LOCUS       NM_007362               2101 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens nuclear cap binding protein subunit 2 (NCBP2),
            transcript variant 1, mRNA.
ACCESSION   NM_007362
VERSION     NM_007362.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2101)
  AUTHORS   Xu,X., Zhao,Y., Ying,Y., Zhu,H., Luo,J., Mou,T. and Zhang,Z.
  TITLE     m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in
            head and neck squamous cell carcinoma by regulating CCL4/CCL5
            expression
  JOURNAL   Mol Carcinog 62 (8), 1091-1106 (2023)
   PUBMED   37067401
  REMARK    GeneRIF: m7G-related genes-NCBP2 and EIF4E3 determine immune
            contexture in head and neck squamous cell carcinoma by regulating
            CCL4/CCL5 expression.
REFERENCE   2  (bases 1 to 2101)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2101)
  AUTHORS   Schob,C., Hempel,M., Safka Brozkova,D., Jiang,H., Kim,S.Y.,
            Batzir,N.A., Orenstein,N., Bierhals,T., Johannsen,J., Uhrova
            Meszarosova,A., Chae,J.H., Seeman,P., Woidy,M., Fang,F.,
            Kubisch,C., Kindler,S. and Denecke,J.
  TITLE     Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic
            Paraplegia
  JOURNAL   Ann Neurol 90 (5), 738-750 (2021)
   PUBMED   34564892
REFERENCE   4  (bases 1 to 2101)
  AUTHORS   Dou,Y., Kalmykova,S., Pashkova,M., Oghbaie,M., Jiang,H.,
            Molloy,K.R., Chait,B.T., Rout,M.P., Fenyo,D., Jensen,T.H.,
            Altukhov,I. and LaCava,J.
  TITLE     Affinity proteomic dissection of the human nuclear cap-binding
            complex interactome
  JOURNAL   Nucleic Acids Res 48 (18), 10456-10469 (2020)
   PUBMED   32960270
  REMARK    GeneRIF: Affinity proteomic dissection of the human nuclear
            cap-binding complex interactome.
REFERENCE   5  (bases 1 to 2101)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2101)
  AUTHORS   Colot,H.V., Stutz,F. and Rosbash,M.
  TITLE     The yeast splicing factor Mud13p is a commitment complex component
            and corresponds to CBP20, the small subunit of the nuclear
            cap-binding complex
  JOURNAL   Genes Dev 10 (13), 1699-1708 (1996)
   PUBMED   8682299
REFERENCE   7  (bases 1 to 2101)
  AUTHORS   Visa,N., Izaurralde,E., Ferreira,J., Daneholt,B. and Mattaj,I.W.
  TITLE     A nuclear cap-binding complex binds Balbiani ring pre-mRNA
            cotranscriptionally and accompanies the ribonucleoprotein particle
            during nuclear export
  JOURNAL   J Cell Biol 133 (1), 5-14 (1996)
   PUBMED   8601613
REFERENCE   8  (bases 1 to 2101)
  AUTHORS   Kataoka,N., Ohno,M., Moda,I. and Shimura,Y.
  TITLE     Identification of the factors that interact with NCBP, an 80 kDa
            nuclear cap binding protein
  JOURNAL   Nucleic Acids Res 23 (18), 3638-3641 (1995)
   PUBMED   7478990
REFERENCE   9  (bases 1 to 2101)
  AUTHORS   Izaurralde,E., Lewis,J., Gamberi,C., Jarmolowski,A., McGuigan,C.
            and Mattaj,I.W.
  TITLE     A cap-binding protein complex mediating U snRNA export
  JOURNAL   Nature 376 (6542), 709-712 (1995)
   PUBMED   7651522
REFERENCE   10 (bases 1 to 2101)
  AUTHORS   Izaurralde,E., Lewis,J., McGuigan,C., Jankowska,M.,
            Darzynkiewicz,E. and Mattaj,I.W.
  TITLE     A nuclear cap binding protein complex involved in pre-mRNA splicing
  JOURNAL   Cell 78 (4), 657-668 (1994)
   PUBMED   8069914
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011322.29.
            
            On Aug 31, 2019 this sequence version replaced NM_007362.4.
            
            Summary: The product of this gene is a component of the nuclear
            cap-binding protein complex (CBC), which binds to the
            monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The
            encoded protein has an RNP domain commonly found in RNA binding
            proteins, and contains the cap-binding activity. The CBC promotes
            pre-mRNA splicing, 3'-end processing, RNA nuclear export, and
            nonsense-mediated mRNA decay. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001255.1, SRR11853567.22307.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMN03267755
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321256.10/ ENSP00000326806.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC011322.29        48064-48166
            104-285             AC011322.29        51160-51341
            286-424             AC011322.29        52944-53082
            425-2101            AC011322.29        53510-55186
FEATURES             Location/Qualifiers
     source          1..2101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..2101
                     /gene="NCBP2"
                     /gene_synonym="CBC2; CBP20; NIP1; PIG55"
                     /note="nuclear cap binding protein subunit 2"
                     /db_xref="GeneID:22916"
                     /db_xref="HGNC:HGNC:7659"
                     /db_xref="MIM:605133"
     exon            1..103
                     /gene="NCBP2"
                     /gene_synonym="CBC2; CBP20; NIP1; PIG55"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..496
                     /gene="NCBP2"
                     /gene_synonym="CBC2; CBP20; NIP1; PIG55"
                     /note="isoform 1 is encoded by transcript variant 1; NCBP
                     interacting protein 1; NCBP 20 kDa subunit; nuclear cap
                     binding protein subunit 2, 20kD; 20 kDa nuclear
                     cap-binding protein; cell proliferation-inducing gene 55
                     protein; nuclear cap binding protein subunit 2, 20kDa"
                     /codon_start=1
                     /product="nuclear cap-binding protein subunit 2 isoform 1"
                     /protein_id="NP_031388.2"
                     /db_xref="CCDS:CCDS3323.1"
                     /db_xref="GeneID:22916"
                     /db_xref="HGNC:HGNC:7659"
                     /db_xref="MIM:605133"
                     /translation="MSGGLLKALRSDSYVELSQYRDQHFRGDNEEQEKLLKKSCTLYV
                     GNLSFYTTEEQIYELFSKSGDIKKIIMGLDKMKKTACGFCFVEYYSRADAENAMRYIN
                     GTRLDDRIIRTDWDAGFKEGRQYGRGRSGGQVRDEYRQDYDAGRGGYGKLAQNQ"
     exon            104..285
                     /gene="NCBP2"
                     /gene_synonym="CBC2; CBP20; NIP1; PIG55"
                     /inference="alignment:Splign:2.1.0"
     exon            286..424
                     /gene="NCBP2"
                     /gene_synonym="CBC2; CBP20; NIP1; PIG55"
                     /inference="alignment:Splign:2.1.0"
     exon            425..2101
                     /gene="NCBP2"
                     /gene_synonym="CBC2; CBP20; NIP1; PIG55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      636..641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCBP2"
                     /gene_synonym="CBC2; CBP20; NIP1; PIG55"
                     /note="hexamer: ATTAAA"
     polyA_site      656
                     /gene="NCBP2"
                     /gene_synonym="CBC2; CBP20; NIP1; PIG55"
                     /note="major polyA site"
     regulatory      2081..2086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCBP2"
                     /gene_synonym="CBC2; CBP20; NIP1; PIG55"
                     /note="hexamer: AATAAA"
     polyA_site      2101
                     /gene="NCBP2"
                     /gene_synonym="CBC2; CBP20; NIP1; PIG55"
ORIGIN      
        1 gcattgtggt ccgcttctct gcactatgtc gggtggcctc ctgaaggcgc tgcgcagcga
       61 ctcctacgtg gagctgagcc agtaccggga ccagcacttc cggggtgaca atgaagaaca
      121 agaaaaatta ctgaagaaaa gctgtacgtt atatgttgga aatctttctt tttacacaac
      181 tgaagaacaa atctatgaac tcttcagcaa aagtggtgac ataaagaaaa tcattatggg
      241 tctggataaa atgaagaaaa cagcatgtgg attctgtttt gtggaatatt actcacgcgc
      301 agatgcggaa aacgccatgc ggtacataaa tgggacgcgt ctggatgacc gaatcattcg
      361 cacagactgg gacgcaggct ttaaggaggg caggcaatac ggccgtgggc gatctggggg
      421 ccaggttcgg gatgagtatc ggcaggacta cgatgctggg agaggaggct atggaaaact
      481 ggcacagaac cagtgagtgg tgagagctct gtcagtgaca aacactcctt tggcctgttg
      541 aatttgctga agaacatcac ctaaagtctg cacacgagcc catttttacc aagatttgat
      601 cagtgtcttt actgagctgg aagcctctga aagttattaa aggacagaat ccaaaagaat
      661 gcctttaatt cttgtctgag aatcttggcc atgtgtcaga ttatcagaac aattttgtta
      721 ccaggtcaga aattgtgttc tttgacaaca gattggatct gtaatgttga ttagtcttta
      781 gccataacca ctacactttt agaaagacag aaaaatgtaa gaatttgttt ttaccataat
      841 gagtcttaag taggttcatg atctacattg gggcctggga ttattttttt aattttaagt
      901 ttgcatgaga tagcctaata aatggaggtg gggccaggca tggtggctca cacgtgtaat
      961 cccaacactt tgggaggctg aggaggaagg atagcttgag gccaggagtt tgagactaga
     1021 ctgggcaaca tagcaagacc ccgtctctac aaagcacaac gaaaaacaac aaatggagtt
     1081 gtgctatgtt gtattgcttt gcacaaaatt aggaacaggt gtttgacaat tgaatttgtt
     1141 ttctgtgaat tctaacctct aaaggcatgc ttagaggtca aggaccttcc tgtgtagttg
     1201 gtgcaaaagc aatctccaca ggacagcact gcttccatgc ttcatacatc aggaaatgag
     1261 gccagaactt gagtatttac taacacgttt ttcaaaagat gtcagtgtta tacctaaagc
     1321 taaaaaaaag caagggtttg tcatagaggg aacctctaaa taatttcagg ggtaggggag
     1381 atgttgtcaa taggaaatgg gataaaatat caagagacaa tgaaaacact gccttgacat
     1441 gaggaccagc aagtttattc ttttcatttt cagtgatgtt gggaatggac tgggttttaa
     1501 aagggagctt gaagagggaa tgtttgacag tcacagaagg ttcctgcagc agatgcctct
     1561 tttagccatt tctcattttt ttcctcaaat tttacctact gaggctcaag ccttcacagt
     1621 gagctgatgg tctctacagg gaggggagtc tagggaattt atttggtatt tgtaaggcaa
     1681 gaggtgattt ctctctaata tatctgagtt attgctcatt taaaactgtt aagtccagta
     1741 taattttccc tgatatgaaa aaatgtgcat ttttttcact tagcaacaaa gtaccttcta
     1801 atttccaata gtccgtgaaa gttggggctg aagtacctaa gtgtgaatgt ctctcccgtt
     1861 aaactgagtg tagaaatctg aatttttaaa agagctgtaa ctagttgtaa gtgcttagga
     1921 agaaactttg caaacattta atgaggatac actgttcatt tttaaaattc cttcacactg
     1981 taatttaatg tgttttatat tcttttgtag taaaacaaca taactcagat ttctacagga
     2041 gacagtggtt ttattcggat tgtcttctgt aataggtttc aataaagctg gatgaactta
     2101 t
//
