LOCUS       NM_001355243             870 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens NCBP2 antisense 2 (head to head) (NCBP2AS2), mRNA.
ACCESSION   NM_001355243 NR_024388 XR_017713 XR_017724 XR_040188
VERSION     NM_001355243.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Xu,W., Deng,B., Lin,P., Liu,C., Li,B., Huang,Q., Zhou,H., Yang,J.
            and Qu,L.
  TITLE     Ribosome profiling analysis identified a KRAS-interacting
            microprotein that represses oncogenic signaling in hepatocellular
            carcinoma cells
  JOURNAL   Sci China Life Sci 63 (4), 529-542 (2020)
   PUBMED   31240521
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Kugeratski,F.G., Atkinson,S.J., Neilson,L.J., Lilla,S.,
            Knight,J.R.P., Serneels,J., Juin,A., Ismail,S., Bryant,D.M.,
            Markert,E.K., Machesky,L.M., Mazzone,M., Sansom,O.J. and Zanivan,S.
  TITLE     Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to
            promote endothelial sprouting through enhanced VEGF signaling
  JOURNAL   Sci Signal 12 (567) (2019)
   PUBMED   30723174
  REMARK    GeneRIF: The uncharacterized protein hypoxia-induced angiogenesis
            regulator (NCBP2-AS2) that was renamed HIAR (hypoxia-induced
            angiogenesis regulator) was the protein most increased in abundance
            in hypoxic cancer-associated fibroblasts (CAFs).
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062368.1 and AC011322.29.
            
            On Nov 24, 2018 this sequence version replaced NM_001355243.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK123020.1, AL832915.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000602845.2/ ENSP00000488305.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-867               BC062368.1         52-918
            868-870             AC011322.29        47049-47051         c
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..870
                     /gene="NCBP2AS2"
                     /gene_synonym="HIAR; KRASIM; NCBP2-AS2"
                     /note="NCBP2 antisense 2 (head to head)"
                     /db_xref="GeneID:152217"
                     /db_xref="HGNC:HGNC:25121"
     exon            1..870
                     /gene="NCBP2AS2"
                     /gene_synonym="HIAR; KRASIM; NCBP2-AS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..343
                     /gene="NCBP2AS2"
                     /gene_synonym="HIAR; KRASIM; NCBP2-AS2"
                     /note="NCBP2 antisense gene protein 2; hypoxia-induced
                     angiogenesis regulator; NCBP2 antisense RNA 2 (head to
                     head); KRAS-interacting microprotein"
                     /codon_start=1
                     /product="protein NCBP2AS2"
                     /protein_id="NP_001342172.1"
                     /db_xref="CCDS:CCDS87189.1"
                     /db_xref="GeneID:152217"
                     /db_xref="HGNC:HGNC:25121"
                     /translation="MVLRRLLAALLHSPQLVERLSESRPIRRAAQLTAFALLQAQLRG
                     QDAARRLQDLAAGPVGSLCRRAERFRDAFTQELRRGLRGRSGPPPGSQRGPGANI"
     regulatory      846..851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCBP2AS2"
                     /gene_synonym="HIAR; KRASIM; NCBP2-AS2"
                     /note="hexamer: AATAAA"
     polyA_site      870
                     /gene="NCBP2AS2"
                     /gene_synonym="HIAR; KRASIM; NCBP2-AS2"
                     /note="major polyA site"
ORIGIN      
        1 gaagacgagg gcggcgaggt cgggttccgg gcgcttggag aagatggtgc tgcggcggct
       61 gctggccgcc ctgctgcaca gcccgcagct ggtggaacgt ctgtcagagt cgcggcctat
      121 ccgacgtgcg gcgcagctca cggccttcgc actgctgcag gcccagctgc ggggccagga
      181 cgcggcccgc cgcctgcagg acctcgcggc tgggcccgtg ggctccctgt gccgccgcgc
      241 tgagcgattt agagacgcct tcacccagga gctacgccgc ggcctccgag gccgctcggg
      301 gccaccacca ggtagccaga ggggccctgg cgcaaacatt taatcctggg ctgtgcgggg
      361 ccgaggccgc ttgcttttcc ttccgggctc tacagtggca tcaatgtgga ggggtcattc
      421 cgggcactgc gcgcggcttc gaatcccgac tgggattgtt ggcctgcaga catcccacgc
      481 ataagagcct aggccagacc gcccgctccg ttgaagtctt gtgattggac aagacacagt
      541 gtggagacag ccctaagcct aacagagatg aaggtaggct gggtccagac acggcaccta
      601 cggagagcca cggaccgaag ccagagagcc tttcctctgc aagtgggact gaaactcttg
      661 acagatgctg ctcaatctga ctggtatagc aggacagtta attccaggga cgatatggat
      721 gaaaagacaa ccctacagct gccaaattcc tttgattaaa tgtgtgagct ggttgatagg
      781 catgagtgtg atacttctca ggcaagatgt gttaagaata ccggggactg taggcctatg
      841 gtaataataa acacgtattt tatgaaatga
//
