacact ccccacacat gtgggcacag
     4441 ggctgcacac tttgtgtgtt cctcttagtc ttatgtgtag gagattttac atacatgttt
     4501 gctgcttgat gataattgca gatacctcat ttgtttccca ctctcctctc tggagagtta
     4561 ccaggtaccc aggataattt gtggcgtcct caggatgtag tctcctcctc tggccccctt
     4621 gtagtctgat cctgtgaacc cctctccgtt cttcagccac tgccctttcc agctgcattt
     4681 gtacagcagc ctcttcactg gtctctgccc tgtctccatt ctgcacactg cagcgggatg
     4741 aacctttgtt gttgttacca gcttaattta gatgtaattt gcatacagtt cagccattta
     4801 aagtgtacac ttgagtggct tttagtatat ttacagttat gcaccagcac cgtaatcaat
     4861 tttaaaacac tttgatcacc caaagaaacc ctgagtccat tagcaattct ccctattccc
     4921 tcttccctct tagcctctgg ccaccactga tcttccttct ctctctgtgg atttgcctgt
     4981 tctggatagt tcatataaat gggatcatat actatgtgtc tatttgtgac tggcttctta
     5041 acatatttct gaggttcatc catgtcatag cttctatcag tatttcattt tttaaaattg
     5101 ccaaataata gtccatttta tgggtatgcc accttttttt taatccacat tggttaatgg
     5161 gcatttgagt tgtttctact ttagggctat atatatatat ttctatttct attatttatt
     5221 tttgagacac agtttcgctc ttgttgtgca ggctggagtg caatggcacg atctcggccc
     5281 actgcaacct ccacctccgg ggttcaagcg attctcctgc ctcagcctcc agagtagctg
     5341 ggattacagg catgtgccac cacgctggct aattttttgt atttttagta gagacagggt
     5401 ttcaccatgt tggtcaggct ggtctcgaac tcctgacctc aggtgatctg cccacctctt
     5461 cctcccaaag ttctgggatt acaggtgtga gccactgcac ctggccctac tttttggcta
     5521 ttatgaatag tgttgctacg aacattcccg aacaagtttt tgcagggaca ggtattttca
     5581 tgactcttgg gtatatacct aggagtggaa ttgctgagtc ataattatct ttaacctttt
     5641 caggaaccac caggtggttt ttccaagcag ctgtatcatt ttccattcca ccagcagtgt
     5701 gcgagggttc cagtttctcc acatctccac caacactcat tattttctgg tgtgaagtgg
     5761 tatctcattg tagttttttg tttttatttt ttctttttaa aatacatttt gtacagatgg
     5821 ggtttcgtta tgttgcccag gccgtctagc actcctggcc tcaagtgatc ctcctgcctt
     5881 gacctcccaa agtgccgaga ttacaggcat gagccaccac gcctggctct cattgtggtt
     5941 ttgatttgta tttccctaat gactaatgat gtcgggcacc ttttcacatg cttcaggatg
     6001 aactttctta aatatatatc tgattctgtt attcctctgc ttgaacgttt tccaaagctt
     6061 cactattgcc ccgagaataa attccacact cctgatcgca tgagcccagt aattcaaggc
     6121 tgtggtgagc tatgatcaag ccactgcact ccagcctggg cagcagagca agacctgtct
     6181 caaaaaatac atacatacat aaattccacc ctttttgata gcatgttatg aggctcacca
     6241 aggtctatcc tctggcagta tccctggcct gttctcccca tctcccctgc cctctgctca
     6301 ccagttccct aaatgtatct tgatctcact agccctacag actgtgcaca gagctgtttc
     6361 tacctccagt gacatgcttc cgcccaggct tctccccctc ccgcctcaat cttcccctca
     6421 ccaacttaag gtcttagggg cccttctagg aggcagtccc caacttccag agccagggta
     6481 taggctactt ctatgtgtcc catggtactg ccacagaaga gtctcagctc tctccaggat
     6541 tcagttctaa ggtcagtgcc taagataaaa atggagtgta attaaaattc ctcttagaaa
     6601 tctaaggaag gtgccctatt gaagaccaac atcttgaggt cccatgtagt catttcttgc
     6661 ccatgtggga acacattact gtttggttga gtaccaggtg aagtgattgg cctgcagtta
     6721 gggctgtgtt gtgcaaaaat cacttgtttt ggggtgttag aaccacattt aggcgagaag
     6781 atcacttttg gggagcttgg gaactgaggc aggccgcagg tgcagcagag gcatgagctt
     6841 gcccgggccc gccctcttgt ctatgctcat ggagtgaagg aggggccagc ggaatggccc
     6901 aaacaactga tttgtttttc tttttttaaa tctttttcag acaaatacca ttgtgtttaa
     6961 gcgaaatgtg tgtataatgc caaatcactg taccccacaa ccctgcacac ctctacactg
     7021 gactgtaatt tcttgttcct agtttgtctt gctagactgt aagctccgtg agagcaggga
     7081 ccgtgtctgc ttgttgagtg ggctttcccc tgtgcctgcc agcatgcctg gcatctagca
     7141 ggtcttctgt aaagatggga tgagtttgta aaccctccag cctcaggagt ggctccatcc
     7201 tctgaggctc tggggccctc tggcaggcta gtcatttttc tgccatgtac gtacaatgct
     7261 ttattttcat gttgtatttt cctttctagc cagtaagcaa gctcctaatg agcaagtttc
     7321 tttgtggtgt tatctctgta tcctttcatc aggccagccc agagtaagta gtgcttcgaa
     7381 agtgtttggt aaatgaatga attatggtaa cccagcccag ttctggcatc actgtctgca
     7441 ggttagtcta attccagatg aaagccccag attcgaaaaa gggaagatta ttcagaagtg
     7501 catatggttg tataagaaaa aaaaatctca ttaaatagac ctgagtaaac ttcaaatttt
     7561 gatgatctgg ccatgtcgga gctgaagctt accagctctc taaagcattt gctagggaat
     7621 catgcagatg gtccaaaata ttttttagaa aagcattcat ctgtcccggg atagaagtag
     7681 aggaagctgg taggcaggcg ctagacccta aagaaggact gctgagccag ttcttaagcc
     7741 tgtggtcctg tcggtgagga aagtgagagc agtccagagc aggtgaaaag agcagagctc
     7801 attcctccag tggctctttt gcctaaagca gcattcctca aacttctcac tcgaagcatt
     7861 aagttacggt gagatgctaa cacacgcttt agacttaagt caaaatttac tgtgaagcca
     7921 cagcaaacca tggcttcaca gatgaattag ttgctacaca aataagttcg atacataagt
     7981 acagtaattg cttttaaacc ttataataag cagtaaatta gaagttaaac catgtttttc
     8041 ttttacgaac tgaaagaaga gaatgctttt gatactgaga atcgcacact gtgtccagga
     8101 agattgttct tgcataacca gacccacaat aaatatctac aacttttctt acatgtttat
     8161 aaaataaatc ttagaagaaa aatattgtag cttttttttt tttttttttt tcaatgaagc
     8221 tctatgaaca tttcacagaa ctttgttcct gggagtagtt agggaaatgc tgcttcaaaa
     8281 agccaatttt aagtagttgt gaggcatccg agtggaattt ggctgcacta tccataaaac
     8341 ttgagagtat aggcggtatt tcacctacca aggtcagtac cctgcctcag gattcttact
     8401 gttcatttga gcaattccgg ggccctctct ggatgaccag gttcgtaaat agttgagact
     8461 ttgtgttatc tcaaattgtc accatcacct ctgggccaat ataggttagt gaggtcgaga
     8521 ggcccacacc attgacagaa gagaattctc aggccgggct tggtggctca cgcctgtaat
     8581 cccagcactt tgggaggccg aggcgggtgg atcacctgag gtcaggagtt caagagcagc
     8641 ctggccaaca tgttggaacc ccgtctctac tagaaataca aaaattagct gggcgtggtg
     8701 gtgggtacct gtagtcccag ctacttggga ggctgagaca ggagaattac ttgaacccgg
     8761 gaggcagagg ttgcagtgag gtgagatcgc gccactgcgc tccagcctgg gcgacagagc
     8821 gagactccgt ctcaaaaaaa aaagaaagga ttctcacctt cctgtccctt cctaggagtt
     8881 ttgtggtagt gttcgatcct gtgatgtggc catcttctcc tcagggcctg tgagaggcag
     8941 gcagcatctt tagctgaggt agaatgcctg ttggggaaag tcaaatagga tggtggctgg
     9001 ggccggggct ctggggactc cttctgcccc acatactcaa ttggaaagac tgagcaagtc
     9061 ccctcacctc cctgggcctc agcttccctg tctgtcaaat ggagggctca actggggtga
     9121 gctccagttt ccttctagtg ctaacgcgtg ttcaaggatc cttgctctcc tttccgggga
     9181 gcatcagggg tgtgggctag atagcaggaa agaagtaggg gtttgtaaac aagagatcca
     9241 agcccctgga cccttggtcc cagcacccag tgcagccctc gccctcccag ccccttcctt
     9301 agaaaggaca agaaaatcca ctccttgttc tctccctgtc ccatcacccc cgcagtcccc
     9361 cacagatctg aggccggagg atgccaacat ggtgagcacc ctcttgctgt cttattcacg
     9421 taggcttttc ttggtgcctg cacatggctc ttgtaaggcc accaatcttg ctggattatg
     9481 acctcatcta accttaatta cttcctaaaa gccatatgtc caagaagagc cacattgggg
     9541 gttagggctt caacatatga atttggagga catttacagt tcagtccaca gcacctggtc
     9601 atgtggagat cccagtctgc atttgtggga tgaaatctct gcttttttaa agtttacaca
     9661 ccacctagct gggcacgtgg ctcacacctg tagtctcagc actttgggag gccgaggcgg
     9721 ggatcacctg atgtcaggag ttcgagacca gcctggccaa catggtgaaa ccccgtctct
     9781 actaaaaata caaaaattag ccgggtgtgg tggcgggcac ctgtagtccc agctactcgg
     9841 gaggctgagg caggagaatc gcttgaaccc aggaggcaga ggttgcagta agctgagatt
     9901 gtgccactgc actccagtct ggatgaaaga gcaagactcc atctcaaaaa caaaaataaa
     9961 aaaagtctac acaccaaaag agctgaaggc aggagagttt gtggtggttc agagtcctga
    10021 ttctggagga aacaggcctg tttggagtcc cagctctgct ccttactagc tatgtggcct
    10081 ctcagaggca gcatccttat ctgagaaatc gggttgacct tgtaggtggc tgagaggctc
    10141 agatgagggc tcgcatgtga ggccttggca ctgagcaggg cactcctacc gagtgttcaa
    10201 aggtcgtgag taccactgct ctgcagccct gggctctggt ctcagcaatg ccgtcactct
    10261 ttctggcttc ctaagagtca gaaggcaagt gggagaatag aaccatttcc tgtgtctgaa
    10321 ggctgtgcct cagtgctttt gactcactct gaagacagca ggcagccctt tctgtttttt
    10381 ttggagatga agtcttgctc ttgtcgccca ggctggagtg caatggcgca gtctcggctc
    10441 actgcaccct ccgcctccca ggttcaagca attctcccac catagcctcc cgaagctggg
    10501 gctacaggca cacgctgcca cgcctggcta attttttgtg tttttagtaa agacagggtt
    10561 tcaccatgtt gcccaggctg gtctcaaact cctgaactca ggcgatccgc ctacctcggc
    10621 ttcccaaagt gctgggatta caggtgtcag ctaccacgcc cgacccacag gcagcccttt
    10681 cacctcacgc cgagcacgtc tcctccatcc atgaacattt tgcaactttt ttttaaagag
    10741 acaggttcat actatgttgt ctagattgga ctcaaactcc tgggctcaag ctttcccaag
    10801 tagcttgaac ctcttaagta actgtgacta caagtgcacc tggccacttt ttctgagacg
    10861 gagtctcgct ctgtcaccca agtggagtgc agtggcatga tctccgccca ctgcgagctc
    10921 cgcctcctgg gttcacgcca ttctcctgcc tcaccctcct gagtagctgg gactacaggc
    10981 acccgccacc acgcctggct aatttttttt gtatttttag tagagaccgg gtttcaccgt
    11041 gttagccagg atggtctcga tctcctgact ttgtgatccg cccgcctcgg cctcccaaag
    11101 tgctgggatt acaggcgtga gccaccgcgc ctggcccacc tgcccatttt ttaaaaactt
    11161 tattcttcct ggtatcaagg ggagaaagaa aaaaattttt taaaatattt aaaactttat
    11221 tttgaaataa tttcaaaatc acagcagttt gaagggtaca acaaagaaca ttttgccaca
    11281 ttttctcttt cattcgttcc ctcctcttct ccctcacccc tgtttcttcc tatcctctct
    11341 gaaccatgaa ccatttgagg attatttgta tacatcatgc tcgtttatcc gtaagatgtt
    11401 ttagtgaaca tttcccaaga acagggacag cctctcacat gcccatggta cagttctcaa
    11461 attcaggaaa tgtgtaatat tctctgatca gcccaggagt tgctaatttg tagttcctgt
    11521 ttcaaatttg ccaactgtcc caataatgat tttgaaagcc gttgtttttc tggtccagga
    11581 tccaatccag gatcaagcgc tgcctttagt tgtcctctct gcagcctcct ttcgtttgga
    11641 gcaggtcctc agcctttctg tctttcatga cattgatgtt tgtgaagagt acagtccagt
    11701 ttctgttgta gaacgtcctt gaagttggtc ccggaatatt tgtttaaagt gagttgggaa
    11761 accacattca catgtctttt ggttatgtgt gtatttgtca aacagccagc cttgtgctgc
    11821 gtgctgtgat ggggagcatt actcaacaga gcctggccct gaccttgggg atgtagtttg
    11881 ggtttgtggg gaaagcagct accgccaggt gggctttacg gacccctgtg tgtctcatga
    11941 ctagaggcac tgacgcttgg ataaatacat actggatgga tgcaggatga gtccgcattc
    12001 tagaagtgtg cagaggtaca gaagtggccc tgctccctgt ccagcaccca gtcatcagct
    12061 ttccctggct tcccgaggca ccctgacgtt cacactccaa acacaaagtc ttctctcagg
    12121 aatctcgagt gagctgcagt ctgggttcta gccctgccct agcagggatc tgctcagtga
    12181 ctgggctgct ctcttcctgc tttaggccaa tgcgggggag aggagaccac tgtgactctc
    12241 cccagtgccc ttggagcgca gaatgaagtg aggggaggag gagggtcacg agccctggag
    12301 cgctgggaag acaggctgta ggccgcaggc cccgatcctg cctgggacga ggttcaacag
    12361 aagtaggatg gtttcatcat gacctggcag gaaaaccacc agacctggaa ttttgctttt
    12421 acaactgttt aacttctgtt tcatacagga tggaaaccgg tgaattgtaa tctcacataa
    12481 ccgagcaaga tctagtagtc ataagcactt tgtcagagca aagcagacaa ggcaaagtgt
    12541 tggaaatgtc atcggatctt cacagaacct tagccaagca gcctttcaat gcgagaaaca
    12601 aaataacatg gatttttatc tagtaatgaa gtcaacacca ttgtccaccc tgggttaaca
    12661 cattcacatc tcaaagcgaa tggggctgca gacactcgtg ttagagagcc ttggaatgtc
    12721 ctgccttttt acgtttaatt aaaattaaat aaaatataca aaattcagtt ca
//
