LOCUS       NM_002486               4983 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nuclear cap binding protein subunit 1 (NCBP1),
            transcript variant 1, mRNA.
ACCESSION   NM_002486
VERSION     NM_002486.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4983)
  AUTHORS   Li,J., Zheng,L., Song,L., Dong,Z., Bai,W. and Qi,L.
  TITLE     Identification and validation of N7 -methylguanosine-associated
            gene NCBP1 as prognostic and immune-associated biomarkers in breast
            cancer patients
  JOURNAL   J Cell Mol Med 28 (2), e18067 (2024)
   PUBMED   38071502
  REMARK    GeneRIF: Identification and validation of N[7]
            -methylguanosine-associated gene NCBP1 as prognostic and
            immune-associated biomarkers in breast cancer patients.
REFERENCE   2  (bases 1 to 4983)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4983)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4983)
  AUTHORS   Schob,C., Hempel,M., Safka Brozkova,D., Jiang,H., Kim,S.Y.,
            Batzir,N.A., Orenstein,N., Bierhals,T., Johannsen,J., Uhrova
            Meszarosova,A., Chae,J.H., Seeman,P., Woidy,M., Fang,F.,
            Kubisch,C., Kindler,S. and Denecke,J.
  TITLE     Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic
            Paraplegia
  JOURNAL   Ann Neurol 90 (5), 738-750 (2021)
   PUBMED   34564892
REFERENCE   5  (bases 1 to 4983)
  AUTHORS   Park,Y., Park,J., Hwang,H.J., Kim,L., Jeong,K., Song,H.K.,
            Rufener,S.C., Muhlemann,O. and Kim,Y.K.
  TITLE     Translation mediated by the nuclear cap-binding complex is confined
            to the perinuclear region via a CTIF-DDX19B interaction
  JOURNAL   Nucleic Acids Res 49 (14), 8261-8276 (2021)
   PUBMED   34232997
  REMARK    GeneRIF: Translation mediated by the nuclear cap-binding complex is
            confined to the perinuclear region via a CTIF-DDX19B interaction.
REFERENCE   6  (bases 1 to 4983)
  AUTHORS   Kataoka,N., Ohno,M., Moda,I. and Shimura,Y.
  TITLE     Identification of the factors that interact with NCBP, an 80 kDa
            nuclear cap binding protein
  JOURNAL   Nucleic Acids Res 23 (18), 3638-3641 (1995)
   PUBMED   7478990
REFERENCE   7  (bases 1 to 4983)
  AUTHORS   Izaurralde,E., Lewis,J., Gamberi,C., Jarmolowski,A., McGuigan,C.
            and Mattaj,I.W.
  TITLE     A cap-binding protein complex mediating U snRNA export
  JOURNAL   Nature 376 (6542), 709-712 (1995)
   PUBMED   7651522
REFERENCE   8  (bases 1 to 4983)
  AUTHORS   Kataoka,N., Ohno,M., Kangawa,K., Tokoro,Y. and Shimura,Y.
  TITLE     Cloning of a complementary DNA encoding an 80 kilodalton nuclear
            cap binding protein
  JOURNAL   Nucleic Acids Res 22 (19), 3861-3865 (1994)
   PUBMED   7937105
REFERENCE   9  (bases 1 to 4983)
  AUTHORS   Izaurralde,E., Lewis,J., McGuigan,C., Jankowska,M.,
            Darzynkiewicz,E. and Mattaj,I.W.
  TITLE     A nuclear cap binding protein complex involved in pre-mRNA splicing
  JOURNAL   Cell 78 (4), 657-668 (1994)
   PUBMED   8069914
REFERENCE   10 (bases 1 to 4983)
  AUTHORS   Ohno,M., Kataoka,N. and Shimura,Y.
  TITLE     A nuclear cap binding protein from HeLa cells
  JOURNAL   Nucleic Acids Res 18 (23), 6989-6995 (1990)
   PUBMED   2148205
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001450.2, AL445531.10 and
            CA418527.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002486.4.
            
            Summary: The product of this gene is a component of the nuclear
            cap-binding protein complex (CBC), which binds to the
            monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The
            encoded protein promotes high-affinity mRNA-cap binding and
            associates with the CTD of RNA polymerase II. The CBC promotes
            pre-mRNA splicing, 3'-end processing, RNA nuclear export, and
            nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.283175.1,
                                           SRR1660809.55272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375147.8/ ENSP00000364289.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2492              BC001450.2         3-2494
            2493-4673           AL445531.10        787-2967
            4674-4983           CA418527.1         16-325              c
FEATURES             Location/Qualifiers
     source          1..4983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..4983
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /note="nuclear cap binding protein subunit 1"
                     /db_xref="GeneID:4686"
                     /db_xref="HGNC:HGNC:7658"
                     /db_xref="MIM:600469"
     exon            1..95
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2434
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /note="isoform 1 is encoded by transcript variant 1; NCBP
                     80 kDa subunit; 80 kDa nuclear cap-binding protein;
                     nuclear cap binding protein subunit 1, 80kDa"
                     /codon_start=1
                     /product="nuclear cap-binding protein subunit 1 isoform 1"
                     /protein_id="NP_002477.1"
                     /db_xref="CCDS:CCDS6728.1"
                     /db_xref="GeneID:4686"
                     /db_xref="HGNC:HGNC:7658"
                     /db_xref="MIM:600469"
                     /translation="MSRRRHSDENDGGQPHKRRKTSDANETEDHLESLICKVGEKSAC
                     SLESNLEGLAGVLEADLPNYKSKILRLLCTVARLLPEKLTIYTTLVGLLNARNYNFGG
                     EFVEAMIRQLKESLKANNYNEAVYLVRFLSDLVNCHVIAAPSMVAMFENFVSVTQEED
                     VPQVRRDWYVYAFLSSLPWVGKELYEKKDAEMDRIFANTESYLKRRQKTHVPMLQVWT
                     ADKPHPQEEYLDCLWAQIQKLKKDRWQERHILRPYLAFDSILCEALQHNLPPFTPPPH
                     TEDSVYPMPRVIFRMFDYTDDPEGPVMPGSHSVERFVIEENLHCIIKSHWKERKTCAA
                     QLVSYPGKNKIPLNYHIVEVIFAELFQLPAPPHIDVMYTTLLIELCKLQPGSLPQVLA
                     QATEMLYMRLDTMNTTCVDRFINWFSHHLSNFQFRWSWEDWSDCLSQDPESPKPKFVR
                     EVLEKCMRLSYHQRILDIVPPTFSALCPANPTCIYKYGDESSNSLPGHSVALCLAVAF
                     KSKATNDEIFSILKDVPNPNQDDDDDEGFSFNPLKIEVFVQTLLHLAAKSFSHSFSAL
                     AKFHEVFKTLAESDEGKLHVLRVMFEVWRNHPQMIAVLVDKMIRTQIVDCAAVANWIF
                     SSELSRDFTRLFVWEILHSTIRKMNKHVLKIQKELEEAKEKLARQHKRRSDDDDRSSD
                     RKDGVLEEQIERLQEKVESAQSEQKNLFLVIFQRFIMILTEHLVRCETDGTSVLTPWY
                     KNCIERLQQIFLQHHQIIQQYMVTLENLLFTAELDPHILAVFQQFCALQA"
     exon            96..184
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..285
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..442
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..550
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..672
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..742
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..958
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1056
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1120
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1231
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1296
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1359
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1434
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1538
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1661
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1764
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1858
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1962
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2077
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2206
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2320
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..4983
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2847..2852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /note="hexamer: ACTAAA"
     polyA_site      2867
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /note="major polyA site"
     regulatory      4831..4836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /note="hexamer: AATAAA"
     polyA_site      4857
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
     regulatory      4927..4932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
                     /note="hexamer: AATAAA"
     polyA_site      4949
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
     polyA_site      4983
                     /gene="NCBP1"
                     /gene_synonym="CBP80; NCBP; Sto1"
ORIGIN      
        1 agacagttcc tgcagcgctt accgcctggc ctctcggttc cgcggcgcac cggagggcag
       61 catgtcgcgg cggcggcaca gcgacgagaa cgacggtggg cagcctcaca aaaggagaaa
      121 gacctctgat gcaaatgaaa ctgaagatca tttggaatct ttaatatgta aagtaggaga
      181 aaagagtgcc tgctctttgg agagcaacct agaaggcttg gctggtgttt tggaagctga
      241 tcttcctaac tacaagagca agatcttaag gcttctttgt acagttgcac gcctattacc
      301 tgagaagctg acaatttata caacattagt tggactactg aatgccagga attacaattt
      361 tggtggagaa tttgtagaag ccatgattcg tcaacttaaa gaatcattga aagcaaacaa
      421 ttataatgaa gccgtgtatt tggtccgttt tttatctgat cttgtgaatt gtcatgtgat
      481 tgccgcccca tcaatggttg ctatgtttga aaattttgta agcgtaactc aggaagaaga
      541 tgtacctcag gtgcgacgag attggtatgt gtatgcattt ctgtcatctt tgccctgggt
      601 tggaaaggag ttgtacgaaa agaaagatgc agagatggac cgcatctttg ccaacactga
      661 aagctatctt aaaagacgcc aaaagactca tgtacccatg ttacaggtat ggactgctga
      721 taaaccacat ccacaagaag agtatttaga ttgcctgtgg gcccagattc agaaattgaa
      781 aaaggatcgc tggcaggaac ggcacatcct aagaccttat cttgcctttg acagcatcct
      841 gtgtgaagca ctgcagcaca atctgcctcc ttttacacca cctcctcaca ctgaagattc
      901 agtgtaccca atgccaaggg tcatcttcag aatgtttgat tacacagatg atcccgaggg
      961 tcctgtcatg ccagggagtc attcagtgga aagatttgta atagaagaga atcttcactg
     1021 catcattaag tcccactgga aggaaaggaa gacttgtgct gcacagttag tgagctatcc
     1081 agggaagaac aagatcccct tgaactacca catagttgag gtgatctttg cagagctgtt
     1141 tcaacttcca gcaccccctc acattgatgt gatgtacaca acactcctca ttgaactgtg
     1201 caaacttcaa cctggctctc taccccaagt tcttgcacag gcaactgaaa tgctatacat
     1261 gcgtttggac acaatgaaca ctacctgtgt agacaggttt attaattggt tttctcatca
     1321 tctaagtaac ttccagttcc gttggagctg ggaagattgg tcagattgtc ttagtcaaga
     1381 tcctgaaagt cccaaaccga agtttgtaag agaagttcta gaaaaatgta tgaggttgtc
     1441 ttaccatcag cgtatattag atattgttcc tcctaccttc tcagctctgt gtcctgcaaa
     1501 cccaacctgc atttacaagt atggagatga aagtagcaat tctcttcctg gacattctgt
     1561 tgccctctgt ttagctgttg cctttaaaag taaggcaacc aatgatgaaa tcttcagcat
     1621 tctgaaagat gtaccaaatc ctaaccagga tgatgacgac gatgaaggat tcagttttaa
     1681 cccattgaaa atagaagtct ttgtacagac tctgctacac ttggcagcca aatcattcag
     1741 ccactccttc agtgctcttg caaagtttca tgaagtcttc aaaaccctag ctgaaagtga
     1801 tgaaggaaag ttacatgtgc taagagttat gtttgaggtc tggaggaacc atccacagat
     1861 gattgctgta ctagtggata agatgattcg tacacaaata gttgattgtg ctgccgtagc
     1921 aaattggatc ttctcttcag aactatctcg tgactttacc agattgtttg tttgggaaat
     1981 tttgcactct acaattcgta agatgaacaa acatgtcctg aagatccaga aagagctgga
     2041 agaagctaaa gagaaacttg ctaggcaaca caaacggcga agtgatgatg acgacagaag
     2101 cagtgacagg aaagacgggg ttcttgagga acaaatagaa cgacttcagg aaaaagtgga
     2161 atctgctcag agtgaacaaa agaatctttt cctcgttata tttcagcggt ttatcatgat
     2221 cttgaccgag cacctagtac gatgcgaaac tgatgggacc agtgtattaa caccatggta
     2281 taagaactgt atagagaggc tgcagcagat cttcctacag catcaccaaa taatccagca
     2341 gtacatggtg accctggaga accttctctt cactgctgaa ttagaccctc atatcttggc
     2401 cgtgttccag cagttctgtg ccctgcaggc ctaagggtca ttttttcctc atgtcaaggt
     2461 tttttttgat atcttaaaat aatttgtctt attttttgat ggtttgaatg cttgctttct
     2521 tgtagtatcc tttcacttct taaaggaaac aaaggggaag aggacagtga atgaacatgg
     2581 cattactttt aattgccctg aaaagcaaat acttcctaac ggcagtaatg tgactatgac
     2641 catgatatat tatatatgtg acagatacaa attctctgtg atcagtttgt tatttttttt
     2701 ctccttaagg cacaaaataa ttggtttgag gtatgtgaaa cactagaggt caaccttaca
     2761 tagtatatag aactgatggg tttacccagc tacccagtag cataactttt cacagctcgg
     2821 ggatgaatta acatggctga aataaaacta aaagtatggt ttttaaactt tggcatttca
     2881 tgatttatca tctcactcta ctctaaaact ggtggtttct tactgaaggt gttctccatt
     2941 tgaaatttta tcttcaaagt atttttaagt agtatcttta agacatgact tgttagtaat
     3001 aaaagtgtta ctagttggaa gagtagctct caaatttgtc ttaatgtaaa tcacctggga
     3061 atctttcaag ttattttgaa atttaaacca ccgtctgggg gtggaacgca gacatcctca
     3121 gtaatcctta aagtttcccc aggtgattcc aggtttggtc accattatct tagagcatct
     3181 actcacttcc tctagccttg gggttatttg tccaaggtct tgtagtgagt tacagaatac
     3241 taaagtggat gtagaagtgg tcagattgac tgaaactata ccctgaatta gatgtgagtt
     3301 tagattttgt ttatatggaa cctgatccaa aaaactacga agtcctgagc ttgtttcctg
     3361 tatagtactg atgctgaaat aagatgacag cagtttgtaa aataatacac aaatatgagg
     3421 aattgtctga cattccaaat ttcgaggatt tttagacttt tttcattaaa ccttagaaaa
     3481 aaattaccag taatcctaca actactggta gtgttgttgt gcatttgcac aaaataggta
     3541 taattttttc ttattacatc ccaagtttat gatgcattaa gcgttttgca tattttgata
     3601 tatttttgct ttggtttacc atacatttta gtggctacag aatgtagtct gcttaataaa
     3661 tgggaattcc tagaatgttt aaataccata ctatttaaga caaaatacaa aatatccaga
     3721 aaaatccagg ttgcgtggct ggttagtaaa ggactaaaac ccaggttctt ggctaaatgt
     3781 tttcgtttat actgtttatc tttcccattg cttaagcaca gcacaaacta tgtaattata
     3841 tataattaca gttgaccctt gaacaacatg ggtttgaact gtgtgagtct ccttacacac
     3901 aggttttctt ccacccctga gatggcaaga ccagcccctt gtcttcctca gcctgctcaa
     3961 cgtgaagatg atgaggatga agacctttat gatgatccac ttctacttat taaatagtaa
     4021 atatattttt ttcttatgat tttattttct tttctctagc ttcataagaa tatagcatat
     4081 gggctgggcg cagtggctca cgcctgtaat cccagcactt tgggaggctg aggcgggcgg
     4141 atcacaaggt caggagattg agaccatcct ggctaacaca gtgaaaccct gtctctacta
     4201 aaaacacaaa aacttagcca ggcgtggtgg tacatggctg tagtcccagc tacttgggag
     4261 gctgagacag gagaatcgct tgaacctggg aggtggaggt ttcagtgagc caagattgtg
     4321 ccactgcact ccagcctggg tgatggagcg aggctctgtc tcaaaaaaga aaaaaaatat
     4381 atagcatata acatacaaaa tgagtttatc aactgtttgt tattggtaag tcagcagtgg
     4441 gctattggtg gttaagtttt gggggagtca aaagttacat gcaaattttt tactgtgcgg
     4501 ggtgtcagca tccctaaccc catgttgttc aagggtcaac tgtagtttaa aatgactcct
     4561 gtctcaaaaa accaaaggat aacctttaag ggattggtaa ctttgactca aaactgcttt
     4621 gtaatctttt cacaatgtac tgaaaagtgt ggctagttat gtttgatcca cattctagag
     4681 aaatttgtag gttttaattt cttttctctt ggtcctctct tcatgtataa tggttgcttt
     4741 taacagctgt tcgctgatgt ggtcctgctc tgtcccagtc tagcagcttt agtgtatgga
     4801 aaaattgaac taggaattga gttttgaaga aataaaggtg taagagcaaa cattcaacag
     4861 ttgctgtccc cagtaatgaa gttcatacag acaaaagatg gcatgtcact gtacatcata
     4921 ccttgcaata aatattctgt taaattgtgc tggtgcaatt taacatgctt ttgtcaaagt
     4981 aaa
//
